MX360034B - Determinacion no invasiva del metiloma fetal o de tumor de plasma. - Google Patents

Determinacion no invasiva del metiloma fetal o de tumor de plasma.

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Publication number
MX360034B
MX360034B MX2015003571A MX2015003571A MX360034B MX 360034 B MX360034 B MX 360034B MX 2015003571 A MX2015003571 A MX 2015003571A MX 2015003571 A MX2015003571 A MX 2015003571A MX 360034 B MX360034 B MX 360034B
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MX
Mexico
Prior art keywords
methylation
fetus
tumor
dna
profile
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MX2015003571A
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English (en)
Other versions
MX2015003571A (es
Inventor
Yuk-Ming Dennis Lo
Wai Kwun Rossa Chiu
Peiyong Jiang
Kwan Chee Chan
Miu Fan Lun
Wai Man Chan
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Univ Hong Kong Chinese
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Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=50340462&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=MX360034(B) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority claimed from US13/842,209 external-priority patent/US9732390B2/en
Application filed by Univ Hong Kong Chinese filed Critical Univ Hong Kong Chinese
Publication of MX2015003571A publication Critical patent/MX2015003571A/es
Publication of MX360034B publication Critical patent/MX360034B/es

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    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
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    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
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    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6869—Methods for sequencing
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    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
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    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
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    • G16B20/00—ICT specially adapted for functional genomics or proteomics, e.g. genotype-phenotype associations
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    • C12Q2523/00—Reactions characterised by treatment of reaction samples
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    • C12Q2535/00—Reactions characterised by the assay type for determining the identity of a nucleotide base or a sequence of oligonucleotides
    • C12Q2535/122—Massive parallel sequencing
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    • C12Q2600/00—Oligonucleotides characterized by their use
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    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/154—Methylation markers

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  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
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  • Engineering & Computer Science (AREA)
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  • Spectroscopy & Molecular Physics (AREA)
  • Bioinformatics & Computational Biology (AREA)
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  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Ultra Sonic Daignosis Equipment (AREA)

Abstract

La presente invención se refiere a sistemas, métodos y aparatos que pueden determinar y utilizar perfiles de metilación de diversos tejidos y muestras. Se proporcionan ejemplos. Un perfil de metilación se puede deducir para el tejido fetal/de tumor con base en una comparación de la metilación del plasma (u otra muestra con el ADN libre de células) con un perfil de metilación de la madre/paciente. Un perfil de metilación se puede determinar para el tejido fetal/de tumor utilizando alelos específicos de tejido para identificar el ADN del feto/tumor cuando la muestra tiene una mezcla de ADN. Un perfil de metilación se puede utilizar para determinar las variaciones de número de copias en el genoma de un feto/tumor. Los marcadores de metilación de un feto se han identificado a través de diversas técnicas. El perfil de metilación se puede determinar mediante la determinación de un parámetro de tamaño de una distribución de tamaño de fragmentos de ADN, donde los valores de referencia para el parámetro de tamaño se pueden utilizar para determinar los niveles de metilación. Además, un nivel de metilación se puede utilizar para determinar un nivel de cáncer.
MX2015003571A 2012-09-20 2013-09-20 Determinacion no invasiva del metiloma fetal o de tumor de plasma. MX360034B (es)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US201261703512P 2012-09-20 2012-09-20
US13/842,209 US9732390B2 (en) 2012-09-20 2013-03-15 Non-invasive determination of methylome of fetus or tumor from plasma
US201361830571P 2013-06-03 2013-06-03
PCT/AU2013/001088 WO2014043763A1 (en) 2012-09-20 2013-09-20 Non-invasive determination of methylome of fetus or tumor from plasma

Publications (2)

Publication Number Publication Date
MX2015003571A MX2015003571A (es) 2015-06-22
MX360034B true MX360034B (es) 2018-10-19

Family

ID=50340462

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2015003571A MX360034B (es) 2012-09-20 2013-09-20 Determinacion no invasiva del metiloma fetal o de tumor de plasma.

Country Status (27)

Country Link
EP (6) EP4335929A3 (es)
JP (5) JP6317354B2 (es)
KR (5) KR20230145530A (es)
CN (2) CN117757932A (es)
AU (4) AU2013317708C1 (es)
BR (3) BR122021021825B1 (es)
CA (2) CA3122779A1 (es)
CY (1) CY1124139T1 (es)
DK (4) DK3536807T3 (es)
EA (1) EA201500327A1 (es)
ES (3) ES2665273T5 (es)
FI (2) FI3536807T3 (es)
HK (3) HK1206797A1 (es)
HR (2) HRP20240210T1 (es)
HU (2) HUE066054T2 (es)
IL (4) IL299444B1 (es)
LT (2) LT3354747T (es)
MX (1) MX360034B (es)
MY (2) MY187444A (es)
NZ (2) NZ717423A (es)
PH (1) PH12015500547A1 (es)
PL (3) PL3354747T3 (es)
PT (4) PT3536807T (es)
SG (2) SG11201501927VA (es)
TW (5) TWI640634B (es)
WO (1) WO2014043763A1 (es)
ZA (1) ZA201501772B (es)

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