JP2015536639A5 - - Google Patents
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- JP2015536639A5 JP2015536639A5 JP2015532250A JP2015532250A JP2015536639A5 JP 2015536639 A5 JP2015536639 A5 JP 2015536639A5 JP 2015532250 A JP2015532250 A JP 2015532250A JP 2015532250 A JP2015532250 A JP 2015532250A JP 2015536639 A5 JP2015536639 A5 JP 2015536639A5
- Authority
- JP
- Japan
- Prior art keywords
- methylation
- region
- determining
- methylation level
- regions
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 230000011987 methylation Effects 0.000 claims 119
- 238000007069 methylation reaction Methods 0.000 claims 119
- 238000000034 method Methods 0.000 claims 118
- 108020004414 DNA Proteins 0.000 claims 75
- 102000053602 DNA Human genes 0.000 claims 39
- 210000001519 tissue Anatomy 0.000 claims 34
- 206010028980 Neoplasm Diseases 0.000 claims 32
- 239000012472 biological sample Substances 0.000 claims 27
- 201000011510 cancer Diseases 0.000 claims 27
- 238000012217 deletion Methods 0.000 claims 15
- 230000037430 deletion Effects 0.000 claims 15
- 108091029523 CpG island Proteins 0.000 claims 13
- 230000001186 cumulative effect Effects 0.000 claims 13
- 230000003321 amplification Effects 0.000 claims 12
- 238000003199 nucleic acid amplification method Methods 0.000 claims 12
- 238000012163 sequencing technique Methods 0.000 claims 9
- 108091029430 CpG site Proteins 0.000 claims 8
- 230000002759 chromosomal effect Effects 0.000 claims 7
- 210000003754 fetus Anatomy 0.000 claims 7
- 208000031404 Chromosome Aberrations Diseases 0.000 claims 6
- 108700028369 Alleles Proteins 0.000 claims 5
- 239000000203 mixture Substances 0.000 claims 5
- 238000011282 treatment Methods 0.000 claims 5
- DWAQJAXMDSEUJJ-UHFFFAOYSA-M Sodium bisulfite Chemical compound [Na+].OS([O-])=O DWAQJAXMDSEUJJ-UHFFFAOYSA-M 0.000 claims 4
- 210000000349 chromosome Anatomy 0.000 claims 4
- 238000004393 prognosis Methods 0.000 claims 4
- 235000010267 sodium hydrogen sulphite Nutrition 0.000 claims 4
- 208000037280 Trisomy Diseases 0.000 claims 3
- 230000005856 abnormality Effects 0.000 claims 3
- 210000004027 cell Anatomy 0.000 claims 3
- 102000039446 nucleic acids Human genes 0.000 claims 3
- 108020004707 nucleic acids Proteins 0.000 claims 3
- 150000007523 nucleic acids Chemical class 0.000 claims 3
- 210000002826 placenta Anatomy 0.000 claims 3
- RYVNIFSIEDRLSJ-UHFFFAOYSA-N 5-(hydroxymethyl)cytosine Chemical compound NC=1NC(=O)N=CC=1CO RYVNIFSIEDRLSJ-UHFFFAOYSA-N 0.000 claims 2
- LSNNMFCWUKXFEE-UHFFFAOYSA-M Bisulfite Chemical compound OS([O-])=O LSNNMFCWUKXFEE-UHFFFAOYSA-M 0.000 claims 2
- 238000000540 analysis of variance Methods 0.000 claims 2
- 238000006243 chemical reaction Methods 0.000 claims 2
- 230000001419 dependent effect Effects 0.000 claims 2
- 230000003211 malignant effect Effects 0.000 claims 2
- 238000010606 normalization Methods 0.000 claims 2
- 238000012360 testing method Methods 0.000 claims 2
- 230000009466 transformation Effects 0.000 claims 2
- 208000010543 22q11.2 deletion syndrome Diseases 0.000 claims 1
- 102000052510 DNA-Binding Proteins Human genes 0.000 claims 1
- 101710096438 DNA-binding protein Proteins 0.000 claims 1
- 208000000398 DiGeorge Syndrome Diseases 0.000 claims 1
- 208000017924 Klinefelter Syndrome Diseases 0.000 claims 1
