PL4574996T3 - Wykrywanie i leczenie chorób wykazujących heterogeniczność komórek chorobowych oraz systemy i sposoby przekazywania wyników testów - Google Patents

Wykrywanie i leczenie chorób wykazujących heterogeniczność komórek chorobowych oraz systemy i sposoby przekazywania wyników testów

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Publication number
PL4574996T3
PL4574996T3 PL25155747.6T PL25155747T PL4574996T3 PL 4574996 T3 PL4574996 T3 PL 4574996T3 PL 25155747 T PL25155747 T PL 25155747T PL 4574996 T3 PL4574996 T3 PL 4574996T3
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systems
detection
treatment
methods
test results
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PL25155747.6T
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English (en)
Inventor
Helmy Eltoukhy
AmirAli TALASAZ
Bahram Ghaffarzadeh Kermani
Nnamdi IHUEGBU
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Guardant Health, Inc.
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First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=56284976&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=PL4574996(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Guardant Health, Inc. filed Critical Guardant Health, Inc.
Publication of PL4574996T3 publication Critical patent/PL4574996T3/pl

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813—Hybridisation assays
    • C12Q1/6827—Hybridisation assays for detection of mutation or polymorphism
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6869—Methods for sequencing
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B30/00—ICT specially adapted for sequence analysis involving nucleotides or amino acids
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/118—Prognosis of disease development
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/156—Polymorphic or mutational markers

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  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Physics & Mathematics (AREA)
  • Genetics & Genomics (AREA)
  • Analytical Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biophysics (AREA)
  • Immunology (AREA)
  • General Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • Pathology (AREA)
  • Hospice & Palliative Care (AREA)
  • Oncology (AREA)
  • Theoretical Computer Science (AREA)
  • Evolutionary Biology (AREA)
  • Medical Informatics (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Biomedical Technology (AREA)
  • Plant Pathology (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medical Treatment And Welfare Office Work (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
PL25155747.6T 2014-12-31 2015-12-28 Wykrywanie i leczenie chorób wykazujących heterogeniczność komórek chorobowych oraz systemy i sposoby przekazywania wyników testów PL4574996T3 (pl)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201462098426P 2014-12-31 2014-12-31
US201562155763P 2015-05-01 2015-05-01

Publications (1)

Publication Number Publication Date
PL4574996T3 true PL4574996T3 (pl) 2026-03-02

Family

ID=56284976

Family Applications (1)

Application Number Title Priority Date Filing Date
PL25155747.6T PL4574996T3 (pl) 2014-12-31 2015-12-28 Wykrywanie i leczenie chorób wykazujących heterogeniczność komórek chorobowych oraz systemy i sposoby przekazywania wyników testów

Country Status (9)

Country Link
US (5) US20170260590A1 (pl)
EP (5) EP4574996B1 (pl)
JP (4) JP6783768B2 (pl)
CN (2) CN113930507A (pl)
AU (3) AU2015374259B2 (pl)
ES (4) ES2828279T3 (pl)
GB (1) GB2552267B (pl)
PL (1) PL4574996T3 (pl)
WO (1) WO2016109452A1 (pl)

