JP2016104045A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2016104045A5 JP2016104045A5 JP2016043151A JP2016043151A JP2016104045A5 JP 2016104045 A5 JP2016104045 A5 JP 2016104045A5 JP 2016043151 A JP2016043151 A JP 2016043151A JP 2016043151 A JP2016043151 A JP 2016043151A JP 2016104045 A5 JP2016104045 A5 JP 2016104045A5
- Authority
- JP
- Japan
- Prior art keywords
- cell
- glycoprotein
- seq
- protein comprises
- amino acid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US18340009P | 2009-06-02 | 2009-06-02 | |
| US61/183,400 | 2009-06-02 | ||
| US34885810P | 2010-05-27 | 2010-05-27 | |
| US61/348,858 | 2010-05-27 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014251541A Division JP2015051021A (ja) | 2009-06-02 | 2014-12-12 | フコシル化欠損細胞 |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016202634A Division JP2017006147A (ja) | 2009-06-02 | 2016-10-14 | フコシル化欠損細胞 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2016104045A JP2016104045A (ja) | 2016-06-09 |
| JP2016104045A5 true JP2016104045A5 (enExample) | 2016-12-01 |
| JP6211642B2 JP6211642B2 (ja) | 2017-10-11 |
Family
ID=42338231
Family Applications (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012514045A Expired - Fee Related JP5744856B2 (ja) | 2009-06-02 | 2010-06-01 | フコシル化欠損細胞 |
| JP2014251541A Withdrawn JP2015051021A (ja) | 2009-06-02 | 2014-12-12 | フコシル化欠損細胞 |
| JP2016043151A Expired - Fee Related JP6211642B2 (ja) | 2009-06-02 | 2016-03-07 | フコシル化欠損細胞 |
| JP2016202634A Pending JP2017006147A (ja) | 2009-06-02 | 2016-10-14 | フコシル化欠損細胞 |
Family Applications Before (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012514045A Expired - Fee Related JP5744856B2 (ja) | 2009-06-02 | 2010-06-01 | フコシル化欠損細胞 |
| JP2014251541A Withdrawn JP2015051021A (ja) | 2009-06-02 | 2014-12-12 | フコシル化欠損細胞 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016202634A Pending JP2017006147A (ja) | 2009-06-02 | 2016-10-14 | フコシル化欠損細胞 |
Country Status (16)
| Country | Link |
|---|---|
| US (8) | US8409838B2 (enExample) |
| EP (3) | EP3279326B1 (enExample) |
| JP (4) | JP5744856B2 (enExample) |
| KR (2) | KR101641526B1 (enExample) |
| CN (1) | CN102459603B (enExample) |
| AU (1) | AU2010256753B2 (enExample) |
| BR (1) | BRPI1010035A2 (enExample) |
| CA (1) | CA2764370C (enExample) |
| DK (3) | DK2808393T3 (enExample) |
| ES (2) | ES2527173T3 (enExample) |
| HU (1) | HUE038596T2 (enExample) |
| IL (1) | IL216624A (enExample) |
| PL (3) | PL2438171T3 (enExample) |
| SG (1) | SG176251A1 (enExample) |
| TW (1) | TWI513818B (enExample) |
| WO (1) | WO2010141478A1 (enExample) |
Families Citing this family (33)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20140161782A1 (en) | 2008-06-09 | 2014-06-12 | Targazyme, Inc. | Augmentation of cell therapy efficacy including treatment with alpha 1-3 fucoslytransferase |
| BRPI1010035A2 (pt) | 2009-06-02 | 2015-08-25 | Regeneron Pharma | Células deficientes em fucosilação |
| WO2012120500A2 (en) | 2011-03-06 | 2012-09-13 | Merck Serono S.A. | Low fucose cell lines and uses thereof |
| WO2013013013A2 (en) * | 2011-07-21 | 2013-01-24 | Alnylam Pharmaceuticals, Inc. | Compositions and methods for producing modified glycoproteins |
| TW201823460A (zh) | 2012-05-29 | 2018-07-01 | 美商再生元醫藥公司 | 生產細胞株增強子 |
| EP2722673B1 (en) | 2012-10-17 | 2017-07-12 | Hexal AG | Improved method of mapping glycans of glycoproteins |
