PL4056712T3 - Nieinwazyjne określanie metylomu guza w osoczu - Google Patents

Nieinwazyjne określanie metylomu guza w osoczu

Info

Publication number
PL4056712T3
PL4056712T3 PL22171427.2T PL22171427T PL4056712T3 PL 4056712 T3 PL4056712 T3 PL 4056712T3 PL 22171427 T PL22171427 T PL 22171427T PL 4056712 T3 PL4056712 T3 PL 4056712T3
Authority
PL
Poland
Prior art keywords
methylome
tumor
plasma
invasive determination
invasive
Prior art date
Application number
PL22171427.2T
Other languages
English (en)
Inventor
Rossa Wai Kwun Chiu
Kwan Chee Chan
Yuk-Ming Dennis Lo
Miu Fan Lun
Peiyong Jiang
Wai Man Chan
Original Assignee
The Chinese University Of Hong Kong
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=50340462&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=PL4056712(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority claimed from US13/842,209 external-priority patent/US9732390B2/en
Application filed by The Chinese University Of Hong Kong filed Critical The Chinese University Of Hong Kong
Publication of PL4056712T3 publication Critical patent/PL4056712T3/pl

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6881—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for tissue or cell typing, e.g. human leukocyte antigen [HLA] probes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6869—Methods for sequencing
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B20/00—ICT specially adapted for functional genomics or proteomics, e.g. genotype-phenotype associations
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2523/00—Reactions characterised by treatment of reaction samples
    • C12Q2523/10—Characterised by chemical treatment
    • C12Q2523/125—Bisulfite(s)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2535/00—Reactions characterised by the assay type for determining the identity of a nucleotide base or a sequence of oligonucleotides
    • C12Q2535/122—Massive parallel sequencing
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/112—Disease subtyping, staging or classification
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/154—Methylation markers

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Analytical Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Immunology (AREA)
  • Physics & Mathematics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Pathology (AREA)
  • Hospice & Palliative Care (AREA)
  • Oncology (AREA)
  • Cell Biology (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Evolutionary Biology (AREA)
  • Medical Informatics (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Theoretical Computer Science (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Ultra Sonic Daignosis Equipment (AREA)
PL22171427.2T 2012-09-20 2013-09-20 Nieinwazyjne określanie metylomu guza w osoczu PL4056712T3 (pl)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201261703512P 2012-09-20 2012-09-20
US13/842,209 US9732390B2 (en) 2012-09-20 2013-03-15 Non-invasive determination of methylome of fetus or tumor from plasma
US201361830571P 2013-06-03 2013-06-03

Publications (1)

Publication Number Publication Date
PL4056712T3 true PL4056712T3 (pl) 2024-12-02

Family

ID=50340462

Family Applications (4)

Application Number Title Priority Date Filing Date
PL19171630.7T PL3536807T3 (pl) 2012-09-20 2013-09-20 Nieinwazyjne określanie metylomu guza z wykorzystaniem osocza
PL13838770.9T PL2898100T5 (pl) 2012-09-20 2013-09-20 Nieinwazyjny sposób określania metylomu płodu lub guza z wykorzystaniem osocza
PL22171427.2T PL4056712T3 (pl) 2012-09-20 2013-09-20 Nieinwazyjne określanie metylomu guza w osoczu
PL17202149T PL3354747T3 (pl) 2012-09-20 2013-09-20 Nieinwazyjne określanie metylomu guza z wykorzystaniem osocza

Family Applications Before (2)

Application Number Title Priority Date Filing Date
PL19171630.7T PL3536807T3 (pl) 2012-09-20 2013-09-20 Nieinwazyjne określanie metylomu guza z wykorzystaniem osocza
PL13838770.9T PL2898100T5 (pl) 2012-09-20 2013-09-20 Nieinwazyjny sposób określania metylomu płodu lub guza z wykorzystaniem osocza

Family Applications After (1)

