JP2015536639A5 - - Google Patents
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- JP2015536639A5 JP2015536639A5 JP2015532250A JP2015532250A JP2015536639A5 JP 2015536639 A5 JP2015536639 A5 JP 2015536639A5 JP 2015532250 A JP2015532250 A JP 2015532250A JP 2015532250 A JP2015532250 A JP 2015532250A JP 2015536639 A5 JP2015536639 A5 JP 2015536639A5
- Authority
- JP
- Japan
- Prior art keywords
- methylation
- region
- determining
- methylation level
- regions
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 230000011987 methylation Effects 0.000 claims 119
- 238000007069 methylation reaction Methods 0.000 claims 119
- 238000000034 method Methods 0.000 claims 118
- 108020004414 DNA Proteins 0.000 claims 75
- 102000053602 DNA Human genes 0.000 claims 39
- 210000001519 tissue Anatomy 0.000 claims 34
- 206010028980 Neoplasm Diseases 0.000 claims 32
- 239000012472 biological sample Substances 0.000 claims 27
- 201000011510 cancer Diseases 0.000 claims 27
- 238000012217 deletion Methods 0.000 claims 15
- 230000037430 deletion Effects 0.000 claims 15
- 108091029523 CpG island Proteins 0.000 claims 13
- 230000001186 cumulative effect Effects 0.000 claims 13
- 230000003321 amplification Effects 0.000 claims 12
- 238000003199 nucleic acid amplification method Methods 0.000 claims 12
- 238000012163 sequencing technique Methods 0.000 claims 9
- 108091029430 CpG site Proteins 0.000 claims 8
- 230000002759 chromosomal effect Effects 0.000 claims 7
- 210000003754 fetus Anatomy 0.000 claims 7
- 208000031404 Chromosome Aberrations Diseases 0.000 claims 6
- 108700028369 Alleles Proteins 0.000 claims 5
- 239000000203 mixture Substances 0.000 claims 5
- 238000011282 treatment Methods 0.000 claims 5
- DWAQJAXMDSEUJJ-UHFFFAOYSA-M Sodium bisulfite Chemical compound [Na+].OS([O-])=O DWAQJAXMDSEUJJ-UHFFFAOYSA-M 0.000 claims 4
- 210000000349 chromosome Anatomy 0.000 claims 4
- 238000004393 prognosis Methods 0.000 claims 4
- 235000010267 sodium hydrogen sulphite Nutrition 0.000 claims 4
- 208000037280 Trisomy Diseases 0.000 claims 3
- 230000005856 abnormality Effects 0.000 claims 3
- 210000004027 cell Anatomy 0.000 claims 3
- 102000039446 nucleic acids Human genes 0.000 claims 3
- 108020004707 nucleic acids Proteins 0.000 claims 3
- 150000007523 nucleic acids Chemical class 0.000 claims 3
- 210000002826 placenta Anatomy 0.000 claims 3
- RYVNIFSIEDRLSJ-UHFFFAOYSA-N 5-(hydroxymethyl)cytosine Chemical compound NC=1NC(=O)N=CC=1CO RYVNIFSIEDRLSJ-UHFFFAOYSA-N 0.000 claims 2
- LSNNMFCWUKXFEE-UHFFFAOYSA-M Bisulfite Chemical compound OS([O-])=O LSNNMFCWUKXFEE-UHFFFAOYSA-M 0.000 claims 2
- 238000000540 analysis of variance Methods 0.000 claims 2
- 238000006243 chemical reaction Methods 0.000 claims 2
- 230000001419 dependent effect Effects 0.000 claims 2
- 230000003211 malignant effect Effects 0.000 claims 2
- 238000010606 normalization Methods 0.000 claims 2
- 238000012360 testing method Methods 0.000 claims 2
- 230000009466 transformation Effects 0.000 claims 2
- 208000010543 22q11.2 deletion syndrome Diseases 0.000 claims 1
- 102000052510 DNA-Binding Proteins Human genes 0.000 claims 1
- 101710096438 DNA-binding protein Proteins 0.000 claims 1
- 208000000398 DiGeorge Syndrome Diseases 0.000 claims 1
- 208000017924 Klinefelter Syndrome Diseases 0.000 claims 1
- 238000012313 Kruskal-Wallis test Methods 0.000 claims 1
- ZLMJMSJWJFRBEC-UHFFFAOYSA-N Potassium Chemical compound [K] ZLMJMSJWJFRBEC-UHFFFAOYSA-N 0.000 claims 1
- 238000000692 Student's t-test Methods 0.000 claims 1
- 208000026928 Turner syndrome Diseases 0.000 claims 1
- 230000002159 abnormal effect Effects 0.000 claims 1
- 238000011230 antibody-based therapy Methods 0.000 claims 1
- 238000001369 bisulfite sequencing Methods 0.000 claims 1
- 238000002512 chemotherapy Methods 0.000 claims 1
- 201000010099 disease Diseases 0.000 claims 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 1
