SI4056712T1 - Neinvazivno določanje metiloma tumorja iz plazme - Google Patents
Neinvazivno določanje metiloma tumorja iz plazmeInfo
- Publication number
- SI4056712T1 SI4056712T1 SI201332088T SI201332088T SI4056712T1 SI 4056712 T1 SI4056712 T1 SI 4056712T1 SI 201332088 T SI201332088 T SI 201332088T SI 201332088 T SI201332088 T SI 201332088T SI 4056712 T1 SI4056712 T1 SI 4056712T1
- Authority
- SI
- Slovenia
- Prior art keywords
- methylome
- tumor
- plasma
- invasive determination
- invasive
- Prior art date
Links
- 206010028980 Neoplasm Diseases 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
- C12Q1/6881—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for tissue or cell typing, e.g. human leukocyte antigen [HLA] probes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6869—Methods for sequencing
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
- C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
- C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
- C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
-
- G—PHYSICS
- G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
- G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
- G16B20/00—ICT specially adapted for functional genomics or proteomics, e.g. genotype-phenotype associations
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2523/00—Reactions characterised by treatment of reaction samples
- C12Q2523/10—Characterised by chemical treatment
- C12Q2523/125—Bisulfite(s)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2535/00—Reactions characterised by the assay type for determining the identity of a nucleotide base or a sequence of oligonucleotides
- C12Q2535/122—Massive parallel sequencing
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/112—Disease subtyping, staging or classification
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/154—Methylation markers
Landscapes
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Analytical Chemistry (AREA)
- Genetics & Genomics (AREA)
- Immunology (AREA)
- Physics & Mathematics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- General Health & Medical Sciences (AREA)
- Biotechnology (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- Microbiology (AREA)
- Pathology (AREA)
- Hospice & Palliative Care (AREA)
- Oncology (AREA)
- Cell Biology (AREA)
- Bioinformatics & Computational Biology (AREA)
- Evolutionary Biology (AREA)
- Medical Informatics (AREA)
- Spectroscopy & Molecular Physics (AREA)
- Theoretical Computer Science (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Apparatus Associated With Microorganisms And Enzymes (AREA)
- Ultra Sonic Daignosis Equipment (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261703512P | 2012-09-20 | 2012-09-20 | |
| US13/842,209 US9732390B2 (en) | 2012-09-20 | 2013-03-15 | Non-invasive determination of methylome of fetus or tumor from plasma |
| US201361830571P | 2013-06-03 | 2013-06-03 | |
| EP22171427.2A EP4056712B1 (en) | 2012-09-20 | 2013-09-20 | Non-invasive determination of methylome of tumor from plasma |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SI4056712T1 true SI4056712T1 (sl) | 2024-10-30 |
Family
ID=50340462
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SI201332088T SI4056712T1 (sl) | 2012-09-20 | 2013-09-20 | Neinvazivno določanje metiloma tumorja iz plazme |
Country Status (28)
| Country | Link |
|---|---|
| EP (6) | EP4056712B1 (enExample) |
