JP2016028081A5 - - Google Patents
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- JP2016028081A5 JP2016028081A5 JP2015179993A JP2015179993A JP2016028081A5 JP 2016028081 A5 JP2016028081 A5 JP 2016028081A5 JP 2015179993 A JP2015179993 A JP 2015179993A JP 2015179993 A JP2015179993 A JP 2015179993A JP 2016028081 A5 JP2016028081 A5 JP 2016028081A5
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- Japan
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Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US76097406P | 2006-01-19 | 2006-01-19 | |
| US60/760,974 | 2006-01-19 | ||
| US11/544,389 US8168584B2 (en) | 2005-10-08 | 2006-10-06 | Methods of treating age-related macular degeneration by compstatin and analogs thereof |
| US11/544,389 | 2006-10-06 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013086862A Division JP2013155189A (ja) | 2006-01-19 | 2013-04-17 | 眼の障害のための注射可能複合療法 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2016028081A JP2016028081A (ja) | 2016-02-25 |
| JP2016028081A5 true JP2016028081A5 (OSRAM) | 2016-05-19 |
Family
ID=38179525
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008551458A Pending JP2009523821A (ja) | 2006-01-19 | 2007-01-19 | 眼の障害のための注射可能複合療法 |
| JP2013086862A Pending JP2013155189A (ja) | 2006-01-19 | 2013-04-17 | 眼の障害のための注射可能複合療法 |
| JP2015179993A Pending JP2016028081A (ja) | 2006-01-19 | 2015-09-11 | 眼の障害のための注射可能複合療法 |
Family Applications Before (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008551458A Pending JP2009523821A (ja) | 2006-01-19 | 2007-01-19 | 眼の障害のための注射可能複合療法 |
| JP2013086862A Pending JP2013155189A (ja) | 2006-01-19 | 2013-04-17 | 眼の障害のための注射可能複合療法 |
Country Status (8)
| Country | Link |
|---|---|
| US (6) | US8168584B2 (OSRAM) |
| EP (1) | EP1993673B1 (OSRAM) |
| JP (3) | JP2009523821A (OSRAM) |
| AU (2) | AU2007207385B2 (OSRAM) |
| DK (1) | DK1993673T3 (OSRAM) |
| ES (1) | ES2644752T3 (OSRAM) |
| PL (1) | PL1993673T3 (OSRAM) |
| WO (1) | WO2007084765A2 (OSRAM) |
Families Citing this family (137)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7431710B2 (en) | 2002-04-08 | 2008-10-07 | Glaukos Corporation | Ocular implants with anchors and methods thereof |
| US8246569B1 (en) | 2004-08-17 | 2012-08-21 | California Institute Of Technology | Implantable intraocular pressure drain |
| US8043609B2 (en) | 2004-10-08 | 2011-10-25 | Potentia Pharmaceuticals, Inc. | Viral complement control proteins for eye disorders |
| US7947267B2 (en) * | 2004-10-08 | 2011-05-24 | Potentia Pharmaceuticals, Inc. | Viral complement control proteins for eye disorders |
| US8168584B2 (en) | 2005-10-08 | 2012-05-01 | Potentia Pharmaceuticals, Inc. | Methods of treating age-related macular degeneration by compstatin and analogs thereof |
| DE602007012417D1 (de) | 2006-03-14 | 2011-03-24 | Univ Southern California | Mems-Vorrichtung zur Wirkstofffreisetzung |
| AU2007237096C1 (en) | 2006-04-07 | 2012-12-13 | EyePoint Pharmaceuticals, Inc. | Antibodies that bind human protein tyrosine phosphatase beta (HPTPbeta) and uses thereof |
| US7622593B2 (en) | 2006-06-27 | 2009-11-24 | The Procter & Gamble Company | Human protein tyrosine phosphatase inhibitors and methods of use |
| WO2008060359A2 (en) | 2006-09-29 | 2008-05-22 | Surmodics, Inc. | Biodegradable ocular implants and methods for treating ocular conditions |
| US8664176B2 (en) * | 2006-10-20 | 2014-03-04 | Celldex Therapeutics, Inc. | Treatment for age-related macular degeneration and other diseases of the eye |
| DK2148691T3 (en) | 2007-02-05 | 2015-08-17 | Apellis Pharmaceuticals Inc | Compstatinanaloger for use in the treatment of inflammatory states of the respiratory system |
| US11078262B2 (en) * | 2007-04-30 | 2021-08-03 | Allergan, Inc. | High viscosity macromolecular compositions for treating ocular conditions |
| WO2009015087A2 (en) * | 2007-07-20 | 2009-01-29 | Potentia Pharmaceuticals, Inc. | Compositions and methods for treatment of trauma |
| KR20100094453A (ko) * | 2007-10-02 | 2010-08-26 | 포텐시아 팔마큐티칼스, 인크. | 겔로부터 콤스타틴 유사체의 지속적 운반 |
| WO2009086112A2 (en) * | 2007-12-20 | 2009-07-09 | University Of Southern California | Apparatus and methods for delivering therapeutic agents |
| DK2240220T3 (en) | 2008-01-03 | 2016-08-01 | Univ Southern California | Implantable devices for drug AND APPARATUS FOR refilling DEVICES |
| WO2009097468A2 (en) * | 2008-01-29 | 2009-08-06 | Kliman Gilbert H | Drug delivery devices, kits and methods therefor |
| JP2011518116A (ja) * | 2008-02-21 | 2011-06-23 | ユニバーシティ オブ ケンタッキー リサーチ ファウンデーション | トール様受容体３拮抗薬としての超小型ｒｎａ |
| WO2009105534A2 (en) * | 2008-02-21 | 2009-08-27 | Ista Pharmaceuticals | Ophthalmic nsaids as adjuvants |
