JP2013545762A5 - - Google Patents
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- Publication number
- JP2013545762A5 JP2013545762A5 JP2013541248A JP2013541248A JP2013545762A5 JP 2013545762 A5 JP2013545762 A5 JP 2013545762A5 JP 2013541248 A JP2013541248 A JP 2013541248A JP 2013541248 A JP2013541248 A JP 2013541248A JP 2013545762 A5 JP2013545762 A5 JP 2013545762A5
- Authority
- JP
- Japan
- Prior art keywords
- lacosamide
- weight
- formulation
- matrix
- hours
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- VPPJLAIAVCUEMN-GFCCVEGCSA-N lacosamide Chemical compound COC[C@@H](NC(C)=O)C(=O)NCC1=CC=CC=C1 VPPJLAIAVCUEMN-GFCCVEGCSA-N 0.000 claims 49
- 229960002623 lacosamide Drugs 0.000 claims 49
- 239000000203 mixture Substances 0.000 claims 35
- 238000009472 formulation Methods 0.000 claims 34
- 239000011159 matrix material Substances 0.000 claims 20
- 238000002360 preparation method Methods 0.000 claims 10
- 239000003795 chemical substances by application Substances 0.000 claims 7
- 238000013270 controlled release Methods 0.000 claims 6
- 238000010828 elution Methods 0.000 claims 6
- 238000000338 in vitro Methods 0.000 claims 6
- 239000000654 additive Substances 0.000 claims 5
- 239000007864 aqueous solution Substances 0.000 claims 5
- 239000001866 hydroxypropyl methyl cellulose Substances 0.000 claims 5
- 229920003088 hydroxypropyl methyl cellulose Polymers 0.000 claims 5
- 235000010979 hydroxypropyl methyl cellulose Nutrition 0.000 claims 5
- UFVKGYZPFZQRLF-UHFFFAOYSA-N hydroxypropyl methyl cellulose Chemical compound OC1C(O)C(OC)OC(CO)C1OC1C(O)C(O)C(OC2C(C(O)C(OC3C(C(O)C(O)C(CO)O3)O)C(CO)O2)O)C(CO)O1 UFVKGYZPFZQRLF-UHFFFAOYSA-N 0.000 claims 5
- 230000036470 plasma concentration Effects 0.000 claims 5
- 229920002153 Hydroxypropyl cellulose Polymers 0.000 claims 4
- 239000011230 binding agent Substances 0.000 claims 4
- -1 hydroxypropyl Chemical group 0.000 claims 4
- 239000001863 hydroxypropyl cellulose Substances 0.000 claims 4
- 235000010977 hydroxypropyl cellulose Nutrition 0.000 claims 4
- 239000000314 lubricant Substances 0.000 claims 4
- 238000000034 method Methods 0.000 claims 4
- 239000000546 pharmaceutical excipient Substances 0.000 claims 4
- 229920002678 cellulose Polymers 0.000 claims 3
- 239000003085 diluting agent Substances 0.000 claims 3
- 229920000609 methyl cellulose Polymers 0.000 claims 3
- 241001465754 Metazoa Species 0.000 claims 2
- 239000002202 Polyethylene glycol Substances 0.000 claims 2
- XTXRWKRVRITETP-UHFFFAOYSA-N Vinyl acetate Chemical class CC(=O)OC=C XTXRWKRVRITETP-UHFFFAOYSA-N 0.000 claims 2
- 238000010521 absorption reaction Methods 0.000 claims 2
- 230000000996 additive effect Effects 0.000 claims 2
- 239000001913 cellulose Substances 0.000 claims 2
- 235000014113 dietary fatty acids Nutrition 0.000 claims 2
- 238000001647 drug administration Methods 0.000 claims 2
- 239000000194 fatty acid Substances 0.000 claims 2
- 229930195729 fatty acid Natural products 0.000 claims 2
- 229920001477 hydrophilic polymer Polymers 0.000 claims 2
- 239000000463 material Substances 0.000 claims 2
- 239000001923 methylcellulose Substances 0.000 claims 2
- 235000010981 methylcellulose Nutrition 0.000 claims 2