- 238000001976 enzyme digestion Methods 0.000 claims 1
- 238000009162 epigenetic therapy Methods 0.000 claims 1
- 230000001605 fetal effect Effects 0.000 claims 1
- 238000009169 immunotherapy Methods 0.000 claims 1
- 238000007855 methylation-specific PCR Methods 0.000 claims 1
- 230000001590 oxidative effect Effects 0.000 claims 1
- 229910052700 potassium Inorganic materials 0.000 claims 1
- 239000011591 potassium Substances 0.000 claims 1
- 201000011461 pre-eclampsia Diseases 0.000 claims 1
- 238000001556 precipitation Methods 0.000 claims 1
- 108090000765 processed proteins & peptides Proteins 0.000 claims 1
- 238000001959 radiotherapy Methods 0.000 claims 1
- 108091008146 restriction endonucleases Proteins 0.000 claims 1
- 238000000926 separation method Methods 0.000 claims 1
- 238000001356 surgical procedure Methods 0.000 claims 1
- 238000002626 targeted therapy Methods 0.000 claims 1
- 230000001131 transforming effect Effects 0.000 claims 1
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261703512P | 2012-09-20 | 2012-09-20 | |
| US61/703,512 | 2012-09-20 | ||
| US13/842,209 US9732390B2 (en) | 2012-09-20 | 2013-03-15 | Non-invasive determination of methylome of fetus or tumor from plasma |
| US13/842,209 | 2013-03-15 | ||
| US201361830571P | 2013-06-03 | 2013-06-03 | |
| US61/830,571 | 2013-06-03 | ||
| PCT/AU2013/001088 WO2014043763A1 (en) | 2012-09-20 | 2013-09-20 | Non-invasive determination of methylome of fetus or tumor from plasma |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018061744A Division JP6683752B2 (ja) | 2012-09-20 | 2018-03-28 | 血漿による胎児または腫瘍のメチロームの非侵襲的決定 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2015536639A JP2015536639A (ja) | 2015-12-24 |
| JP2015536639A5 true JP2015536639A5 (enExample) | 2016-08-25 |
| JP6317354B2 JP6317354B2 (ja) | 2018-04-25 |
Family
ID=50340462
Family Applications (6)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015532250A Active JP6317354B2 (ja) | 2012-09-20 | 2013-09-20 | 血漿による胎児または腫瘍のメチロームの非侵襲的決定 |
| JP2018061744A Active JP6683752B2 (ja) | 2012-09-20 | 2018-03-28 | 血漿による胎児または腫瘍のメチロームの非侵襲的決定 |
| JP2020055387A Active JP6985753B2 (ja) | 2012-09-20 | 2020-03-26 | 血漿による胎児または腫瘍のメチロームの非侵襲的決定 |
| JP2021188060A Pending JP2022031753A (ja) | 2012-09-20 | 2021-11-18 | 血漿による胎児または腫瘍のメチロームの非侵襲的決定 |
| JP2023167714A Active JP7594817B2 (ja) | 2012-09-20 | 2023-09-28 | 血漿による胎児または腫瘍のメチロームの非侵襲的決定 |
| JP2024200780A Pending JP2025026936A (ja) | 2012-09-20 | 2024-11-18 | 血漿による胎児または腫瘍のメチロームの非侵襲的決定 |
Family Applications After (5)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018061744A Active JP6683752B2 (ja) | 2012-09-20 | 2018-03-28 | 血漿による胎児または腫瘍のメチロームの非侵襲的決定 |
| JP2020055387A Active JP6985753B2 (ja) | 2012-09-20 | 2020-03-26 | 血漿による胎児または腫瘍のメチロームの非侵襲的決定 |
| JP2021188060A Pending JP2022031753A (ja) | 2012-09-20 | 2021-11-18 | 血漿による胎児または腫瘍のメチロームの非侵襲的決定 |
| JP2023167714A Active JP7594817B2 (ja) | 2012-09-20 | 2023-09-28 | 血漿による胎児または腫瘍のメチロームの非侵襲的決定 |
| JP2024200780A Pending JP2025026936A (ja) | 2012-09-20 | 2024-11-18 | 血漿による胎児または腫瘍のメチロームの非侵襲的決定 |
Country Status (28)
| Country | Link |
|---|---|
| EP (6) | EP3536807B1 (enExample) |
| JP (6) | JP6317354B2 (enExample) |
| KR (5) | KR102390711B1 (enExample) |
| CN (2) | CN117757932A (enExample) |
| AU (5) | AU2013317708C1 (enExample) |
| BR (3) | BR112015006183B1 (enExample) |
| CA (2) | CA2884066C (enExample) |
| CY (1) | CY1124139T1 (enExample) |
| DK (4) | DK3536807T3 (enExample) |
| EA (1) | EA201500327A1 (enExample) |
| ES (4) | ES2862726T3 (enExample) |
| FI (2) | FI3536807T3 (enExample) |
| HR (3) | HRP20240210T1 (enExample) |
| HU (3) | HUE053822T2 (enExample) |
| IL (4) | IL299444B2 (enExample) |
| LT (2) | LT3354747T (enExample) |
| MX (1) | MX360034B (enExample) |
| MY (2) | MY187444A (enExample) |
| NZ (2) | NZ717423A (enExample) |
| PH (2) | PH12022552061A1 (enExample) |