| WO2009121065A2 (en) * | 2008-03-28 | 2009-10-01 | Apellis Ag | Modulation and repletion/enhancement of the complement system for treatment of trauma |
| ES2338400B1 (es) * | 2008-05-06 | 2011-09-14 | David Benet Ferrus | Conjunto de moleculas antiangiogenicas y su uso. |
| CN103349803B (zh) | 2008-05-08 | 2016-12-28 | 迷你泵有限责任公司 | 可植入药物传送装置与用于填充该装置的设备和方法 |
| ES2534864T3 (es) | 2008-05-08 | 2015-04-29 | Minipumps, Llc | Bombas implantables y cánulas para las mismas |
| EP2891501B1 (en) | 2008-05-08 | 2016-09-21 | MiniPumps, LLC | Methods of manufacture of drug-delivery pumps |
| US9849238B2 (en) | 2008-05-08 | 2017-12-26 | Minipumps, Llc | Drug-delivery pump with intelligent control |
| US9877973B2 (en) | 2008-05-12 | 2018-01-30 | University Of Utah Research Foundation | Intraocular drug delivery device and associated methods |
| US9095404B2 (en) | 2008-05-12 | 2015-08-04 | University Of Utah Research Foundation | Intraocular drug delivery device and associated methods |
| WO2009140246A2 (en) | 2008-05-12 | 2009-11-19 | University Of Utah Research Foundation | Intraocular drug delivery device and associated methods |
| US10064819B2 (en) | 2008-05-12 | 2018-09-04 | University Of Utah Research Foundation | Intraocular drug delivery device and associated methods |
| US8821870B2 (en) * | 2008-07-18 | 2014-09-02 | Allergan, Inc. | Method for treating atrophic age related macular degeneration |
| US8623395B2 (en) | 2010-01-29 | 2014-01-07 | Forsight Vision4, Inc. | Implantable therapeutic device |
| US8399006B2 (en) | 2009-01-29 | 2013-03-19 | Forsight Vision4, Inc. | Posterior segment drug delivery |
| WO2010093945A2 (en) | 2009-02-13 | 2010-08-19 | Glaukos Corporation | Uveoscleral drug delivery implant and methods for implanting the same |
| GB0904427D0 (en) | 2009-03-13 | 2009-04-29 | Lachmann Peter | Treatment of diseases related to hyperactivity of the complement system |
| WO2010126833A1 (en) * | 2009-04-27 | 2010-11-04 | Jerini Ophthalmic Inc. | Sustained release formulations of peptidomimetic drugs and uses thereof |
| ES2655389T3 (es) * | 2009-05-01 | 2018-02-19 | The Trustees Of The University Of Pennsylvania | Compstatina modificada con esqueleto peptídico y modificaciones c-terminales |
| US12478503B2 (en) | 2009-05-18 | 2025-11-25 | Glaukos Corporation | Implants with controlled drug delivery features and methods of using same |
| US10206813B2 (en) | 2009-05-18 | 2019-02-19 | Dose Medical Corporation | Implants with controlled drug delivery features and methods of using same |
| AU2010249683B2 (en) | 2009-05-18 | 2015-06-25 | Glaukos Corporation | Drug eluting ocular implant |
| GB2470378A (en) * | 2009-05-20 | 2010-11-24 | Univ Westminster | A controlled release composition for intraocular delivery of a therapeutic agent |
| US9291622B2 (en) | 2009-05-21 | 2016-03-22 | Apellis Pharmaceuticals, Inc. | Complement assays and uses thereof |
| KR101697388B1 (ko) | 2009-08-18 | 2017-01-17 | 미니펌프스, 엘엘씨 | 적응 제어기를 갖춘 전해 약품 운반 펌프 |
| TWI492769B (zh) * | 2009-09-23 | 2015-07-21 | Alcon Res Ltd | 可注射的水性眼用組成物及其使用之方法 |
| WO2011106702A2 (en) | 2010-02-25 | 2011-09-01 | The Johns Hopkins University | Sustained delivery of therapeutic agents to an eye compartment |
| WO2011135400A1 (en) * | 2010-04-30 | 2011-11-03 | Indian Institute Of Technology Bombay | Nanoparticulate in-situ gels as vitreous humor substitutes for ocular diseases |
| US9421240B2 (en) | 2010-06-22 | 2016-08-23 | Apellis Pharmaceuticals, Inc. | Compstatin analogs for treatment of neuropathic pain |
| US20130324482A1 (en) * | 2010-07-09 | 2013-12-05 | Apellis Pharmaceuticals, Inc. | Compstatin analogs for treatment of rhinosinusitis and nasal polyposis |
| PL2600930T3 (pl) | 2010-08-05 | 2021-09-06 | Forsight Vision4, Inc. | Urządzenie wstrzykujące do dostarczania leku |
| EP2600876B1 (en) * | 2010-08-05 | 2015-04-29 | Forsight Vision4, Inc. | Combined drug delivery methods and apparatus |
| CA2807508A1 (en) * | 2010-08-05 | 2012-02-09 | Forsight Vision4, Inc. | Subconjunctival implant for posterior segment drug delivery |
| ES2894940T3 (es) * | 2010-08-05 | 2022-02-16 | Forsight Vision4 Inc | Aparato para tratar un ojo |
| CA2818612C (en) | 2010-11-19 | 2020-12-29 | Forsight Vision4, Inc. | Therapeutic agent formulations for implanted devices |
| EP2654715B1 (en) * | 2010-11-24 | 2017-01-25 | Dose Medical Corporation | Drug eluting ocular implant |
| US8349005B2 (en) | 2011-01-03 | 2013-01-08 | Masatoshi Murata | Method for burying implant to choroid |
| US9327037B2 (en) | 2011-02-08 | 2016-05-03 | The Johns Hopkins University | Mucus penetrating gene carriers |
| US9919099B2 (en) | 2011-03-14 | 2018-03-20 | Minipumps, Llc | Implantable drug pumps and refill devices therefor |