| JP (6) | JP6317354B2 (enExample) |
| KR (5) | KR102587176B1 (enExample) |
| CN (2) | CN117757932A (enExample) |
| AU (5) | AU2013317708C1 (enExample) |
| BR (3) | BR112015006183B1 (enExample) |
| CA (2) | CA2884066C (enExample) |
| CY (1) | CY1124139T1 (enExample) |
| DK (4) | DK4056712T3 (enExample) |
| EA (1) | EA201500327A1 (enExample) |
| ES (4) | ES2969567T3 (enExample) |
| FI (2) | FI4056712T3 (enExample) |
| HR (3) | HRP20241142T1 (enExample) |
| HU (3) | HUE053822T2 (enExample) |
| IL (4) | IL313451A (enExample) |
| LT (2) | LT4056712T (enExample) |
| MX (1) | MX360034B (enExample) |
| MY (2) | MY173356A (enExample) |
| NZ (2) | NZ717423A (enExample) |
| PH (2) | PH12015500547B1 (enExample) |
| PL (4) | PL3354747T3 (enExample) |
| PT (4) | PT3354747T (enExample) |
| SG (2) | SG11201501927VA (enExample) |
| SI (1) | SI4056712T1 (enExample) |
| SM (1) | SMT202100256T1 (enExample) |
| TW (4) | TWI707953B (enExample) |
| WO (1) | WO2014043763A1 (enExample) |
| ZA (1) | ZA201501772B (enExample) |
Families Citing this family (94)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101153336B (zh) | 2006-09-27 | 2011-09-07 | 香港中文大学 | 检测dna甲基化程度的方法和试剂盒 |
| US9892230B2 (en) | 2012-03-08 | 2018-02-13 | The Chinese University Of Hong Kong | Size-based analysis of fetal or tumor DNA fraction in plasma |
| FI4056712T3 (fi) | 2012-09-20 | 2024-08-29 | Univ Hong Kong Chinese | Kasvaimen metyloomin nonivasiivinen määrittäminen plasmasta |
| US10706957B2 (en) | 2012-09-20 | 2020-07-07 | The Chinese University Of Hong Kong | Non-invasive determination of methylome of tumor from plasma |
| US9732390B2 (en) | 2012-09-20 | 2017-08-15 | The Chinese University Of Hong Kong | Non-invasive determination of methylome of fetus or tumor from plasma |
| US20130309666A1 (en) | 2013-01-25 | 2013-11-21 | Sequenom, Inc. | Methods and processes for non-invasive assessment of genetic variations |
| ES2685893T3 (es) * | 2013-07-30 | 2018-10-15 | Bgi Genomics Co., Limited | Método para determinar la composición de ácidos nucleicos de una mezcla de ácidos nucleicos |
| US10174375B2 (en) * | 2013-09-20 | 2019-01-08 | The Chinese University Of Hong Kong | Sequencing analysis of circulating DNA to detect and monitor autoimmune diseases |
| CN106029909B (zh) * | 2014-02-18 | 2021-02-02 | 生物纳米基因公司 | 测定核酸结构信息的改进方法 |
| US12492429B2 (en) | 2014-04-21 | 2025-12-09 | Natera, Inc. | Detecting mutations and ploidy in chromosomal segments |
| EP3134541B1 (en) * | 2014-04-21 | 2020-08-19 | Natera, Inc. | Detecting copy number variations (cnv) of chromosomal segments in cancer |
| EP2942400A1 (en) | 2014-05-09 | 2015-11-11 | Lifecodexx AG | Multiplex detection of DNA that originates from a specific cell-type |
| EP3521454A1 (en) | 2014-05-09 | 2019-08-07 | LifeCodexx AG | Detection of dna that originates from a specific cell-type and related methods |
| WO2016010401A1 (ko) * | 2014-07-18 | 2016-01-21 | 에스케이텔레콘 주식회사 | 산모의 혈청 dna를 이용한 태아의 단일유전자 유전변이의 예측방법 |
| US11062789B2 (en) * | 2014-07-18 | 2021-07-13 | The Chinese University Of Hong Kong | Methylation pattern analysis of tissues in a DNA mixture |
| US20170211143A1 (en) | 2014-07-25 | 2017-07-27 | University Of Washington | Methods of determining tissues and/or cell types giving rise to cell-free dna, and methods of identifying a disease or disorder using same |