Application Number Title Priority Date Filing Date
PL17202149T PL3354747T3 (pl) 2012-09-20 2013-09-20 Nieinwazyjne określanie metylomu guza z wykorzystaniem osocza

Country Status (28)

Country Link
EP (6) EP3536807B1 (pl)
JP (6) JP6317354B2 (pl)
KR (5) KR20230145530A (pl)
CN (2) CN104781422B (pl)
AU (5) AU2013317708C1 (pl)
BR (3) BR122021021825B1 (pl)
CA (2) CA2884066C (pl)
CY (1) CY1124139T1 (pl)
DK (4) DK3354747T3 (pl)
EA (1) EA201500327A1 (pl)
ES (4) ES2665273T5 (pl)
FI (2) FI4056712T3 (pl)
HR (3) HRP20241142T1 (pl)
HU (3) HUE066054T2 (pl)
IL (4) IL313451A (pl)
LT (2) LT3354747T (pl)
MX (1) MX360034B (pl)
MY (2) MY173356A (pl)
NZ (2) NZ706269A (pl)
PH (2) PH12022552061A1 (pl)
PL (4) PL3536807T3 (pl)
PT (4) PT2898100T (pl)
SG (2) SG10201705198UA (pl)
SI (1) SI4056712T1 (pl)
SM (1) SMT202100256T1 (pl)
TW (4) TWI707953B (pl)
WO (1) WO2014043763A1 (pl)
ZA (1) ZA201501772B (pl)

