JP2016052331A5 - - Google Patents

Download PDF

Info

Publication number
JP2016052331A5
JP2016052331A5 JP2016000233A JP2016000233A JP2016052331A5 JP 2016052331 A5 JP2016052331 A5 JP 2016052331A5 JP 2016000233 A JP2016000233 A JP 2016000233A JP 2016000233 A JP2016000233 A JP 2016000233A JP 2016052331 A5 JP2016052331 A5 JP 2016052331A5
Authority
JP
Japan
Prior art keywords
nucleic acid
signal peptide
seq
plant
influenza
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP2016000233A
Other languages
English (en)
Japanese (ja)
Other versions
JP6215363B2 (ja
JP2016052331A (ja
Filing date
Publication date
Priority claimed from PCT/CA2008/001281 external-priority patent/WO2009009876A1/en
Priority claimed from PCT/CA2009/000032 external-priority patent/WO2009076778A1/en
Application filed filed Critical
Publication of JP2016052331A publication Critical patent/JP2016052331A/ja
Publication of JP2016052331A5 publication Critical patent/JP2016052331A5/ja
Application granted granted Critical
Publication of JP6215363B2 publication Critical patent/JP6215363B2/ja
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

JP2016000233A 2007-11-27 2016-01-04 赤血球凝集素を含むインフルエンザウイルス様粒子（ＶＬＰｓ） Active JP6215363B2 (ja)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US99060307P 2007-11-27 2007-11-27
US1327207P 2007-12-12 2007-12-12
US2277508P 2008-01-22 2008-01-22
CAPCT/CA2008/001281 2008-07-11
PCT/CA2008/001281 WO2009009876A1 (en) 2007-07-13 2008-07-11 Influenza virus-like particles (vlps) comprising hemagglutinin produced within a plant
CAPCT/CA2009/000032 2009-01-12
PCT/CA2009/000032 WO2009076778A1 (en) 2007-11-27 2009-01-12 Recombinant influenza virus-like particles (vlps) produced in transgenic plants expressing hemagglutinin

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
JP2011516934A Division JP5921884B2 (ja) 2008-07-11 2009-07-02 赤血球凝集素を含むインフルエンザウイルス様粒子（ｖｌｐｓ）

Publications (3)

Publication Number Publication Date
JP2016052331A JP2016052331A (ja) 2016-04-14
JP2016052331A5 true JP2016052331A5 (OSRAM) 2016-06-30
JP6215363B2 JP6215363B2 (ja) 2017-10-18

Family

ID=40795157

Family Applications (4)

Application Number Title Priority Date Filing Date
JP2010542486A Pending JP2011509661A (ja) 2007-11-27 2009-01-12 ヘマグルチニンを発現するトランスジェニック植物において産生された組換え型インフルエンザウイルス様粒子（ｖｌｐ）
JP2014039035A Active JP5990207B2 (ja) 2007-11-27 2014-02-28 ヘマグルチニンを発現するトランスジェニック植物において産生された組換え型インフルエンザウイルス様粒子（ｖｌｐ）
JP2015231583A Withdrawn JP2016032477A (ja) 2007-11-27 2015-11-27 ヘマグルチニンを発現するトランスジェニック植物において産生された組換え型インフルエンザウイルス様粒子（ｖｌｐ）
JP2016000233A Active JP6215363B2 (ja) 2007-11-27 2016-01-04 赤血球凝集素を含むインフルエンザウイルス様粒子（ＶＬＰｓ）

Family Applications Before (3)

Application Number Title Priority Date Filing Date
JP2010542486A Pending JP2011509661A (ja) 2007-11-27 2009-01-12 ヘマグルチニンを発現するトランスジェニック植物において産生された組換え型インフルエンザウイルス様粒子（ｖｌｐ）
JP2014039035A Active JP5990207B2 (ja) 2007-11-27 2014-02-28 ヘマグルチニンを発現するトランスジェニック植物において産生された組換え型インフルエンザウイルス様粒子（ｖｌｐ）
JP2015231583A Withdrawn JP2016032477A (ja) 2007-11-27 2015-11-27 ヘマグルチニンを発現するトランスジェニック植物において産生された組換え型インフルエンザウイルス様粒子（ｖｌｐ）

