SG11202106114XA - Cell-free dna end characteristics - Google Patents

Cell-free dna end characteristics

Info

Publication number
SG11202106114XA
SG11202106114XA SG11202106114XA SG11202106114XA SG11202106114XA SG 11202106114X A SG11202106114X A SG 11202106114XA SG 11202106114X A SG11202106114X A SG 11202106114XA SG 11202106114X A SG11202106114X A SG 11202106114XA SG 11202106114X A SG11202106114X A SG 11202106114XA
Authority
SG
Singapore
Prior art keywords
cell
free dna
dna end
end characteristics
free
Prior art date
Application number
SG11202106114XA
Inventor
Yuk-Ming Dennis Lo
Rossa Wai Kwun Chiu
Kwan Chee Chan
Peiyong Jiang
Wing Yan Chan
Kun Sun
Original Assignee
Univ Hong Kong Chinese
Grail Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Hong Kong Chinese, Grail Inc filed Critical Univ Hong Kong Chinese
Publication of SG11202106114XA publication Critical patent/SG11202106114XA/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6809—Methods for determination or identification of nucleic acids involving differential detection
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6869—Methods for sequencing
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B20/00—ICT specially adapted for functional genomics or proteomics, e.g. genotype-phenotype associations
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B20/00—ICT specially adapted for functional genomics or proteomics, e.g. genotype-phenotype associations
    • G16B20/10—Ploidy or copy number detection
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B40/00—ICT specially adapted for biostatistics; ICT specially adapted for bioinformatics-related machine learning or data mining, e.g. knowledge discovery or pattern finding
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16H—HEALTHCARE INFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR THE HANDLING OR PROCESSING OF MEDICAL OR HEALTHCARE DATA
    • G16H50/00—ICT specially adapted for medical diagnosis, medical simulation or medical data mining; ICT specially adapted for detecting, monitoring or modelling epidemics or pandemics
    • G16H50/30—ICT specially adapted for medical diagnosis, medical simulation or medical data mining; ICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for calculating health indices; for individual health risk assessment
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/36—Gynecology or obstetrics
    • G01N2800/368—Pregnancy complicated by disease or abnormalities of pregnancy, e.g. preeclampsia, preterm labour
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/38—Pediatrics
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/70—Mechanisms involved in disease identification
    • G01N2800/7042—Aging, e.g. cellular aging
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16H—HEALTHCARE INFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR THE HANDLING OR PROCESSING OF MEDICAL OR HEALTHCARE DATA
    • G16H10/00—ICT specially adapted for the handling or processing of patient-related medical or healthcare data
    • G16H10/40—ICT specially adapted for the handling or processing of patient-related medical or healthcare data for data related to laboratory analysis, e.g. patient specimen analysis

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Analytical Chemistry (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Physics & Mathematics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Biotechnology (AREA)
  • Biophysics (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Pathology (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Medical Informatics (AREA)
  • Public Health (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Theoretical Computer Science (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Evolutionary Biology (AREA)
  • Hospice & Palliative Care (AREA)
  • Oncology (AREA)
  • Epidemiology (AREA)
  • Databases & Information Systems (AREA)
  • Data Mining & Analysis (AREA)
  • Artificial Intelligence (AREA)
  • Evolutionary Computation (AREA)
  • Software Systems (AREA)
  • Bioethics (AREA)
  • Computer Vision & Pattern Recognition (AREA)
  • Biomedical Technology (AREA)
  • Primary Health Care (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
SG11202106114XA 2018-12-19 2019-12-19 Cell-free dna end characteristics SG11202106114XA (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201862782316P 2018-12-19 2018-12-19
PCT/CN2019/126565 WO2020125709A1 (en) 2018-12-19 2019-12-19 Cell-free dna end characteristics

Publications (1)

Publication Number Publication Date
SG11202106114XA true SG11202106114XA (en) 2021-07-29

Family

ID=71099178

Family Applications (1)

Application Number Title Priority Date Filing Date
SG11202106114XA SG11202106114XA (en) 2018-12-19 2019-12-19 Cell-free dna end characteristics

Country Status (11)

Country Link
US (1) US20200199656A1 (en)
EP (2) EP4300500A3 (en)
JP (1) JP2022514879A (en)
KR (1) KR20210113237A (en)
CN (2) CN117778576A (en)
AU (1) AU2019410635A1 (en)
CA (1) CA3123474A1 (en)
DK (1) DK3899018T3 (en)
SG (1) SG11202106114XA (en)
TW (1) TW202039860A (en)
WO (1) WO2020125709A1 (en)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TWI803477B (en) * 2017-01-25 2023-06-01 香港中文大學 Diagnostic applications using nucleic acid fragments
CA3162089A1 (en) * 2020-01-08 2021-07-15 Yuk-Ming Dennis Lo Biterminal dna fragment types in cell-free samples and uses thereof
JP2023540016A (en) * 2020-08-19 2023-09-21 アキュラーゲン ホールディングス リミテッド Method for selective cell-free nucleic acid analysis
CA3205119A1 (en) * 2020-12-15 2022-06-23 Gateway Genomics, Llc Methods, compositions, and devices for the rapid determination of fetal sex
KR20220160806A (en) 2021-05-28 2022-12-06 주식회사 지씨지놈 Method for diagnosing and predicting cancer type using fragment end motif frequency and size of cell-free nucleic acid
KR20230064172A (en) * 2021-11-03 2023-05-10 주식회사 지씨지놈 Method for detecting cancer using fragment end sequence frequency and size by position of cell-free nucleic acid
US20230279498A1 (en) * 2021-11-24 2023-09-07 Centre For Novostics Limited Molecular analyses using long cell-free dna molecules for disease classification
US20240011105A1 (en) * 2022-07-08 2024-01-11 The Chinese University Of Hong Kong Analysis of microbial fragments in plasma
CN114898802B (en) * 2022-07-14 2022-09-30 臻和(北京)生物科技有限公司 Terminal sequence frequency distribution characteristic determination method, evaluation method and device based on plasma free DNA methylation sequencing data
US20240043935A1 (en) * 2022-07-29 2024-02-08 Centre For Novostics Limited Epigenetics analysis of cell-free dna

