SG11201706529TA - Detecting mutations for cancer screening and fetal analysis - Google Patents

Detecting mutations for cancer screening and fetal analysis

Info

Publication number
SG11201706529TA
SG11201706529TA SG11201706529TA SG11201706529TA SG11201706529TA SG 11201706529T A SG11201706529T A SG 11201706529TA SG 11201706529T A SG11201706529T A SG 11201706529TA SG 11201706529T A SG11201706529T A SG 11201706529TA SG 11201706529T A SG11201706529T A SG 11201706529TA
Authority
SG
Singapore
Prior art keywords
cancer screening
detecting mutations
fetal analysis
fetal
analysis
Prior art date
Application number
SG11201706529TA
Inventor
Yuk-Ming Dennis Lo
Rossa Wai Kwun Chiu
Kwan Chee Chan
Peiyong Jiang
Original Assignee
Univ Hong Kong Chinese
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US201562114471P external-priority
Application filed by Univ Hong Kong Chinese filed Critical Univ Hong Kong Chinese
Publication of SG11201706529TA publication Critical patent/SG11201706529TA/en

Links

Classifications

    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B20/00—ICT specially adapted for functional genomics or proteomics, e.g. genotype-phenotype associations
    • G16B20/50—Mutagenesis
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6806—Preparing nucleic acids for analysis, e.g. for polymerase chain reaction [PCR] assay
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B20/00—ICT specially adapted for functional genomics or proteomics, e.g. genotype-phenotype associations
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B20/00—ICT specially adapted for functional genomics or proteomics, e.g. genotype-phenotype associations
    • G16B20/20—Allele or variant detection, e.g. single nucleotide polymorphism [SNP] detection
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B30/00—ICT specially adapted for sequence analysis involving nucleotides or amino acids
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B30/00—ICT specially adapted for sequence analysis involving nucleotides or amino acids
    • G16B30/10—Sequence alignment; Homology search
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/154—Methylation markers
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/156—Polymorphic or mutational markers
SG11201706529TA 2015-02-10 2016-02-14 Detecting mutations for cancer screening and fetal analysis SG11201706529TA (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201562114471P 2015-02-10 2015-02-10
US201562271196P 2015-12-22 2015-12-22
PCT/CN2016/073753 WO2016127944A1 (en) 2015-02-10 2016-02-14 Detecting mutations for cancer screening and fetal analysis

Publications (1)

Publication Number Publication Date
SG11201706529TA true SG11201706529TA (en) 2017-09-28

Family

ID=56615337

Family Applications (1)

Application Number Title Priority Date Filing Date
SG11201706529TA SG11201706529TA (en) 2015-02-10 2016-02-14 Detecting mutations for cancer screening and fetal analysis

Country Status (15)

Country Link
US (3) US10240209B2 (en)
EP (2) EP4012715A1 (en)
JP (3) JP6829211B2 (en)
KR (1) KR20170125044A (en)
CN (2) CN113957124A (en)
AU (2) AU2016218631B2 (en)
CA (1) CA2976303A1 (en)
DK (1) DK3256605T3 (en)
ES (1) ES2908347T3 (en)
HK (2) HK1244515A1 (en)
HU (1) HUE058263T2 (en)
PT (1) PT3256605T (en)
SG (1) SG11201706529TA (en)
TW (2) TW202146657A (en)
WO (1) WO2016127944A1 (en)