| US9603997B2 (en) | 2011-03-14 | 2017-03-28 | Minipumps, Llc | Implantable drug pumps and refill devices therefor |
| US10286146B2 (en) | 2011-03-14 | 2019-05-14 | Minipumps, Llc | Implantable drug pumps and refill devices therefor |
| JP6522337B2 (ja) * | 2011-05-11 | 2019-05-29 | アペリス・ファーマシューティカルズ・インコーポレイテッドＡｐｅｌｌｉｓ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ，Ｉｎｃ． | 細胞反応性、長時間作用型または標的化コンプスタチン類似体およびその使用 |
| US10245178B1 (en) | 2011-06-07 | 2019-04-02 | Glaukos Corporation | Anterior chamber drug-eluting ocular implant |
| EP2726016B1 (en) | 2011-06-28 | 2023-07-19 | ForSight Vision4, Inc. | An apparatus for collecting a sample of fluid from a reservoir chamber of a therapeutic device for the eye |
| EP2739252A4 (en) | 2011-08-05 | 2015-08-12 | Forsight Vision4 Inc | SMALL MOLECULE ADMINISTRATION USING AN IMPLANTABLE THERAPEUTIC DEVICE |
| SI2755600T1 (sl) | 2011-09-16 | 2021-08-31 | Forsight Vision4, Inc. | Naprava za izmenjavo tekočine |
| US20130095065A1 (en) | 2011-10-13 | 2013-04-18 | Aerpio Therapeutics, Inc. | Methods for Treating Vascular Leak Syndrome and Cancer |
| ES2810003T3 (es) | 2011-11-18 | 2021-03-08 | Regeneron Pharma | Micropartícula que contiene proteína terapéutica recubierta con polímero biodegradable para uso médico |
| AU2012318288B2 (en) * | 2011-12-01 | 2015-09-17 | Ap Biosciences, Inc. | Protein inhibitors to complement and VEGF pathways and methods of use thereof |
| KR20140109430A (ko) * | 2012-01-04 | 2014-09-15 | 쿠아크 파마수티칼스 인코퍼레이티드 | Casp2에 대한 이중-가닥 rna 화합물 및 그 용도 |
| WO2013116061A1 (en) | 2012-02-03 | 2013-08-08 | Forsight Vision4, Inc. | Insertion and removal methods and apparatus for therapeutic devices |
| JP6138904B2 (ja) | 2012-03-16 | 2017-05-31 | ザ・ジョンズ・ホプキンス・ユニバーシティー | 活性剤の送達のための非線状マルチブロックコポリマー薬物コンジュゲート |
| CN104363924B (zh) | 2012-03-16 | 2018-04-17 | 约翰霍普金斯大学 | 用于递送hif‑1抑制剂的控制释放调配物 |
| US9533068B2 (en) | 2012-05-04 | 2017-01-03 | The Johns Hopkins University | Drug loaded microfiber sutures for ophthalmic application |
| JOP20200175A1 (ar) | 2012-07-03 | 2017-06-16 | Novartis Ag | حقنة |
| AU2013100070B4 (en) * | 2012-07-03 | 2013-04-04 | Novartis Ag | Use of device |
| US20160194359A1 (en) * | 2012-11-15 | 2016-07-07 | Apellis Pharmaceuticals, Inc. | Cell-reactive, long-acting, or targeted compstatin analogs and related compositions and methods |
| PT2920201T (pt) * | 2012-11-15 | 2020-04-03 | Apellis Pharmaceuticals Inc | Análogos de compstatina de longa ação e composições e métodos relacionados |
| US10568975B2 (en) | 2013-02-05 | 2020-02-25 | The Johns Hopkins University | Nanoparticles for magnetic resonance imaging tracking and methods of making and using thereof |
| US9968603B2 (en) | 2013-03-14 | 2018-05-15 | Forsight Vision4, Inc. | Systems for sustained intraocular delivery of low solubility compounds from a port delivery system implant |
| US9597227B2 (en) | 2013-03-15 | 2017-03-21 | Abbott Medical Optics Inc. | Trans-sclera portal for delivery of therapeutic agents |
| WO2014152391A1 (en) | 2013-03-15 | 2014-09-25 | Apellis Pharmaceuticals, Inc. | Cell-penetrating compstatin analogs and uses thereof |
| US10517759B2 (en) | 2013-03-15 | 2019-12-31 | Glaukos Corporation | Glaucoma stent and methods thereof for glaucoma treatment |
| CN105246438B (zh) | 2013-03-28 | 2018-01-26 | 弗赛特影像4股份有限公司 | 用于输送治疗物质的眼科植入物 |
| US9968623B2 (en) * | 2013-08-29 | 2018-05-15 | Lanny Leo Johnson | Prepackaged sterile syringe or containers with various substance concentrations with or without bioactive reagent |
| US9655862B2 (en) * | 2013-10-29 | 2017-05-23 | Shaker A. Mousa | Ocular nanoformulation and method of use in angiogenesis-mediated disorders |
| CA2950187A1 (en) | 2014-05-29 | 2015-12-03 | Glaukos Corporation | Implants with controlled drug delivery features and methods of using same |
| JP6794343B2 (ja) | 2014-07-11 | 2020-12-02 | ザ ユナイテッド ステイツ オブ アメリカ， アズ リプレゼンテッド バイ ザ セクレタリー， デパートメント オブ ヘルス アンド ヒューマン サービシーズ | 手術器具および眼組織移植方法 |
| CA2955186C (en) | 2014-07-15 | 2023-08-29 | Forsight Vision4, Inc. | Ocular implant delivery device and method |
| JP2017524034A (ja) | 2014-08-08 | 2017-08-24 | フォーサイト・ビジョン フォー・インコーポレーテッドＦｏｒｓｉｇｈｔ Ｖｉｓｉｏｎ４， Ｉｎｃ． | 受容体型チロシンキナーゼ阻害剤の安定で可溶な製剤およびその調製の方法 |
| WO2016077371A1 (en) | 2014-11-10 | 2016-05-19 | Forsight Vision4, Inc. | Expandable drug delivery devices and method of use |
| EP3250184B1 (en) | 2015-01-27 | 2024-12-18 | The Johns Hopkins University | Hypotonic hydrogel formulations for enhanced transport of active agents at mucosal surfaces |
| AR106018A1 (es) | 2015-08-26 | 2017-12-06 | Achillion Pharmaceuticals Inc | Compuestos de arilo, heteroarilo y heterocíclicos para el tratamiento de trastornos médicos |