| ES2923602T3 (es) * | 2014-12-31 | 2022-09-28 | Guardant Health Inc | Detección y tratamiento de enfermedades que muestran heterogeneidad celular de enfermedad y sistemas y métodos para comunicar los resultados de las pruebas |
| US10364467B2 (en) * | 2015-01-13 | 2019-07-30 | The Chinese University Of Hong Kong | Using size and number aberrations in plasma DNA for detecting cancer |
| EP4012715B1 (en) | 2015-02-10 | 2025-09-24 | The Chinese University Of Hong Kong | Detecting mutations for cancer screening and fetal analysis |
| EP3739061B1 (en) | 2015-07-20 | 2022-03-23 | The Chinese University Of Hong Kong | Methylation pattern analysis of haplotypes in tissues in dna mixture |
| CN108026572B (zh) | 2015-07-23 | 2022-07-01 | 香港中文大学 | 游离dna的片段化模式的分析 |
| CN115433769A (zh) | 2015-08-12 | 2022-12-06 | 香港中文大学 | 血浆dna的单分子测序 |
| SG10202107693TA (en) | 2015-09-22 | 2021-09-29 | Univ Hong Kong Chinese | Accurate quantification of fetal dna fraction by shallow-depth sequencing of maternal plasma dna |
| US10260088B2 (en) * | 2015-10-30 | 2019-04-16 | New England Biolabs, Inc. | Compositions and methods for analyzing modified nucleotides |
| EP4180532A1 (en) * | 2015-11-09 | 2023-05-17 | Roche Molecular Systems, Inc. | Methods for determining the origin of dna molecules |
| DK3168309T3 (da) | 2015-11-10 | 2020-06-22 | Eurofins Lifecodexx Gmbh | Detektion af føtale kromosomale aneuploidier under anvendelse af dna-regioner med forskellig metylering mellem fosteret og det gravide hunkøn |
| EP3798321B1 (en) * | 2015-12-17 | 2025-08-27 | Illumina, Inc. | Distinguishing methylation levels in complex biological samples |
| WO2017136603A1 (en) * | 2016-02-02 | 2017-08-10 | Guardant Health, Inc. | Cancer evolution detection and diagnostic |
| US11514289B1 (en) | 2016-03-09 | 2022-11-29 | Freenome Holdings, Inc. | Generating machine learning models using genetic data |
| CA3022606A1 (en) | 2016-05-03 | 2017-11-09 | University Health Network | Methods of capturing cell-free methylated dna and uses of same |
| EP3452620B1 (en) * | 2016-05-04 | 2025-11-05 | Queen's University at Kingston | Cell-free detection of methylated tumour dna |
| US10781490B2 (en) * | 2016-05-30 | 2020-09-22 | The Chinese University Of Hong Kong | Detecting hematological disorders using cell-free DNA in blood |
| WO2017218908A2 (en) * | 2016-06-16 | 2017-12-21 | The Johns Hopkins University | Methods and system for epigenetic analysis |
| US11999998B2 (en) | 2016-08-24 | 2024-06-04 | Center For Excellence In Molecular Cell Science, Chinese Academy Of Sciences | Modification of 5-methylcytosine catalyzed by Cmd1 enzyme and application thereof |
| IL265769B2 (en) * | 2016-10-19 | 2023-12-01 | Univ Hong Kong Chinese | Estimation of gestational age using methylation and size profile of maternal plasma DNA |
| SG11201903509QA (en) | 2016-10-24 | 2019-05-30 | Univ Hong Kong Chinese | Methods and systems for tumor detection |
| WO2018099418A1 (en) * | 2016-11-30 | 2018-06-07 | The Chinese University Of Hong Kong | Analysis of cell-free dna in urine and other samples |
| EP3555311B1 (en) * | 2016-12-13 | 2024-06-26 | Bellwether Bio, Inc. | Determining a physiological condition in an individual by analyzing cell-free dna fragment endpoints in a biological sample |
| MX2019008320A (es) * | 2017-01-11 | 2019-09-09 | Quest Diagnostics Invest Llc | Metodo para la deteccion prenatal no invasiva de aneuploidia. |
| HUE067465T2 (hu) * | 2017-01-24 | 2024-10-28 | Bgi Genomics Co Ltd | Eljárás elõre meghatározott forrásból származó sejtmentes nukleinsavak arányának meghatározására biológiai mintában |
