PL2808393T3 - Komórki z brakiem fukozylacji - Google Patents
Komórki z brakiem fukozylacjiInfo
- Publication number
- PL2808393T3 PL2808393T3 PL14179885T PL14179885T PL2808393T3 PL 2808393 T3 PL2808393 T3 PL 2808393T3 PL 14179885 T PL14179885 T PL 14179885T PL 14179885 T PL14179885 T PL 14179885T PL 2808393 T3 PL2808393 T3 PL 2808393T3
- Authority
- PL
- Poland
- Prior art keywords
- fucosylation
- deficient cells
- deficient
- cells
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/10—Cells modified by introduction of foreign genetic material
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P21/00—Preparation of peptides or proteins
- C12P21/005—Glycopeptides, glycoproteins
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2863—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for growth factors, growth regulators
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2866—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for cytokines, lymphokines, interferons
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/52—Genes encoding for enzymes or proenzymes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/0004—Oxidoreductases (1.)
- C12N9/0006—Oxidoreductases (1.) acting on CH-OH groups as donors (1.1)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P21/00—Preparation of peptides or proteins
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y101/00—Oxidoreductases acting on the CH-OH group of donors (1.1)
- C12Y101/01—Oxidoreductases acting on the CH-OH group of donors (1.1) with NAD+ or NADP+ as acceptor (1.1.1)
- C12Y101/01271—GDP-L-fucose synthase (1.1.1.271)
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/10—Immunoglobulins specific features characterized by their source of isolation or production
- C07K2317/14—Specific host cells or culture conditions, e.g. components, pH or temperature
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/40—Immunoglobulins specific features characterized by post-translational modification
- C07K2317/41—Glycosylation, sialylation, or fucosylation
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/52—Improvements relating to the production of bulk chemicals using catalysts, e.g. selective catalysts
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US18340009P | 2009-06-02 | 2009-06-02 | |
| US34885810P | 2010-05-27 | 2010-05-27 | |
| PCT/US2010/036914 WO2010141478A1 (en) | 2009-06-02 | 2010-06-01 | Fucosylation-deficient cells |
| EP10721096.5A EP2438171B1 (en) | 2009-06-02 | 2010-06-01 | Fucosylation-deficient cells |
| EP14179885.0A EP2808393B1 (en) | 2009-06-02 | 2010-06-01 | Fucosylation-deficient cells |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PL2808393T3 true PL2808393T3 (pl) | 2018-04-30 |
Family
ID=42338231
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PL17192430T PL3279326T3 (pl) | 2009-06-02 | 2010-06-01 | Komórki z deficytem fukozylacji |
| PL10721096T PL2438171T3 (pl) | 2009-06-02 | 2010-06-01 | Komórki z niedoborem fukozylacji |
| PL14179885T PL2808393T3 (pl) | 2009-06-02 | 2010-06-01 | Komórki z brakiem fukozylacji |