| EP3340983B1 (en) | 2015-08-26 | 2023-10-04 | Achillion Pharmaceuticals, Inc. | Aryl, heteroaryl, and heterocyclic compounds for treatment of immune and inflammatory disorders |
| WO2017035405A1 (en) | 2015-08-26 | 2017-03-02 | Achillion Pharmaceuticals, Inc. | Amino compounds for treatment of immune and inflammatory disorders |
| WO2017035401A1 (en) | 2015-08-26 | 2017-03-02 | Achillion Pharmaceuticals, Inc. | Amide compounds for treatment of immune and inflammatory disorders |
| US11925578B2 (en) | 2015-09-02 | 2024-03-12 | Glaukos Corporation | Drug delivery implants with bi-directional delivery capacity |
| ES2981607T3 (es) | 2015-09-23 | 2024-10-09 | Eyepoint Pharmaceuticals Inc | Activadores de Tie-2 para uso en el tratamiento de la presión intraocular |
| WO2017053885A1 (en) | 2015-09-25 | 2017-03-30 | Glaukos Corporation | Punctal implants with controlled drug delivery features and methods of using same |
| MX392574B (es) * | 2015-10-07 | 2025-03-24 | Apellis Pharmaceuticals Inc | Análogos de compstatina de acción prolongada para usarse en el tratamiento de trastornos oculares |
| KR20180084104A (ko) | 2015-11-20 | 2018-07-24 | 포사이트 비젼4, 인크. | 연장 방출 약물 전달 장치를 위한 다공성 구조물 |
| CA3007276C (en) | 2015-12-03 | 2021-12-28 | Regeneron Pharmaceuticals, Inc. | Use of vegf inhibitor to treat macular degeneration in a patient population |
| JP2019506159A (ja) * | 2016-01-20 | 2019-03-07 | ヴィトリサ セラピューティクス， インコーポレイテッド | Ｄ因子を阻害するための組成物および方法 |
| BR112018069732A2 (pt) * | 2016-03-31 | 2019-02-05 | Omeros Corporation | métodos para prevenir, tratar, reverter e/ou retardar angiogênese em um sujeito mamífero, para tratar um sujeito que sofre de uma doença ou condição angiogênica ocular e para inibir angiogênese do tumor |
| JP7009384B2 (ja) | 2016-04-05 | 2022-01-25 | フォーサイト・ビジョン フォー・インコーポレーテッド | 移植可能な眼薬送達デバイス |
| EP3442479A1 (en) | 2016-04-20 | 2019-02-20 | Harold Alexander Heitzmann | Bioresorbable ocular drug delivery device |
| US11666655B2 (en) * | 2016-11-28 | 2023-06-06 | Indian Institute Of Technology, Delhi | Formulation for stabilizing bio-therapeutics |
| WO2018136827A1 (en) | 2017-01-20 | 2018-07-26 | Vitrisa Therapeutics, Inc. | Stem-loop compositions and methods for inhibiting factor d |
| IL291628B2 (en) * | 2017-02-16 | 2024-01-01 | Yeda res & development co ltd | Liposomic drug-delivery vehicles |
| AU2018227849B2 (en) | 2017-03-01 | 2022-04-28 | Achillion Pharmaceuticals, Inc. | Aryl, heteroaryl, and heterocyclic pharmaceutical compounds for treatment of medical disorders |
| WO2018160891A1 (en) | 2017-03-01 | 2018-09-07 | Achillion Pharmaceutical, Inc. | Pharmaceutical compounds for treatment of medical disorders |
| EP3589287B1 (en) | 2017-03-01 | 2022-09-14 | Achillion Pharmaceuticals, Inc. | Macrocyclic compounds for treatment of medical disorders |
| KR20190139931A (ko) | 2017-04-07 | 2019-12-18 | 아펠리스 파마슈티컬스 인코포레이티드 | 투여 요법 및 관련 조성물 및 방법 |
| US10406102B2 (en) * | 2017-07-11 | 2019-09-10 | Sustained Nano Systems Llc | Hypercompressed pharmaceutical formulations |
| CN111163767A (zh) | 2017-08-02 | 2020-05-15 | 艾其林医药公司 | 治疗阵发性睡眠性血红蛋白尿症的治疗方案 |
| IT201700101582A1 (it) * | 2017-09-12 | 2019-03-12 | Milano Politecnico | Dispositivo per rilascio intraoculare |
| CN111372950B (zh) | 2017-10-12 | 2024-11-05 | 免疫苏醒公司 | Vegfr-抗体轻链融合蛋白 |
| KR20200093581A (ko) | 2017-11-21 | 2020-08-05 | 포사이트 비젼4, 인크. | 확장 가능한 포트 전달 시스템을 위한 유체 교환 기기 및 사용 방법 |
| MA51162A (fr) | 2017-12-15 | 2020-10-21 | Apellis Pharmaceuticals Inc | Schémas posologiques et compositions et procédés associés |
| AR117565A1 (es) | 2018-04-03 | 2021-08-18 | Ngm Biopharmaceuticals Inc | Agentes de unión a c3 y método de uso de los mismos |
| MX2020010520A (es) | 2018-04-06 | 2021-01-15 | Univ Pennsylvania | Analogos de compstatina con mayor solubilidad y mejores propiedades farmacocineticas. |
| EP4365299A3 (en) * | 2018-05-17 | 2024-08-07 | Olives Biotherapeutics Inc. | Pharmaceutical composition comprising ccn5 as active ingredient for preventing or treating retinal disease |
| US11519020B2 (en) | 2018-05-25 | 2022-12-06 | Regeneron Pharmaceuticals, Inc. | Methods of associating genetic variants with a clinical outcome in patients suffering from age-related macular degeneration treated with anti-VEGF |
| EP3841086B1 (en) | 2018-08-20 | 2025-04-23 | Achillion Pharmaceuticals, Inc. | Pharmaceutical compounds for the treatment of complement factor d medical disorders |
| JP7443375B2 (ja) | 2018-09-06 | 2024-03-05 | アキリオン ファーマシューティカルズ， インコーポレーテッド | 医学的障害の治療のための大環状化合物 |
| EP3847174A4 (en) | 2018-09-06 | 2022-06-15 | Achillion Pharmaceuticals, Inc. | MORPHIC FORMS OF COMPLEMENT D FACTOR INHIBITORS |