| MY197535A (en) | 2017-01-25 | 2023-06-21 | Univ Hong Kong Chinese | Diagnostic applications using nucleic acid fragments |
| CN107247873B (zh) * | 2017-03-29 | 2020-04-14 | 电子科技大学 | 一种差异甲基化位点识别方法 |
| AU2018266964B2 (en) * | 2017-05-12 | 2024-10-31 | Dana-Farber Cancer Institute, Inc. | Universal early cancer diagnostics |
| US12227737B2 (en) | 2017-07-12 | 2025-02-18 | University Health Network | Cancer detection and classification using methylome analysis |
| CN118782138A (zh) * | 2017-07-12 | 2024-10-15 | 安德股份有限公司 | 模式识别系统 |
| EP3652741A4 (en) * | 2017-07-12 | 2021-04-21 | University Health Network | DETECTION AND CLASSIFICATION OF CANCER USING METHYLOMA ANALYSIS |
| DK3658684T3 (da) * | 2017-07-26 | 2023-10-09 | Univ Hong Kong Chinese | Forbedring af cancerscreening ved hjælp af cellefrie, virale nukleinsyrer |
| US20200263170A1 (en) | 2017-09-14 | 2020-08-20 | Grail, Inc. | Methods for preparing a sequencing library from single-stranded dna |
| EP4269583A3 (en) | 2017-09-28 | 2024-01-17 | Grail, LLC | Enrichment of short nucleic acid fragments in sequencing library preparation |
| US11168356B2 (en) | 2017-11-02 | 2021-11-09 | The Chinese University Of Hong Kong | Using nucleic acid size range for noninvasive cancer detection |
| US12027237B2 (en) | 2018-03-13 | 2024-07-02 | Grail, Llc | Anomalous fragment detection and classification |
| EP3766076A4 (en) * | 2018-03-15 | 2021-12-29 | Grail, Inc. | Tissue-specific methylation marker |
| WO2019195268A2 (en) * | 2018-04-02 | 2019-10-10 | Grail, Inc. | Methylation markers and targeted methylation probe panels |
| JP7455757B2 (ja) * | 2018-04-13 | 2024-03-26 | フリーノーム・ホールディングス・インコーポレイテッド | 生体試料の多検体アッセイのための機械学習実装 |
| WO2019204360A1 (en) * | 2018-04-16 | 2019-10-24 | Grail, Inc. | Systems and methods for determining tumor fraction in cell-free nucleic acid |
| WO2019209884A1 (en) | 2018-04-23 | 2019-10-31 | Grail, Inc. | Methods and systems for screening for conditions |
| US11932899B2 (en) * | 2018-06-07 | 2024-03-19 | 10X Genomics, Inc. | Methods and systems for characterizing nucleic acid molecules |
| CN109448789A (zh) * | 2018-09-17 | 2019-03-08 | 上海派森诺生物科技股份有限公司 | 一种基于perl语言的种群特异SNP位点的自动化分析方法 |
| AU2019351130B2 (en) | 2018-09-27 | 2025-10-23 | GRAIL, Inc | Methylation markers and targeted methylation probe panel |
| CN109295230A (zh) * | 2018-10-24 | 2019-02-01 | 福建翊善生物科技有限公司 | 一种基于ctDNA的多基因联合突变检测评估肿瘤动态变化的方法 |
| GB2595076B8 (en) | 2018-11-21 | 2023-08-23 | Agilent Technologies Inc | Methods for targeted nucleic acid library formation |
| ES2968457T3 (es) * | 2018-12-19 | 2024-05-09 | Univ Hong Kong Chinese | Características de los extremos del ADN extracelular circulante |
| US12234514B2 (en) | 2018-12-21 | 2025-02-25 | Grail, Inc. | Source of origin deconvolution based on methylation fragments in cell-free DNA samples |
| EP4485464A3 (en) | 2019-02-05 | 2025-02-19 | Grail, Inc. | Detecting cancer, cancer tissue of origin, and/or a cancer cell type |
| WO2020163410A1 (en) | 2019-02-05 | 2020-08-13 | Grail, Inc. | Detecting cancer, cancer tissue of origin, and/or a cancer cell type |
| EP3947717A4 (en) | 2019-03-25 | 2022-12-28 | The Chinese University Of Hong Kong | DETERMINATION OF LINEAR AND ROUND SHAPES OF CIRCULATION NUCLEIC ACIDS |
| US11773450B2 (en) | 2019-04-03 | 2023-10-03 | Grail, Llc | Methylation-based false positive duplicate marking reduction |