Families Citing this family (74)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2625288T3 (es) 2011-04-15 2017-07-19 The Johns Hopkins University Sistema de secuenciación segura
US9892230B2 (en) 2012-03-08 2018-02-13 The Chinese University Of Hong Kong Size-based analysis of fetal or tumor DNA fraction in plasma
AU2013338393C1 (en) 2012-10-29 2024-07-25 The Johns Hopkins University Papanicolaou test for ovarian and endometrial cancers
EP4293125A3 (en) 2012-12-10 2024-02-28 Resolution Bioscience, Inc. Methods for targeted genomic analysis
ES2741400T3 (es) 2014-07-18 2020-02-10 Univ Hong Kong Chinese Análisis de patrones de metilación de tejidos en mezcla de ADN
US20160053301A1 (en) 2014-08-22 2016-02-25 Clearfork Bioscience, Inc. Methods for quantitative genetic analysis of cell free dna
WO2016109452A1 (en) * 2014-12-31 2016-07-07 Guardant Health , Inc. Detection and treatment of disease exhibiting disease cell heterogeneity and systems and methods for communicating test results
US10364467B2 (en) 2015-01-13 2019-07-30 The Chinese University Of Hong Kong Using size and number aberrations in plasma DNA for detecting cancer
EP3256605B1 (en) 2015-02-10 2022-02-09 The Chinese University Of Hong Kong Detecting mutations for cancer screening and fetal analysis
IL305462A (en) 2015-07-23 2023-10-01 Univ Hong Kong Chinese DNA fragmentation pattern analysis suitable clean
US11286531B2 (en) 2015-08-11 2022-03-29 The Johns Hopkins University Assaying ovarian cyst fluid
JP6991134B2 (ja) 2015-10-09 2022-01-12 ガーダント ヘルス， インコーポレイテッド 無細胞ｄｎａを使用する集団ベースの処置レコメンダ
RU2018121254A (ru) 2015-11-11 2019-12-16 Резолюшн Байосайенс, Инк. Высокоэффективное построение библиотек днк
WO2017106768A1 (en) 2015-12-17 2017-06-22 Guardant Health, Inc. Methods to determine tumor gene copy number by analysis of cell-free dna
US11319594B2 (en) 2016-08-25 2022-05-03 Resolution Bioscience, Inc. Methods for the detection of genomic copy changes in DNA samples
US9850523B1 (en) 2016-09-30 2017-12-26 Guardant Health, Inc. Methods for multi-resolution analysis of cell-free nucleic acids
JP6560465B1 (ja) 2016-09-30 2019-08-21 ガーダント ヘルス， インコーポレイテッド 無細胞核酸の多重解像度分析のための方法
WO2018099418A1 (en) 2016-11-30 2018-06-07 The Chinese University Of Hong Kong Analysis of cell-free dna in urine and other samples
ES2928773T3 (es) 2017-01-17 2022-11-22 Heparegenix Gmbh Inhibidores de proteína cinasas para fomentar la regeneración hepática o reducir o prevenir la muerte de hepatocitos
EP4421489B1 (en) 2017-01-25 2026-03-11 The Chinese University of Hong Kong Diagnostic applications using nucleic acid fragments
KR102083501B1 (ko) * 2017-02-09 2020-03-02 사회복지법인 삼성생명공익재단 종양 치료를 위한 표적 유전자 판별 방법
US10535434B2 (en) 2017-04-28 2020-01-14 4D Path Inc. Apparatus, systems, and methods for rapid cancer detection
WO2018213498A1 (en) * 2017-05-16 2018-11-22 Guardant Health, Inc. Identification of somatic or germline origin for cell-free dna
US10636512B2 (en) 2017-07-14 2020-04-28 Cofactor Genomics, Inc. Immuno-oncology applications using next generation sequencing
IL316163A (en) 2017-07-26 2024-12-01 Univ Hong Kong Chinese Enhancement of cancer screening using cell-free viral nucleic acids
IL319255A (en) 2017-08-07 2025-04-01 Univ Johns Hopkins Methods and materials for cancer assessment and treatment
JP7072825B2 (ja) * 2017-09-13 2022-05-23 三菱電機ソフトウエア株式会社 コピー数計測装置、コピー数計測プログラムおよびコピー数計測方法
EP3685386A1 (en) * 2017-09-20 2020-07-29 Guardant Health, Inc. Methods and systems for differentiating somatic and germline variants
EP3704268B1 (en) * 2017-11-03 2025-01-22 Guardant Health, Inc. Normalizing tumor mutation burden
AU2018375302A1 (en) * 2017-11-28 2020-06-11 Grail, Llc Models for targeted sequencing
CA3083787A1 (en) * 2017-12-01 2019-06-06 Personal Genome Diagnositics Inc. Process for microsatellite instability detection
EP3622522A1 (en) 2017-12-01 2020-03-18 Illumina, Inc. Methods and systems for determining somatic mutation clonality
CN108491689B (zh) * 2018-02-01 2019-07-09 杭州纽安津生物科技有限公司 基于转录组的肿瘤新抗原鉴定方法
CA3090951C (en) * 2018-02-12 2023-10-17 F.Hoffmann-La Roche Ag Method of predicting response to therapy by assessing tumor genetic heterogeneity
JP7506380B2 (ja) * 2018-02-27 2024-06-26 コーネル・ユニバーシティー 残存病変の検出システム及び方法