Families Citing this family (94)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TWI335354B (en) 2006-09-27 2011-01-01 Univ Hong Kong Chinese Methods for the detection of the degree of the methylation of a target dna and kits
US9892230B2 (en) 2012-03-08 2018-02-13 The Chinese University Of Hong Kong Size-based analysis of fetal or tumor DNA fraction in plasma
US9732390B2 (en) 2012-09-20 2017-08-15 The Chinese University Of Hong Kong Non-invasive determination of methylome of fetus or tumor from plasma
CA2884066C (en) * 2012-09-20 2021-08-10 The Chinese University Of Hong Kong Non-invasive determination of methylome of fetus or tumor from plasma
US10706957B2 (en) 2012-09-20 2020-07-07 The Chinese University Of Hong Kong Non-invasive determination of methylome of tumor from plasma
US20130309666A1 (en) 2013-01-25 2013-11-21 Sequenom, Inc. Methods and processes for non-invasive assessment of genetic variations
WO2015013885A1 (zh) * 2013-07-30 2015-02-05 深圳华大基因科技有限公司 确定核酸混合物中核酸组成的方法
US10174375B2 (en) 2013-09-20 2019-01-08 The Chinese University Of Hong Kong Sequencing analysis of circulating DNA to detect and monitor autoimmune diseases
US12054771B2 (en) * 2014-02-18 2024-08-06 Bionano Genomics, Inc. Methods of determining nucleic acid structural information
US12492429B2 (en) 2014-04-21 2025-12-09 Natera, Inc. Detecting mutations and ploidy in chromosomal segments
JP6659575B2 (ja) * 2014-04-21 2020-03-04 ナテラ， インコーポレイテッド 変異の検出および染色体分節の倍数性
EP2942400A1 (en) 2014-05-09 2015-11-11 Lifecodexx AG Multiplex detection of DNA that originates from a specific cell-type
WO2015169947A1 (en) 2014-05-09 2015-11-12 Lifecodexx Ag Detection of dna that originates from a specific cell-type and related methods
WO2016008451A1 (en) * 2014-07-18 2016-01-21 The Chinese University Of Hong Kong Methylation pattern analysis of tissues in dna mixture
WO2016010401A1 (ko) * 2014-07-18 2016-01-21 에스케이텔레콘 주식회사 산모의 혈청 dna를 이용한 태아의 단일유전자 유전변이의 예측방법
KR102696857B1 (ko) 2014-07-25 2024-08-19 유니버시티 오브 워싱톤 무세포 dna를 생성하는 조직 및/또는 세포 유형을 결정하는 방법 및 이를 사용하여 질환 또는 장애를 확인하는 방법
EP4574996B1 (en) * 2014-12-31 2025-11-05 Guardant Health, Inc. Detection and treatment of disease exhibiting disease cell heterogeneity and systems and methods for communicating test results
US10364467B2 (en) * 2015-01-13 2019-07-30 The Chinese University Of Hong Kong Using size and number aberrations in plasma DNA for detecting cancer
ES2908347T3 (es) * 2015-02-10 2022-04-28 Univ Hong Kong Chinese Detección de mutaciones para cribado de cáncer y análisis fetal
EP4063517A1 (en) * 2015-07-20 2022-09-28 The Chinese University Of Hong Kong Methylation pattern analysis of haplotypes in tissues in dna mixture
PT3967775T (pt) * 2015-07-23 2023-10-10 Univ Hong Kong Chinese Análise de padrões de fragmentação de adn sem células