| US11807627B2 (en) | 2018-09-25 | 2023-11-07 | Achillon Pharmaceuticals, Inc. | Morphic forms of complement factor D inhibitors |
| CA3123583A1 (en) | 2018-12-17 | 2020-06-25 | Achillion Pharmaceuticals, Inc. | Targeted dosing for the treatment of complement mediated disorders |
| AU2020245434A1 (en) | 2019-03-22 | 2021-09-30 | Achillion Pharmaceuticals, Inc. | Pharmaceutical compounds for the treatment of complement mediated disorders |
| WO2020210805A1 (en) | 2019-04-11 | 2020-10-15 | The Johns Hopkins University | Nanoparticles for drug delivery to brain |
| AU2020264969B2 (en) | 2019-04-29 | 2025-06-05 | EyePoint Pharmaceuticals, Inc. | Tie-2 activators targeting the schlemm's canal |
| US20220211654A1 (en) * | 2019-05-06 | 2022-07-07 | The Regents Of The University Of California | Materials and methods for treating age-related macular degeneration |
| US20220280598A1 (en) * | 2019-07-18 | 2022-09-08 | Apellis Pharmaceuticals, Inc. | Complement inhibitor dosing regimens |
| JP2023515073A (ja) | 2020-02-20 | 2023-04-12 | アキリオン ファーマシューティカルズ， インコーポレーテッド | 補体因子ｄ媒介障害の処置用のヘテロアリール化合物 |
| JP2023529845A (ja) * | 2020-06-05 | 2023-07-12 | オキュルクス プロプライエタリー リミテッド | 眼の障害の治療のための化合物及び方法 |
| US20250171423A1 (en) | 2020-09-23 | 2025-05-29 | Achillion Pharmaceuticals, Inc. | Pharmaceutical compounds for the treatment of complement mediated disorders |
| USD1033637S1 (en) | 2022-01-24 | 2024-07-02 | Forsight Vision4, Inc. | Fluid exchange device |
| IL318067A (en) * | 2022-07-14 | 2025-02-01 | Character Biosciences Inc | Medical compositions and methods for age-related macular degeneration |
| CN120359233A (zh) | 2022-11-24 | 2025-07-22 | 阿麦达斯制药美国有限责任公司 | 用于基于载体的疗法的坎普他汀类似物 |
| WO2025176843A1 (en) | 2024-02-21 | 2025-08-28 | Ags Therapeutics Sas | Microalgae extracellular vesicle based gene therapy vectors (mev-gtvs), their preparation, and uses thereof |
Family Cites Families (118)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2295746A1 (fr) | 1974-12-23 | 1976-07-23 | Francaise Coop Pharma | Nouveaux derives du tryptophane a activite nerveuse centrale renforcee |
| US4816567A (en) | 1983-04-08 | 1989-03-28 | Genentech, Inc. | Recombinant immunoglobin preparations |
| IT1179866B (it) | 1984-12-12 | 1987-09-16 | Rotta Research Lab | Derivati del triptofano farmaceuticamente attivi e composizioni farmaceutiche che li contengono |
| US4576750A (en) | 1985-04-22 | 1986-03-18 | Merck & Co., Inc. | Tryptophan derivative |
| US5157110A (en) | 1988-08-20 | 1992-10-20 | The Government Of The United States Of America | Synthetic, anti-complement protein |
| IL95942A0 (en) | 1989-10-13 | 1991-07-18 | Syntex Inc | Collagen-containing ophthalmic formulation |
| US6395888B1 (en) | 1996-02-01 | 2002-05-28 | Gilead Sciences, Inc. | High affinity nucleic acid ligands of complement system proteins |
| US6582959B2 (en) * | 1991-03-29 | 2003-06-24 | Genentech, Inc. | Antibodies to vascular endothelial cell growth factor |
| EP1413587A2 (en) * | 1991-05-03 | 2004-04-28 | Washington University | Modified complement system regulator |
| US5492135A (en) * | 1992-09-09 | 1996-02-20 | Devore; Dale P. | Collagen modulators for use in photoablation excimer laser keratectomy |
| US5482135A (en) | 1993-06-29 | 1996-01-09 | Deere & Company | Combined hydraulic reservoir and vehicle axle |
| WO1995003009A1 (en) | 1993-07-22 | 1995-02-02 | Oculex Pharmaceuticals, Inc. | Method of treatment of macular degeneration |
| US5770589A (en) | 1993-07-27 | 1998-06-23 | The University Of Sydney | Treatment of macular degeneration |
| US5470952A (en) | 1993-10-20 | 1995-11-28 | Regeneron Pharmaceuticals, Inc. | CNTF and IL-6 antagonists |
| US5443505A (en) | 1993-11-15 | 1995-08-22 | Oculex Pharmaceuticals, Inc. | Biocompatible ocular implants |
| US5776970A (en) | 1994-04-28 | 1998-07-07 | Yeda Research And Development Co. Ltd. | Tryptophan derivatives as protein tyrosine kinase blockers and their use in the treatment of neoplastic diseases |
| IL117645A (en) * | 1995-03-30 | 2005-08-31 | Genentech Inc | Vascular endothelial cell growth factor antagonists for use as medicaments in the treatment of age-related macular degeneration |
| JPH08280800A (ja) * | 1995-04-12 | 1996-10-29 | Nissho Corp | ２液注射用プレフィルドシリンジ |
| US5869079A (en) | 1995-06-02 | 1999-02-09 | Oculex Pharmaceuticals, Inc. | Formulation for controlled release of drugs by combining hydrophilic and hydrophobic agents |
| US6129761A (en) * | 1995-06-07 | 2000-10-10 | Reprogenesis, Inc. | Injectable hydrogel compositions |
| US6346398B1 (en) | 1995-10-26 | 2002-02-12 | Ribozyme Pharmaceuticals, Inc. | Method and reagent for the treatment of diseases or conditions related to levels of vascular endothelial growth factor receptor |