| BR112021022084A2 (pt) * | 2019-05-03 | 2022-02-08 | Univ Cornell | Marcadores para identificar e quantificar a mutação da sequência de ácido nucleico, expressão, variante de splice, translocação, número de cópias ou alterações de metilação |
| EP4020484A4 (en) * | 2019-08-19 | 2023-08-30 | Green Cross Genome Corporation | METHOD FOR DETECTING A CHROMOSOME ABNORMALITY USING INFORMATION CONCERNING THE DISTANCE BETWEEN NUCLEIC ACID FRAGMENTS |
| KR102452413B1 (ko) * | 2019-08-19 | 2022-10-11 | 주식회사 지씨지놈 | 핵산 단편간 거리 정보를 이용한 염색체 이상 검출 방법 |
| GB201915469D0 (en) | 2019-10-24 | 2019-12-11 | Univ London | Cancer detection methods |
| AU2020391488A1 (en) * | 2019-11-27 | 2022-06-09 | GRAIL, Inc | Systems and methods for evaluating longitudinal biological feature data |
| EP4097231B1 (en) | 2020-01-31 | 2025-03-19 | Agilent Technologies, Inc. | Systems and methods for targeted nucleic acid capture |
| WO2021163163A1 (en) * | 2020-02-10 | 2021-08-19 | Palogen, Inc. | Nanopore device and methods of detecting and classifying charged particles using same |
| US11211144B2 (en) | 2020-02-18 | 2021-12-28 | Tempus Labs, Inc. | Methods and systems for refining copy number variation in a liquid biopsy assay |
| US11211147B2 (en) | 2020-02-18 | 2021-12-28 | Tempus Labs, Inc. | Estimation of circulating tumor fraction using off-target reads of targeted-panel sequencing |
| US11475981B2 (en) | 2020-02-18 | 2022-10-18 | Tempus Labs, Inc. | Methods and systems for dynamic variant thresholding in a liquid biopsy assay |
| AU2021228737A1 (en) * | 2020-02-28 | 2022-09-22 | Grail, LLC. | Identifying methylation patterns that discriminate or indicate a cancer condition |
| CN112662764A (zh) * | 2020-03-17 | 2021-04-16 | 博尔诚(北京)科技有限公司 | 一种检测11种癌症的探针组合物 |
| RU2738675C1 (ru) * | 2020-07-28 | 2020-12-15 | Федеральное государственное автономное образовательное учреждение высшего образования "Белгородский государственный национальный исследовательский университет" (НИУ "БелГУ") | Способ прогнозирования риска развития преэклампсии у женщин без отягощенного семейного анамнеза с учетом генетических факторов |
| WO2022107145A1 (en) * | 2020-11-19 | 2022-05-27 | Nucleix Ltd. | Detecting methylation changes in dna samples using restriction enzymes and high throughput sequencing |
| US20240327922A1 (en) * | 2020-12-17 | 2024-10-03 | Jiantao Shi | Methods of cancer detection using extraembryonically methylated cpg islands |
| CN112813148A (zh) * | 2021-02-02 | 2021-05-18 | 博淼生物科技(北京)有限公司 | 飞行时间质谱检测5-羟甲基胞嘧啶的方法 |
| EP4409468A4 (en) * | 2021-09-28 | 2025-08-13 | Act Genomics Ip Ltd | APPARATUS AND METHODS FOR SELECTING METHYLATION BIOMARKERS |
| KR20230059423A (ko) * | 2021-10-26 | 2023-05-03 | 주식회사 지씨지놈 | 메틸화된 무세포 핵산을 이용한 암 진단 및 암 종 예측방법 |
| EP4384633A1 (en) * | 2021-11-04 | 2024-06-19 | Universal Diagnostics, S.A. | Systems and methods for preparing biological samples for genetic sequencing |
| EP4530356A3 (en) | 2022-02-07 | 2025-07-09 | Centre for Novostics | Fragmentation for measuring methylation and disease |
| EP4482985A2 (en) * | 2022-02-22 | 2025-01-01 | Flagship Pioneering Innovations VI, LLC | Intra-individual analysis for presence of health conditions |
| CN115064211B (zh) * | 2022-08-15 | 2023-01-24 | 臻和(北京)生物科技有限公司 | 一种基于全基因组甲基化测序的ctDNA预测方法及装置 |
| CN115612723B (zh) * | 2022-09-26 | 2023-07-14 | 广州女娲生命科技有限公司 | 植入前胚胎的筛选方法 |
| WO2024203348A1 (ja) * | 2023-03-31 | 2024-10-03 | ソニーグループ株式会社 | 腫瘍の解析方法、腫瘍の解析システム、及び腫瘍の解析データ生成方法 |