Country Status (18)

Country Link
US (4) US20100310604A1 (OSRAM)
EP (2) EP2238253B1 (OSRAM)
JP (4) JP2011509661A (OSRAM)
KR (1) KR20100120157A (OSRAM)
CN (2) CN103122354B (OSRAM)
AU (1) AU2009202819B2 (OSRAM)
CA (1) CA2707235C (OSRAM)
CR (1) CR11612A (OSRAM)
DK (1) DK2610345T3 (OSRAM)
ES (1) ES2554703T3 (OSRAM)
IL (1) IL206967A (OSRAM)
IS (1) IS2982B (OSRAM)
MA (1) MA32439B1 (OSRAM)
MX (1) MX2010007962A (OSRAM)
NZ (1) NZ587108A (OSRAM)
PT (1) PT2610345E (OSRAM)
WO (1) WO2009076778A1 (OSRAM)
ZA (1) ZA201005917B (OSRAM)

Families Citing this family (54)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2615372A1 (en) 2007-07-13 2009-01-13 Marc-Andre D'aoust Influenza virus-like particles (vlps) comprising hemagglutinin
EP2238253B1 (en) 2007-11-27 2012-09-12 Medicago Inc. Recombinant influenza virus-like particles (vlps) produced in transgenic plants expressing hemagglutinin
CA2730171C (en) * 2008-07-08 2016-10-11 Medicago Inc. Soluble recombinant influenza antigens
ES2593277T3 (es) 2008-07-18 2016-12-07 Medicago Inc. Nuevo epítopo de inmunización contra el virus de la influenza
MY159543A (en) 2008-11-28 2017-01-13 Merial Inc Recombinant avian influenza vaccine and uses thereof
JP2012521786A (ja) 2009-03-30 2012-09-20 モウント シナイ スクール オフ メディシネ インフルエンザウイルスワクチン及びその使用
NZ597401A (en) * 2009-06-24 2013-09-27 Medicago Inc Chimeric influenza virus-like particles comprising hemagglutinin
DK2480560T3 (en) 2009-09-22 2018-04-16 Medicago Inc PROCEDURE FOR THE PREPARATION OF PLANT DERIVATIVE PROTEINS
AU2010343095B2 (en) * 2009-12-28 2017-01-05 Sanofi Vaccine Technologies, S.A.S. Production of heterologous polypeptides in microalgae, microalgal extracellular bodies, compositions, and methods of making and uses thereof
MX351643B (es) 2009-12-28 2017-10-23 Merial Ltd Antigeno ndv recombinante y usos del mismo.
JP2013520172A (ja) 2010-02-18 2013-06-06 モウント シナイ スクール オフ メディシネ インフルエンザウイルス疾患の予防及び治療で用いるためのワクチン
NZ702145A (en) 2010-03-12 2016-03-31 Merial Inc Bluetongue virus recombinant vaccines and uses thereof
AU2011235220B2 (en) 2010-03-30 2016-03-10 Mount Sinai School Of Medicine Influenza virus vaccines and uses thereof
BR112013007593A2 (pt) 2010-09-30 2016-08-09 Franvax S R L partícula de virossoma produzida sinteticamente, vacina, método para produzir uma partícula de virossoma, uso de uma partícula de virossoma e de uma vacina
US20130295609A1 (en) * 2010-11-04 2013-11-07 Medicago Inc. Plant expression system
TWI526539B (zh) * 2010-12-22 2016-03-21 苜蓿股份有限公司 植物中生產類病毒顆粒(vlp)的方法及以該方法生產之vlp
TWI620816B (zh) * 2011-03-23 2018-04-11 苜蓿股份有限公司 植物衍生蛋白回收方法
EP2700399B1 (en) 2011-04-18 2017-05-31 National Center of Neurology and Psychiatry Drug delivery particles and method for producing same
WO2012145759A2 (en) * 2011-04-21 2012-10-26 Arizona Board Of Regents, A Body Corporate Of The State Of Arizona Acting For And On Behalf Of Arizona State University Methods of protein production and compositions thereof
JP5846624B2 (ja) * 2011-05-30 2016-01-20 公益財団法人ヒューマンサイエンス振興財団 Ｈ５ｎ１型インフルエンザワクチン及び感染防御キット
KR101963792B1 (ko) * 2011-06-13 2019-07-31 메디카고 인코포레이티드 식물에서 광견병 바이러스 유사 입자 생성
ES2953393T3 (es) 2011-09-20 2023-11-10 Icahn School Med Mount Sinai Vacunas contra el virus de la influenza y sus usos
GB201116416D0 (en) * 2011-09-23 2011-11-02 Isis Innovation Composition
US11390878B2 (en) * 2011-09-30 2022-07-19 Medicago Inc. Increasing protein yield in plants
CN116218900A (zh) * 2011-09-30 2023-06-06 麦迪卡格公司 增加植物中病毒样颗粒的产率
SG11201406996VA (en) * 2012-05-11 2014-11-27 Medicago Inc Rotavirus-like particle production in plants