| CA2248772C (en) | 1996-03-13 | 2007-06-12 | John D. Lambris | Novel peptides which inhibit complement activation |
| US6299895B1 (en) | 1997-03-24 | 2001-10-09 | Neurotech S.A. | Device and method for treating ophthalmic diseases |
| WO1997047321A1 (en) | 1996-06-14 | 1997-12-18 | The Johns Hopkins University School Of Medicine | Use of chimeric vaccinia virus complement control proteins to inhibit complement |
| JPH1087700A (ja) | 1996-06-17 | 1998-04-07 | Smithkline Beecham Corp | Ｃ３ａ受容体およびＣ３ａを用いる治療およびスクリーニング方法 |
| US5797898A (en) | 1996-07-02 | 1998-08-25 | Massachusetts Institute Of Technology | Microchip drug delivery devices |
| US6051698A (en) * | 1997-06-06 | 2000-04-18 | Janjic; Nebojsa | Vascular endothelial growth factor (VEGF) nucleic acid ligand complexes |
| AUPO755097A0 (en) | 1997-06-25 | 1997-07-17 | University Of Queensland, The | Receptor agonist and antagonist |
| US6169057B1 (en) | 1997-09-04 | 2001-01-02 | The Regents Of The University Of California | Use of tryptophan and analogs as plant growth regulators |
| AU4648197A (en) | 1997-09-17 | 1999-04-05 | Burnham Institute, The | Peptides and peptidomimetics for inhibiting complement activation |
| US8088386B2 (en) | 1998-03-20 | 2012-01-03 | Genentech, Inc. | Treatment of complement-associated disorders |
| JPH11197234A (ja) | 1998-01-09 | 1999-07-27 | Koken Co Ltd | 眼科用コラーゲンゲル成形物 |
| US7112327B2 (en) | 1998-02-20 | 2006-09-26 | Tanox, Inc. | Inhibition of complement activation |
| AU3066699A (en) | 1998-03-03 | 1999-09-20 | Johns Hopkins University, The | Smallpox inhibitor of complement enzymes (spice) protein and methods of inhibiting complement activation |
| EP1067950B1 (en) | 1998-04-10 | 2008-05-14 | Mayo Foundation For Medical Education And Research | Neo-tryptophan |
| US6197934B1 (en) * | 1998-05-22 | 2001-03-06 | Collagenesis, Inc. | Compound delivery using rapidly dissolving collagen film |
| US6378526B1 (en) | 1998-08-03 | 2002-04-30 | Insite Vision, Incorporated | Methods of ophthalmic administration |
| US7084106B1 (en) * | 1999-01-19 | 2006-08-01 | University Of Louisville Research Foundation, Inc. | Application of a viral complement inhibitory protein in the treatment and diagnosis of Alzheimer's Disease |
| CA2361569A1 (en) | 1999-02-12 | 2000-08-17 | Dale P. Devore | Injectable collagen-based system for delivery of cells or therapeutic agents |
| US20020102581A1 (en) * | 1999-02-19 | 2002-08-01 | Hageman Gregory S. | Diagnostics and therapeutics for ocular disorders |
| US7108982B1 (en) * | 1999-02-19 | 2006-09-19 | University Of Iowa Research Foundation | Diagnostics and the therapeutics for macular degeneration |
| EP1185283B1 (en) | 1999-05-25 | 2005-09-07 | King Faisal Specialist Hospital And Research Centre | Novel therapeutic use of viral inflammation modulatory protein in blocking xenograft rejection |
| US6331313B1 (en) | 1999-10-22 | 2001-12-18 | Oculex Pharmaceticals, Inc. | Controlled-release biocompatible ocular drug delivery implant devices and methods |
| GB9930659D0 (en) | 1999-12-24 | 2000-02-16 | Bio Discovery Ltd | Inhibitors of complement activation |
| US20050020525A1 (en) | 2002-02-20 | 2005-01-27 | Sirna Therapeutics, Inc. | RNA interference mediated inhibition of gene expression using chemically modified short interfering nucleic acid (siNA) |
| US20050032733A1 (en) | 2001-05-18 | 2005-02-10 | Sirna Therapeutics, Inc. | RNA interference mediated inhibition of gene expression using chemically modified short interfering nucleic acid (SiNA) |
| US7011952B2 (en) * | 2000-02-22 | 2006-03-14 | University Of Iowa Research Foundation | Diagnostics and therapeutics for macular degeneration-related disorders |
| EP1309726B2 (en) | 2000-03-30 | 2018-10-03 | Whitehead Institute For Biomedical Research | Rna sequence-specific mediators of rna interference |
| EP2026073B1 (en) | 2000-04-29 | 2016-03-30 | University Of Iowa Research Foundation | Diagnostics and therapeutics for macular degeneration-related disorders |
| US6692759B1 (en) | 2000-06-28 | 2004-02-17 | The Regents Of The University Of California | Methods for preparing and using implantable substance delivery devices |
| WO2002011793A1 (fr) * | 2000-08-08 | 2002-02-14 | Medical Information Services, Inc. | Seringue pour preparation de necessaire d'injection, valve coulissante intermediaire pour seringues et preparation de necessaire d'injection |
| US7118737B2 (en) | 2000-09-08 | 2006-10-10 | Amylin Pharmaceuticals, Inc. | Polymer-modified synthetic proteins |
| WO2002030985A2 (en) | 2000-10-10 | 2002-04-18 | Tanox, Inc. | Inhibition of complement c5 activation for the treatment and prevention of delayed xenograft or acute vascular rejection |