- 238000012313 Kruskal-Wallis test Methods 0.000 claims 1
- ZLMJMSJWJFRBEC-UHFFFAOYSA-N Potassium Chemical compound [K] ZLMJMSJWJFRBEC-UHFFFAOYSA-N 0.000 claims 1
- 238000000692 Student's t-test Methods 0.000 claims 1
- 208000026928 Turner syndrome Diseases 0.000 claims 1
- 230000002159 abnormal effect Effects 0.000 claims 1
- 238000011230 antibody-based therapy Methods 0.000 claims 1
- 238000001369 bisulfite sequencing Methods 0.000 claims 1
- 238000002512 chemotherapy Methods 0.000 claims 1
- 201000010099 disease Diseases 0.000 claims 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 1
- 238000001976 enzyme digestion Methods 0.000 claims 1
- 238000009162 epigenetic therapy Methods 0.000 claims 1
- 230000001605 fetal effect Effects 0.000 claims 1
- 238000009169 immunotherapy Methods 0.000 claims 1
- 238000007855 methylation-specific PCR Methods 0.000 claims 1
- 230000001590 oxidative effect Effects 0.000 claims 1
- 229910052700 potassium Inorganic materials 0.000 claims 1
- 239000011591 potassium Substances 0.000 claims 1
- 201000011461 pre-eclampsia Diseases 0.000 claims 1
- 238000001556 precipitation Methods 0.000 claims 1
- 108090000765 processed proteins & peptides Proteins 0.000 claims 1
- 238000001959 radiotherapy Methods 0.000 claims 1
- 108091008146 restriction endonucleases Proteins 0.000 claims 1
- 238000000926 separation method Methods 0.000 claims 1
- 238000001356 surgical procedure Methods 0.000 claims 1
- 238000002626 targeted therapy Methods 0.000 claims 1
- 230000001131 transforming effect Effects 0.000 claims 1
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261703512P | 2012-09-20 | 2012-09-20 | |
| US61/703,512 | 2012-09-20 | ||
| US13/842,209 | 2013-03-15 | ||
| US13/842,209 US9732390B2 (en) | 2012-09-20 | 2013-03-15 | Non-invasive determination of methylome of fetus or tumor from plasma |
| US201361830571P | 2013-06-03 | 2013-06-03 | |
| US61/830,571 | 2013-06-03 | ||
| PCT/AU2013/001088 WO2014043763A1 (en) | 2012-09-20 | 2013-09-20 | Non-invasive determination of methylome of fetus or tumor from plasma |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018061744A Division JP6683752B2 (ja) | 2012-09-20 | 2018-03-28 | 血漿による胎児または腫瘍のメチロームの非侵襲的決定 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2015536639A JP2015536639A (ja) | 2015-12-24 |
| JP2015536639A5 true JP2015536639A5 (enExample) | 2016-08-25 |
| JP6317354B2 JP6317354B2 (ja) | 2018-04-25 |
Family
ID=50340462
Family Applications (6)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015532250A Active JP6317354B2 (ja) | 2012-09-20 | 2013-09-20 | 血漿による胎児または腫瘍のメチロームの非侵襲的決定 |
| JP2018061744A Active JP6683752B2 (ja) | 2012-09-20 | 2018-03-28 | 血漿による胎児または腫瘍のメチロームの非侵襲的決定 |
| JP2020055387A Active JP6985753B2 (ja) | 2012-09-20 | 2020-03-26 | 血漿による胎児または腫瘍のメチロームの非侵襲的決定 |
| JP2021188060A Pending JP2022031753A (ja) | 2012-09-20 | 2021-11-18 | 血漿による胎児または腫瘍のメチロームの非侵襲的決定 |
| JP2023167714A Active JP7594817B2 (ja) | 2012-09-20 | 2023-09-28 | 血漿による胎児または腫瘍のメチロームの非侵襲的決定 |
| JP2024200780A Pending JP2025026936A (ja) | 2012-09-20 | 2024-11-18 | 血漿による胎児または腫瘍のメチロームの非侵襲的決定 |
Family Applications After (5)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018061744A Active JP6683752B2 (ja) | 2012-09-20 | 2018-03-28 | 血漿による胎児または腫瘍のメチロームの非侵襲的決定 |