EP2934581B1 (en) 2012-12-18 2022-09-14 Icahn School of Medicine at Mount Sinai Influenza virus vaccines and uses thereof
US9908930B2 (en) 2013-03-14 2018-03-06 Icahn School Of Medicine At Mount Sinai Antibodies against influenza virus hemagglutinin and uses thereof
ES2803508T3 (es) 2013-03-28 2021-01-27 Medicago Inc Producción de partículas similares al virus de la gripe en plantas
US12467058B2 (en) 2013-03-28 2025-11-11 Aramis Biotechnologies Inc. Influenza virus-like particle production in plants
EP3092309B1 (en) * 2014-01-10 2021-02-24 Medicago Inc. Cpmv enhancer elements
ES2912291T3 (es) 2014-03-27 2022-05-25 Medicago Inc Elementos potenciadores de CPMV modificados
US11959088B2 (en) 2014-07-11 2024-04-16 Aramis Biotechnologies Inc. Modifying protein production in plants
JP2018504412A (ja) 2015-01-23 2018-02-15 アイカーン スクール オブ メディシン アット マウント サイナイ インフルエンザウイルスワクチン接種レジメン
EA201791683A1 (ru) 2015-01-23 2017-12-29 Медикаго Инк. Получение ротавирусоподобных частиц в растениях
US10584148B2 (en) * 2015-06-02 2020-03-10 Sanofi Pasteur Inc. Engineered influenza antigenic polypeptides and immunogenic compositions thereof
JP2018524345A (ja) 2015-07-02 2018-08-30 メディカゴ インコーポレイテッド ジャスモン酸経路アクチベーター
MA45165A (fr) 2016-06-02 2019-04-10 Sanofi Pasteur Inc Polypeptides antigéniques de la grippe modifiés et compositions immunogéniques associées
EP3471767A4 (en) 2016-06-15 2020-01-15 Icahn School of Medicine at Mount Sinai Influenza virus hemagglutinin proteins and uses thereof
FR3054547B1 (fr) * 2016-07-29 2020-06-05 Angany Inc. Particules pseudo-virales et leurs utilisations
WO2018053178A1 (en) * 2016-09-16 2018-03-22 Vaccitech, Inc. Compositions and methods for vaccination against influenza
US11254733B2 (en) 2017-04-07 2022-02-22 Icahn School Of Medicine At Mount Sinai Anti-influenza B virus neuraminidase antibodies and uses thereof
GB201708866D0 (en) * 2017-06-02 2017-07-19 Univ Cape Town Expression of chaperone proteins in planta for increased expression of heterologous polypeptides of interest
CN107058377A (zh) * 2017-06-16 2017-08-18 深圳惠升生物科技有限公司 植物作为宿主在表达中东呼吸综合征的疫苗中的应用
US11649465B2 (en) * 2017-09-11 2023-05-16 R.J. Reynolds Tobacco Company Methods and compositions for increasing expression of genes of interest in a plant by co-expression with p21
CN112400021A (zh) 2018-03-14 2021-02-23 麦迪卡格公司 植物表达增强子
EP3810634A4 (en) 2018-06-21 2022-07-27 Icahn School of Medicine at Mount Sinai Mosaic influenza virus hemagglutinin polypeptides and uses thereof
MX2020013957A (es) * 2018-06-27 2021-03-09 Medicago Inc Mutantes de hemaglutinina del virus de la influenza.
US20210324394A1 (en) 2018-08-17 2021-10-21 Centre National De La Recherche Scientifique (Cnrs) Rna-based biocontrol methods to protect plants against pathogenic bacteria and / or promote beneficial effects of symbiotic and commensal bacteria
EP3938511A4 (en) 2019-03-14 2023-02-08 Mitsubishi Tanabe Pharma Corporation Endogenous plant expression enhancer
KR20220118421A (ko) * 2019-12-18 2022-08-25 제네똥 식물 모상근으로부터 재조합 바이러스 벡터의 제조
EP4141121A4 (en) * 2020-04-22 2024-07-10 POSTECH Research and Business Development Foundation RECOMBINANT HEMAGGLUTININ PROTEIN DERIVED FROM TRIMER-FORMING INFLUENZA VIRUS SURFACE PROTEIN AND USE THEREOF
EP4139331A4 (en) * 2020-04-22 2024-10-02 Aramis Biotechnologies Inc. SUPRASTRUCTURE WITH MODIFIED INFLUENZA HEMAGGLUTININ WITH REDUCED INTERACTION WITH SIALIC ACID
CN111888390B (zh) * 2020-08-27 2021-12-14 广州白云山星群(药业)股份有限公司 夏桑菊提取物在抑制人类冠状病毒中的应用