- 229920001223 polyethylene glycol Polymers 0.000 claims 2
- 230000002265 prevention Effects 0.000 claims 2
- 239000007787 solid Substances 0.000 claims 2
- LNAZSHAWQACDHT-XIYTZBAFSA-N (2r,3r,4s,5r,6s)-4,5-dimethoxy-2-(methoxymethyl)-3-[(2s,3r,4s,5r,6r)-3,4,5-trimethoxy-6-(methoxymethyl)oxan-2-yl]oxy-6-[(2r,3r,4s,5r,6r)-4,5,6-trimethoxy-2-(methoxymethyl)oxan-3-yl]oxyoxane Chemical compound CO[C@@H]1[C@@H](OC)[C@H](OC)[C@@H](COC)O[C@H]1O[C@H]1[C@H](OC)[C@@H](OC)[C@H](O[C@H]2[C@@H]([C@@H](OC)[C@H](OC)O[C@@H]2COC)OC)O[C@@H]1COC LNAZSHAWQACDHT-XIYTZBAFSA-N 0.000 claims 1
- 239000004925 Acrylic resin Substances 0.000 claims 1
- 229920000178 Acrylic resin Polymers 0.000 claims 1
- 206010010904 Convulsion Diseases 0.000 claims 1
- 239000001856 Ethyl cellulose Substances 0.000 claims 1
- ZZSNKZQZMQGXPY-UHFFFAOYSA-N Ethyl cellulose Chemical compound CCOCC1OC(OC)C(OCC)C(OCC)C1OC1C(O)C(O)C(OC)C(CO)O1 ZZSNKZQZMQGXPY-UHFFFAOYSA-N 0.000 claims 1
- 229920000663 Hydroxyethyl cellulose Polymers 0.000 claims 1
- 239000004354 Hydroxyethyl cellulose Substances 0.000 claims 1
- 229920000881 Modified starch Polymers 0.000 claims 1
- WHNWPMSKXPGLAX-UHFFFAOYSA-N N-Vinyl-2-pyrrolidone Chemical class C=CN1CCCC1=O WHNWPMSKXPGLAX-UHFFFAOYSA-N 0.000 claims 1
- 239000006057 Non-nutritive feed additive Substances 0.000 claims 1
- 229920002472 Starch Polymers 0.000 claims 1
- 229920003086 cellulose ether Polymers 0.000 claims 1
- 208000015114 central nervous system disease Diseases 0.000 claims 1
- 239000011248 coating agent Substances 0.000 claims 1
- 238000000576 coating method Methods 0.000 claims 1
- 238000004090 dissolution Methods 0.000 claims 1
- 206010015037 epilepsy Diseases 0.000 claims 1
- 229920001249 ethyl cellulose Polymers 0.000 claims 1
- 235000019325 ethyl cellulose Nutrition 0.000 claims 1
- 239000001761 ethyl methyl cellulose Substances 0.000 claims 1
- 235000010944 ethyl methyl cellulose Nutrition 0.000 claims 1
- 239000003925 fat Substances 0.000 claims 1
- 150000004665 fatty acids Chemical class 0.000 claims 1
- 150000002191 fatty alcohols Chemical class 0.000 claims 1
- 150000004676 glycans Chemical class 0.000 claims 1
- 230000002209 hydrophobic effect Effects 0.000 claims 1
- 235000019447 hydroxyethyl cellulose Nutrition 0.000 claims 1
- 239000012729 immediate-release (IR) formulation Substances 0.000 claims 1
- 150000002632 lipids Chemical class 0.000 claims 1
- 235000019426 modified starch Nutrition 0.000 claims 1
- 229920000728 polyester Polymers 0.000 claims 1
- 229920000642 polymer Polymers 0.000 claims 1
- 229920001282 polysaccharide Polymers 0.000 claims 1
- 239000005017 polysaccharide Substances 0.000 claims 1
- 102000004169 proteins and genes Human genes 0.000 claims 1
- 108090000623 proteins and genes Proteins 0.000 claims 1
- 239000008107 starch Substances 0.000 claims 1
- 235000019698 starch Nutrition 0.000 claims 1
- 239000001993 wax Substances 0.000 claims 1
Applications Claiming Priority (17)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US41915810P | 2010-12-02 | 2010-12-02 | |
| US41915310P | 2010-12-02 | 2010-12-02 | |
| EP10193561A EP2468261A1 (en) | 2010-12-02 | 2010-12-02 | Formulation of lacosamide |
| EP10193559 | 2010-12-02 | ||