Family Applications Before (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PL17192430T PL3279326T3 (pl) | 2009-06-02 | 2010-06-01 | Komórki z deficytem fukozylacji |
| PL10721096T PL2438171T3 (pl) | 2009-06-02 | 2010-06-01 | Komórki z niedoborem fukozylacji |
Country Status (17)
| Country | Link |
|---|---|
| US (8) | US8409838B2 (pl) |
| EP (3) | EP2808393B1 (pl) |
| JP (4) | JP5744856B2 (pl) |
| KR (2) | KR101641526B1 (pl) |
| CN (1) | CN102459603B (pl) |
| AU (1) | AU2010256753B2 (pl) |
| BR (1) | BRPI1010035A2 (pl) |
| CA (1) | CA2764370C (pl) |
| DK (3) | DK3279326T3 (pl) |
| ES (2) | ES2527173T3 (pl) |
| HK (3) | HK1198180A1 (pl) |
| HU (1) | HUE038596T2 (pl) |
| IL (1) | IL216624A (pl) |
| PL (3) | PL3279326T3 (pl) |
| SG (1) | SG176251A1 (pl) |
| TW (1) | TWI513818B (pl) |
| WO (1) | WO2010141478A1 (pl) |
Families Citing this family (30)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102459603B (zh) | 2009-06-02 | 2013-11-06 | 瑞泽恩制药公司 | 岩藻糖基化缺陷型细胞 |
| EP2683821B1 (en) | 2011-03-06 | 2018-07-25 | Merck Serono SA | Low fucose cell lines and uses thereof |
| WO2013013013A2 (en) * | 2011-07-21 | 2013-01-24 | Alnylam Pharmaceuticals, Inc. | Compositions and methods for producing modified glycoproteins |
| TW201823460A (zh) | 2012-05-29 | 2018-07-01 | 美商再生元醫藥公司 | 生產細胞株增強子 |
| EP2722673B1 (en) | 2012-10-17 | 2017-07-12 | Hexal AG | Improved method of mapping glycans of glycoproteins |
| AR095196A1 (es) | 2013-03-15 | 2015-09-30 | Regeneron Pharma | Medio de cultivo celular libre de suero |
| WO2015033343A1 (en) | 2013-09-03 | 2015-03-12 | Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd. | Compositions and methods for expressing recombinant polypeptides |
| WO2015057393A1 (en) * | 2013-10-01 | 2015-04-23 | University Of Wyoming | Compositions and methods for reducing fucosylation of glycoproteins in insect cells and methods of use thereof for production recombinant glycoproteins |
| HUE045307T2 (hu) | 2014-03-11 | 2019-12-30 | Regeneron Pharma | EGFRVIII-ellenes antitestek és alkalmazásaik |
| CN106604930B (zh) * | 2014-05-30 | 2021-10-29 | 新英格兰生物实验室公司 | 去糖基化试剂和方法 |
| WO2016007506A1 (en) * | 2014-07-07 | 2016-01-14 | Targazyme, Inc. | Manufacture and cryopreservation of fucosylated cells for therapeutic use |
| CN105671109B (zh) * | 2014-11-20 | 2019-08-23 | 中国人民解放军军事医学科学院生物工程研究所 | 用糖基工程酵母制备具有动物细胞糖基化修饰流感血凝素糖蛋白的方法 |
| TWI710573B (zh) | 2015-01-26 | 2020-11-21 | 美商再生元醫藥公司 | 抗伊波拉病毒醣蛋白之人類抗體 |
| TW202330904A (zh) | 2015-08-04 | 2023-08-01 | 美商再生元醫藥公司 | 補充牛磺酸之細胞培養基及用法 |
| CN116731147A (zh) * | 2015-11-02 | 2023-09-12 | 豪夫迈·罗氏有限公司 | 制备岩藻糖基化和去岩藻糖基化形式的蛋白质的方法 |
| AU2017206006B2 (en) | 2016-01-06 | 2019-08-29 | Outlook Therapeutics, Inc. | Modulation of afucosylated species in a monoclonal antibody composition |
| JP7084308B2 (ja) | 2016-02-03 | 2022-06-14 | アウトルック セラピューティクス，インコーポレイティド | 抗体安定性を増大させるための緩衝液製剤 |
| EP3445781A1 (en) * | 2016-04-20 | 2019-02-27 | Regeneron Pharmaceuticals, Inc. | Compositions and methods for making antibodies based on use of expression-enhancing loci |
| CN116004544A (zh) | 2016-04-20 | 2023-04-25 | 瑞泽恩制药公司 | 基于使用表达增强性基因座来制备抗体的组合物和方法 |