CN112601826B (zh) 2018-02-27 2025-03-11 康奈尔大学 通过全基因组整合进行循环肿瘤dna的超灵敏检测
CN119753091A (zh) 2018-04-02 2025-04-04 格里尔公司 用于扩增与癌症相关联的cfDNA分子的化验板
WO2019195769A1 (en) * 2018-04-06 2019-10-10 The Brigham And Women's Hospital, Inc. Methods of diagnosing and treating aggressive cutaneous t-cell lymphomas
CN112218957B (zh) * 2018-04-16 2025-08-08 格里尔公司 用于确定在无细胞核酸中的肿瘤分数的系统及方法
US20240254547A1 (en) * 2018-04-27 2024-08-01 Kao Corporation Highly accurate sequencing method
JP7274504B2 (ja) * 2018-05-08 2023-05-16 エフ． ホフマン－ラ ロシュ アーゲー 多様度指数を確立することで腫瘍バリアント多様度を評価することによるがん予後診断の方法
JP7466519B2 (ja) 2018-07-23 2024-04-12 ガーダント ヘルス， インコーポレイテッド 腫瘍遺伝子変異量を腫瘍割合およびカバレッジによって調整するための方法およびシステム
IL281741B2 (en) 2018-09-27 2026-04-01 Grail Inc Methylation markers and a targeted methylation detection panel
GB2577548B (en) 2018-09-28 2022-10-26 Siemens Healthcare Gmbh Method for determining a subject's genetic copy number value
CN118932031A (zh) * 2018-11-13 2024-11-12 麦利亚德基因公司 用于体细胞突变的方法和系统及其用途
CA3118742A1 (en) * 2018-11-21 2020-05-28 Karius, Inc. Detection and prediction of infectious disease
CN109712671B (zh) * 2018-12-20 2020-06-26 北京优迅医学检验实验室有限公司 基于ctDNA的基因检测装置、存储介质及计算机系统
EP3912007A4 (en) * 2019-01-10 2022-11-02 Travera LLC IDENTIFICATION OF CANCER THERAPIES
EP4567131A3 (en) 2019-01-31 2025-09-03 Guardant Health, Inc. Compositions and methods for isolating cell-free dna
US20220310208A1 (en) * 2019-06-13 2022-09-29 Roche Sequencing Solutions, Inc. Systems and methods with improved user interface for interpreting and visualizing longitudinal
CN110428905B (zh) * 2019-07-02 2022-03-29 江南大学附属医院 一种肿瘤生长趋势预测方法
EP4682889A3 (en) * 2019-07-22 2026-04-15 F. Hoffmann-La Roche AG Systems and methods for cell of origin determination from variant calling data
CA3150630A1 (en) * 2019-09-09 2021-03-18 Katherine E. Varley Targeted sequencing to detect and quantify low levels of methylated dna
EP3809414A1 (en) * 2019-10-15 2021-04-21 Koninklijke Philips N.V. Method and apparatus for assessing patient's response to therapy
CN110895963A (zh) * 2019-10-31 2020-03-20 深圳兰丁医学检验实验室 一种基于人工智能的细胞dna定量检测系统
JP2023513606A (ja) 2020-02-14 2023-03-31 ザ・ジョンズ・ホプキンス・ユニバーシティー 核酸を評価するための方法および材料
US11475981B2 (en) 2020-02-18 2022-10-18 Tempus Labs, Inc. Methods and systems for dynamic variant thresholding in a liquid biopsy assay
US11211147B2 (en) 2020-02-18 2021-12-28 Tempus Labs, Inc. Estimation of circulating tumor fraction using off-target reads of targeted-panel sequencing
US11211144B2 (en) 2020-02-18 2021-12-28 Tempus Labs, Inc. Methods and systems for refining copy number variation in a liquid biopsy assay
CA3180386A1 (en) * 2020-05-29 2021-12-02 Yi-Wen Chen Genetic diagnostic tool for facioscapulohumeral muscular dystrophy (fshd)
JP2023540904A (ja) 2020-08-25 2023-09-27 シアー， インコーポレイテッド タンパク質および核酸をアッセイするための組成物および方法
KR20230104966A (ko) * 2020-12-07 2023-07-11 에프. 호프만-라 로슈 아게 인공 지능을 이용한 종양 치료 라인과 관련된 예측 결과를 생성하기 위한 기법
CN117063239A (zh) * 2021-03-05 2023-11-14 夸登特健康公司 用于分析分子响应的方法和相关方面
US12423593B2 (en) * 2021-06-11 2025-09-23 Massachusetts Institute Of Technology Systems and methods for synthetic interventions
US12548645B2 (en) * 2021-07-30 2026-02-10 Guardant Health, Inc. Computer architecture for identifying lines of therapy
CN114267445B (zh) * 2021-12-23 2024-09-06 众阳健康科技集团有限公司 一种诊断一致性检验方法、系统、设备及介质
US20250115550A1 (en) 2022-02-18 2025-04-10 Dic Corporation Method for producing sulfurized olefin
EP4496905A4 (en) * 2022-03-23 2026-03-18 Found Medicine Inc METHODS AND SYSTEMS FOR DETERMINING TUMOR HETEROGENEITY
US20240294982A1 (en) * 2023-03-01 2024-09-05 Personal Genomics Taiwan, Inc. Method, kit and cartridge for detecting nucleic acid molecule
CN116403644B (zh) * 2023-03-03 2023-12-05 深圳吉因加信息科技有限公司 一种用于癌症风险预测的方法及装置
US20240339215A1 (en) * 2023-04-06 2024-10-10 Board Of Regents, The University Of Texas System System and method for drug selection
US20240363198A1 (en) * 2023-04-27 2024-10-31 Cardiai Technologies System for identifying genetic variants and method thereof
CN117219162B (zh) * 2023-09-12 2024-07-02 四川大学 针对肿瘤组织str图谱进行身源鉴定的证据强度评估方法
USD1118634S1 (en) * 2023-10-11 2026-03-17 Open Text Inc. Display screen or portion thereof with graphical user interface for visualizing connections between base entities of a story corresponding to a security issue