| PL (4) | PL3536807T3 (enExample) |
| PT (4) | PT3354747T (enExample) |
| SG (2) | SG11201501927VA (enExample) |
| SI (1) | SI4056712T1 (enExample) |
| SM (1) | SMT202100256T1 (enExample) |
| TW (4) | TWI806621B (enExample) |
| WO (1) | WO2014043763A1 (enExample) |
| ZA (1) | ZA201501772B (enExample) |
Families Citing this family (94)
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| CN101153336B (zh) | 2006-09-27 | 2011-09-07 | 香港中文大学 | 检测dna甲基化程度的方法和试剂盒 |
| US9892230B2 (en) | 2012-03-08 | 2018-02-13 | The Chinese University Of Hong Kong | Size-based analysis of fetal or tumor DNA fraction in plasma |
| US9732390B2 (en) | 2012-09-20 | 2017-08-15 | The Chinese University Of Hong Kong | Non-invasive determination of methylome of fetus or tumor from plasma |
| BR112015006183B1 (pt) | 2012-09-20 | 2022-04-26 | The Chinese University Of Hong Kong | Métodos para analisar uma amostra biológica de um organismo, para determinar um primeiro perfil de metilação de uma amostra biológica de um organismo, para detecção de uma anormalidade cromossômica de uma amostra biológica de um organismo e para estimar um nível de metilação do dna em uma amostra biológica de um organismo, produto de computador, e, kit para análise de dna fetal |
| US10706957B2 (en) | 2012-09-20 | 2020-07-07 | The Chinese University Of Hong Kong | Non-invasive determination of methylome of tumor from plasma |
| US20130309666A1 (en) | 2013-01-25 | 2013-11-21 | Sequenom, Inc. | Methods and processes for non-invasive assessment of genetic variations |
| WO2015013885A1 (zh) * | 2013-07-30 | 2015-02-05 | 深圳华大基因科技有限公司 | 确定核酸混合物中核酸组成的方法 |
| US10174375B2 (en) | 2013-09-20 | 2019-01-08 | The Chinese University Of Hong Kong | Sequencing analysis of circulating DNA to detect and monitor autoimmune diseases |
| WO2015126840A1 (en) * | 2014-02-18 | 2015-08-27 | Bionano Genomics, Inc. | Improved methods of determining nucleic acid structural information |
| EP3561075A1 (en) * | 2014-04-21 | 2019-10-30 | Natera, Inc. | Detecting mutations in tumour biopsies and cell-free samples |
| US12492429B2 (en) | 2014-04-21 | 2025-12-09 | Natera, Inc. | Detecting mutations and ploidy in chromosomal segments |
| EP2942400A1 (en) | 2014-05-09 | 2015-11-11 | Lifecodexx AG | Multiplex detection of DNA that originates from a specific cell-type |
| CA2985134A1 (en) | 2014-05-09 | 2015-11-12 | Sebastian Gromminger | Detection of dna that originates from a specific cell-type and related methods |
| TWI727156B (zh) * | 2014-07-18 | 2021-05-11 | 香港中文大學 | Ｄｎａ混合物中之組織甲基化模式分析 |
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| EP4358097A1 (en) | 2014-07-25 | 2024-04-24 | University of Washington | Methods of determining tissues and/or cell types giving rise to cell-free dna, and methods of identifying a disease or disorder using same |
| EP4574996B1 (en) | 2014-12-31 | 2025-11-05 | Guardant Health, Inc. | Detection and treatment of disease exhibiting disease cell heterogeneity and systems and methods for communicating test results |
| US10364467B2 (en) * | 2015-01-13 | 2019-07-30 | The Chinese University Of Hong Kong | Using size and number aberrations in plasma DNA for detecting cancer |
| ES2908347T3 (es) | 2015-02-10 | 2022-04-28 | Univ Hong Kong Chinese | Detección de mutaciones para cribado de cáncer y análisis fetal |
| WO2017012544A1 (en) * | 2015-07-20 | 2017-01-26 | The Chinese University Of Hong Kong | Methylation pattern analysis of haplotypes in tissues in dna mixture |
| EP4279612B1 (en) * | 2015-07-23 | 2025-07-02 | The Chinese University of Hong Kong | Analysis of fragmentation patterns of cell-free dna |
| CA2995422A1 (en) | 2015-08-12 | 2017-02-16 | The Chinese University Of Hong Kong | Single-molecule sequencing of plasma dna |
| CN108026576B (zh) | 2015-09-22 | 2022-06-28 | 香港中文大学 | 通过母亲血浆dna的浅深度测序准确定量胎儿dna分数 |
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