JP2016183182A5 - - Google Patents
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- JP2016183182A5 JP2016183182A5 JP2016114970A JP2016114970A JP2016183182A5 JP 2016183182 A5 JP2016183182 A5 JP 2016183182A5 JP 2016114970 A JP2016114970 A JP 2016114970A JP 2016114970 A JP2016114970 A JP 2016114970A JP 2016183182 A5 JP2016183182 A5 JP 2016183182A5
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- JP
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- Prior art keywords
- leukemia
- antibody
- cell
- use according
- antagonistic
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 238000000034 method Methods 0.000 claims description 23
- 101000868279 Homo sapiens Leukocyte surface antigen CD47 Proteins 0.000 claims description 22
- 102100032913 Leukocyte surface antigen CD47 Human genes 0.000 claims description 22
- 210000004027 cell Anatomy 0.000 claims description 18
- 206010028980 Neoplasm Diseases 0.000 claims description 12
- 201000011510 cancer Diseases 0.000 claims description 9
- 208000032839 leukemia Diseases 0.000 claims description 9
- 206010057249 Phagocytosis Diseases 0.000 claims description 7
- 230000008782 phagocytosis Effects 0.000 claims description 7
- 230000008685 targeting Effects 0.000 claims description 5
- 101000863873 Homo sapiens Tyrosine-protein phosphatase non-receptor type substrate 1 Proteins 0.000 claims description 4
- 102100029948 Tyrosine-protein phosphatase non-receptor type substrate 1 Human genes 0.000 claims description 4
- 230000003042 antagnostic effect Effects 0.000 claims 6
- 206010025323 Lymphomas Diseases 0.000 claims 3
- 206010000830 Acute leukaemia Diseases 0.000 claims 1
- 102100026423 Adhesion G protein-coupled receptor E5 Human genes 0.000 claims 1
- 102000024905 CD99 Human genes 0.000 claims 1
- 108060001253 CD99 Proteins 0.000 claims 1
- 108010007707 Hepatitis A Virus Cellular Receptor 2 Proteins 0.000 claims 1
- 102100034458 Hepatitis A virus cellular receptor 2 Human genes 0.000 claims 1
- 101000718243 Homo sapiens Adhesion G protein-coupled receptor E5 Proteins 0.000 claims 1
- 101001084266 Homo sapiens Parathyroid hormone 2 receptor Proteins 0.000 claims 1
- 101000596234 Homo sapiens T-cell surface protein tactile Proteins 0.000 claims 1
- 102100030869 Parathyroid hormone 2 receptor Human genes 0.000 claims 1
- 102100035268 T-cell surface protein tactile Human genes 0.000 claims 1
- 239000005557 antagonist Substances 0.000 claims 1
- 239000003550 marker Substances 0.000 claims 1
- 208000025113 myeloid leukemia Diseases 0.000 claims 1
- 210000001539 phagocyte Anatomy 0.000 claims 1
- 102000005962 receptors Human genes 0.000 claims 1
- 108020003175 receptors Proteins 0.000 claims 1
- 229940127089 cytotoxic agent Drugs 0.000 description 6
- 210000003958 hematopoietic stem cell Anatomy 0.000 description 6
- 208000031261 Acute myeloid leukaemia Diseases 0.000 description 4
- 239000002254 cytotoxic agent Substances 0.000 description 4
- 231100000599 cytotoxic agent Toxicity 0.000 description 4
- 239000003112 inhibitor Substances 0.000 description 4
- 210000000601 blood cell Anatomy 0.000 description 3
- 239000000203 mixture Substances 0.000 description 3
- 210000000130 stem cell Anatomy 0.000 description 3
- 239000002246 antineoplastic agent Substances 0.000 description 2
- 210000004369 blood Anatomy 0.000 description 2
- 239000008280 blood Substances 0.000 description 2
- 230000000779 depleting effect Effects 0.000 description 2
- 230000003993 interaction Effects 0.000 description 2
- 239000000376 reactant Substances 0.000 description 2
- 239000003053 toxin Substances 0.000 description 2
- 231100000765 toxin Toxicity 0.000 description 2
- 208000033776 Myeloid Acute Leukemia Diseases 0.000 description 1
- 210000001185 bone marrow Anatomy 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 210000005259 peripheral blood Anatomy 0.000 description 1
- 239000011886 peripheral blood Substances 0.000 description 1
- 238000000746 purification Methods 0.000 description 1
- 230000011664 signaling Effects 0.000 description 1
- 238000002054 transplantation Methods 0.000 description 1
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US1132408P | 2008-01-15 | 2008-01-15 | |