Family Cites Families (75)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5428147A (en) 1983-04-15 1995-06-27 Mycogen Plant Science, Inc. Octopine T-DNA promoters
US5036006A (en) 1984-11-13 1991-07-30 Cornell Research Foundation, Inc. Method for transporting substances into living cells and tissues and apparatus therefor
US5100792A (en) 1984-11-13 1992-03-31 Cornell Research Foundation, Inc. Method for transporting substances into living cells and tissues
US4945050A (en) 1984-11-13 1990-07-31 Cornell Research Foundation, Inc. Method for transporting substances into living cells and tissues and apparatus therefor
WO1986003224A1 (en) 1984-11-29 1986-06-05 Scripps Clinic And Research Foundation Polypeptides and antibodies related to deglycosylated viral glycoproteins
JPS61265086A (ja) 1985-05-21 1986-11-22 Mitsui Toatsu Chem Inc プロトプラストの培養法
US4962028A (en) 1986-07-09 1990-10-09 Dna Plant Technology Corporation Plant promotors
US5232833A (en) 1988-09-14 1993-08-03 Stressgen Biotechnologies Corporation Accumulation of heat shock proteins for evaluating biological damage due to chronic exposure of an organism to sublethal levels of pollutants
US6403865B1 (en) 1990-08-24 2002-06-11 Syngenta Investment Corp. Method of producing transgenic maize using direct transformation of commercially important genotypes
EP0509656B1 (en) * 1991-03-28 1996-09-18 Rooperol (Na) Nv Compositions of phytosterols and phytosterolins as immunmodulators
UA48104C2 (uk) 1991-10-04 2002-08-15 Новартіс Аг Фрагмент днк, який містить послідовність,що кодує інсектицидний протеїн, оптимізовану для кукурудзи,фрагмент днк, який забезпечує направлену бажану для серцевини стебла експресію зв'язаного з нею структурного гена в рослині, фрагмент днк, який забезпечує специфічну для пилку експресію зв`язаного з нею структурного гена в рослині, рекомбінантна молекула днк, спосіб одержання оптимізованої для кукурудзи кодуючої послідовності інсектицидного протеїну, спосіб захисту рослин кукурудзи щонайменше від однієї комахи-шкідника
US6326470B1 (en) 1997-04-15 2001-12-04 The Penn State Research Foundation Enhancement of accessibility of cellulose by expansins
US5762939A (en) * 1993-09-13 1998-06-09 Mg-Pmc, Llc Method for producing influenza hemagglutinin multivalent vaccines using baculovirus
GB9414118D0 (en) * 1994-07-13 1994-08-31 Axis Genetics Ltd Modified plant viruses as vectors of heterologous peptides
US6020169A (en) 1995-07-20 2000-02-01 Washington State University Research Foundation Production of secreted foreign polypeptides in plant cell culture
US5773695A (en) 1996-01-26 1998-06-30 North Carolina State University Plant nuclear scaffold attachment region and method for increasing gene expression in transgenic cells
US6042832A (en) 1996-08-28 2000-03-28 Thomas Jefferson University Polypeptides fused with alfalfa mosaic virus or ilarvirus capsid proteins
US20010006950A1 (en) 1998-02-11 2001-07-05 Juha Punnonen Genetic vaccine vector engineering
US6489537B1 (en) 1998-08-07 2002-12-03 The Trustees Of The University Of Pennsylvania Phytochelatin synthases and uses therefor
AU759813B2 (en) 1998-08-11 2003-05-01 Kentucky Bioprocessing, Llc Method for recovering proteins from the interstitial fluid of plant tissues