| EP3339444A1 (en) * | 2016-12-20 | 2018-06-27 | Mabxience Research, S.L. | Method for obtaining a glycoprotein with an increased percentage of afucosylated glycans |
| AU2018438767B9 (en) * | 2018-08-29 | 2023-10-05 | United Biopharma Inc | Afucosylated antibodies and manufacture thereof |
| CN113423731A (zh) | 2018-10-29 | 2021-09-21 | 株式会社免疫生物研究所 | 抗hiv抗体及其制造方法 |
| MX2022014598A (es) | 2020-05-26 | 2023-03-31 | Regeneron Pharma | Anticuerpos anti-glicoproteína espicular sars-cov-2 y fragmentos de unión al antígeno. |
| CA3181026A1 (en) | 2020-06-03 | 2021-12-09 | Samit GANGULY | Methods for treating or preventing sars-cov-2 infections and covid-19 with anti-sars-cov-2 spike glycoprotein antibodies |
| CN112843234B (zh) * | 2021-01-20 | 2022-09-06 | 四川大学华西第二医院 | 一种调控生物机体内gdp-甘露糖的浓度的装置 |
| CA3222409A1 (en) | 2021-06-07 | 2022-12-15 | Amgen Inc. | Using fucosidase to control afucosylation level of glycosylated proteins |
| AU2022298653A1 (en) | 2021-06-22 | 2023-10-12 | Regeneron Pharmaceuticals, Inc. | Anti-egfrviii antibody drug conjugates and uses thereof |
| IL310012A (en) | 2021-07-14 | 2024-03-01 | Regeneron Pharma | Antibodies against SARS-COV-2 spike glycoprotein and antigen-binding fragments |
| WO2023081434A2 (en) | 2021-11-07 | 2023-05-11 | Regeneron Pharmaceuticals, Inc. | Methods for treating or preventing sars-cov-2 infections and covid-19 with anti-sars-cov-2 spike glycoprotein antibodies |
| WO2023167857A1 (en) | 2022-03-02 | 2023-09-07 | Regeneron Pharmaceuticals, Inc. | Cell culture methods for antibody production |
Family Cites Families (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DK2270150T4 (da) | 1999-04-09 | 2019-08-26 | Kyowa Hakko Kirin Co Ltd | Fremgangsmåde til at kontrollere aktiviteten af immunologisk funktionelt molekyle. |
| JP2001145488A (ja) | 1999-11-19 | 2001-05-29 | Natl Inst Of Advanced Industrial Science & Technology Meti | シロイヌナズナ由来のｇｄｐ−４−ケト−６−デオキシ−ｄ−マンノース−３，５−エピメラーゼ−４−レダクターゼ遺伝子 |
| FR2807767B1 (fr) | 2000-04-12 | 2005-01-14 | Lab Francais Du Fractionnement | Anticorps monoclonaux anti-d |
| US6946292B2 (en) | 2000-10-06 | 2005-09-20 | Kyowa Hakko Kogyo Co., Ltd. | Cells producing antibody compositions with increased antibody dependent cytotoxic activity |
| PL218428B1 (pl) * | 2000-10-06 | 2014-12-31 | Kyowa Hakko Kogyo Kk | Komórka, sposoby wytwarzania przeciwciał, leki zawierające przeciwciała, komórka CHO i przeciwciało klasy IgG |
| US20020150968A1 (en) | 2001-01-10 | 2002-10-17 | Wang Peng G. | Glycoconjugate and sugar nucleotide synthesis using solid supports |
| DE60211329T2 (de) | 2001-01-16 | 2007-05-24 | Regeneron Pharmaceuticals, Inc. | Isolierung von sezernierte proteine exprimierenden zellen |
| KR100988949B1 (ko) | 2001-10-25 | 2010-10-20 | 제넨테크, 인크. | 당단백질 조성물 |
| KR100585140B1 (ko) | 2004-04-26 | 2006-05-30 | 삼성전자주식회사 | 와이어 본딩 장치 및 이를 이용한 반도체 패키지의 와이어본딩 방법 |
| US20060223147A1 (en) | 2004-08-05 | 2006-10-05 | Kyowa Hakko Kogyo Co., Ltd., | Process for producing glycoprotein composition |
| MX2007015107A (es) | 2005-06-03 | 2008-02-15 | Genentech Inc | Metodo para producir anticuerpos con funcion mejorada. |
| WO2008022152A2 (en) | 2006-08-14 | 2008-02-21 | Xencor, Inc. | Optimized antibodies that target cd19 |