| EP10193561.7 | 2010-12-02 | ||
| EP10193559.1 | 2010-12-02 | ||
| US61/419,158 | 2010-12-02 | ||
| US61/419,153 | 2010-12-02 | ||
| US201161444439P | 2011-02-18 | 2011-02-18 | |
| US201161444447P | 2011-02-18 | 2011-02-18 | |
| US61/444,447 | 2011-02-18 | ||
| US61/444,439 | 2011-02-18 | ||
| US201161485361P | 2011-05-12 | 2011-05-12 | |
| US201161485354P | 2011-05-12 | 2011-05-12 | |
| US61/485,354 | 2011-05-12 | ||
| US61/485,361 | 2011-05-12 | ||
| PCT/EP2011/006027 WO2012072256A2 (en) | 2010-12-02 | 2011-12-01 | Once daily formulation of lacosamide |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016202383A Division JP6357687B2 (ja) | 2010-12-02 | 2016-10-14 | ラコサミドの１日１回投与用製剤 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2013545762A JP2013545762A (ja) | 2013-12-26 |
| JP2013545762A5 true JP2013545762A5 (enExample) | 2015-01-22 |
| JP6027539B2 JP6027539B2 (ja) | 2016-11-16 |
Family
ID=46172318
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013541248A Active JP6027539B2 (ja) | 2010-12-02 | 2011-12-01 | ラコサミドの１日１回投与用製剤 |
| JP2016202383A Active JP6357687B2 (ja) | 2010-12-02 | 2016-10-14 | ラコサミドの１日１回投与用製剤 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016202383A Active JP6357687B2 (ja) | 2010-12-02 | 2016-10-14 | ラコサミドの１日１回投与用製剤 |
Country Status (14)
| Country | Link |
|---|---|
| US (4) | US20130251813A1 (enExample) |
| EP (3) | EP2646001A2 (enExample) |
| JP (2) | JP6027539B2 (enExample) |
| KR (1) | KR101980386B1 (enExample) |
| CN (1) | CN103561727B (enExample) |
| AU (1) | AU2011335415B2 (enExample) |
| BR (1) | BR112013013525A2 (enExample) |
| CA (1) | CA2817654A1 (enExample) |
| EA (1) | EA029180B1 (enExample) |
| IL (1) | IL226231B (enExample) |
| MX (1) | MX2013005974A (enExample) |
| NZ (1) | NZ610701A (enExample) |
| WO (2) | WO2012072256A2 (enExample) |
| ZA (1) | ZA201303289B (enExample) |
Families Citing this family (34)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1642889A1 (en) * | 2004-10-02 | 2006-04-05 | Schwarz Pharma Ag | Improved synthesis scheme for lacosamide |
| EP1873527A1 (en) * | 2006-06-30 | 2008-01-02 | Schwarz Pharma Ag | Method for identifying CRMP modulators |
| EA019757B1 (ru) | 2006-06-15 | 2014-06-30 | ЮСиБи ФАРМА ГМБХ | Фармацевтическая композиция с синергетическим противосудорожным эффектом |
| CN101466390B (zh) * | 2006-06-15 | 2014-03-12 | 优时比制药有限公司 | 用于治疗难治性癫痫持续状态的肽类化合物 |
| ES2594867T3 (es) | 2007-03-09 | 2016-12-23 | Alexza Pharmaceuticals, Inc. | Unidad de calentamiento para usar en un dispositivo de administración de fármaco |
| EP2468261A1 (en) | 2010-12-02 | 2012-06-27 | UCB Pharma GmbH | Formulation of lacosamide |
| CN102805733B (zh) * | 2011-06-01 | 2016-03-09 | 日东电工株式会社 | 颗粒制剂及其制造方法 |
| US8779355B2 (en) * | 2011-12-28 | 2014-07-15 | Quest Diagnostics Investments, Inc. | Methods for detecting lacosamide by mass spectrometry |
| KR101732731B1 (ko) | 2013-04-02 | 2017-05-08 | 주식회사 바이오파마티스 | 라코사마이드(lacosamide) 또는 이의 약학적으로 허용 가능한 염의 용출 패턴 조절이 용이한 약학 조성물 |
| WO2014180895A1 (en) * | 2013-05-08 | 2014-11-13 | Sanovel Ilac Sanayi Ve Ticaret A.S. | Pharmaceutical formulations of lacosamide |
| WO2015079010A2 (en) * | 2013-11-29 | 2015-06-04 | Ucb Pharma Gmbh | Pharmaceutical composition comprising lacosamide and levetiracetam |
