JP2014531205A5 - - Google Patents
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- Publication number
- JP2014531205A5 JP2014531205A5 JP2014530196A JP2014530196A JP2014531205A5 JP 2014531205 A5 JP2014531205 A5 JP 2014531205A5 JP 2014530196 A JP2014530196 A JP 2014530196A JP 2014530196 A JP2014530196 A JP 2014530196A JP 2014531205 A5 JP2014531205 A5 JP 2014531205A5
- Authority
- JP
- Japan
- Prior art keywords
- sequence
- polypeptide
- seq
- glycoprotein
- amino acid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 229920001184 polypeptide Polymers 0.000 claims 9
- 102000004196 processed proteins & peptides Human genes 0.000 claims 9
- 108090000765 processed proteins & peptides Proteins 0.000 claims 9
- 102000003886 Glycoproteins Human genes 0.000 claims 7
- 108090000288 Glycoproteins Proteins 0.000 claims 7
- 125000003275 alpha amino acid group Chemical group 0.000 claims 4
- 238000000034 method Methods 0.000 claims 4
- 102000040430 polynucleotide Human genes 0.000 claims 3
- 108091033319 polynucleotide Proteins 0.000 claims 3
- 239000002157 polynucleotide Substances 0.000 claims 3
- 102000005744 Glycoside Hydrolases Human genes 0.000 claims 2
- 108010031186 Glycoside Hydrolases Proteins 0.000 claims 2
- 230000000694 effects Effects 0.000 claims 2
- 239000012634 fragment Substances 0.000 claims 2
- 150000004676 glycans Chemical class 0.000 claims 2
- 230000003301 hydrolyzing effect Effects 0.000 claims 2
- 102000004169 proteins and genes Human genes 0.000 claims 2
- 108090000623 proteins and genes Proteins 0.000 claims 2
- 150000001413 amino acids Chemical class 0.000 claims 1
- 230000000295 complement effect Effects 0.000 claims 1
- 239000013604 expression vector Substances 0.000 claims 1
- 230000002068 genetic effect Effects 0.000 claims 1
- 230000013595 glycosylation Effects 0.000 claims 1
- 238000006206 glycosylation reaction Methods 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB201115841A GB201115841D0 (en) | 2011-09-13 | 2011-09-13 | Protein and method |
| GB1115841.7 | 2011-09-13 | ||
| PCT/EP2012/067841 WO2013037824A1 (en) | 2011-09-13 | 2012-09-12 | Endoglycosidase from streptococcus pyogenes and methods using it |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2014531205A JP2014531205A (ja) | 2014-11-27 |
| JP2014531205A5 true JP2014531205A5 (OSRAM) | 2015-10-29 |
| JP6076349B2 JP6076349B2 (ja) | 2017-02-08 |
Family
ID=44908522
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014530196A Active JP6076349B2 (ja) | 2011-09-13 | 2012-09-12 | ストレプトコッカス・ピオゲネス由来のエンドグリコシダーゼ及びその使用方法 |
Country Status (20)
| Country | Link |
|---|---|
| US (1) | US9493752B2 (OSRAM) |
| EP (1) | EP2756077B1 (OSRAM) |
| JP (1) | JP6076349B2 (OSRAM) |
| KR (1) | KR102001427B1 (OSRAM) |
| CN (1) | CN103946377B (OSRAM) |
| AU (1) | AU2012307461B2 (OSRAM) |
| BR (1) | BR112014005816A2 (OSRAM) |
| CA (1) | CA2848230C (OSRAM) |
| DK (1) | DK2756077T3 (OSRAM) |
| EA (1) | EA028490B8 (OSRAM) |
| ES (1) | ES2627334T3 (OSRAM) |
| GB (2) | GB201115841D0 (OSRAM) |
| IL (1) | IL231410A0 (OSRAM) |
| IN (1) | IN2014CN02163A (OSRAM) |
| MX (1) | MX347727B (OSRAM) |
| PL (1) | PL2756077T3 (OSRAM) |