US6287570B1 (en) 1998-11-23 2001-09-11 Patricia L. Foley Vaccine against swine influenza virus
FR2791358B1 (fr) 1999-03-22 2003-05-16 Meristem Therapeutics Promoteurs chimeriques d'expression, cassettes d'expression, plasmides, vecteurs, plantes et semences transgeniques les contenant et leurs methodes d'obtention
ES2262514T3 (es) 1999-04-29 2006-12-01 Syngenta Limited Plantas resistentes a herbicidas.
US7125978B1 (en) 1999-10-04 2006-10-24 Medicago Inc. Promoter for regulating expression of foreign genes
DE60022369T2 (de) 1999-10-04 2006-05-18 Medicago Inc., Sainte Foy Verfahren zur regulation der transkription von fremden genen in gegenwart von stickstoff
CA2435000C (en) 2001-01-18 2014-03-25 Vlaams Interuniversitair Instituut Voor Biotechnologie Vzw Oligomeric complexes of chimeric proteins with enhanced immunogenic potential
ES2563402T3 (es) * 2002-02-13 2016-03-15 Wisconsin Alumni Research Foundation Señal para el empaquetamiento de vectores del virus de la gripe
AU2003217413A1 (en) 2002-02-14 2003-09-04 Novavax, Inc. Method for isolation and purification of expressed gene products in vitro
WO2003078614A2 (en) * 2002-03-19 2003-09-25 Plant Research International B.V. Gntiii (udp-n-acethylglucosamine:beta-d mannoside beta (1,4)-n-acethylglucosaminy ltransferase iii) expression in plants
ES2224792B1 (es) 2002-06-28 2007-02-16 Era Plantech, S.L. Produccion de peptidos y proteinas por acumulacion de cuerpos proteicos derivados de reticulos endoplasmico en plantas.
WO2004098533A2 (en) * 2003-05-05 2004-11-18 Boyce Thompson Institute For Plant Research Vectors and cells for preparing immunoprotective compositions derived from transgenic plants
KR20060029214A (ko) * 2003-05-05 2006-04-05 다우 아그로사이언시즈 엘엘씨 이식 유전자 식물 세포들로부터 유래된 안정한 면역예방적및 치료적 조성물들 및 생산방법
US7566458B2 (en) 2003-06-16 2009-07-28 Medimmune, Llc Influenza hemagglutinin and neuraminidase variants
US8592197B2 (en) * 2003-07-11 2013-11-26 Novavax, Inc. Functional influenza virus-like particles (VLPs)
US7226781B1 (en) 2003-07-24 2007-06-05 Belyaev Alexander S Chaperone expression genomes
CN101065145B (zh) 2004-08-13 2010-12-15 印度科学工业研究所 嵌合g蛋白基狂犬疫苗
US9155483B2 (en) 2004-12-03 2015-10-13 The Invention Science Fund I, Llc Vision modification with reflected image
CN103031310B (zh) 2005-04-29 2018-09-14 开普敦大学 在植物中表达蛋白质
CN100410378C (zh) * 2005-05-09 2008-08-13 中国农业科学院生物技术研究所 编码禽流感血凝素的基因及其植物表达载体和应用
CA2615658A1 (en) 2005-07-19 2007-01-25 Dow Global Technolgies Inc. Recombinant flu vaccines
US7871626B2 (en) 2005-08-04 2011-01-18 St. Jude Children's Research Hospital Modified influenza virus for monitoring and improving vaccine efficiency
AU2006279323B2 (en) 2005-08-16 2013-08-01 Merck Sharp & Dohme Corp. Influenza recombinant subunit vaccine
AU2006304640B2 (en) 2005-10-18 2012-10-11 Novavax, Inc. Functional influenza virus like particles (VLPs)
EP1969001A2 (en) 2005-11-22 2008-09-17 Novartis Vaccines and Diagnostics, Inc. Norovirus and sapovirus antigens
AU2007215080A1 (en) 2006-02-13 2007-08-23 Fraunhofer Usa, Inc. Influenza antigens, vaccine compositions, and related methods
KR20090034297A (ko) 2006-02-16 2009-04-07 더 거번먼트 오브 더 유나이티드 스테이츠 오브 어메리카 애즈 레프리젠티드 바이 더 세크러터리 오브 더 디파트먼트 오브 헬쓰 앤드 휴먼 써비시즈 인플루엔자에 대한 항바이러스제 및 백신
JP2009535306A (ja) 2006-04-21 2009-10-01 ダウ・アグロサイエンス・エル・エル・シー 鳥インフルエンザに対するワクチンおよび使用方法