| EP2878296A1 (en) | 2013-11-29 | 2015-06-03 | UCB Pharma GmbH | Pharmaceutical composition comprising lacosamide and levetiracetam |
| WO2015175982A1 (en) * | 2014-05-16 | 2015-11-19 | Vivus, Inc. | Orally administrable formulations for the controlled release of a pharmacologically active agent |
| WO2016131947A1 (en) | 2015-02-20 | 2016-08-25 | Ucb Biopharma Sprl | Combination treatment |
| JO3543B1 (ar) * | 2015-09-28 | 2020-07-05 | Applied Pharma Res | تراكيب حمض أميني إصدار معدل تعطى عن طريق الفم |
| WO2017058869A1 (en) | 2015-09-29 | 2017-04-06 | Acorda Therapeutics, Inc. | Sustained release compositions of 4-aminopyridine |
| EP3397253A1 (en) * | 2015-12-30 | 2018-11-07 | Adamas Pharmaceuticals, Inc. | Methods and compositions for the treatment of seizure-related disorders |
| WO2018062955A1 (ko) * | 2016-09-29 | 2018-04-05 | 에스케이케미칼(주) | 라코사미드 서방성 제제 |
| CN106551900A (zh) * | 2016-12-05 | 2017-04-05 | 北京万全德众医药生物技术有限公司 | 一种拉科酰胺口服溶液及其制备工艺 |
| EP3551189B1 (en) | 2016-12-09 | 2023-11-01 | Alexza Pharmaceuticals, Inc. | Alprazolam for use in treating epilepsy |
| EP3824906A1 (en) | 2016-12-21 | 2021-05-26 | Amgen Inc. | Anti-tnf alpha antibody formulations |
| MX2020007997A (es) | 2018-02-02 | 2020-12-03 | Alexza Pharmaceuticals Inc | Dispositivo electrico de aerosol de condensacion. |
| KR102083241B1 (ko) | 2018-02-14 | 2020-03-02 | 환인제약 주식회사 | 라코사미드를 함유하는 약제학적 서방성 조성물 |
| CN110833528A (zh) * | 2018-08-17 | 2020-02-25 | 北京万全德众医药生物技术有限公司 | 一种拉科酰胺脂质体冻干粉针剂及其制备方法 |
| CN109010301B (zh) * | 2018-09-05 | 2021-01-26 | 上海上药第一生化药业有限公司 | 一种拉考沙胺晶型ii片剂及其制备方法和应用 |
| US12042474B2 (en) | 2019-06-06 | 2024-07-23 | Shanghai Aucta Pharmaceuticals Co., Ltd. | Lacosamide pharmaceutical composition and dosage form thereof |
| EP3981390B1 (en) | 2019-06-06 | 2025-12-03 | Shanghai Aucta Pharmaceuticals Co., Ltd. | Lacosamide pharmaceutical composition and pharmaceutical preparation thereof |
| CN112022804A (zh) * | 2020-09-28 | 2020-12-04 | 健民药业集团股份有限公司 | 一种拉考沙胺口服溶液及制备方法 |
| WO2022073151A1 (en) | 2020-10-05 | 2022-04-14 | Theracos Sub, Llc | Pharmaceutical formulations |
| WO2022194198A1 (zh) * | 2021-03-17 | 2022-09-22 | 上海博志研新药物技术有限公司 | 一种拉考沙胺药物组合物、其制备方法及应用 |
| JP2024007837A (ja) * | 2022-07-06 | 2024-01-19 | 東和薬品株式会社 | ラコサミドを含む医薬組成物及びその利用 |
| WO2024054987A1 (en) * | 2022-09-08 | 2024-03-14 | The Children's Hospital Of Philadlphia | Gpcr latrophilin-3 as biomarker for detecting increased risk for mild brain injury and methods of use thereof for diagnosis and treatment of the same |
| CN115581676A (zh) * | 2022-09-30 | 2023-01-10 | 澳美制药(苏州)有限公司 | 拉考沙胺片剂及其制备工艺 |
| US12478587B1 (en) | 2025-02-06 | 2025-11-25 | Shanghai Aucta Pharmaceuticals Co., Ltd. | Formulation for lacosamide |
Family Cites Families (38)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PT1038522E (pt) | 1996-03-15 | 2004-10-29 | Res Corp Technologies Inc | Derivados enantiomericos anticonvulsivos de aminoacidos |
| DE69808475T2 (de) | 1997-07-15 | 2003-01-30 | Research Corp. Technologies, Inc. | Aminosäurederivate zur behandlung von schlaganfall |
| ATE327744T1 (de) | 2001-03-20 | 2006-06-15 | Sanol Arznei Schwarz Gmbh | Neue verwendung von peptidverbindungen bei der behandlung von nicht-neuropathischem entzündungsschmerz |