Families Citing this family (54)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101153336B (en) 2006-09-27 2011-09-07 香港中文大学 Diagnostic method for detecting DNA methylation degree
WO2012129363A2 (en) 2011-03-24 2012-09-27 President And Fellows Of Harvard College Single cell nucleic acid detection and analysis
US9892230B2 (en) 2012-03-08 2018-02-13 The Chinese University Of Hong Kong Size-based analysis of fetal or tumor DNA fraction in plasma
EP3591073B1 (en) 2012-09-04 2021-12-01 Guardant Health, Inc. Methods to detect rare mutations and copy number variation
US20160040229A1 (en) 2013-08-16 2016-02-11 Guardant Health, Inc. Systems and methods to detect rare mutations and copy number variation
US10876152B2 (en) 2012-09-04 2020-12-29 Guardant Health, Inc. Systems and methods to detect rare mutations and copy number variation
ES2822125T3 (en) 2013-12-28 2021-04-29 Guardant Health Inc Methods and systems to detect genetic variants
TWI727156B (en) 2014-07-18 2021-05-11 香港中文大學 Methylation pattern analysis of tissues in a dna mixture
CA2956208A1 (en) 2014-07-25 2016-01-28 University Of Washington Methods of determining tissues and/or cell types giving rise to cell-free dna, and methods of identifying a disease or disorder using same
US10364467B2 (en) 2015-01-13 2019-07-30 The Chinese University Of Hong Kong Using size and number aberrations in plasma DNA for detecting cancer
DK3256605T3 (en) 2015-02-10 2022-03-14 Univ Hong Kong Chinese Detection of mutations for cancer screening and fetal analysis
SG10202106935UA (en) 2015-07-23 2021-08-30 Univ Hong Kong Chinese Analysis of fragmentation patterns of cell-free dna
EP3374525B1 (en) 2015-11-11 2021-01-20 Resolution Bioscience, Inc. High efficiency construction of dna libraries
CN108603228A (en) 2015-12-17 2018-09-28 夸登特健康公司 The method for determining oncogene copy number by analyzing Cell-free DNA
US11514289B1 (en) 2016-03-09 2022-11-29 Freenome Holdings, Inc. Generating machine learning models using genetic data
EP3427183A1 (en) * 2016-03-10 2019-01-16 Genomic Vision Method of curvilinear signal detection and analysis and associated platform
CN109804086A (en) 2016-08-10 2019-05-24 格里尔公司 Prepare method of double label dna libraries for sulphite conversion sequencing
WO2018039463A1 (en) 2016-08-25 2018-03-01 Resolution Bioscience, Inc. Methods for the detection of genomic copy changes in dna samples
US9850523B1 (en) 2016-09-30 2017-12-26 Guardant Health, Inc. Methods for multi-resolution analysis of cell-free nucleic acids
JP6560465B1 (en) 2016-09-30 2019-08-21 ガーダント ヘルス， インコーポレイテッド Method for multi-resolution analysis of cell-free nucleic acids
AU2017347790A1 (en) * 2016-10-24 2019-05-23 Grail, Inc. Methods and systems for tumor detection
WO2018099418A1 (en) 2016-11-30 2018-06-07 The Chinese University Of Hong Kong Analysis of cell-free dna in urine and other samples
US20200087731A1 (en) * 2016-12-21 2020-03-19 The Regents Of The University Of California Deconvolution and Detection of Rare DNA in Plasma
SG11201906397UA (en) 2017-01-25 2019-08-27 Univ Hong Kong Chinese Diagnostic applications using nucleic acid fragments
EP3366780B1 (en) * 2017-02-23 2020-05-06 Siemens Healthcare GmbH Single-molecule sequence and high sensitivity methylation analysis for tissue-specific analysis
IT201700045353A1 (en) * 2017-04-26 2018-10-26 Bioscience Services S R L METHOD FOR RESEARCH AND THE DETERMINATION OF A PRODROMIC GENETIC CONDITION FOR THE ABSORBENCE OF SOLID TUMORS
EP3625341A4 (en) * 2017-05-16 2021-05-19 Guardant Health, Inc. Identification of somatic or germline origin for cell-free dna