| US61/011,324 | 2008-01-15 | ||
| US18978608P | 2008-08-22 | 2008-08-22 | |
| US61/189,786 | 2008-08-22 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014077464A Division JP6002710B2 (ja) | 2008-01-15 | 2014-04-04 | Ｃｄ４７によって媒介される食作用を操作するための方法 |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018006391A Division JP6556271B2 (ja) | 2008-01-15 | 2018-01-18 | Ｃｄ４７によって媒介される食作用を操作するための方法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2016183182A JP2016183182A (ja) | 2016-10-20 |
| JP2016183182A5 true JP2016183182A5 (enExample) | 2017-03-09 |
| JP6280161B2 JP6280161B2 (ja) | 2018-02-14 |
Family
ID=40885608
Family Applications (9)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010543147A Active JP5547656B2 (ja) | 2008-01-15 | 2009-01-15 | Ｃｄ４７によって媒介される食作用を操作するための方法 |
| JP2014077464A Active JP6002710B2 (ja) | 2008-01-15 | 2014-04-04 | Ｃｄ４７によって媒介される食作用を操作するための方法 |
| JP2016114970A Active JP6280161B2 (ja) | 2008-01-15 | 2016-06-09 | Ｃｄ４７によって媒介される食作用を操作するための方法 |
| JP2018006391A Active JP6556271B2 (ja) | 2008-01-15 | 2018-01-18 | Ｃｄ４７によって媒介される食作用を操作するための方法 |
| JP2019127276A Active JP6742482B2 (ja) | 2008-01-15 | 2019-07-09 | Ｃｄ４７によって媒介される食作用を操作するための方法 |
| JP2020126940A Active JP6960507B2 (ja) | 2008-01-15 | 2020-07-28 | Ｃｄ４７によって媒介される食作用を操作するための方法 |
| JP2021166657A Active JP7193601B2 (ja) | 2008-01-15 | 2021-10-11 | Ｃｄ４７によって媒介される食作用を操作するための方法 |
| JP2022196360A Active JP7412513B2 (ja) | 2008-01-15 | 2022-12-08 | Ｃｄ４７によって媒介される食作用を操作するための方法 |
| JP2023218727A Active JP7638360B2 (ja) | 2008-01-15 | 2023-12-26 | Ｃｄ４７によって媒介される食作用を操作するための方法 |
Family Applications Before (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010543147A Active JP5547656B2 (ja) | 2008-01-15 | 2009-01-15 | Ｃｄ４７によって媒介される食作用を操作するための方法 |
| JP2014077464A Active JP6002710B2 (ja) | 2008-01-15 | 2014-04-04 | Ｃｄ４７によって媒介される食作用を操作するための方法 |
Family Applications After (6)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018006391A Active JP6556271B2 (ja) | 2008-01-15 | 2018-01-18 | Ｃｄ４７によって媒介される食作用を操作するための方法 |
| JP2019127276A Active JP6742482B2 (ja) | 2008-01-15 | 2019-07-09 | Ｃｄ４７によって媒介される食作用を操作するための方法 |
| JP2020126940A Active JP6960507B2 (ja) | 2008-01-15 | 2020-07-28 | Ｃｄ４７によって媒介される食作用を操作するための方法 |
| JP2021166657A Active JP7193601B2 (ja) | 2008-01-15 | 2021-10-11 | Ｃｄ４７によって媒介される食作用を操作するための方法 |
| JP2022196360A Active JP7412513B2 (ja) | 2008-01-15 | 2022-12-08 | Ｃｄ４７によって媒介される食作用を操作するための方法 |
| JP2023218727A Active JP7638360B2 (ja) | 2008-01-15 | 2023-12-26 | Ｃｄ４７によって媒介される食作用を操作するための方法 |
Country Status (10)
| Country | Link |
|---|---|
| US (14) | US8562997B2 (enExample) |
| EP (2) | EP2242512B1 (enExample) |
| JP (9) | JP5547656B2 (enExample) |
| AU (1) | AU2009205665B2 (enExample) |
| CA (3) | CA2711938C (enExample) |
| DK (3) | DK3056514T4 (enExample) |
| ES (3) | ES2582340T3 (enExample) |
| FI (2) | FI3056515T4 (enExample) |
| PT (3) | PT3056515T (enExample) |
| WO (1) | WO2009091601A1 (enExample) |
Families Citing this family (114)
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| US11072655B2 (en) | 2008-01-15 | 2021-07-27 | The Board Of Trustees Of The Leland Stanford Junior University | Markers of acute myeloid leukemia stem cells |
| EP2111869A1 (en) | 2008-04-23 | 2009-10-28 | Stichting Sanquin Bloedvoorziening | Compositions and methods to enhance the immune system |
| PL2429574T3 (pl) | 2009-05-15 | 2015-12-31 | Univ Health Network | Kompozycje i sposoby leczenia nowotworów hematologicznych celujące w oddziaływanie SIRP-CD47 |
| CA2771336C (en) | 2009-09-15 | 2019-11-26 | The Board Of Trustees Of The Leland Stanford Junior University | Synergistic anti-cd47 therapy for hematologic cancers |
| HRP20170254T1 (hr) * | 2010-05-14 | 2017-04-21 | The Board of Trustees of the Leland Stanford Junior University Office of the General Counsel | Humanizirana i kimerna monoklonska protutijela usmjerena na cd47 |
| CN102070719A (zh) * | 2010-11-24 | 2011-05-25 | 中国人民解放军第四军医大学 | 一种白血病干细胞靶向可溶性蛋白TrxHis-hCD47 |
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| US20140140989A1 (en) * | 2012-02-06 | 2014-05-22 | Inhibrx Llc | Non-Platelet Depleting and Non-Red Blood Cell Depleting CD47 Antibodies and Methods of Use Thereof |
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