| JP2020055387A Active JP6985753B2 (ja) | 2012-09-20 | 2020-03-26 | 血漿による胎児または腫瘍のメチロームの非侵襲的決定 |
| JP2021188060A Pending JP2022031753A (ja) | 2012-09-20 | 2021-11-18 | 血漿による胎児または腫瘍のメチロームの非侵襲的決定 |
| JP2023167714A Active JP7594817B2 (ja) | 2012-09-20 | 2023-09-28 | 血漿による胎児または腫瘍のメチロームの非侵襲的決定 |
| JP2024200780A Pending JP2025026936A (ja) | 2012-09-20 | 2024-11-18 | 血漿による胎児または腫瘍のメチロームの非侵襲的決定 |
Country Status (28)
| Country | Link |
|---|---|
| EP (6) | EP3839065A1 (enExample) |
| JP (6) | JP6317354B2 (enExample) |
| KR (5) | KR102307424B1 (enExample) |
| CN (2) | CN117757932A (enExample) |
| AU (5) | AU2013317708C1 (enExample) |
| BR (3) | BR112015006183B1 (enExample) |
| CA (2) | CA2884066C (enExample) |
| CY (1) | CY1124139T1 (enExample) |
| DK (4) | DK3536807T3 (enExample) |
| EA (1) | EA201500327A1 (enExample) |
| ES (4) | ES2862726T3 (enExample) |
| FI (2) | FI3536807T3 (enExample) |
| HR (3) | HRP20241142T1 (enExample) |
| HU (3) | HUE068129T2 (enExample) |
| IL (4) | IL299444B2 (enExample) |
| LT (2) | LT3354747T (enExample) |
| MX (1) | MX360034B (enExample) |
| MY (2) | MY173356A (enExample) |
| NZ (2) | NZ717423A (enExample) |
| PH (2) | PH12015500547B1 (enExample) |
| PL (4) | PL3354747T3 (enExample) |
| PT (4) | PT3354747T (enExample) |
| SG (2) | SG10201705198UA (enExample) |
| SI (1) | SI4056712T1 (enExample) |
| SM (1) | SMT202100256T1 (enExample) |
| TW (5) | TWI784258B (enExample) |
| WO (1) | WO2014043763A1 (enExample) |
| ZA (1) | ZA201501772B (enExample) |
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| DK3536807T3 (da) * | 2012-09-20 | 2024-02-05 | Univ Hong Kong Chinese | Ikkeinvasiv bestemmelse af foster- eller tumormethylom fra plasma |
| US10706957B2 (en) | 2012-09-20 | 2020-07-07 | The Chinese University Of Hong Kong | Non-invasive determination of methylome of tumor from plasma |
| US20130309666A1 (en) | 2013-01-25 | 2013-11-21 | Sequenom, Inc. | Methods and processes for non-invasive assessment of genetic variations |
| CN105555965B (zh) * | 2013-07-30 | 2020-06-05 | 深圳华大基因股份有限公司 | 确定核酸混合物中核酸组成的方法 |
| US10174375B2 (en) * | 2013-09-20 | 2019-01-08 | The Chinese University Of Hong Kong | Sequencing analysis of circulating DNA to detect and monitor autoimmune diseases |
| CN106029909B (zh) * | 2014-02-18 | 2021-02-02 | 生物纳米基因公司 | 测定核酸结构信息的改进方法 |
| CN109971852A (zh) * | 2014-04-21 | 2019-07-05 | 纳特拉公司 | 检测染色体片段中的突变和倍性 |
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| SG11201608993RA (en) | 2014-05-09 | 2016-11-29 | Lifecodexx Ag | Detection of dna that originates from a specific cell-type and related methods |
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| TWI703216B (zh) | 2014-07-18 | 2020-09-01 | 香港中文大學 | Ｄｎａ混合物中之組織甲基化模式分析 |
| CN107002122B (zh) | 2014-07-25 | 2023-09-19 | 华盛顿大学 | 确定导致无细胞dna的产生的组织和/或细胞类型的方法以及使用其鉴定疾病或紊乱的方法 |
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| EP4012715B1 (en) | 2015-02-10 | 2025-09-24 | The Chinese University Of Hong Kong | Detecting mutations for cancer screening and fetal analysis |
| CA2993588A1 (en) | 2015-07-20 | 2017-01-26 | The Chinese University Of Hong Kong | Methylation pattern analysis of haplotypes in tissues in dna mixture |
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