HK1248286A1 (zh) 2015-08-12 2018-10-12 The Chinese University Of Hong Kong 血浆dna的单分子测序
MY199897A (en) 2015-09-22 2023-11-28 Univ Hong Kong Chinese Accurate quantification of fetal dna fraction by shallow-depth sequencing of maternal plasma dna
US10260088B2 (en) * 2015-10-30 2019-04-16 New England Biolabs, Inc. Compositions and methods for analyzing modified nucleotides
CA3004527A1 (en) * 2015-11-09 2017-05-18 Progenity, Inc. Methods for determining the origin of dna molecules
HUE050491T2 (hu) 2015-11-10 2020-12-28 Eurofins Lifecodexx Gmbh Magzati kromoszomális aneuploidiák kimutatása olyan DNS régiókat alkalmazva, amelyek különbözõképpen vannak metilezve a magzat és a terhes nõstény között
CN109072300B (zh) 2015-12-17 2023-01-31 伊路敏纳公司 区分复杂生物样品中的甲基化水平
US11335463B2 (en) * 2016-02-02 2022-05-17 Guardant Health, Inc. Cancer evolution detection and diagnostic
US11514289B1 (en) 2016-03-09 2022-11-29 Freenome Holdings, Inc. Generating machine learning models using genetic data
BR112018072536A2 (pt) * 2016-05-03 2019-03-26 University Health Network métodos de captura de dna metilatado de célula livre e usos dos mesmos
WO2017201606A1 (en) 2016-05-04 2017-11-30 Queen's University At Kingston Cell-free detection of methylated tumour dna
AU2017274038B2 (en) * 2016-05-30 2023-03-16 The Chinese University Of Hong Kong Detecting hematological disorders using cell-free DNA in blood
WO2017218908A2 (en) * 2016-06-16 2017-12-21 The Johns Hopkins University Methods and system for epigenetic analysis
CN107779485B (zh) * 2016-08-24 2022-03-18 中国科学院分子细胞科学卓越创新中心 Cmd1酶催化的5-甲基胞嘧啶核酸的新修饰及其应用
EP3529377B1 (en) * 2016-10-19 2023-04-05 The Chinese University Of Hong Kong Gestational age assessment by methylation and size profiling of maternal plasma dna
EP3535415A4 (en) 2016-10-24 2020-07-01 The Chinese University of Hong Kong TUMOR DETECTION METHODS AND SYSTEMS
AU2017369018B2 (en) 2016-11-30 2021-02-25 The Chinese University Of Hong Kong Analysis of cell-free DNA in urine and other samples
ES2983411T3 (es) * 2016-12-13 2024-10-23 Bellwether Bio Inc Determinación de un estado fisiológico en un individuo analizando los puntos finales de fragmentos de ADN libre de células en una muestra biológica
CN110770341A (zh) * 2017-01-11 2020-02-07 奎斯特诊断投资有限责任公司 非整倍性无创产前筛查方法
CN110191964B (zh) * 2017-01-24 2023-12-05 深圳华大基因股份有限公司 确定生物样本中预定来源的游离核酸比例的方法及装置
WO2018137685A1 (en) 2017-01-25 2018-08-02 The Chinese University Of Hong Kong Diagnostic applications using nucleic acid fragments
CN107247873B (zh) * 2017-03-29 2020-04-14 电子科技大学 一种差异甲基化位点识别方法
CA3063405A1 (en) 2017-05-12 2018-11-15 President And Fellows Of Harvard College Universal early cancer diagnostics
JP7434143B2 (ja) * 2017-07-12 2024-02-20 アンディ・コーポレイション パターン認識システム
