JP2019529416A5 - - Google Patents
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- Publication number
- JP2019529416A5 JP2019529416A5 JP2019514735A JP2019514735A JP2019529416A5 JP 2019529416 A5 JP2019529416 A5 JP 2019529416A5 JP 2019514735 A JP2019514735 A JP 2019514735A JP 2019514735 A JP2019514735 A JP 2019514735A JP 2019529416 A5 JP2019529416 A5 JP 2019529416A5
- Authority
- JP
- Japan
- Prior art keywords
- klrg1
- antibody
- composition according
- depleting agent
- composition
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 101000971533 Homo sapiens Killer cell lectin-like receptor subfamily G member 1 Proteins 0.000 claims 39
- 102100021457 Killer cell lectin-like receptor subfamily G member 1 Human genes 0.000 claims 38
- 239000000203 mixture Substances 0.000 claims 37
- 239000003795 chemical substances by application Substances 0.000 claims 21
- 230000000779 depleting effect Effects 0.000 claims 21
- 108020001507 fusion proteins Proteins 0.000 claims 8
- 102000037865 fusion proteins Human genes 0.000 claims 8
- 239000012636 effector Substances 0.000 claims 7
- 230000010056 antibody-dependent cellular cytotoxicity Effects 0.000 claims 6
- 239000000427 antigen Substances 0.000 claims 6
- 102000036639 antigens Human genes 0.000 claims 6
- 108091007433 antigens Proteins 0.000 claims 6
- 230000004540 complement-dependent cytotoxicity Effects 0.000 claims 6
- 239000012634 fragment Substances 0.000 claims 6
- 210000000822 natural killer cell Anatomy 0.000 claims 6
- 208000023275 Autoimmune disease Diseases 0.000 claims 4
- 102000000905 Cadherin Human genes 0.000 claims 4
- 108050007957 Cadherin Proteins 0.000 claims 4
- 108010019670 Chimeric Antigen Receptors Proteins 0.000 claims 4
- 208000002250 Hematologic Neoplasms Diseases 0.000 claims 4
- 206010028980 Neoplasm Diseases 0.000 claims 4
- 206010052779 Transplant rejections Diseases 0.000 claims 4
- 239000000611 antibody drug conjugate Substances 0.000 claims 4
- 229940049595 antibody-drug conjugate Drugs 0.000 claims 4
- 210000001151 cytotoxic T lymphocyte Anatomy 0.000 claims 4
- 238000001727 in vivo Methods 0.000 claims 4
- 238000002560 therapeutic procedure Methods 0.000 claims 4
- 210000001744 T-lymphocyte Anatomy 0.000 claims 3
- 239000002299 complementary DNA Substances 0.000 claims 3
- 108020004999 messenger RNA Proteins 0.000 claims 3
- 102100029758 Cadherin-4 Human genes 0.000 claims 2
- 208000006404 Large Granular Lymphocytic Leukemia Diseases 0.000 claims 2
- 206010025323 Lymphomas Diseases 0.000 claims 2
- 241000282567 Macaca fascicularis Species 0.000 claims 2
- 108050000637 N-cadherin Proteins 0.000 claims 2
- 108010086890 R-cadherin Proteins 0.000 claims 2
- 201000008717 T-cell large granular lymphocyte leukemia Diseases 0.000 claims 2
- 101150071882 US17 gene Proteins 0.000 claims 2
- 201000008319 inclusion body myositis Diseases 0.000 claims 2
- 208000032839 leukemia Diseases 0.000 claims 2
- 239000000126 substance Substances 0.000 claims 2
- 206010073478 Anaplastic large-cell lymphoma Diseases 0.000 claims 1
- 208000010839 B-cell chronic lymphocytic leukemia Diseases 0.000 claims 1