| AR095196A1 (es) | 2013-03-15 | 2015-09-30 | Regeneron Pharma | Medio de cultivo celular libre de suero |
| US20160251410A1 (en) | 2013-09-03 | 2016-09-01 | Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd. | Compositions and methods for expressing recombinant polypeptides |
| US20150093782A1 (en) * | 2013-10-01 | 2015-04-02 | The University Of Wyoming | Compositions and methods for reducing fucosylation of glycoproteins in insect cells and methods of use thereof for production of recombinant glycoproteins |
| KR102399005B1 (ko) | 2014-03-11 | 2022-05-17 | 리제너론 파마슈티칼스 인코포레이티드 | 항-egfrviii 항체 및 그것의 용도 |
| EP3149034B1 (en) * | 2014-05-30 | 2022-07-13 | New England Biolabs, Inc. | Deglycosylation reagents and methods |
| CN106687581A (zh) * | 2014-07-07 | 2017-05-17 | 塔尔加泽梅股份有限公司 | 用于治疗用途的岩藻糖基化细胞的制备和冷冻干燥 |
| CN105671109B (zh) * | 2014-11-20 | 2019-08-23 | 中国人民解放军军事医学科学院生物工程研究所 | 用糖基工程酵母制备具有动物细胞糖基化修饰流感血凝素糖蛋白的方法 |
| TWI710573B (zh) | 2015-01-26 | 2020-11-21 | 美商再生元醫藥公司 | 抗伊波拉病毒醣蛋白之人類抗體 |
| TW202440903A (zh) | 2015-08-04 | 2024-10-16 | 美商再生元醫藥公司 | 補充牛磺酸之細胞培養基及用法（一） |
| KR102793554B1 (ko) * | 2015-11-02 | 2025-04-14 | 제넨테크, 인크. | 단백질의 푸코실화 및 탈푸코실화 형태를 제조하는 방법 |
| WO2017120347A1 (en) | 2016-01-06 | 2017-07-13 | Oncobiologics, Inc. | Modulation of afucosylated species in a monoclonal antibody composition |
| CA3013336A1 (en) | 2016-02-03 | 2017-08-10 | Oncobiologics, Inc. | Buffer formulations for enhanced antibody stability |
| CN109195986B (zh) * | 2016-04-20 | 2023-01-03 | 瑞泽恩制药公司 | 基于使用表达增强性基因座来制备抗体的组合物和方法 |
| EP3445780A1 (en) | 2016-04-20 | 2019-02-27 | Regeneron Pharmaceuticals, Inc. | Compositions and methods for making antibodies based on use of an expression-enhancing locus |
| EP3339444A1 (en) * | 2016-12-20 | 2018-06-27 | Mabxience Research, S.L. | Method for obtaining a glycoprotein with an increased percentage of afucosylated glycans |
| AU2019243848B2 (en) | 2018-03-26 | 2025-01-02 | Amgen Inc. | Total afucosylated glycoforms of antibodies produced in cell culture |
| SG11202101099PA (en) * | 2018-08-29 | 2021-03-30 | United Biopharma Inc | Afucosylated antibodies and manufacture thereof |
| WO2020090747A1 (ja) | 2018-10-29 | 2020-05-07 | 株式会社免疫生物研究所 | 抗ｈｉｖ抗体及びその製造方法 |
| US12297451B1 (en) | 2019-10-25 | 2025-05-13 | Regeneron Pharmaceuticals, Inc. | Cell culture medium |
| CN116096745A (zh) | 2020-05-26 | 2023-05-09 | 瑞泽恩制药公司 | 抗sars-cov-2纤突糖蛋白抗体和抗原结合片段 |
| US11999777B2 (en) | 2020-06-03 | 2024-06-04 | Regeneron Pharmaceuticals, Inc. | Methods for treating or preventing SARS-CoV-2 infections and COVID-19 with anti-SARS-CoV-2 spike glycoprotein antibodies |
| CN112843234B (zh) * | 2021-01-20 | 2022-09-06 | 四川大学华西第二医院 | 一种调控生物机体内gdp-甘露糖的浓度的装置 |
| EP4352094A1 (en) | 2021-06-07 | 2024-04-17 | Amgen Inc. | Using fucosidase to control afucosylation level of glycosylated proteins |
| JP2024527235A (ja) | 2021-06-22 | 2024-07-24 | リジェネロン・ファーマシューティカルズ・インコーポレイテッド | 抗ＥＧＦＲｖＩＩＩ抗体薬物コンジュゲート及びその使用 |
| JP2024527607A (ja) | 2021-07-14 | 2024-07-25 | リジェネロン・ファーマシューティカルズ・インコーポレイテッド | 抗ｓａｒｓ－ｃｏｖ－２－スパイク糖タンパク質抗体及び抗原結合断片 |
| WO2023081434A2 (en) | 2021-11-07 | 2023-05-11 | Regeneron Pharmaceuticals, Inc. | Methods for treating or preventing sars-cov-2 infections and covid-19 with anti-sars-cov-2 spike glycoprotein antibodies |
| US20230332084A1 (en) | 2022-03-02 | 2023-10-19 | Regeneron Pharmaceuticals, Inc. | Bioreactor for antibody production |