| RU2479629C2 (ru) | 2007-03-07 | 2013-04-20 | Гликофи, Инк. | Продукция гликопротеинов с модифицированным фукозилированием |
| ES2522615T3 (es) | 2007-06-04 | 2014-11-17 | Regeneron Pharmaceuticals, Inc. | Regiones de expresión y estabilidad potenciadas |
| WO2010018847A1 (ja) | 2008-08-13 | 2010-02-18 | 協和発酵キリン株式会社 | 遺伝子組換えプロテインs組成物 |
| CN102459603B (zh) | 2009-06-02 | 2013-11-06 | 瑞泽恩制药公司 | 岩藻糖基化缺陷型细胞 |
| EP2683821B1 (en) | 2011-03-06 | 2018-07-25 | Merck Serono SA | Low fucose cell lines and uses thereof |
-
2010
- 2010-06-01 CN CN2010800294912A patent/CN102459603B/zh active Active
- 2010-06-01 EP EP14179885.0A patent/EP2808393B1/en active Active
- 2010-06-01 US US12/791,637 patent/US8409838B2/en active Active
- 2010-06-01 PL PL17192430T patent/PL3279326T3/pl unknown
- 2010-06-01 EP EP10721096.5A patent/EP2438171B1/en active Active
- 2010-06-01 JP JP2012514045A patent/JP5744856B2/ja active Active
- 2010-06-01 KR KR1020147007025A patent/KR101641526B1/ko active IP Right Grant
- 2010-06-01 EP EP17192430.1A patent/EP3279326B1/en active Active
- 2010-06-01 WO PCT/US2010/036914 patent/WO2010141478A1/en active Application Filing
- 2010-06-01 CA CA2764370A patent/CA2764370C/en active Active
- 2010-06-01 ES ES10721096.5T patent/ES2527173T3/es active Active
- 2010-06-01 HU HUE14179885A patent/HUE038596T2/hu unknown
- 2010-06-01 DK DK17192430.1T patent/DK3279326T3/da active
- 2010-06-01 PL PL10721096T patent/PL2438171T3/pl unknown
- 2010-06-01 ES ES14179885.0T patent/ES2661074T3/es active Active
- 2010-06-01 SG SG2011087517A patent/SG176251A1/en unknown
- 2010-06-01 DK DK14179885.0T patent/DK2808393T3/en active
- 2010-06-01 TW TW099117652A patent/TWI513818B/zh active
- 2010-06-01 DK DK10721096.5T patent/DK2438171T3/en active
- 2010-06-01 KR KR1020117031320A patent/KR101441437B1/ko active IP Right Grant
- 2010-06-01 BR BRPI1010035-0A patent/BRPI1010035A2/pt not_active Application Discontinuation
- 2010-06-01 PL PL14179885T patent/PL2808393T3/pl unknown
- 2010-06-01 AU AU2010256753A patent/AU2010256753B2/en active Active
-
2011
- 2011-11-27 IL IL216624A patent/IL216624A/en active IP Right Grant
-
2012
- 2012-05-07 HK HK14112533.3A patent/HK1198180A1/xx unknown
- 2012-05-07 HK HK12104409.3A patent/HK1163745A1/xx unknown
-
2013
- 2013-02-28 US US13/779,952 patent/US9206455B2/en active Active
-
2014
- 2014-12-12 JP JP2014251541A patent/JP2015051021A/ja not_active Withdrawn
-
2015
- 2015-12-08 US US14/963,178 patent/US9550823B2/en active Active
-
2016
- 2016-03-07 JP JP2016043151A patent/JP6211642B2/ja active Active
- 2016-10-14 JP JP2016202634A patent/JP2017006147A/ja active Pending
- 2016-12-14 US US15/378,670 patent/US10006070B2/en active Active
-
2018
- 2018-05-23 US US15/987,286 patent/US20190024129A1/en not_active Abandoned
- 2018-07-12 HK HK18109072.2A patent/HK1249547A1/zh unknown
-
2019
- 2019-08-30 US US16/556,334 patent/US20200080124A1/en not_active Abandoned
-
2021
- 2021-05-04 US US17/307,255 patent/US11560550B2/en active Active
-
2022
- 2022-12-15 US US18/066,303 patent/US20230295583A1/en active Pending
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