EP3652741A4 (en) * 2017-07-12 2021-04-21 University Health Network DETECTION AND CLASSIFICATION OF CANCER USING METHYLOMA ANALYSIS
US12227737B2 (en) 2017-07-12 2025-02-18 University Health Network Cancer detection and classification using methylome analysis
CN111051536A (zh) 2017-07-26 2020-04-21 香港中文大学 利用不含细胞的病毒核酸改善癌症筛选
US20200263170A1 (en) 2017-09-14 2020-08-20 Grail, Inc. Methods for preparing a sequencing library from single-stranded dna
EP3688191B1 (en) 2017-09-28 2022-03-02 Grail, LLC Enrichment of short nucleic acid fragments in sequencing library preparation
US11168356B2 (en) * 2017-11-02 2021-11-09 The Chinese University Of Hong Kong Using nucleic acid size range for noninvasive cancer detection
EP3765637A1 (en) 2018-03-13 2021-01-20 Grail, Inc. Anomalous fragment detection and classification
JP7620803B2 (ja) * 2018-03-15 2025-01-24 グレイル インコーポレイテッド 組織特異的メチル化マーカー
CN119753091A (zh) 2018-04-02 2025-04-04 格里尔公司 用于扩增与癌症相关联的cfDNA分子的化验板
JP7455757B2 (ja) * 2018-04-13 2024-03-26 フリーノーム・ホールディングス・インコーポレイテッド 生体試料の多検体アッセイのための機械学習実装
US20210104297A1 (en) * 2018-04-16 2021-04-08 Grail, Inc. Systems and methods for determining tumor fraction in cell-free nucleic acid
WO2019209884A1 (en) 2018-04-23 2019-10-31 Grail, Inc. Methods and systems for screening for conditions
US11932899B2 (en) * 2018-06-07 2024-03-19 10X Genomics, Inc. Methods and systems for characterizing nucleic acid molecules
CN109448789A (zh) * 2018-09-17 2019-03-08 上海派森诺生物科技股份有限公司 一种基于perl语言的种群特异SNP位点的自动化分析方法
EP3856903A4 (en) 2018-09-27 2022-07-27 Grail, LLC METHYLATION MARKER AND TARGETED METHYLATION PROBE PANEL
CN109295230A (zh) * 2018-10-24 2019-02-01 福建翊善生物科技有限公司 一种基于ctDNA的多基因联合突变检测评估肿瘤动态变化的方法
KR20210141915A (ko) 2018-11-21 2021-11-23 아비다 바이오메드 인코포레이티드 표적화된 핵산 라이브러리 형성을 위한 방법
CA3123474A1 (en) * 2018-12-19 2020-06-25 The Chinese University Of Hong Kong Cell-free dna end characteristics
WO2020132572A1 (en) 2018-12-21 2020-06-25 Grail, Inc. Source of origin deconvolution based on methylation fragments in cell-free-dna samples
EP4485464A3 (en) 2019-02-05 2025-02-19 Grail, Inc. Detecting cancer, cancer tissue of origin, and/or a cancer cell type
WO2020163410A1 (en) 2019-02-05 2020-08-13 Grail, Inc. Detecting cancer, cancer tissue of origin, and/or a cancer cell type
CN114072527B (zh) 2019-03-25 2025-03-04 香港中文大学 确定循环核酸的线性和环状形式
US11773450B2 (en) 2019-04-03 2023-10-03 Grail, Llc Methylation-based false positive duplicate marking reduction
WO2020227100A1 (en) * 2019-05-03 2020-11-12 Cornell University Markers for identifying and quantifying of nucleic acid sequence mutation, expression, splice variant, translocation, copy number, or methylation changes
JP2022544626A (ja) * 2019-08-19 2022-10-19 グリーン クロス ゲノム コーポレーション 核酸断片間距離情報を用いた染色体異常検出方法
KR102452413B1 (ko) * 2019-08-19 2022-10-11 주식회사 지씨지놈 핵산 단편간 거리 정보를 이용한 염색체 이상 검출 방법