Family Cites Families (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US1006070A (en) | 1909-05-11 | 1911-10-17 | George Walter Durbrow | Method of and means for extracting micro-organisms and solids from water. |
| EP2275540B1 (en) | 1999-04-09 | 2016-03-23 | Kyowa Hakko Kirin Co., Ltd. | Method for controlling the activity of immunologically functional molecule |
| JP2001145488A (ja) | 1999-11-19 | 2001-05-29 | Natl Inst Of Advanced Industrial Science & Technology Meti | シロイヌナズナ由来のｇｄｐ−４−ケト−６−デオキシ−ｄ−マンノース−３，５−エピメラーゼ−４−レダクターゼ遺伝子 |
| FR2807767B1 (fr) | 2000-04-12 | 2005-01-14 | Lab Francais Du Fractionnement | Anticorps monoclonaux anti-d |
| US6946292B2 (en) | 2000-10-06 | 2005-09-20 | Kyowa Hakko Kogyo Co., Ltd. | Cells producing antibody compositions with increased antibody dependent cytotoxic activity |
| CA2424602C (en) | 2000-10-06 | 2012-09-18 | Kyowa Hakko Kogyo Co., Ltd. | Antibody composition-producing cell |
| US20020150968A1 (en) | 2001-01-10 | 2002-10-17 | Wang Peng G. | Glycoconjugate and sugar nucleotide synthesis using solid supports |
| CA2434802C (en) | 2001-01-16 | 2013-05-28 | Regeneron Pharmaceuticals, Inc. | Isolating cells expressing secreted proteins |
| MXPA04003798A (es) | 2001-10-25 | 2004-07-30 | Genentech Inc | Composiciones de glicoproteina. |
| KR100585140B1 (ko) | 2004-04-26 | 2006-05-30 | 삼성전자주식회사 | 와이어 본딩 장치 및 이를 이용한 반도체 패키지의 와이어본딩 방법 |
| US20060223147A1 (en) * | 2004-08-05 | 2006-10-05 | Kyowa Hakko Kogyo Co., Ltd., | Process for producing glycoprotein composition |
| KR20080032065A (ko) | 2005-06-03 | 2008-04-14 | 제넨테크, 인크. | 푸코실화 수준이 조절된 항체의 생성 방법 |
| DK2059536T3 (da) | 2006-08-14 | 2014-04-14 | Xencor Inc | Optimerede antistoffer, der er rettet mod cd19 |
| US20100028951A1 (en) | 2007-03-07 | 2010-02-04 | Stephen Hamilton | Production of glycoproteins with modified fucosylation |
| EP2150617B1 (en) | 2007-06-04 | 2014-10-22 | Regeneron Pharmaceuticals, Inc. | Enhanced expression and stability regions |
| EP2311864A4 (en) | 2008-08-13 | 2013-07-31 | Kyowa Hakko Kirin Co Ltd | RECOMBINANT PROTEIN-S COMPOSITION |
| BRPI1010035A2 (pt) | 2009-06-02 | 2015-08-25 | Regeneron Pharma | Células deficientes em fucosilação |
| WO2012120500A2 (en) | 2011-03-06 | 2012-09-13 | Merck Serono S.A. | Low fucose cell lines and uses thereof |
-
2010
- 2010-06-01 BR BRPI1010035-0A patent/BRPI1010035A2/pt not_active Application Discontinuation
- 2010-06-01 ES ES10721096.5T patent/ES2527173T3/es active Active
- 2010-06-01 JP JP2012514045A patent/JP5744856B2/ja not_active Expired - Fee Related
- 2010-06-01 TW TW099117652A patent/TWI513818B/zh not_active IP Right Cessation
- 2010-06-01 DK DK14179885.0T patent/DK2808393T3/en active
- 2010-06-01 DK DK17192430.1T patent/DK3279326T3/da active
- 2010-06-01 SG SG2011087517A patent/SG176251A1/en unknown
- 2010-06-01 AU AU2010256753A patent/AU2010256753B2/en not_active Ceased
- 2010-06-01 PL PL10721096T patent/PL2438171T3/pl unknown
- 2010-06-01 PL PL14179885T patent/PL2808393T3/pl unknown
- 2010-06-01 CA CA2764370A patent/CA2764370C/en active Active
- 2010-06-01 PL PL17192430T patent/PL3279326T3/pl unknown
- 2010-06-01 KR KR1020147007025A patent/KR101641526B1/ko not_active Expired - Fee Related
- 2010-06-01 WO PCT/US2010/036914 patent/WO2010141478A1/en not_active Ceased
- 2010-06-01 EP EP17192430.1A patent/EP3279326B1/en active Active
- 2010-06-01 CN CN2010800294912A patent/CN102459603B/zh not_active Expired - Fee Related