| US20040259247A1 (en) | 2000-12-01 | 2004-12-23 | Thomas Tuschl | Rna interference mediating small rna molecules |
| DE60219607T2 (de) | 2001-01-09 | 2007-12-27 | Microchips, Inc., Bedford | Flexible mikrochip-vorrichtungen zur ophthalmologischen und anderen applikation |
| US20050054596A1 (en) | 2001-11-30 | 2005-03-10 | Mcswiggen James | RNA interference mediated inhibition of vascular endothelial growth factor and vascular endothelial growth factor receptor gene expression using short interfering nucleic acid (siNA) |
| US20030175950A1 (en) | 2001-05-29 | 2003-09-18 | Mcswiggen James A. | RNA interference mediated inhibition of HIV gene expression using short interfering RNA |
| EA006746B1 (ru) * | 2001-11-09 | 2006-04-28 | Айтек Фармасьютикалз | Способы лечения глазных неоваскулярных заболеваний |
| EP1453546A2 (en) | 2001-12-04 | 2004-09-08 | Nanospectra Biosciences, Inc. | Treatment of angiogenesis disorders using targeted nanoparticles |
| US7261876B2 (en) | 2002-03-01 | 2007-08-28 | Bracco International Bv | Multivalent constructs for therapeutic and diagnostic applications |
| AUPS160602A0 (en) | 2002-04-08 | 2002-05-16 | University Of Queensland, The | Therapeutic method |
| US20040092470A1 (en) | 2002-06-18 | 2004-05-13 | Leonard Sherry A. | Dry powder oligonucleotide formualtion, preparation and its uses |
| ITMI20021527A1 (it) | 2002-07-11 | 2004-01-12 | Consiglio Nazionale Ricerche | Anticorpi anti componente c5 del complemento e loro uso |
| US7148342B2 (en) | 2002-07-24 | 2006-12-12 | The Trustees Of The University Of Pennyslvania | Compositions and methods for sirna inhibition of angiogenesis |
| JP3976635B2 (ja) * | 2002-08-05 | 2007-09-19 | 久光製薬株式会社 | キット製剤用注射器、注射器型キット製剤用中間摺動弁、及び、注射器型キット製剤、並びにｘ線造影剤キット製剤 |
| WO2004026326A2 (en) | 2002-09-20 | 2004-04-01 | Stichting Katholieke Universiteit | Antigen uptake receptor for candida albicans on dendritic cells |
| ES2373649T3 (es) | 2002-09-20 | 2012-02-07 | The Trustees Of The University Of Pennsylvania | Análogos de compstatina con actividad mejorada. |
| US20060251621A1 (en) | 2002-09-27 | 2006-11-09 | Campochiaro Peter A | Ocular gene therapy |
| JP5030383B2 (ja) | 2002-10-21 | 2012-09-19 | アルヴィヴォ インコーポレイテッド | 生物活性化合物を含む表面コーティング |
| US7595430B2 (en) | 2002-10-30 | 2009-09-29 | University Of Kentucky Research Foundation | Methods and animal model for analyzing age-related macular degeneration |
| US20050048099A1 (en) | 2003-01-09 | 2005-03-03 | Allergan, Inc. | Ocular implant made by a double extrusion process |
| CN1750844B (zh) * | 2003-02-21 | 2010-09-08 | 健泰科生物技术公司 | 凝集素途径特异性补体抑制剂在制备用于预防或抑制组织损伤的药物中的用途 |
| JP2006518750A (ja) * | 2003-02-21 | 2006-08-17 | リクスホスピタレット−ラジウムホスピタレット・ホーエフ | 胎便吸引症候群の治療のための方法および組成物 |
| US20050255144A1 (en) * | 2003-04-09 | 2005-11-17 | Directcontact Llc | Methods and articles for the delivery of medicaments to the eye for the treatment of posterior segment diseases |
| WO2005023296A1 (en) | 2003-09-05 | 2005-03-17 | University Of Louisville Research Foundation, Inc. | Treatment of rheumatic diseases |
| WO2005023866A2 (en) | 2003-09-10 | 2005-03-17 | Baxter International Inc. | Peptides that inhibit complement activation |
| PT1713503E (pt) | 2004-02-10 | 2013-11-14 | Nat Jewish Health | Inibição do factor b, a via alternativa do complemento e métodos relacionados |
| ES2674129T3 (es) | 2004-02-12 | 2018-06-27 | Archemix Llc | Agentes terapéuticos de base aptámeros útiles en el tratamiento de trastornos relacionados con complemento |
| US20050244469A1 (en) | 2004-04-30 | 2005-11-03 | Allergan, Inc. | Extended therapeutic effect ocular implant treatments |
| WO2005110374A1 (en) | 2004-04-30 | 2005-11-24 | Allergan, Inc. | Intraocular drug delivery systems containing a therapeutic component, a cyclodextrin, and a polymeric component |
| AU2005244061A1 (en) | 2004-05-10 | 2005-11-24 | Novacea, Inc. | Prevention of arterial restenosis with active vitamin D compounds |
| US8840893B2 (en) | 2004-06-10 | 2014-09-23 | Omeros Corporation | Methods for treating conditions associated with MASP-2 dependent complement activation |
| WO2006080951A2 (en) * | 2004-07-01 | 2006-08-03 | Yale University | Targeted and high density drug loaded polymeric materials |
| US8043609B2 (en) * | 2004-10-08 | 2011-10-25 | Potentia Pharmaceuticals, Inc. | Viral complement control proteins for eye disorders |
| US7947267B2 (en) * | 2004-10-08 | 2011-05-24 | Potentia Pharmaceuticals, Inc. | Viral complement control proteins for eye disorders |
| AU2005314461B2 (en) | 2004-11-18 | 2012-02-02 | The Rockefeller University | Methods and compositions for treating ocular disorders |