GB201915469D0 (en) 2019-10-24 2019-12-11 Univ London Cancer detection methods
WO2021108654A1 (en) * 2019-11-27 2021-06-03 Grail, Inc. Systems and methods for evaluating longitudinal biological feature data
GB2612412B (en) 2020-01-31 2025-10-10 Agilent Technologies Inc Systems and methods for targeted nucleic acid capture
CN115398007A (zh) * 2020-02-10 2022-11-25 帕洛根公司 纳米孔装置和使用其检测和分类带电粒子的方法
US11211147B2 (en) 2020-02-18 2021-12-28 Tempus Labs, Inc. Estimation of circulating tumor fraction using off-target reads of targeted-panel sequencing
US11211144B2 (en) 2020-02-18 2021-12-28 Tempus Labs, Inc. Methods and systems for refining copy number variation in a liquid biopsy assay
US11475981B2 (en) 2020-02-18 2022-10-18 Tempus Labs, Inc. Methods and systems for dynamic variant thresholding in a liquid biopsy assay
CA3169488A1 (en) * 2020-02-28 2021-09-02 Collin MELTON Identifying methylation patterns that discriminate or indicate a cancer condition
CN112662764A (zh) * 2020-03-17 2021-04-16 博尔诚（北京）科技有限公司 一种检测11种癌症的探针组合物
RU2738675C1 (ru) * 2020-07-28 2020-12-15 Федеральное государственное автономное образовательное учреждение высшего образования "Белгородский государственный национальный исследовательский университет" (НИУ "БелГУ") Способ прогнозирования риска развития преэклампсии у женщин без отягощенного семейного анамнеза с учетом генетических факторов
IL302988A (en) * 2020-11-19 2023-07-01 Nucleix Ltd Detection of methylation changes in DNA samples using restriction enzymes and high-throughput sequencing
US20240327922A1 (en) * 2020-12-17 2024-10-03 Jiantao Shi Methods of cancer detection using extraembryonically methylated cpg islands
CN112813148A (zh) * 2021-02-02 2021-05-18 博淼生物科技（北京）有限公司 飞行时间质谱检测5-羟甲基胞嘧啶的方法
US20240371467A1 (en) * 2021-09-28 2024-11-07 Act Genomics (ip) Limited Methylation biomarker selection apparatuses and methods
KR20230059423A (ko) * 2021-10-26 2023-05-03 주식회사 지씨지놈 메틸화된 무세포 핵산을 이용한 암 진단 및 암 종 예측방법
EP4384633A1 (en) * 2021-11-04 2024-06-19 Universal Diagnostics, S.A. Systems and methods for preparing biological samples for genetic sequencing
IL317918A (en) 2022-02-07 2025-02-01 Centre For Novostics Fragmentation for measuring mitotic and disease
US20240150840A1 (en) * 2022-02-22 2024-05-09 Flagship Pioneering Innovations Vi, Llc Intra-individual analysis for presence of health conditions
CN115064211B (zh) * 2022-08-15 2023-01-24 臻和(北京)生物科技有限公司 一种基于全基因组甲基化测序的ctDNA预测方法及装置
CN115612723B (zh) * 2022-09-26 2023-07-14 广州女娲生命科技有限公司 植入前胚胎的筛选方法
WO2024203348A1 (ja) * 2023-03-31 2024-10-03 ソニーグループ株式会社 腫瘍の解析方法、腫瘍の解析システム、及び腫瘍の解析データ生成方法
CN116555426B (zh) * 2023-05-04 2024-07-12 杭州圣庭医疗科技有限公司 一种鉴定肿瘤组织来源的试剂盒及数据分析方法
CN117025753A (zh) * 2023-08-15 2023-11-10 广州女娲生命科技有限公司 检测染色体变异的方法和装置
CN117079822B (zh) * 2023-10-17 2024-01-02 北京大学第三医院（北京大学第三临床医学院） 一种妊娠早中期四因子预测胎儿脑损伤的系统