| PT (1) | PT2756077T (OSRAM) |
| SG (1) | SG11201400505YA (OSRAM) |
| WO (1) | WO2013037824A1 (OSRAM) |
| ZA (1) | ZA201401840B (OSRAM) |
Families Citing this family (34)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU1686302A (en) * | 2000-12-21 | 2002-07-01 | Shire Biochem Inc | Streptococcus pyogenes antigens and corresponding dna fragments |
| HRP20230690T1 (hr) | 2012-10-23 | 2023-10-13 | Synaffix B.V. | Modificirano antitijelo, konjugat antitijela i postupak za njihovo pripremanje |
| PL2991683T3 (pl) * | 2013-05-02 | 2020-03-31 | Glykos Finland Oy | Koniugaty glikoproteiny lub glikanu z toksycznym ładunkiem |
| JP2016538877A (ja) | 2013-10-14 | 2016-12-15 | シンアフィックス ビー．ブイ． | 修飾糖タンパク質、タンパク質コンジュゲート及びそれらの調製方法 |
| JP2016538878A (ja) | 2013-10-14 | 2016-12-15 | シンアフィックス ビー．ブイ． | 糖鎖工学的に操作された抗体、抗体コンジュゲート、及びそれらの調製方法 |
| US9987373B2 (en) | 2013-10-14 | 2018-06-05 | Synaffix B.V. | Modified glycoprotein, protein-conjugate and process for the preparation thereof |
| WO2015057065A1 (en) | 2013-10-14 | 2015-04-23 | Synaffix B.V. | Glycoengineered antibody, antibody-conjugate and methods for their preparation |
| GB201318490D0 (en) * | 2013-10-18 | 2013-12-04 | Genovis Ab | Method |
| US11168085B2 (en) | 2014-01-24 | 2021-11-09 | Synaffix B.V. | Process for the cycloaddition of a hetero(aryl) 1,3-dipole compound with a (hetero)cycloalkyne |
| DK3160513T3 (da) | 2014-06-30 | 2020-04-06 | Glykos Finland Oy | Saccharidderivat af en toksisk payload og antistofkonjugater deraf |
| GB201413240D0 (en) | 2014-07-25 | 2014-09-10 | Hansa Medical Ab | Method |
| WO2016022027A1 (en) | 2014-08-04 | 2016-02-11 | Synaffix B.V. | Process for the modification of a glycoprotein using a βeta-(1,4)-n-acetylgalactosaminyltransferase or a mutant thereof |
| GB201502305D0 (en) * | 2015-02-12 | 2015-04-01 | Hansa Medical Ab | Protein |
| GB201502306D0 (en) | 2015-02-12 | 2015-04-01 | Hansa Medical Ab | Protein |
| EP3354726B1 (en) | 2015-04-23 | 2024-10-30 | Synaffix B.V. | Process for the modification of a glycoprotein using a glycosyltransferase that is or is derived from a beta-(1,4)-n-acetylgalactosaminyltransferase |
| EP3402815B1 (en) * | 2016-01-15 | 2023-12-06 | University of Maryland, College Park | Endo-s2 mutants as glycosynthases, method of making and use for glycoengineering of glycoproteins |
| JP7123801B2 (ja) * | 2016-02-04 | 2022-08-23 | ジェノビス エービー | 新しい連鎖球菌プロテアーゼ |
| EP3532090A4 (en) * | 2016-08-24 | 2021-01-13 | Cho Pharma Inc | ENDOGLYCOSIDASE MUTANTS FOR GLYCOPROTEIN REMODELING AND METHOD OF USING THEREOF |
| CN111183221B (zh) | 2017-05-26 | 2024-04-09 | 杰诺维斯公司 | 用于o-糖蛋白的蛋白酶和结合多肽 |
| US20210228738A1 (en) | 2017-07-17 | 2021-07-29 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Compositions and methods for increasing or enhancing transduction of gene therapy vectors and for removing or reducing immunoglobulins |
| AU2019291176A1 (en) | 2018-06-19 | 2020-12-10 | Glykos Finland Oy | Conjugate |
| JP2021529163A (ja) | 2018-06-29 | 2021-10-28 | グリコス バイオメディカル オーワイ | コンジュゲート |
| US20230038373A1 (en) | 2019-12-18 | 2023-02-09 | Glykos Biomedical Oy | Stabile conjugate |
| CN111044731B (zh) * | 2019-12-19 | 2021-05-07 | 北京科技大学 | 脉冲温育免疫反应分离富集多肽药物中肽类杂质的方法 |