| EP2377951A1 (en) * | 2005-02-14 | 2011-10-19 | University of Iowa Research Foundation | Methods and reagents for treatment and diagnosis of age-related macular degeneration |
| US20060257359A1 (en) * | 2005-02-28 | 2006-11-16 | Cedric Francois | Modifying macrophage phenotype for treatment of disease |
| WO2006099330A2 (en) | 2005-03-11 | 2006-09-21 | Potentia Pharmaceuticals, Inc. | Compositions comprising modulators of g-protein-coupled receptor for treatment of macular degeneration |
| US8168584B2 (en) | 2005-10-08 | 2012-05-01 | Potentia Pharmaceuticals, Inc. | Methods of treating age-related macular degeneration by compstatin and analogs thereof |
| CN105582523B (zh) | 2005-10-08 | 2022-04-15 | 阿佩利斯制药公司 | 用于眼部病症的补体抑制素和其类似物 |
| KR20180002911A (ko) | 2005-11-04 | 2018-01-08 | 제넨테크, 인크. | 안질환 치료를 위한 보체 경로 억제제의 용도 |
| DK1960422T3 (da) | 2005-11-28 | 2012-08-13 | Univ Pennsylvania | Meget virksomme compstatin-analoger |
| EP1963529A2 (en) * | 2005-12-22 | 2008-09-03 | Alcon Research, Ltd. | C3-convertase inhibitors for the prevention and treatment of age-related macular degeneration in patients with at risk variants of complement factor h |
| US20070196367A1 (en) * | 2006-02-22 | 2007-08-23 | Valentin Dinu | Methods of preventing and treating Alzheimer's disease, age related macular degeneration and other diseases involving extra-cellular debris through the inhibition of the complement system |
| KR101394768B1 (ko) | 2006-03-30 | 2014-05-21 | 드라이스 파마슈티컬스 아이엔씨 | 캄토테신-세포 투과 펩티드 결합체 및 이를 포함하는 약학 조성물 |
| DK2148691T3 (en) | 2007-02-05 | 2015-08-17 | Apellis Pharmaceuticals Inc | Compstatinanaloger for use in the treatment of inflammatory states of the respiratory system |
| MX341715B (es) | 2007-07-19 | 2016-08-23 | Allexcel Inc | Polímeros anfifílicos de autoensamblaje como agentes anticáncer. |
| WO2009015087A2 (en) | 2007-07-20 | 2009-01-29 | Potentia Pharmaceuticals, Inc. | Compositions and methods for treatment of trauma |
| KR20100094453A (ko) * | 2007-10-02 | 2010-08-26 | 포텐시아 팔마큐티칼스, 인크. | 겔로부터 콤스타틴 유사체의 지속적 운반 |
| WO2009097468A2 (en) | 2008-01-29 | 2009-08-06 | Kliman Gilbert H | Drug delivery devices, kits and methods therefor |
| WO2009121065A2 (en) | 2008-03-28 | 2009-10-01 | Apellis Ag | Modulation and repletion/enhancement of the complement system for treatment of trauma |
| ES2655389T3 (es) | 2009-05-01 | 2018-02-19 | The Trustees Of The University Of Pennsylvania | Compstatina modificada con esqueleto peptídico y modificaciones c-terminales |
| US9291622B2 (en) | 2009-05-21 | 2016-03-22 | Apellis Pharmaceuticals, Inc. | Complement assays and uses thereof |
| EP2338520A1 (de) | 2009-12-21 | 2011-06-29 | Ludwig Maximilians Universität | Konjugat mit Zielfindungsligand und dessen Verwendung |
| US8468925B2 (en) | 2010-05-06 | 2013-06-25 | Warwick Mills Inc. | Suicide bomber blast threat mitigation system |
| US9421240B2 (en) | 2010-06-22 | 2016-08-23 | Apellis Pharmaceuticals, Inc. | Compstatin analogs for treatment of neuropathic pain |
| US20130324482A1 (en) | 2010-07-09 | 2013-12-05 | Apellis Pharmaceuticals, Inc. | Compstatin analogs for treatment of rhinosinusitis and nasal polyposis |
| WO2012040259A2 (en) | 2010-09-23 | 2012-03-29 | The Trustees Of The University Of Pennsylvania | Modified compstatin with improved stability and binding properties |
| JP6522337B2 (ja) | 2011-05-11 | 2019-05-29 | アペリス・ファーマシューティカルズ・インコーポレイテッドＡｐｅｌｌｉｓ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ，Ｉｎｃ． | 細胞反応性、長時間作用型または標的化コンプスタチン類似体およびその使用 |
| EP3524258B1 (en) * | 2011-06-22 | 2025-10-01 | Apellis Pharmaceuticals, Inc. | Methods of treating chronic disorders with complement inhibitors |
| WO2013036778A2 (en) | 2011-09-07 | 2013-03-14 | The Trustees Of The University Of Pennsylvania | Compstatin analogs with improved pharmacokinetic properties |
| US20160067357A1 (en) | 2012-08-17 | 2016-03-10 | Apellis Pharmaceuticals, Inc. | Detection of high risk drusen |
| US20160194359A1 (en) | 2012-11-15 | 2016-07-07 | Apellis Pharmaceuticals, Inc. | Cell-reactive, long-acting, or targeted compstatin analogs and related compositions and methods |
| PT2920201T (pt) | 2012-11-15 | 2020-04-03 | Apellis Pharmaceuticals Inc | Análogos de compstatina de longa ação e composições e métodos relacionados |
| US9512180B2 (en) | 2012-12-19 | 2016-12-06 | The Regents Of The University Of California | Compstatin analogs |
| WO2014152391A1 (en) * | 2013-03-15 | 2014-09-25 | Apellis Pharmaceuticals, Inc. | Cell-penetrating compstatin analogs and uses thereof |
| JP6159886B2 (ja) | 2013-07-16 | 2017-07-05 | 北京机械▲設▼▲備▼研究所 | 高層及び超高層ビルの消火活動に適用する消防車 |
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