Family Cites Families (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6927028B2 (en) 2001-08-31 2005-08-09 Chinese University Of Hong Kong Non-invasive methods for detecting non-host DNA in a host using epigenetic differences between the host and non-host DNA
DE60207979T2 (de) † 2002-03-05 2006-09-28 Epigenomics Ag Verfahren und Vorrichtung zur Bestimmung der Gewebespezifität von freier DNA in Körperflüssigkeiten
AU2003294315A1 (en) † 2002-11-19 2004-06-15 Amgen Inc. Amplified genes involved in cancer
US20060183128A1 (en) † 2003-08-12 2006-08-17 Epigenomics Ag Methods and compositions for differentiating tissues for cell types using epigenetic markers
DE10348407A1 (de) 2003-10-17 2005-05-19 Widschwendter, Martin, Prof. Prognostische und diagnostische Marker für Zell-proliferative Erkrankungen von Brustgeweben
CA2902980A1 (en) * 2004-03-08 2005-09-29 Rubicon Genomics, Inc. Methods and compositions for generating and amplifying dna libraries for sensitive detection and analysis of dna methylation
EP1888786A4 (en) 2005-05-27 2009-12-30 Wayne John Cancer Inst USE OF FREE CIRCULATION DNA FOR THE DIAGNOSIS, PROGNOSIS AND TREATMENT OF CANCER
US7901884B2 (en) * 2006-05-03 2011-03-08 The Chinese University Of Hong Kong Markers for prenatal diagnosis and monitoring
US7754428B2 (en) 2006-05-03 2010-07-13 The Chinese University Of Hong Kong Fetal methylation markers
TWI335354B (en) * 2006-09-27 2011-01-01 Univ Hong Kong Chinese Methods for the detection of the degree of the methylation of a target dna and kits
EP2173897A2 (en) 2007-06-19 2010-04-14 Oncomethylome Sciences SA Improved urine sample collecting and processing
CN106834481A (zh) 2007-07-23 2017-06-13 香港中文大学 用于分析遗传变异的方法
JP4347372B2 (ja) 2007-08-10 2009-10-21 トヨタ自動車株式会社 静電塗装装置
US20110028333A1 (en) 2009-05-01 2011-02-03 Brown University Diagnosing, prognosing, and early detection of cancers by dna methylation profiling
US8563242B2 (en) * 2009-08-11 2013-10-22 The Chinese University Of Hong Kong Method for detecting chromosomal aneuploidy
WO2011038507A1 (en) * 2009-10-02 2011-04-07 Centre For Addiction And Mental Health Method for analysis of dna methylation profiles of cell-free circulating dna in bodily fluids
EP2496717B1 (en) * 2009-11-05 2017-06-07 The Chinese University of Hong Kong Fetal genomic analysis from a maternal biological sample
ES3026544T3 (en) 2009-11-06 2025-06-11 Univ Hong Kong Chinese Size-based genomic analysis for prenatal diagnosis
EP2513341B1 (en) * 2010-01-19 2017-04-12 Verinata Health, Inc Identification of polymorphic sequences in mixtures of genomic dna by whole genome sequencing
EA023565B1 (ru) * 2010-01-26 2016-06-30 ЭнАйПиДи ДЖЕНЕТИКС ЛТД. Способы и композиции для неинвазивной пренатальной диагностики анеуплоидии плода
CN110322924A (zh) † 2010-04-29 2019-10-11 加利福尼亚大学董事会 利用关于基因组模型的数据集成的途径识别方法(paradigm)
GB201007944D0 (en) 2010-05-12 2010-06-30 Univ Aberystwyth Methods
WO2011150075A2 (en) 2010-05-25 2011-12-01 The Johns Hopkins University Compositions and methods for detecting a neoplasia
MX382244B (es) * 2010-07-23 2025-03-13 Harvard College Metodos para detectar firmas de enfermedad o condiciones en fluidos corporales
EP2596127A2 (en) * 2010-07-23 2013-05-29 Esoterix Genetic Laboratories, LLC Identification of differentially represented fetal or maternal genomic regions and uses thereof
WO2012031329A1 (en) 2010-09-10 2012-03-15 Murdoch Childrens Research Institute Assay for detection and monitoring of cancer
KR102040307B1 (ko) † 2010-11-30 2019-11-27 더 차이니즈 유니버시티 오브 홍콩 암과 연관된 유전적 또는 분자적 이상들의 검출
CA2884066C (en) * 2012-09-20 2021-08-10 The Chinese University Of Hong Kong Non-invasive determination of methylome of fetus or tumor from plasma