| CN118737268A (zh) * | 2023-05-04 | 2024-10-01 | 杭州圣庭医疗科技有限公司 | 一种鉴定肿瘤组织来源的试剂盒的数据分析方法 |
| CN117025753A (zh) * | 2023-08-15 | 2023-11-10 | 广州女娲生命科技有限公司 | 检测染色体变异的方法和装置 |
| CN117079822B (zh) * | 2023-10-17 | 2024-01-02 | 北京大学第三医院(北京大学第三临床医学院) | 一种妊娠早中期四因子预测胎儿脑损伤的系统 |
Family Cites Families (28)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6927028B2 (en) * | 2001-08-31 | 2005-08-09 | Chinese University Of Hong Kong | Non-invasive methods for detecting non-host DNA in a host using epigenetic differences between the host and non-host DNA |
| ATE312946T1 (de) | 2002-03-05 | 2005-12-15 | Epigenomics Ag | Verfahren und vorrichtung zur bestimmung der gewebespezifität von freier dna in körperflüssigkeiten |
| US20040171037A1 (en) * | 2002-11-19 | 2004-09-02 | Jing Li | Amplified genes involved in cancer |
| US20060183128A1 (en) | 2003-08-12 | 2006-08-17 | Epigenomics Ag | Methods and compositions for differentiating tissues for cell types using epigenetic markers |
| DE10348407A1 (de) | 2003-10-17 | 2005-05-19 | Widschwendter, Martin, Prof. | Prognostische und diagnostische Marker für Zell-proliferative Erkrankungen von Brustgeweben |
| EP1725682B1 (en) | 2004-03-08 | 2015-09-09 | Rubicon Genomics, Inc. | Methods and compositions for generating and amplifying dna libraries for sensitive detection and analysis of dna methylation |
| US20090280479A1 (en) | 2005-05-27 | 2009-11-12 | John Wayne Cancer Institute | Use of free circulating dna for diagnosis, prognosis, and treatment of cancer funding |
| US7754428B2 (en) | 2006-05-03 | 2010-07-13 | The Chinese University Of Hong Kong | Fetal methylation markers |
| US7901884B2 (en) * | 2006-05-03 | 2011-03-08 | The Chinese University Of Hong Kong | Markers for prenatal diagnosis and monitoring |
| CN101153336B (zh) * | 2006-09-27 | 2011-09-07 | 香港中文大学 | 检测dna甲基化程度的方法和试剂盒 |
| EP2173897A2 (en) | 2007-06-19 | 2010-04-14 | Oncomethylome Sciences SA | Improved urine sample collecting and processing |
| EP3892736A1 (en) | 2007-07-23 | 2021-10-13 | The Chinese University of Hong Kong | Determining a nucleic acid sequence imbalance |
| JP4347372B2 (ja) | 2007-08-10 | 2009-10-21 | トヨタ自動車株式会社 | 静電塗装装置 |
| US20110028333A1 (en) | 2009-05-01 | 2011-02-03 | Brown University | Diagnosing, prognosing, and early detection of cancers by dna methylation profiling |
| US8563242B2 (en) * | 2009-08-11 | 2013-10-22 | The Chinese University Of Hong Kong | Method for detecting chromosomal aneuploidy |
| WO2011038507A1 (en) | 2009-10-02 | 2011-04-07 | Centre For Addiction And Mental Health | Method for analysis of dna methylation profiles of cell-free circulating dna in bodily fluids |
| HUE061110T2 (hu) * | 2009-11-05 | 2023-05-28 | Univ Hong Kong Chinese | Magzati genomelemzés anyai biológiai mintából |
| MX357692B (es) | 2009-11-06 | 2018-07-19 | Univ Hong Kong Chinese | Analisis genomico a base de tamaño. |
| US10662474B2 (en) * | 2010-01-19 | 2020-05-26 | Verinata Health, Inc. | Identification of polymorphic sequences in mixtures of genomic DNA by whole genome sequencing |
| NZ601079A (en) | 2010-01-26 | 2014-08-29 | Nipd Genetics Ltd | Methods and compositions for noninvasive prenatal diagnosis of fetal aneuploidies |
| CA3007805C (en) | 2010-04-29 | 2019-11-26 | The Regents Of The University Of California | Pathway recognition algorithm using data integration on genomic models (paradigm) |
| GB201007944D0 (en) * | 2010-05-12 | 2010-06-30 | Univ Aberystwyth | Methods |