Family Cites Families (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7385605B2 (en) * 2003-12-04 2008-06-10 International Business Machines Corporation Computer display system for dynamically modifying stacked area line graphs to change the order or presence of a set of stacked areas in the graph respectively representative of the proportions contributed to a total by each of a set of time dependent variables
US20060199189A1 (en) * 2005-03-07 2006-09-07 Bradford Sherry A Low-dose, sequenced, individualized chemotherapy dosing method
US10095829B2 (en) * 2009-07-08 2018-10-09 Worldwide Innovative Network Computer implemented methods of treating lung cancer
JP2013540995A (ja) * 2010-08-18 2013-11-07 カリス ライフ サイエンシズ ルクセンブルク ホールディングス エス．アー．エール．エル． 疾患に対する循環バイオマーカー
ES2625288T3 (es) 2011-04-15 2017-07-19 The Johns Hopkins University Sistema de secuenciación segura
WO2013007702A1 (en) 2011-07-08 2013-01-17 Epigenomics Ag Methods and nucleic acids for determining the prognosis of a cancer subject
JP6161607B2 (ja) * 2011-07-26 2017-07-12 ベリナタ ヘルス インコーポレイテッド サンプルにおける異なる異数性の有無を決定する方法
HK1199313A1 (en) * 2011-09-16 2015-06-26 考利达基因组股份有限公司 Determining variants in a genome of a heterogeneous sample
SG190466A1 (en) * 2011-11-18 2013-06-28 Agency Science Tech & Res Methods for diagnosis and/or prognosis of ovarian cancer
EP3744857A1 (en) 2012-03-20 2020-12-02 University Of Washington Through Its Center For Commercialization Methods of lowering the error rate of massively parallel dna sequencing using duplex consensus sequencing
US11261494B2 (en) * 2012-06-21 2022-03-01 The Chinese University Of Hong Kong Method of measuring a fractional concentration of tumor DNA
GB2533006B (en) * 2012-09-04 2017-06-07 Guardant Health Inc Systems and methods to detect copy number variation
BR122021021823B1 (pt) * 2012-09-20 2023-04-25 The Chinese University Of Hong Kong Método para determinar um primeiro perfil de metilação de uma amostra biológica de um organismo, e, meio de armazenamento de memória
US20140287937A1 (en) 2013-02-21 2014-09-25 Toma Biosciences, Inc. Methods for assessing cancer
GB2528205B (en) 2013-03-15 2020-06-03 Guardant Health Inc Systems and methods to detect rare mutations and copy number variation
CN113337604A (zh) * 2013-03-15 2021-09-03 莱兰斯坦福初级大学评议会 循环核酸肿瘤标志物的鉴别和用途
US10435740B2 (en) 2013-04-01 2019-10-08 University Of Florida Research Foundation, Incorporated Determination of methylation state and chromatin structure of target genetic loci
EP3003377A1 (en) * 2013-05-31 2016-04-13 Novartis AG Combination therapy containing a pi3k-alpha inhibitor and fgfr kinase inhibitor for treating cancer
WO2016109452A1 (en) * 2014-12-31 2016-07-07 Guardant Health , Inc. Detection and treatment of disease exhibiting disease cell heterogeneity and systems and methods for communicating test results
JP6991134B2 (ja) * 2015-10-09 2022-01-12 ガーダント ヘルス， インコーポレイテッド 無細胞ｄｎａを使用する集団ベースの処置レコメンダ
WO2017106768A1 (en) 2015-12-17 2017-06-22 Guardant Health, Inc. Methods to determine tumor gene copy number by analysis of cell-free dna
US11384382B2 (en) * 2016-04-14 2022-07-12 Guardant Health, Inc. Methods of attaching adapters to sample nucleic acids
USD810111S1 (en) * 2016-09-08 2018-02-13 Sap Se Electronic display screen with a graphical user interface
EP3785269A4 (en) 2018-03-29 2021-12-29 Freenome Holdings, Inc. Methods and systems for analyzing microbiota
USD1013704S1 (en) * 2021-07-09 2024-02-06 The Regents Of The University Of Colorado, A Body Corporate Display screen or portion thereof with graphical user interface
US20240052419A1 (en) * 2022-08-10 2024-02-15 Guardant Health, Inc. Methods and systems for detecting genetic variants
US20240071628A1 (en) * 2022-08-24 2024-02-29 Guardant Health, Inc. Database for therapeutic interventions