- 206010006187 Breast cancer Diseases 0.000 claims 1
- 208000026310 Breast neoplasm Diseases 0.000 claims 1
- 229940045513 CTLA4 antagonist Drugs 0.000 claims 1
- 206010056979 Colitis microscopic Diseases 0.000 claims 1
- 206010009900 Colitis ulcerative Diseases 0.000 claims 1
- 208000032612 Glial tumor Diseases 0.000 claims 1
- 206010018338 Glioma Diseases 0.000 claims 1
- 206010066476 Haematological malignancy Diseases 0.000 claims 1
- 241000282412 Homo Species 0.000 claims 1
- 206010021245 Idiopathic thrombocytopenic purpura Diseases 0.000 claims 1
- 208000008839 Kidney Neoplasms Diseases 0.000 claims 1
- 208000032004 Large-Cell Anaplastic Lymphoma Diseases 0.000 claims 1
- 206010058467 Lung neoplasm malignant Diseases 0.000 claims 1
- 206010028811 Natural killer-cell leukaemia Diseases 0.000 claims 1
- 206010033128 Ovarian cancer Diseases 0.000 claims 1
- 206010061535 Ovarian neoplasm Diseases 0.000 claims 1
- 206010060862 Prostate cancer Diseases 0.000 claims 1
- 208000000236 Prostatic Neoplasms Diseases 0.000 claims 1
- 201000004681 Psoriasis Diseases 0.000 claims 1
- 206010038389 Renal cancer Diseases 0.000 claims 1
- 208000005718 Stomach Neoplasms Diseases 0.000 claims 1
- 208000000389 T-cell leukemia Diseases 0.000 claims 1
- 208000028530 T-cell lymphoblastic leukemia/lymphoma Diseases 0.000 claims 1
- 206010042971 T-cell lymphoma Diseases 0.000 claims 1
- 208000027585 T-cell non-Hodgkin lymphoma Diseases 0.000 claims 1
- 208000031981 Thrombocytopenic Idiopathic Purpura Diseases 0.000 claims 1
- 206010062129 Tongue neoplasm Diseases 0.000 claims 1
- 206010067584 Type 1 diabetes mellitus Diseases 0.000 claims 1
- 201000006704 Ulcerative Colitis Diseases 0.000 claims 1
- 208000015230 aggressive NK-cell leukemia Diseases 0.000 claims 1
- 201000003710 autoimmune thrombocytopenic purpura Diseases 0.000 claims 1
- 210000004027 cell Anatomy 0.000 claims 1
- 231100000433 cytotoxic Toxicity 0.000 claims 1
- 230000001472 cytotoxic effect Effects 0.000 claims 1
- 206010017758 gastric cancer Diseases 0.000 claims 1
- 208000005017 glioblastoma Diseases 0.000 claims 1
- 102000050855 human KLRG1 Human genes 0.000 claims 1
- 201000010982 kidney cancer Diseases 0.000 claims 1
- 238000002372 labelling Methods 0.000 claims 1
- 201000005202 lung cancer Diseases 0.000 claims 1
- 208000020816 lung neoplasm Diseases 0.000 claims 1
- 208000004341 lymphocytic colitis Diseases 0.000 claims 1
- 230000001404 mediated effect Effects 0.000 claims 1
- 201000001441 melanoma Diseases 0.000 claims 1
- 201000006417 multiple sclerosis Diseases 0.000 claims 1
- 238000011275 oncology therapy Methods 0.000 claims 1
- 206010039073 rheumatoid arthritis Diseases 0.000 claims 1
- 201000011549 stomach cancer Diseases 0.000 claims 1
- 230000002195 synergetic effect Effects 0.000 claims 1
- 230000008685 targeting Effects 0.000 claims 1
- 201000006134 tongue cancer Diseases 0.000 claims 1
- 238000002054 transplantation Methods 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662395551P | 2016-09-16 | 2016-09-16 | |
| US62/395,551 | 2016-09-16 | ||