Also Published As

Publication number Publication date
PT2898100T (pt) 2018-02-26
SMT202100256T1 (it) 2021-05-07
BR112015006183B1 (pt) 2022-04-26
EP3354747B1 (en) 2021-02-17
EA201500327A1 (ru) 2015-07-30
ES2969567T3 (es) 2024-05-21
EP2898100B1 (en) 2017-11-22
JP7594817B2 (ja) 2024-12-05
AU2013317708C1 (en) 2017-11-23
FI3536807T3 (fi) 2024-02-01
MY187444A (en) 2021-09-22
HUE053822T2 (hu) 2021-07-28
KR102307424B1 (ko) 2021-09-29
AU2022201026B2 (en) 2025-04-03
HK1207124A1 (en) 2016-01-22
EP2898100B9 (en) 2023-08-02
PT3536807T (pt) 2024-02-01
JP6317354B2 (ja) 2018-04-25
EP3536807B1 (en) 2023-11-29
CA2884066A1 (en) 2014-03-27
CN104781422B (zh) 2023-12-26
MX360034B (es) 2018-10-19
CN104781422A (zh) 2015-07-15
IL299444A (en) 2023-02-01
TW202043483A (zh) 2020-12-01
JP2015536639A (ja) 2015-12-24
JP2018121644A (ja) 2018-08-09
TWI640634B (zh) 2018-11-11
PH12015500547B1 (en) 2024-05-17
EP4335929A2 (en) 2024-03-13
HRP20241142T1 (hr) 2024-11-22
KR20220065034A (ko) 2022-05-19
PH12022552061A1 (en) 2024-03-11
PT3354747T (pt) 2021-05-07
EP2898100B2 (en) 2023-05-10
DK2898100T4 (da) 2023-07-24
AU2022201026A1 (en) 2022-03-10
DK3536807T3 (da) 2024-02-05
EP3536807A1 (en) 2019-09-11
IL299444B1 (en) 2024-07-01
IL299444B2 (en) 2024-11-01
TW201418474A (zh) 2014-05-16
NZ717423A (en) 2017-08-25
AU2025205087A1 (en) 2025-07-24
HK1206797A1 (en) 2016-01-15
KR102148547B1 (ko) 2020-08-26
SG10201705198UA (en) 2017-07-28
SG11201501927VA (en) 2015-04-29
EP4056712B1 (en) 2024-07-31
CY1124139T1 (el) 2022-05-27
KR20230145530A (ko) 2023-10-17
EP3839065A1 (en) 2021-06-23
DK4056712T3 (da) 2024-08-26
IL237495B (en) 2019-09-26
HRP20240210T1 (hr) 2024-05-10
CN117757932A (zh) 2024-03-26
PL3536807T3 (pl) 2024-05-06
DK3354747T3 (da) 2021-04-19
EP2898100A1 (en) 2015-07-29
HUE068129T2 (hu) 2024-12-28
KR102587176B1 (ko) 2023-10-06
IL268512B2 (en) 2023-06-01
JP6985753B2 (ja) 2021-12-22
BR122021021823B1 (pt) 2023-04-25
ES2665273T3 (es) 2018-04-25
SI4056712T1 (sl) 2024-10-30
DK2898100T3 (en) 2018-02-26
HRP20210716T1 (hr) 2021-06-11
HK1257868A1 (en) 2019-11-01
EP2898100A4 (en) 2016-05-11
ES2665273T5 (es) 2023-10-02
AU2020200128B2 (en) 2021-11-18
MX2015003571A (es) 2015-06-22
EP4056712A1 (en) 2022-09-14
CA3122779A1 (en) 2014-03-27
AU2017251832A1 (en) 2017-11-16
ZA201501772B (en) 2016-10-26
IL237495A0 (en) 2015-04-30
JP2020108400A (ja) 2020-07-16
TW202334438A (zh) 2023-09-01
AU2013317708A1 (en) 2015-04-09
AU2017251832B2 (en) 2019-10-10
CA2884066C (en) 2021-08-10
LT4056712T (lt) 2024-09-10
PL3354747T3 (pl) 2021-07-26
NZ706269A (en) 2016-08-26
KR20200085928A (ko) 2020-07-15
TW201907013A (zh) 2019-02-16
AU2013317708B2 (en) 2017-08-03
PL2898100T5 (pl) 2023-11-06
IL268512A (en) 2019-09-26
IL313451A (en) 2024-08-01
AU2020200128A1 (en) 2020-01-30
FI4056712T3 (fi) 2024-08-29
JP2025026936A (ja) 2025-02-26
EP3354747A1 (en) 2018-08-01
LT3354747T (lt) 2021-04-12
BR112015006183A2 (pt) 2017-07-04
TWI784258B (zh) 2022-11-21
HUE066054T2 (hu) 2024-07-28
KR102390711B1 (ko) 2022-04-26
PT4056712T (pt) 2024-08-08
MY173356A (en) 2020-01-21
EP4335929A3 (en) 2024-05-29
PL2898100T3 (pl) 2018-06-29
JP2024009833A (ja) 2024-01-23
TW202305145A (zh) 2023-02-01
WO2014043763A1 (en) 2014-03-27
ES2994426T3 (en) 2025-01-23
ES2862726T3 (es) 2021-10-07
BR122021021825B1 (pt) 2022-05-24
KR20210120124A (ko) 2021-10-06
PH12015500547A1 (en) 2015-05-04
JP6683752B2 (ja) 2020-04-22
KR20150082228A (ko) 2015-07-15
TWI707953B (zh) 2020-10-21
TWI806621B (zh) 2023-06-21
JP2022031753A (ja) 2022-02-22

Similar Documents

Publication Publication Date Title
IL268512A (en) Non-invasive determination of fetal or tumor methylation from plasma
IL288181A (en) Cancer treatment methods
IL232530A0 (en) Combined cancer treatment
ZA201307036B (en) Treatment of solid tumours
IL228430A0 (en) Cancer treatment
EP2903644A4 (en) TREATMENT OF CANCER
GB201217892D0 (en) Treatment of cancer
SI2892925T1 (sl) Kombinacijsko zdravljenje raka
GB201217890D0 (en) Treatment of cancer
GB201222952D0 (en) Treatent of cancer
GB201208296D0 (en) Treatment of cancer
GB201222950D0 (en) Combination treatment of cancer
GB201222949D0 (en) Combination Treatment of Cancer
IL229109A0 (en) Cancer diagnosis
GB201121791D0 (en) Combination treatment of cancer
GB201121783D0 (en) Treatment of cancer
ZA201104679B (en) Suppression of cancers