JP2016041071A5 - - Google Patents
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- JP2016041071A5 JP2016041071A5 JP2015204285A JP2015204285A JP2016041071A5 JP 2016041071 A5 JP2016041071 A5 JP 2016041071A5 JP 2015204285 A JP2015204285 A JP 2015204285A JP 2015204285 A JP2015204285 A JP 2015204285A JP 2016041071 A5 JP2016041071 A5 JP 2016041071A5
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- JP
- Japan
- Prior art keywords
- expression level
- patient
- beneficial response
- gbp1
- rna transcript
- Prior art date
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- 229920000160 (ribonucleotides)n+m Polymers 0.000 claims 4
- 102100017773 GBP1 Human genes 0.000 claims 3
- 101700001333 GBP1 Proteins 0.000 claims 3
- 206010028980 Neoplasm Diseases 0.000 claims 3
- 206010006187 Breast cancer Diseases 0.000 claims 2
- 229940045698 antineoplastic Taxanes Drugs 0.000 claims 2
- 238000002512 chemotherapy Methods 0.000 claims 2
- AOJJSUZBOXZQNB-TZSSRYMLSA-N ADRIAMYCIN Chemical compound O([C@H]1C[C@@](O)(CC=2C(O)=C3C(=O)C=4C=CC=C(C=4C(=O)C3=C(O)C=21)OC)C(=O)CO)[C@H]1C[C@H](N)[C@H](O)[C@H](C)O1 AOJJSUZBOXZQNB-TZSSRYMLSA-N 0.000 claims 1
- STQGQHZAVUOBTE-VGBVRHCVSA-N DAUNOMYCIN Chemical compound O([C@H]1C[C@@](O)(CC=2C(O)=C3C(=O)C=4C=CC=C(C=4C(=O)C3=C(O)C=21)OC)C(C)=O)[C@H]1C[C@H](N)[C@H](O)[C@H](C)O1 STQGQHZAVUOBTE-VGBVRHCVSA-N 0.000 claims 1
- ZDZOTLJHXYCWBA-VCVYQWHSSA-N Docetaxel Chemical compound O([C@H]1[C@H]2[C@@](C([C@H](O)C3=C(C)[C@@H](OC(=O)[C@H](O)[C@@H](NC(=O)OC(C)(C)C)C=4C=CC=CC=4)C[C@]1(O)C3(C)C)=O)(C)[C@@H](O)C[C@H]1OC[C@]12OC(=O)C)C(=O)C1=CC=CC=C1 ZDZOTLJHXYCWBA-VCVYQWHSSA-N 0.000 claims 1
- 229960004679 Doxorubicin Drugs 0.000 claims 1
- RCINICONZNJXQF-MZXODVADSA-N Intaxel Chemical compound O([C@@H]1[C@@]2(C[C@@H](C(C)=C(C2(C)C)[C@H](C([C@]2(C)[C@@H](O)C[C@H]3OC[C@]3([C@H]21)OC(C)=O)=O)OC(=O)C)OC(=O)[C@H](O)[C@@H](NC(=O)C=1C=CC=CC=1)C=1C=CC=CC=1)O)C(=O)C1=CC=CC=C1 RCINICONZNJXQF-MZXODVADSA-N 0.000 claims 1
- 229960001592 Paclitaxel Drugs 0.000 claims 1
- 230000000973 chemotherapeutic Effects 0.000 claims 1
- 229960003668 docetaxel Drugs 0.000 claims 1
- 239000012188 paraffin wax Substances 0.000 claims 1
- 230000001575 pathological Effects 0.000 claims 1
- 238000003757 reverse transcription PCR Methods 0.000 claims 1
- 229930003347 taxol Natural products 0.000 claims 1
- 210000001519 tissues Anatomy 0.000 claims 1
Claims (9)
- ヒト乳癌患者がアントラサイクリンおよびタキサンを含む化学療法治療に対して有益な応答をする可能性を予測するための方法であって、
a)化学療法治療前の患者から得られた腫瘍サンプル中におけるGBP1のRNA転写物またはその発現産物の発現レベルを決定すること、
b)前記発現レベルを、前記腫瘍サンプルにおける参照遺伝子のセットのRNA転写物またはその発現産物の発現レベルに対して正規化して、正規化されたGBP1発現レベルを提供すること、そして、
c)前記正規化されたGBP1発現レベルの増大から、該患者がアントラサイクリンおよびタキサンを含む化学療法治療に対して有益な応答をする可能性の増加を予測することを含む、方法。 - 前記アントラサイクリンがドキソルビシンである、請求項1に記載の方法。
- 前記タキサンがドセタキセルである、請求項1又は2に記載の方法。
- 前記タキサンがパクリタキセルである、請求項1又は2に記載の方法。
- 前記腫瘍サンプルが固定されるか、パラフィン包埋されるか、または新鮮であるかもしくは凍結される、請求項1から4のいずれか一項に記載の方法。
- 前記RNAが、前記患者の固定されパラフィン包埋された乳癌組織試料から単離される、請求項1から5のいずれか一項に記載の方法。
- 前記有益な応答が臨床上の完全寛解である、請求項1から6のいずれか一項に記載の方法。
- 前記有益な応答が病理学上の完全寛解である、請求項1から6のいずれか一項に記載の方法。
- 前記RNA転写物の発現レベルが、逆転写ポリメラーゼ連鎖反応によって決定される、請求項1から8のいずれか一項に記載の方法。
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US56103504P | 2004-04-09 | 2004-04-09 | |
US60/561,035 | 2004-04-09 |
Related Parent Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2013103045A Division JP6130726B2 (ja) | 2004-04-09 | 2013-05-15 | 化学療法剤に対する応答を予測するための遺伝子発現マーカー |
Publications (3)
Publication Number | Publication Date |
---|---|
JP2016041071A JP2016041071A (ja) | 2016-03-31 |
JP2016041071A5 true JP2016041071A5 (ja) | 2016-09-08 |
JP6190434B2 JP6190434B2 (ja) | 2017-08-30 |
Family
ID=34981928
Family Applications (3)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2007507495A Active JP5813908B2 (ja) | 2004-04-09 | 2005-04-07 | 化学療法剤に対する応答を予測するための遺伝子発現マーカー |
JP2013103045A Active JP6130726B2 (ja) | 2004-04-09 | 2013-05-15 | 化学療法剤に対する応答を予測するための遺伝子発現マーカー |
JP2015204285A Active JP6190434B2 (ja) | 2004-04-09 | 2015-10-16 | 化学療法剤に対する応答を予測するための遺伝子発現マーカー |
Family Applications Before (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2007507495A Active JP5813908B2 (ja) | 2004-04-09 | 2005-04-07 | 化学療法剤に対する応答を予測するための遺伝子発現マーカー |
JP2013103045A Active JP6130726B2 (ja) | 2004-04-09 | 2013-05-15 | 化学療法剤に対する応答を予測するための遺伝子発現マーカー |
Country Status (10)
Country | Link |
---|---|
US (2) | US7871769B2 (ja) |
EP (4) | EP1737980A2 (ja) |
JP (3) | JP5813908B2 (ja) |
AU (2) | AU2005233593B2 (ja) |
CA (2) | CA2563074C (ja) |
DK (1) | DK2163650T3 (ja) |
ES (2) | ES2636470T3 (ja) |
HK (1) | HK1217737A1 (ja) |
IL (4) | IL178508A (ja) |
WO (1) | WO2005100606A2 (ja) |
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