| EP2576832B1 (en) | 2010-05-25 | 2016-05-04 | The Johns Hopkins University | Compositions and methods for detecting a neoplasia |
| KR20130041961A (ko) * | 2010-07-23 | 2013-04-25 | 프레지던트 앤드 펠로우즈 오브 하바드 칼리지 | 체액에서 질환 또는 상태의 특징을 검출하는 방법 |
| WO2012012703A2 (en) * | 2010-07-23 | 2012-01-26 | Esoterix Genetic Laboratories, Llc | Identification of differentially represented fetal or maternal genomic regions and uses thereof |
| WO2012031329A1 (en) | 2010-09-10 | 2012-03-15 | Murdoch Childrens Research Institute | Assay for detection and monitoring of cancer |
| SG190344A1 (en) | 2010-11-30 | 2013-06-28 | Univ Hong Kong Chinese | Detection of genetic or molecular aberrations associated with cancer |
| FI4056712T3 (fi) * | 2012-09-20 | 2024-08-29 | Univ Hong Kong Chinese | Kasvaimen metyloomin nonivasiivinen määrittäminen plasmasta |
-
2013
- 2013-09-20 FI FIEP22171427.2T patent/FI4056712T3/fi active
- 2013-09-20 JP JP2015532250A patent/JP6317354B2/ja active Active
- 2013-09-20 ES ES19171630T patent/ES2969567T3/es active Active
- 2013-09-20 HU HUE17202149A patent/HUE053822T2/hu unknown
- 2013-09-20 CA CA2884066A patent/CA2884066C/en active Active
- 2013-09-20 ES ES13838770T patent/ES2665273T5/es active Active
- 2013-09-20 CN CN202311671688.1A patent/CN117757932A/zh active Pending
- 2013-09-20 HR HRP20241142TT patent/HRP20241142T1/hr unknown
- 2013-09-20 EP EP22171427.2A patent/EP4056712B1/en active Active
- 2013-09-20 KR KR1020227013227A patent/KR102587176B1/ko active Active
- 2013-09-20 SG SG11201501927VA patent/SG11201501927VA/en unknown
- 2013-09-20 KR KR1020217030373A patent/KR102390711B1/ko active Active
- 2013-09-20 LT LTEP22171427.2T patent/LT4056712T/lt unknown
- 2013-09-20 IL IL313451A patent/IL313451A/en unknown
- 2013-09-20 FI FIEP19171630.7T patent/FI3536807T3/fi active
- 2013-09-20 PL PL17202149T patent/PL3354747T3/pl unknown
- 2013-09-20 PH PH1/2015/500547A patent/PH12015500547B1/en unknown
- 2013-09-20 BR BR112015006183-4A patent/BR112015006183B1/pt active IP Right Grant
- 2013-09-20 EP EP21151739.6A patent/EP3839065A1/en active Pending
- 2013-09-20 MY MYPI2015000628A patent/MY173356A/en unknown
- 2013-09-20 DK DK22171427.2T patent/DK4056712T3/da active
- 2013-09-20 PL PL13838770.9T patent/PL2898100T5/pl unknown
- 2013-09-20 MX MX2015003571A patent/MX360034B/es active IP Right Grant
- 2013-09-20 WO PCT/AU2013/001088 patent/WO2014043763A1/en not_active Ceased
- 2013-09-20 BR BR122021021823-4A patent/BR122021021823B1/pt active IP Right Grant
- 2013-09-20 HR HRP20240210TT patent/HRP20240210T1/hr unknown
- 2013-09-20 SI SI201332088T patent/SI4056712T1/sl unknown
- 2013-09-20 SG SG10201705198UA patent/SG10201705198UA/en unknown
- 2013-09-20 KR KR1020207019527A patent/KR102307424B1/ko active Active
- 2013-09-20 LT LTEP17202149.5T patent/LT3354747T/lt unknown
- 2013-09-20 EP EP24153604.4A patent/EP4335929A3/en active Pending
- 2013-09-20 SM SM20210256T patent/SMT202100256T1/it unknown
- 2013-09-20 DK DK13838770.9T patent/DK2898100T4/da active
- 2013-09-20 KR KR1020237033920A patent/KR20230145530A/ko not_active Ceased
- 2013-09-20 ES ES17202149T patent/ES2862726T3/es active Active
- 2013-09-20 PH PH1/2022/552061A patent/PH12022552061A1/en unknown
- 2013-09-20 PL PL19171630.7T patent/PL3536807T3/pl unknown
- 2013-09-20 PT PT172021495T patent/PT3354747T/pt unknown
- 2013-09-20 CA CA3122779A patent/CA3122779A1/en active Pending
- 2013-09-20 DK DK19171630.7T patent/DK3536807T3/da active