WO2007130327A2 (en) 2006-05-01 2007-11-15 Technovax, Inc. Influenza virus-like particle (vlp) compositions
EP2023952B1 (en) 2006-05-18 2015-07-15 Epimmune Inc. Inducing immune responses to influenza virus using polypeptide and nucleic acid compositions
WO2007135480A1 (en) 2006-05-22 2007-11-29 Plant Bioscience Limited Bipartite system, method and composition for the constitutive and inducible expression of high levels of foreign proteins in plants
US20070286873A1 (en) * 2006-05-23 2007-12-13 Williams John V Recombinant Influenza H5 Hemagluttinin Protein And Nucleic Acid Coding Therefor
US7730950B2 (en) 2007-01-19 2010-06-08 Halliburton Energy Services, Inc. Methods for treating intervals of a subterranean formation having variable permeability
WO2008148104A1 (en) 2007-05-25 2008-12-04 Novavax, Inc. Novel vlps derived from cells that do not express a viral matrix or core protein
MX2009013665A (es) 2007-06-15 2010-06-02 Medicago Inc Produccion modificada de glicoproteinas en plantas.
KR100964462B1 (ko) * 2007-07-10 2010-06-16 성균관대학교산학협력단 형질전환 식물 유래의 조류독감 바이러스 백신 및 그 제조방법
CA2615372A1 (en) 2007-07-13 2009-01-13 Marc-Andre D'aoust Influenza virus-like particles (vlps) comprising hemagglutinin
CN101820903A (zh) 2007-08-20 2010-09-01 美国弗劳恩霍夫股份有限公司 预防性和治疗性流感疫苗、抗原、组合物和方法
EP2238253B1 (en) 2007-11-27 2012-09-12 Medicago Inc. Recombinant influenza virus-like particles (vlps) produced in transgenic plants expressing hemagglutinin
WO2009083420A1 (en) 2007-12-28 2009-07-09 Unilever Plc Process for recovering aroma from tea
GB0800272D0 (en) 2008-01-08 2008-02-13 Plant Bioscience Ltd Protein expression systems
KR101956910B1 (ko) 2008-01-21 2019-03-12 메디카고 인코포레이티드 헤마글루티닌을 발현하는 트랜스제닉 식물에서 생산된 재조합 인플루엔자 바이러스-유사 입자(ＶＬＰｓ)
CA2730171C (en) 2008-07-08 2016-10-11 Medicago Inc. Soluble recombinant influenza antigens
ES2593277T3 (es) 2008-07-18 2016-12-07 Medicago Inc. Nuevo epítopo de inmunización contra el virus de la influenza
WO2010025285A1 (en) 2008-08-27 2010-03-04 Arizona Board Of Regents For And On Behalf Of Arizona State University A dna replicon system for high-level rapid production of vaccines and monoclonal antibody therapeutics in plants
US20100167376A1 (en) 2008-10-06 2010-07-01 Genvault Corporation Methods for providing cellular lysates from cell wall-containing samples
WO2010077712A1 (en) 2008-12-09 2010-07-08 Novavax, Inc. Bovine respiratory syncytial virus virus-like particle (vlps)
JP2012521786A (ja) 2009-03-30 2012-09-20 モウント シナイ スクール オフ メディシネ インフルエンザウイルスワクチン及びその使用
NZ597401A (en) * 2009-06-24 2013-09-27 Medicago Inc Chimeric influenza virus-like particles comprising hemagglutinin
WO2011011390A1 (en) 2009-07-20 2011-01-27 Novavax, Inc. Purified recombinant influenza virus ha proteins
DK2480560T3 (en) 2009-09-22 2018-04-16 Medicago Inc PROCEDURE FOR THE PREPARATION OF PLANT DERIVATIVE PROTEINS
US9352031B2 (en) 2010-02-18 2016-05-31 Technovax, Inc. Universal virus-like particle (VLP) influenza vaccines
US20130295609A1 (en) * 2010-11-04 2013-11-07 Medicago Inc. Plant expression system
KR101847908B1 (ko) 2010-11-05 2018-04-11 노바백스, 인코포레이티드 광견병 당단백질 바이러스-유사 입자(VLPs)
TWI526539B (zh) 2010-12-22 2016-03-21 苜蓿股份有限公司 植物中生產類病毒顆粒(vlp)的方法及以該方法生產之vlp
CN108611793B (zh) 2018-05-18 2020-11-20 北京化工大学 一种高强度静电纺丝聚丙烯腈基纳米碳纤维毡的制备方法

