MX2022012384A - Composiciones y metodos para cribar mutaciones en el cancer de tiroides. - Google Patents

Composiciones y metodos para cribar mutaciones en el cancer de tiroides.

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Publication number
MX2022012384A
MX2022012384A MX2022012384A MX2022012384A MX2022012384A MX 2022012384 A MX2022012384 A MX 2022012384A MX 2022012384 A MX2022012384 A MX 2022012384A MX 2022012384 A MX2022012384 A MX 2022012384A MX 2022012384 A MX2022012384 A MX 2022012384A
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MX
Mexico
Prior art keywords
methods
thyroid cancer
compositions
screening
patient
Prior art date
Application number
MX2022012384A
Other languages
English (en)
Inventor
Kevin Qu
Joseph J Catanese
Andrew Grupe
Feras Hantash
Frederic M Waldman
Shih-Min Cheng
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Quest Diagnostics Invest Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Quest Diagnostics Invest Llc filed Critical Quest Diagnostics Invest Llc
Publication of MX2022012384A publication Critical patent/MX2022012384A/es

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6869—Methods for sequencing
    • C12Q1/6874—Methods for sequencing involving nucleic acid arrays, e.g. sequencing by hybridisation
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6869—Methods for sequencing
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
    • C12N15/1034—Isolating an individual clone by screening libraries
    • C12N15/1068—Template (nucleic acid) mediated chemical library synthesis, e.g. chemical and enzymatical DNA-templated organic molecule synthesis, libraries prepared by non ribosomal polypeptide synthesis [NRPS], DNA/RNA-polymerase mediated polypeptide synthesis
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/106—Pharmacogenomics, i.e. genetic variability in individual responses to drugs and drug metabolism
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/118—Prognosis of disease development
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/156—Polymorphic or mutational markers

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • General Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • Immunology (AREA)
  • Analytical Chemistry (AREA)
  • Molecular Biology (AREA)
  • Microbiology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Pathology (AREA)
  • Biomedical Technology (AREA)
  • Oncology (AREA)
  • Hospice & Palliative Care (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Plant Pathology (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Chemical Kinetics & Catalysis (AREA)

Abstract

La presente tecnología se refiere a métodos para determinar si un paciente que tiene nódulos tiroideos con citología indeterminada se beneficiará de una cirugía diagnostica, por ejemplo, lobectomía. Estos métodos se basan en el cribado de los nódulos tiroideos de un paciente y la detección de alteraciones en las secuencias de ácido nucleicos diana que corresponden a una serie específica de genes relacionados con el cáncer de tiroides. También se proveen kits para usarse en la práctica de los métodos.
MX2022012384A 2015-12-31 2018-06-29 Composiciones y metodos para cribar mutaciones en el cancer de tiroides. MX2022012384A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201562273783P 2015-12-31 2015-12-31
US201662439572P 2016-12-28 2016-12-28

Publications (1)

Publication Number Publication Date
MX2022012384A true MX2022012384A (es) 2023-01-16

Family

ID=59225391

Family Applications (2)

Application Number Title Priority Date Filing Date
MX2018008197A MX2018008197A (es) 2015-12-31 2016-12-30 Composiciones y metodos para cribar mutaciones en el cancer de tiroides.
MX2022012384A MX2022012384A (es) 2015-12-31 2018-06-29 Composiciones y metodos para cribar mutaciones en el cancer de tiroides.

Family Applications Before (1)

Application Number Title Priority Date Filing Date
MX2018008197A MX2018008197A (es) 2015-12-31 2016-12-30 Composiciones y metodos para cribar mutaciones en el cancer de tiroides.

Country Status (5)

Country Link
US (2) US11053542B2 (es)
EP (2) EP3397766B1 (es)
CN (1) CN108699553B (es)
MX (2) MX2018008197A (es)
WO (1) WO2017117523A1 (es)

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CN109652535A (zh) * 2019-01-30 2019-04-19 上海安甲生物科技有限公司 鉴别人甲状腺结节良恶性的试剂盒及其使用方法和应用
US20210010060A1 (en) * 2019-07-02 2021-01-14 Genenius Genetics Highly Multiplexed PCR with Bioinformatically Optimized Primers to Prepare Targeted Libraries for Next-Generation Sequencing
CN110241215B (zh) * 2019-07-03 2020-05-19 上海润安医学科技有限公司 一种用于检测甲状腺结节良恶性相关基因变异的引物及试剂盒
CN115003826A (zh) * 2019-07-19 2022-09-02 奎斯特诊断投资有限责任公司 检测遗传性癌症的方法
IT201900024009A1 (it) * 2019-12-13 2021-06-13 Univ Degli Studi Roma La Sapienza Nuovo procedimento per la diagnosi di un tumore tiroideo e relativo kit
CN110878358B (zh) * 2019-12-19 2020-08-25 上海宝藤生物医药科技股份有限公司 一组甲状腺癌标志物及其应用
CN112080566B (zh) * 2020-08-25 2021-08-17 上海交通大学医学院附属瑞金医院 基于高通量测序法的甲状腺癌检测产品及用途
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CN117286247A (zh) * 2022-09-07 2023-12-26 上海医创云康生物科技有限公司 一种甲状腺基因检测试剂盒
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Also Published As

Publication number Publication date
EP3397766A1 (en) 2018-11-07
EP4246144A2 (en) 2023-09-20
US20210324468A1 (en) 2021-10-21
US11053542B2 (en) 2021-07-06
CN108699553B (zh) 2023-08-04
MX2018008197A (es) 2019-02-20
US20190112653A1 (en) 2019-04-18
EP3397766A4 (en) 2019-10-02
EP4246144A3 (en) 2023-12-20
EP3397766B1 (en) 2023-05-17
CN108699553A (zh) 2018-10-23
CA3010013A1 (en) 2017-07-06
BR112018013430A2 (pt) 2018-12-18
WO2017117523A1 (en) 2017-07-06

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