- 2013-09-20 PT PT221714272T patent/PT4056712T/pt unknown
- 2013-09-20 MY MYPI2018000607A patent/MY187444A/en unknown
- 2013-09-20 IL IL299444A patent/IL299444B2/en unknown
- 2013-09-20 CN CN201380058654.3A patent/CN104781422B/zh active Active
- 2013-09-20 AU AU2013317708A patent/AU2013317708C1/en active Active
- 2013-09-20 ES ES22171427T patent/ES2994426T3/es active Active
- 2013-09-20 PT PT191716307T patent/PT3536807T/pt unknown
- 2013-09-20 DK DK17202149.5T patent/DK3354747T3/da active
- 2013-09-20 EA EA201500327A patent/EA201500327A1/ru unknown
- 2013-09-20 KR KR1020157010184A patent/KR102148547B1/ko active Active
- 2013-09-20 HU HUE19171630A patent/HUE066054T2/hu unknown
- 2013-09-20 NZ NZ717423A patent/NZ717423A/en unknown
- 2013-09-20 PT PT138387709T patent/PT2898100T/pt unknown
- 2013-09-20 PL PL22171427.2T patent/PL4056712T3/pl unknown
- 2013-09-20 EP EP13838770.9A patent/EP2898100B9/en active Active
- 2013-09-20 HU HUE22171427A patent/HUE068129T2/hu unknown
- 2013-09-20 NZ NZ706269A patent/NZ706269A/en unknown
- 2013-09-20 EP EP17202149.5A patent/EP3354747B1/en not_active Revoked
- 2013-09-20 BR BR122021021825-0A patent/BR122021021825B1/pt active IP Right Grant
- 2013-09-20 EP EP19171630.7A patent/EP3536807B1/en active Active
- 2013-09-23 TW TW107123815A patent/TWI707953B/zh active
- 2013-09-23 TW TW109112451A patent/TWI784258B/zh active
- 2013-09-23 TW TW111119079A patent/TWI806621B/zh active
- 2013-09-23 TW TW102134227A patent/TWI640634B/zh active
-
2015
- 2015-03-02 IL IL237495A patent/IL237495B/en active IP Right Grant
- 2015-03-16 ZA ZA2015/01772A patent/ZA201501772B/en unknown
-
2017
- 2017-10-27 AU AU2017251832A patent/AU2017251832B2/en active Active
-
2018
- 2018-03-28 JP JP2018061744A patent/JP6683752B2/ja active Active
-
2019
- 2019-08-05 IL IL268512A patent/IL268512B2/en unknown
-
2020
- 2020-01-08 AU AU2020200128A patent/AU2020200128B2/en active Active
- 2020-03-26 JP JP2020055387A patent/JP6985753B2/ja active Active
-
2021
- 2021-05-07 HR HRP20210716TT patent/HRP20210716T1/hr unknown
- 2021-05-14 CY CY20211100417T patent/CY1124139T1/el unknown
- 2021-11-18 JP JP2021188060A patent/JP2022031753A/ja active Pending
-
2022
- 2022-02-16 AU AU2022201026A patent/AU2022201026B2/en active Active
-
2023
- 2023-09-28 JP JP2023167714A patent/JP7594817B2/ja active Active
-
2024
- 2024-11-18 JP JP2024200780A patent/JP2025026936A/ja active Pending
-
2025
- 2025-07-03 AU AU2025205087A patent/AU2025205087A1/en active Pending
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| IL268512A (en) | Non-invasive determination of fetal or tumor methylation from plasma | |
| IL288181A (en) | Cancer treatment methods | |
| IL232530A0 (en) | Combined cancer treatment | |
| ZA201307036B (en) | Treatment of solid tumours | |
| IL228430A0 (en) | Cancer treatment | |
| EP2903644A4 (en) | TREATMENT OF CANCER | |
| GB201217892D0 (en) | Treatment of cancer | |
| SI2892925T1 (sl) | Kombinacijsko zdravljenje raka | |
| GB201217890D0 (en) | Treatment of cancer | |
| GB201222952D0 (en) | Treatent of cancer | |
| GB201208296D0 (en) | Treatment of cancer | |
| GB201222949D0 (en) | Combination Treatment of Cancer | |
| GB201222950D0 (en) | Combination treatment of cancer | |
| IL229109A0 (en) | Cancer diagnosis | |
| GB201121791D0 (en) | Combination treatment of cancer | |
| GB201121783D0 (en) | Treatment of cancer | |
| ZA201104679B (en) | Suppression of cancers |