US10081829B1 (en) 2017-06-13 2018-09-25 Genetics Research, Llc Detection of targeted sequence regions
US10636512B2 (en) 2017-07-14 2020-04-28 Cofactor Genomics, Inc. Immuno-oncology applications using next generation sequencing
EP3431610A1 (en) * 2017-07-19 2019-01-23 Noscendo GmbH Methods and devices for nucleic acid-based real-time determination of disease states
CN111051536A (en) 2017-07-26 2020-04-21 香港中文大学 Improved cancer screening using cell-free viral nucleic acids
EP3676846A1 (en) * 2017-10-06 2020-07-08 Grail, Inc. Site-specific noise model for targeted sequencing
EP3704268A4 (en) 2017-11-03 2021-08-11 Guardant Health, Inc. Normalizing tumor mutation burden
KR20200129092A (en) * 2018-01-12 2020-11-17 그레일, 인코포레이티드. Methods for analyzing viral nucleic acids
US20210158895A1 (en) * 2018-04-13 2021-05-27 Dana-Farber Cancer Institute, Inc. Ultra-sensitive detection of cancer by algorithmic analysis
CN112218957A (en) * 2018-04-16 2021-01-12 格里尔公司 Systems and methods for determining tumor fraction in cell-free nucleic acids
WO2019209954A1 (en) * 2018-04-24 2019-10-31 Grail, Inc. Systems and methods for using pathogen nucleic acid load to determine whether a subject has a cancer condition
CN108900319B (en) * 2018-05-30 2021-05-25 北京百度网讯科技有限公司 Fault detection method and device
CA3107983A1 (en) * 2018-07-23 2020-01-30 Guardant Health, Inc. Methods and systems for adjusting tumor mutational burden by tumor fraction and coverage
WO2020023671A1 (en) * 2018-07-24 2020-01-30 Protocol Intelligence, Inc. Methods and systems for treating cancer and predicting and optimizing treatment outcomes in individual cancer patients
CN109022619A (en) * 2018-08-27 2018-12-18 郑州安图生物工程股份有限公司 It is a kind of for detecting the kit of ebb virus
WO2020069350A1 (en) 2018-09-27 2020-04-02 Grail, Inc. Methylation markers and targeted methylation probe panel
AU2019410635A1 (en) * 2018-12-19 2021-06-17 Grail, Inc. Cell-free DNA end characteristics
CN113661249A (en) 2019-01-31 2021-11-16 夸登特健康公司 Compositions and methods for isolating cell-free DNA
CN109841265B (en) * 2019-02-22 2021-09-21 清华大学 Method and system for determining tissue source of plasma free nucleic acid molecules by using fragmentation mode and application
US20210065842A1 (en) * 2019-07-23 2021-03-04 Grail, Inc. Systems and methods for determining tumor fraction
WO2021137770A1 (en) * 2019-12-30 2021-07-08 Geneton S.R.O. Method for fetal fraction estimation based on detection and interpretation of single nucleotide variants
US11475981B2 (en) 2020-02-18 2022-10-18 Tempus Labs, Inc. Methods and systems for dynamic variant thresholding in a liquid biopsy assay
US11211147B2 (en) 2020-02-18 2021-12-28 Tempus Labs, Inc. Estimation of circulating tumor fraction using off-target reads of targeted-panel sequencing
US11211144B2 (en) 2020-02-18 2021-12-28 Tempus Labs, Inc. Methods and systems for refining copy number variation in a liquid biopsy assay
US20220177971A1 (en) * 2020-12-08 2022-06-09 The Chinese University Of Hong Kong Methods using characteristics of urinary and other dna
CN114582429A (en) * 2022-03-03 2022-06-03 四川大学 Method and device for predicting drug resistance of mycobacterium tuberculosis based on hierarchical attention neural network
CN115394358B (en) * 2022-08-31 2023-05-12 西安理工大学 Single-cell sequencing gene expression data interpolation method and system based on deep learning
CN115424666A (en) * 2022-09-13 2022-12-02 江苏先声医学诊断有限公司 Method and system for screening pan-cancer early-screening molecular marker based on whole genome bisulfite sequencing data