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN105243295B (en) 2010-11-30 2018-08-17 香港中文大学 With the relevant heredity of cancer or the detection of molecular distortion
US9892230B2 (en) 2012-03-08 2018-02-13 The Chinese University Of Hong Kong Size-based analysis of fetal or tumor DNA fraction in plasma
US11261494B2 (en) 2012-06-21 2022-03-01 The Chinese University Of Hong Kong Method of measuring a fractional concentration of tumor DNA
NZ706269A (en) * 2012-09-20 2016-08-26 Univ Hong Kong Chinese Non-invasive determination of methylome of fetus or tumor from plasma
US9732390B2 (en) 2012-09-20 2017-08-15 The Chinese University Of Hong Kong Non-invasive determination of methylome of fetus or tumor from plasma
PT3543356T (en) * 2014-07-18 2021-10-04 Univ Hong Kong Chinese Methylation pattern analysis of tissues in dna mixture
EP4358097A1 (en) * 2014-07-25 2024-04-24 University of Washington Methods of determining tissues and/or cell types giving rise to cell-free dna, and methods of identifying a disease or disorder using same
US11242559B2 (en) * 2015-01-13 2022-02-08 The Chinese University Of Hong Kong Method of nuclear DNA and mitochondrial DNA analysis
PT3256605T (en) * 2015-02-10 2022-03-17 Univ Hong Kong Chinese Detecting mutations for cancer screening and fetal analysis
IL305462A (en) * 2015-07-23 2023-10-01 Univ Hong Kong Chinese Analysis of fragmentation patterns of cell-free dna
WO2018009723A1 (en) * 2016-07-06 2018-01-11 Guardant Health, Inc. Methods for fragmentome profiling of cell-free nucleic acids
EP3535415A4 (en) * 2016-10-24 2020-07-01 The Chinese University of Hong Kong Methods and systems for tumor detection
CN109983134A (en) * 2016-11-30 2019-07-05 香港中文大学 The analysis of Cell-free DNA in urine and other samples
WO2019210873A1 (en) 2018-05-03 2019-11-07 The Chinese University Of Hong Kong Size-tagged preferred ends and orientation-aware analysis for measuring properties of cell-free mixtures

Also Published As

Publication number Publication date
CN113366122A (en) 2021-09-07
EP4300500A3 (en) 2024-03-27
CA3123474A1 (en) 2020-06-25
CN117778576A (en) 2024-03-29
DK3899018T3 (en) 2024-01-08
EP3899018A4 (en) 2022-09-14
AU2019410635A1 (en) 2021-06-17
KR20210113237A (en) 2021-09-15
EP3899018B1 (en) 2023-12-06
WO2020125709A1 (en) 2020-06-25
CN113366122B (en) 2024-01-12
US20200199656A1 (en) 2020-06-25
TW202039860A (en) 2020-11-01
EP3899018A1 (en) 2021-10-27
JP2022514879A (en) 2022-02-16
EP4300500A2 (en) 2024-01-03

Similar Documents

Publication Publication Date Title
SG11202106114XA (en) Cell-free dna end characteristics
DK3793565T3 (en) Mcl-1-inhibitorer
IL274442A (en) Rna sequence adaptation
DK3467457T3 (en) Vibrationssensor
DK3759096T3 (en) Cd73-inhibitorer
CA185382S (en) Casque
CA185384S (en) Casque
SG11202009192PA (en) Nano-satellite
CA185385S (en) Casque
DK3773537T3 (en) Stat3-hæmmere
DK3554057T3 (en) Audioheadsetsystem
DK3613739T3 (en) Integrin-antagonister
CA184991S (en) Uroflowmeter
DK3872428T3 (en) Indvendigt luftstyringssystem
CA184992S (en) Uroflowmeter
GB201806174D0 (en) Improved downlighter
HUE064581T2 (en) End effectors
EP3766087C0 (en) Sensformer
GB201805799D0 (en) b
DK3674425T3 (en) Stålwire
CA187782S (en) Pompon-maker
DK3542617T3 (en) Etikette
CA185267S (en) Corkscrew
EP3784424C0 (en) Millstand
GB201901706D0 (en) b