Also Published As

Publication number Publication date
EP3766986A1 (en) 2021-01-20
CN107406876A (zh) 2017-11-28
EP3240911A1 (en) 2017-11-08
EP4123032B1 (en) 2025-02-05
JP2020127408A (ja) 2020-08-27
JP7458360B2 (ja) 2024-03-29
EP4574996B1 (en) 2025-11-05
GB2552267A (en) 2018-01-17
CN113930507A (zh) 2022-01-14
JP2024029174A (ja) 2024-03-05
US20210395837A1 (en) 2021-12-23
AU2015374259B2 (en) 2020-08-13
US20170260590A1 (en) 2017-09-14
EP4574996C0 (en) 2025-11-05
CA2972433A1 (en) 2016-07-07
CN107406876B (zh) 2021-09-07
EP4574996A2 (en) 2025-06-25
AU2023206196A1 (en) 2023-08-10
EP4123032A1 (en) 2023-01-25
EP4574996A3 (en) 2025-07-16
ES2828279T3 (es) 2021-05-25
GB201712299D0 (en) 2017-09-13
ES2923602T3 (es) 2022-09-28
ES3059886T3 (en) 2026-03-24
JP2018507682A (ja) 2018-03-22
US20220213562A1 (en) 2022-07-07
EP4715065A2 (en) 2026-03-25
GB2552267B (en) 2020-06-10
JP2022024040A (ja) 2022-02-08
EP4715065A3 (en) 2026-04-29
JP6783768B2 (ja) 2020-11-11
EP3240911A4 (en) 2018-11-21
AU2020264326B2 (en) 2023-05-18
WO2016109452A1 (en) 2016-07-07
EP3766986B1 (en) 2022-06-01
US20240141432A9 (en) 2024-05-02
AU2020264326A1 (en) 2020-11-26
USD1077824S1 (en) 2025-06-03
AU2015374259A1 (en) 2017-08-10
EP4123032C0 (en) 2025-02-05
US20210040565A1 (en) 2021-02-11
EP3240911B1 (en) 2020-08-26
JP7145907B2 (ja) 2022-10-03
ES3017068T3 (en) 2025-05-12

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