Family Cites Families (50)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AT399793T (en) 1999-04-02 2008-07-15 Corixa Corp COMPOUNDS AND METHODS FOR THERAPY AND DIAGNOSIS OF LUNG CANCER
US20030219765A1 (en) 2000-03-23 2003-11-27 Jose Costa Methods for evaluating cancer risk
US20030211522A1 (en) 2002-01-18 2003-11-13 Landes Gregory M. Methods for fetal DNA detection and allele quantitation
US7704687B2 (en) 2002-11-15 2010-04-27 The Johns Hopkins University Digital karyotyping
EP1599608A4 (en) 2003-03-05 2007-07-18 Genetic Technologies Ltd Identification of fetal dna and fetal cell markers in maternal plasma or serum
PL201608B1 (en) 2003-06-13 2009-04-30 Cezary Cybulski Method and set designed for detection of high genetic predisposition for prostate gland cancer as well as use of germinal change within the NBS1 gene
EP1524321B2 (en) 2003-10-16 2014-07-23 Sequenom, Inc. Non-invasive detection of fetal genetic traits
CA2562310A1 (en) 2004-04-30 2005-11-17 Yale University Methods and compositions for cancer diagnosis
US20070122823A1 (en) 2005-09-01 2007-05-31 Bianchi Diana W Amniotic fluid cell-free fetal DNA fragment size pattern for prenatal diagnosis
SI3002338T1 (en) 2006-02-02 2019-11-29 Univ Leland Stanford Junior Non-invasive fetal genetic screening by digital analysis
US7799531B2 (en) 2006-02-28 2010-09-21 University Of Louisville Research Foundation Detecting fetal chromosomal abnormalities using tandem single nucleotide polymorphisms
WO2008024009A1 (en) 2006-08-15 2008-02-28 Institut Molekulyarnoi Genetiki Rossiiskoi Akademii Nauk (Img Ran) Transcriptional level of a timp3 gene in the form of a diagnosis marker of a non-small cell carcinoma of lung
CA2688312A1 (en) 2007-05-25 2008-12-04 Decode Genetics Ehf. Genetic variants on chr 5p12 and 10q26 as markers for use in breast cancer risk assessment, diagnosis, prognosis and treatment
KR102339760B1 (en) 2007-07-23 2021-12-14 더 차이니즈 유니버시티 오브 홍콩 Diagnosing fetal chromosomal aneuploidy using massively parallel genomic sequencing
US20090053719A1 (en) 2007-08-03 2009-02-26 The Chinese University Of Hong Kong Analysis of nucleic acids by digital pcr
US20100041048A1 (en) 2008-07-31 2010-02-18 The Johns Hopkins University Circulating Mutant DNA to Assess Tumor Dynamics
ES2620294T3 (en) 2008-09-20 2017-06-28 The Board Of Trustees Of The Leland Stanford Junior University Non-invasive diagnosis of fetal aneuploidy by sequencing
US20100136560A1 (en) 2008-12-02 2010-06-03 The Johns Hopkins University Integrated Analyses of Breast and Colorectal Cancers
CA2757131A1 (en) 2009-03-31 2010-10-07 Marcus Otte Method for diagnosis of cancer and monitoring of cancer treatments
WO2011038507A1 (en) 2009-10-02 2011-04-07 Centre For Addiction And Mental Health Method for analysis of dna methylation profiles of cell-free circulating dna in bodily fluids
WO2011053790A2 (en) 2009-10-30 2011-05-05 Fluidigm Corporation Assay of closely linked targets in fetal diagnosis and coincidence detection assay for genetic analysis
US8467976B2 (en) * 2009-11-05 2013-06-18 The Chinese University Of Hong Kong Fetal genomic analysis from a maternal biological sample
JP5770737B2 (en) 2009-11-06 2015-08-26 ザ チャイニーズ ユニバーシティ オブ ホンコン Genome analysis based on size
GB0922006D0 (en) 2009-12-17 2010-02-03 Genome Res Ltd Diagnostic
EP2513341B1 (en) 2010-01-19 2017-04-12 Verinata Health, Inc Identification of polymorphic sequences in mixtures of genomic dna by whole genome sequencing
CA2785718C (en) 2010-01-19 2017-04-04 Verinata Health, Inc. Methods for determining fraction of fetal nucleic acid in maternal samples
US20130210645A1 (en) 2010-02-18 2013-08-15 The Johns Hopkins University Personalized tumor biomarkers
EP2426217A1 (en) 2010-09-03 2012-03-07 Centre National de la Recherche Scientifique (CNRS) Analytical methods for cell free nucleic acids and applications
EA038374B1 (en) 2010-11-30 2021-08-17 Те Чайниз Юниверсити Ов Гонконг Method of analyzing a biological sample of an organism for chromosomal deletions or amplifications associated with cancer
KR101974492B1 (en) 2011-07-26 2019-05-02 베리나타 헬스, 인코포레이티드 Method for determining the presence or absence of different aneuploidies in a sample
EP2764459B1 (en) * 2011-10-06 2021-06-30 Sequenom, Inc. Methods and processes for non-invasive assessment of genetic variations
WO2013086352A1 (en) 2011-12-07 2013-06-13 Chronix Biomedical Prostate cancer associated circulating nucleic acid biomarkers
US9892230B2 (en) 2012-03-08 2018-02-13 The Chinese University Of Hong Kong Size-based analysis of fetal or tumor DNA fraction in plasma
EP2825675B1 (en) 2012-03-13 2017-12-27 Patel, Abhijit Ajit Measurement of nucleic acid variants using highly-multiplexed error-suppressed deep sequencing
US20150105261A1 (en) 2012-05-31 2015-04-16 Sumitomo Electric Industries, Ltd. Oxide superconducting thin film and method of manufacturing the same
US11261494B2 (en) 2012-06-21 2022-03-01 The Chinese University Of Hong Kong Method of measuring a fractional concentration of tumor DNA
EP3591073B1 (en) * 2012-09-04 2021-12-01 Guardant Health, Inc. Methods to detect rare mutations and copy number variation
US9732390B2 (en) 2012-09-20 2017-08-15 The Chinese University Of Hong Kong Non-invasive determination of methylome of fetus or tumor from plasma
PT2898100T (en) 2012-09-20 2018-02-26 Univ Hong Kong Chinese Non-invasive determination of methylome of fetus or tumor from plasma
US20160186267A1 (en) * 2013-02-21 2016-06-30 Toma Biosciences, Inc. Methods, compositions, and kits for nucleic acid analysis
WO2014145078A1 (en) 2013-03-15 2014-09-18 Verinata Health, Inc. Generating cell-free dna libraries directly from blood
US10174375B2 (en) * 2013-09-20 2019-01-08 The Chinese University Of Hong Kong Sequencing analysis of circulating DNA to detect and monitor autoimmune diseases
US10262755B2 (en) * 2014-04-21 2019-04-16 Natera, Inc. Detecting cancer mutations and aneuploidy in chromosomal segments
US20160002717A1 (en) 2014-07-02 2016-01-07 Boreal Genomics, Inc. Determining mutation burden in circulating cell-free nucleic acid and associated risk of disease
CA2956208A1 (en) 2014-07-25 2016-01-28 University Of Washington Methods of determining tissues and/or cell types giving rise to cell-free dna, and methods of identifying a disease or disorder using same
US10683552B2 (en) 2014-11-25 2020-06-16 Presidents And Fellows Of Harvard College Clonal haematopoiesis
US20170356053A1 (en) 2014-12-05 2017-12-14 Foundation Medicine, Inc. Multigene analysis of tumor samples
CN113930507A (en) 2014-12-31 2022-01-14 夸登特健康公司 Detection and treatment of disease and system and method for communicating test results
DK3256605T3 (en) 2015-02-10 2022-03-14 Univ Hong Kong Chinese Detection of mutations for cancer screening and fetal analysis
CN107750279A (en) 2015-03-16 2018-03-02 个人基因组诊断公司 Foranalysis of nucleic acids system and method