| PCT/US2017/051776 WO2018053264A2 (en) | 2016-09-16 | 2017-09-15 | Klrg1 depletion therapy |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2019529416A JP2019529416A (ja) | 2019-10-17 |
| JP2019529416A5 true JP2019529416A5 (enExample) | 2020-09-17 |
Family
ID=61619243
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019514735A Pending JP2019529416A (ja) | 2016-09-16 | 2017-09-15 | Ｋｌｒｇ１枯渇療法 |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US20190194333A1 (enExample) |
| EP (1) | EP3512553A4 (enExample) |
| JP (1) | JP2019529416A (enExample) |
| CN (1) | CN110300598A (enExample) |
| AU (1) | AU2017326003A1 (enExample) |
| CA (1) | CA3036835A1 (enExample) |
| WO (1) | WO2018053264A2 (enExample) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20210002373A1 (en) * | 2018-03-01 | 2021-01-07 | Nextcure, Inc. | KLRG1 Binding Compositions and Methods of Use Thereof |
| AU2019344524A1 (en) * | 2018-09-17 | 2021-03-25 | The Brigham And Women’S Hospital, Inc. | Anti-KLRG1 antibodies |
| CA3136625A1 (en) * | 2019-04-09 | 2020-10-15 | Abcuro, Inc. | Killer cell lectin-like receptor subfamily g member 1 (klrg1) depleting antibodies |
| WO2022056289A1 (en) * | 2020-09-11 | 2022-03-17 | National Jewish Health | Methods and compositions for treating respiratory diseases or conditions related to innate lymphoid cells |
| CN113058029A (zh) * | 2021-03-18 | 2021-07-02 | 西安交通大学 | 胶原凝集素-11在制备防治泌尿系统感染的药物中的应用 |
| EP4377346A1 (en) | 2021-07-26 | 2024-06-05 | Abcuro, Inc. | Killer cell lectin-like receptor subfamily g member 1 (klrg1) depleting antibodies |
| AU2023367648A1 (en) * | 2022-10-25 | 2025-05-01 | The Brigham And Women's Hospital, Inc. | Klrb1 binding agents and methods of use thereof |
| WO2025147544A1 (en) | 2024-01-02 | 2025-07-10 | Abcuro, Inc. | Methods of treating inclusion body myositis (ibm) |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0672142B1 (en) * | 1992-12-04 | 2001-02-28 | Medical Research Council | Multivalent and multispecific binding proteins, their manufacture and use |
| US8637084B2 (en) * | 2009-07-14 | 2014-01-28 | Asahi Kasei Medical Co., Ltd. | Treatment method for epithelial cancerous organism |
| JP2012025694A (ja) * | 2010-07-23 | 2012-02-09 | Asahi Kasei Kuraray Medical Co Ltd | 癌治療剤 |
| EA036591B1 (ru) * | 2013-06-25 | 2020-11-26 | Вэксинекс, Инк. | Способ ингибирования, замедления или уменьшения роста раковой опухоли у субъекта |
| US10416160B2 (en) * | 2014-07-25 | 2019-09-17 | Riken | Memory invariant NKT cell marker |
| CN109600990A (zh) * | 2016-06-03 | 2019-04-09 | 布里格姆妇女医院 | Klrg1信号传导治疗 |
-
2017
- 2017-09-15 CN CN201780069194.2A patent/CN110300598A/zh not_active Withdrawn
- 2017-09-15 EP EP17851602.7A patent/EP3512553A4/en not_active Withdrawn
- 2017-09-15 AU AU2017326003A patent/AU2017326003A1/en not_active Abandoned
- 2017-09-15 US US16/327,576 patent/US20190194333A1/en not_active Abandoned
- 2017-09-15 WO PCT/US2017/051776 patent/WO2018053264A2/en not_active Ceased
- 2017-09-15 CA CA3036835A patent/CA3036835A1/en not_active Abandoned
- 2017-09-15 JP JP2019514735A patent/JP2019529416A/ja active Pending
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