Similar Documents

Publication Publication Date Title
JP2016052331A5 (OSRAM)
NZ590144A (en) Influenza virus-like particles (vlps) comprising hemagglutinin
Elliott et al. Emerging phleboviruses
WO2013044203A3 (en) Novel influenza hemagglutinin protein-based vaccines
EA201890220A1 (ru) Вакцина против rsv
PH12018501912A1 (en) Vaccine against rsv
NZ587108A (en) Recombinant influenza virus-like particles (vlps) produced in transgenic plants expressing hemagglutinin
IL253187B (en) Novel multivalent nanoparticle-based vaccines
JP2012095652A5 (OSRAM)
JP2016516415A5 (OSRAM)
JP2015119730A5 (OSRAM)
JP2016034981A5 (OSRAM)
ZA202100386B (en) Influenza virus hemagglutinin mutants
JP2015096070A5 (OSRAM)
JP2019530462A5 (OSRAM)
JP2014531205A5 (OSRAM)
WO2006119516A3 (en) Expression of viral proteins in plants
JP2010088434A5 (OSRAM)
JP2016533332A5 (OSRAM)
JP2014507146A5 (OSRAM)
JP2014506785A5 (OSRAM)
FI2760882T3 (fi) Viruksen kaltaisen partikkelin saantojen lisääminen kasveissa
HRP20200012T1 (hr) Atenuirani virusi i cjepiva gripe
FI3511015T9 (fi) Geneettisesti stabiili elävä heikennetty respiratory syncytial -virusrokote ja sen tuottaminen
JP2019506168A5 (OSRAM)