| AU2021205312A1 (en) | 2020-01-09 | 2022-07-14 | Mersana Therapeutics, Inc. | Site specific antibody-drug conjugates with peptide-containing linkers |
| GB202002072D0 (en) * | 2020-02-14 | 2020-04-01 | Hansa Biopharma AB | immunoglobulin detection and associated therapies |
| EP4215208A4 (en) * | 2020-09-21 | 2024-11-20 | Shanghai Bao Pharmaceuticals Co., Ltd. | PHARMACEUTICAL COMBINATION AND USE THEREOF |
| WO2022147532A1 (en) | 2021-01-04 | 2022-07-07 | Mersana Therapeutics, Inc. | B7h4-targeted antibody-drug conjugates and methods of use thereof |
| EP4079848A1 (en) | 2021-04-22 | 2022-10-26 | Genovis Ab | Immunoglobulin cleaving enzyme |
| CN115873833B (zh) * | 2022-11-08 | 2024-08-16 | 上海泰昶生物技术有限公司 | 生产免疫球蛋白g降解酶的工程菌株和工艺 |
| CN117165643B (zh) * | 2023-08-17 | 2025-10-28 | 山东大学 | 一种糖苷内切酶在水解高甘露糖型n-糖蛋白中的应用 |
| WO2025098484A1 (zh) * | 2023-11-10 | 2025-05-15 | 上海齐鲁制药研究中心有限公司 | 新型Endo S2突变体酶 |
| WO2025180451A1 (zh) * | 2024-03-01 | 2025-09-04 | 上海齐鲁制药研究中心有限公司 | 新型Endo S2突变体酶 |
| WO2025248500A1 (en) | 2024-05-31 | 2025-12-04 | Janssen Biotech, Inc. | Antibody drug conjugates that target enpp3 |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB0130228D0 (en) | 2001-12-18 | 2002-02-06 | Hansa Medica Ab | Protein |
| GB0624874D0 (en) * | 2006-12-13 | 2007-01-24 | Hansa Medical Ab | Treatment |
| EP2190984B1 (en) * | 2007-09-14 | 2013-09-04 | Genovis Ab | Methods and kits for purification and detection of glycosylated IgG |
| GB0821100D0 (en) | 2008-11-18 | 2008-12-24 | Hansa Medical Ab | Antibodies |
| EP2483693B1 (en) * | 2009-10-02 | 2014-12-03 | Roche Glycart AG | A-fucosylation detection in antibodies |
-
2011
- 2011-09-13 GB GB201115841A patent/GB201115841D0/en not_active Ceased
-
2012
- 2012-09-12 ES ES12756523.2T patent/ES2627334T3/es active Active
- 2012-09-12 GB GB1406321.8A patent/GB2509284A/en not_active Withdrawn
- 2012-09-12 EP EP12756523.2A patent/EP2756077B1/en active Active
- 2012-09-12 SG SG11201400505YA patent/SG11201400505YA/en unknown
- 2012-09-12 CA CA2848230A patent/CA2848230C/en active Active
- 2012-09-12 US US14/343,938 patent/US9493752B2/en active Active
- 2012-09-12 IN IN2163CHN2014 patent/IN2014CN02163A/en unknown
- 2012-09-12 EA EA201490447A patent/EA028490B8/ru not_active IP Right Cessation
- 2012-09-12 CN CN201280044106.0A patent/CN103946377B/zh active Active
- 2012-09-12 MX MX2014002906A patent/MX347727B/es active IP Right Grant
- 2012-09-12 AU AU2012307461A patent/AU2012307461B2/en active Active
- 2012-09-12 WO PCT/EP2012/067841 patent/WO2013037824A1/en not_active Ceased
- 2012-09-12 KR KR1020147009205A patent/KR102001427B1/ko active Active
- 2012-09-12 DK DK12756523.2T patent/DK2756077T3/en active
- 2012-09-12 PL PL12756523T patent/PL2756077T3/pl unknown
- 2012-09-12 JP JP2014530196A patent/JP6076349B2/ja active Active
- 2012-09-12 PT PT127565232T patent/PT2756077T/pt unknown
- 2012-09-12 BR BR112014005816-4A patent/BR112014005816A2/pt not_active IP Right Cessation
-
2014
- 2014-03-09 IL IL231410A patent/IL231410A0/en unknown
- 2014-03-12 ZA ZA2014/01840A patent/ZA201401840B/en unknown
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