- 2010-06-01 ES ES14179885.0T patent/ES2661074T3/es active Active
- 2010-06-01 DK DK10721096.5T patent/DK2438171T3/en active
- 2010-06-01 KR KR1020117031320A patent/KR101441437B1/ko not_active Expired - Fee Related
- 2010-06-01 EP EP14179885.0A patent/EP2808393B1/en active Active
- 2010-06-01 HU HUE14179885A patent/HUE038596T2/hu unknown
- 2010-06-01 US US12/791,637 patent/US8409838B2/en active Active
- 2010-06-01 EP EP10721096.5A patent/EP2438171B1/en active Active
-
2011
- 2011-11-27 IL IL216624A patent/IL216624A/en active IP Right Grant
-
2013
- 2013-02-28 US US13/779,952 patent/US9206455B2/en active Active
-
2014
- 2014-12-12 JP JP2014251541A patent/JP2015051021A/ja not_active Withdrawn
-
2015
- 2015-12-08 US US14/963,178 patent/US9550823B2/en active Active
-
2016
- 2016-03-07 JP JP2016043151A patent/JP6211642B2/ja not_active Expired - Fee Related
- 2016-10-14 JP JP2016202634A patent/JP2017006147A/ja active Pending
- 2016-12-14 US US15/378,670 patent/US10006070B2/en active Active
-
2018
- 2018-05-23 US US15/987,286 patent/US20190024129A1/en not_active Abandoned
-
2019
- 2019-08-30 US US16/556,334 patent/US20200080124A1/en not_active Abandoned
-
2021
- 2021-05-04 US US17/307,255 patent/US11560550B2/en active Active
-
2022
- 2022-12-15 US US18/066,303 patent/US12054751B2/en active Active
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2016104045A5 (enExample) | ||
| AR132934A2 (es) | Medio de cultivo celular suplementado con taurina y métodos de utilización | |
| JP2019505164A5 (enExample) | ||
| BR112019007433A2 (pt) | sistemas de replicon de vírus recombinante e usos dos mesmos | |
| MY189819A (en) | Genetically modified cells and uses thereof | |
| EP3597664A3 (en) | Temperature shift for high yield expression of polypeptides in yeast and other transformed cells | |
| IL310186B1 (en) | Plasma kallikrein binding proteins | |
| EP4477668A3 (en) | Heterodimeric antibody fc-containing proteins and methods for production thereof | |
| HK1218297A1 (zh) | 用於生产单克隆抗体的改进方法 | |
| GB201003701D0 (en) | System for the expression of a protein | |
| PH12022551580A1 (en) | Anti-ctla-4 antibody and use thereof | |
| PL439808A1 (pl) | Sposoby i kompozycje hodowli komórkowych do produkcji przeciwciał | |
| MX381844B (es) | Dsba y dsbc ultrapurificado y métodos para elaborarlos y utilizarlos | |
| MX2015011781A (es) | Medio de cultivo celular y metodos de produccion de anticuerpos. | |
| EA202091349A1 (ru) | Способы культивирования клеток | |
| RU2015129656A (ru) | Гуманизированное моноклональное антитело, специфичное к синдекану-1 | |
| BR112016028538A2 (pt) | processo de produção de proteína glicosilada, processos de produção de proteína de fusão e anticorpo monoclonal e fragmento do mesmo, processo de produção de proteína de fusão tnfr-fc, proteína de fusão ou anticorpo monoclonal e fragmento do mesmo | |
| PL439807A1 (pl) | Sposoby oczyszczania przeciwciał i ich kompozycje | |
| MX2019007924A (es) | Vacunas contra la influenza. | |
| BR112016023980A2 (pt) | anticorpos monoclonais recombinantes vnar que neutralizam o fator de crescimento endotelial vascular (vegf) | |
| JP2016512251A5 (enExample) | ||
| JP2015536347A5 (enExample) | ||
| SG11201902998SA (en) | PROMOTER OF Hspa5 GENE | |
| EA201790241A1 (ru) | Эффективная селективность в отношении рекомбинантных белков | |
| CU20170011A7 (es) | Composiciones que comprenden un polipéptido aglicosilado y métodos para la producción de las mismas |