| DE60100055T2 (de) | 2001-03-21 | 2003-07-24 | Schwarz Pharma Ag | Neue Verwendung einer Klasse von Peptidverbindungen zur Behandlung von Allodynie oder andere Arten von chronischen oder Phantomschmerzen |
| US7794987B2 (en) | 2003-12-02 | 2010-09-14 | Ucb Pharma Gmbh | Method for treating central neuropathic pain |
| US20060009384A1 (en) | 2003-12-05 | 2006-01-12 | David Rudd | Novel use of peptide compounds for treating status epilepticus or related conditions |
| EP1541138A1 (en) | 2003-12-05 | 2005-06-15 | Schwarz Pharma Ag | Novel use of peptide compounds for treating status epilepticus or related conditions |
| US20100256179A1 (en) * | 2004-03-26 | 2010-10-07 | Ucb Pharma Gmbh | Combination therapy for pain in painful diabetic neuropathy |
| EP1579858A1 (en) | 2004-03-26 | 2005-09-28 | Schwarz Pharma Ag | Novel use of peptide compounds for treating pain in painful diabetic neuropathy |
| KR20070007931A (ko) | 2004-04-16 | 2007-01-16 | 쉬바르츠파르마에이지 | 만성 두통의 예방 및 치료를 위한 펩티드 화합물의 용도 |
| EP1604654A1 (en) | 2004-05-18 | 2005-12-14 | Schwarz Pharma Ag | Novel use of peptide compounds for treating dyskinesia |
| EP1604656A1 (en) | 2004-06-09 | 2005-12-14 | Schwarz Pharma Ag | Novel use of peptide compounds for treating amyotrophic lateral sclerosis (ALS) |
| EP1604655A1 (en) | 2004-06-09 | 2005-12-14 | Schwarz Pharma Ag | Novel use of peptide compounds for treating pain in trigeminal neuralgia |
| US7427601B2 (en) | 2004-06-24 | 2008-09-23 | Schwarz Pharma Ag | Method for treating tremor |
| PL1781276T3 (pl) | 2004-08-27 | 2010-11-30 | Ucb Pharma Gmbh | Zastosowanie związków peptydowych do leczenia bólu związanego z rakiem kości, bólu indukowanego przez chemioterapię oraz nukleozydy |
| JP2006124385A (ja) * | 2004-09-30 | 2006-05-18 | Takeda Chem Ind Ltd | 放出制御製剤 |
| US20060105663A1 (en) * | 2004-10-04 | 2006-05-18 | Stefan Greulich | Polymer assemblies with decorative surfaces |
| AU2005325930B2 (en) * | 2005-01-27 | 2012-01-19 | Alembic Limited | Extended release formulation of Levetiracetam |
| KR20070096058A (ko) | 2005-01-28 | 2007-10-01 | 쉬바르츠파르마에이지 | 정신분열증의 부가 요법용 ｓｐｍ 927 |
| BRPI0612802A2 (pt) * | 2005-07-07 | 2010-11-30 | Farnam Co Inc | composições farmacêuticas de liberação sustentada para medicamentos extremamente hidrossolúveis |
| EP1754476A1 (en) | 2005-08-18 | 2007-02-21 | Schwarz Pharma Ag | Lacosamide (SPM 927) for treating myalgia, e.g. fibromyalgia |
| NL2000281C2 (nl) | 2005-11-02 | 2007-08-07 | Pfizer Prod Inc | Vaste farmaceutische samenstellingen die pregabaline bevatten. |
| WO2007120485A2 (en) * | 2006-03-30 | 2007-10-25 | Cinergen, Llc | Methods of treating pain with alkylxanthines and antiepileptics and compositions for use therefor |
| EP1925314A1 (en) | 2006-11-22 | 2008-05-28 | Schwarz Pharma Ag | Pharmaceutical composition with synergistic anticonvulsant effect |
| CN101466390B (zh) | 2006-06-15 | 2014-03-12 | 优时比制药有限公司 | 用于治疗难治性癫痫持续状态的肽类化合物 |
| EP1873527A1 (en) | 2006-06-30 | 2008-01-02 | Schwarz Pharma Ag | Method for identifying CRMP modulators |
| EA019757B1 (ru) | 2006-06-15 | 2014-06-30 | ЮСиБи ФАРМА ГМБХ | Фармацевтическая композиция с синергетическим противосудорожным эффектом |