Also Published As

Publication number Publication date
JP6829211B2 (en) 2021-02-10
EP4012715A1 (en) 2022-06-15
JP2018512048A (en) 2018-05-10
ES2908347T3 (en) 2022-04-28
US20190153541A1 (en) 2019-05-23
JP2022185149A (en) 2022-12-13
JP2021061861A (en) 2021-04-22
US20220127683A1 (en) 2022-04-28
TW202146657A (en) 2021-12-16
WO2016127944A1 (en) 2016-08-18
EP3256605B1 (en) 2022-02-09
TWI740817B (en) 2021-10-01
CN107771221A (en) 2018-03-06
AU2022203114A1 (en) 2022-05-26
TW201700732A (en) 2017-01-01
US20170073774A1 (en) 2017-03-16
CN107771221B (en) 2021-11-02
PT3256605T (en) 2022-03-17
KR20170125044A (en) 2017-11-13
JP7168247B2 (en) 2022-11-09
CA2976303A1 (en) 2016-08-18
CN113957124A (en) 2022-01-21
AU2016218631B2 (en) 2022-03-10
US10240209B2 (en) 2019-03-26
HUE058263T2 (en) 2022-07-28
HK1251018A1 (en) 2019-01-18
AU2016218631A1 (en) 2017-08-17
EP3256605A1 (en) 2017-12-20
DK3256605T3 (en) 2022-03-14
HK1244515A1 (en) 2018-08-10
EP3256605A4 (en) 2018-10-17
US11168370B2 (en) 2021-11-09

Similar Documents

Publication Publication Date Title
HK1251018A1 (en) Detecting mutations for cancer screening and fetal analysis
HK1249179A1 (en) Devices and methods for sample analysis
ZA201706572B (en) Devices and methods for sample analysis
HK1245345A1 (en) Multigene analysis of tumor samples
HK1258539A1 (en) Micro-moment analysis
SG10201408391RA (en) Means and methods for multimodality analysis and processing ofdrilling mud
SG11201706341RA (en) Systems and methods for biological analysis
SG10202103903UA (en) Systems and methods for assessing biological samples
HRP20190787T1 (en) METHODS FOR DETECTING CpG METHYLATION AND FOR DIAGNOSING CANCER
IL255346A0 (en) Liposomal preparations for non-invasive-prenatal or cancer screening
GB202117492D0 (en) iKnife - cell line identification and analysis
GB201419814D0 (en) Data traffic processing and analysis
GB201503364D0 (en) A device for receiving and analysing a sample
PL3336511T3 (en) Direct analysis sampler
HK1209480A1 (en) Gas-phase substance analysis device and gas-phase introduction device
SG10201601097XA (en) Amplitude-versus-angle analysis for quantitative interpretation
HK1247370A1 (en) Tissue sample analysis technique
GB2559921B (en) Measuring reagent and analysis device for analyzing biopolymer
HK1231405A1 (en) Methods and compositions for screening and detecting cancer
GB2527672B (en) Measuring device analysis
HK1250778A1 (en) Analyte detection and methods therefor
GB201611057D0 (en) Spectroscopic analysis
GB2558160B (en) Shaker imaging and analysis
HK1256263A1 (en) Methods and means for dysplasia analysis
GB2542329B (en) Analysis Apparatus