| EP1920780A1 (en) | 2006-10-12 | 2008-05-14 | Schwarz Pharma Ag | Peptide compounds for the treatment of hyperexcitability disorders |
| US20080014271A1 (en) * | 2006-07-13 | 2008-01-17 | Ucb, S.A. | Novel pharmaceutical compositions comprising levetiracetam |
| CA2674610C (en) | 2007-01-11 | 2013-06-18 | Xenoport, Inc. | Sustained release oral dosage forms of a prodrug of r-baclofen and methods of treatment |
| WO2009069089A1 (en) | 2007-11-29 | 2009-06-04 | Ranbaxy Laboratories Limited | Levetiracetam controlled release composition |
| US20090143362A1 (en) | 2007-12-04 | 2009-06-04 | Barabde Umesh Vinayakrao | Carbamazepine formulations |
| DE102008059155A1 (de) * | 2008-11-27 | 2010-06-02 | Ratiopharm Gmbh | Trockenverarbeitung und neue Formen von Lacosamid |
| KR100980999B1 (ko) * | 2008-11-28 | 2010-09-07 | 기아자동차주식회사 | 차량용 시거라이터조립체 |
| WO2010148300A1 (en) | 2009-06-19 | 2010-12-23 | The University Of North Carolina At Chapel Hill | Methods of treatment of neurological disorders |
| US8829033B2 (en) | 2009-09-23 | 2014-09-09 | The University Of North Carolina At Chapel Hill | N-benzylamide substituted derivatives of 2-(acylamido)acetic acid and 2-(acylamido)propionic acids: potent neurological agents |
| ES2753141T3 (es) * | 2009-11-03 | 2020-04-07 | Lupin Ltd | Formulación de liberación modificada de lacosamida |
| WO2011101863A2 (en) * | 2010-02-19 | 2011-08-25 | Cadila Healthcare Limited | Extended release pharmaceutical compositions of lacosamide |
-
2011
- 2011-12-01 EP EP11817472.1A patent/EP2646001A2/en not_active Withdrawn
- 2011-12-01 AU AU2011335415A patent/AU2011335415B2/en not_active Ceased
- 2011-12-01 BR BR112013013525A patent/BR112013013525A2/pt not_active Application Discontinuation
- 2011-12-01 NZ NZ610701A patent/NZ610701A/en not_active IP Right Cessation
- 2011-12-01 WO PCT/EP2011/006027 patent/WO2012072256A2/en not_active Ceased
- 2011-12-01 CA CA 2817654 patent/CA2817654A1/en not_active Abandoned
- 2011-12-01 EP EP20188230.5A patent/EP3766485A1/en not_active Withdrawn
- 2011-12-01 US US13/990,863 patent/US20130251813A1/en not_active Abandoned
- 2011-12-01 JP JP2013541248A patent/JP6027539B2/ja active Active
- 2011-12-01 MX MX2013005974A patent/MX2013005974A/es not_active Application Discontinuation
- 2011-12-01 CN CN201180057820.9A patent/CN103561727B/zh not_active Expired - Fee Related
- 2011-12-01 EP EP11791442.4A patent/EP2645997B1/en not_active Revoked
- 2011-12-01 EA EA201390804A patent/EA029180B1/ru not_active IP Right Cessation
- 2011-12-01 WO PCT/EP2011/006026 patent/WO2012084126A2/en not_active Ceased
-
2012
- 2012-02-01 KR KR1020137017171A patent/KR101980386B1/ko not_active Expired - Fee Related
-
2013
- 2013-05-07 ZA ZA2013/03289A patent/ZA201303289B/en unknown
- 2013-05-08 IL IL226231A patent/IL226231B/en active IP Right Grant
-
2014
- 2014-10-21 US US14/519,338 patent/US20150104507A1/en not_active Abandoned
-
2016
- 2016-10-14 JP JP2016202383A patent/JP6357687B2/ja active Active
-
2018
- 2018-07-05 US US16/027,963 patent/US20190008758A1/en not_active Abandoned
- 2018-08-21 US US16/106,655 patent/US20190054009A1/en not_active Abandoned
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