AU2013317708C1 - Non-invasive determination of methylome of fetus or tumor from plasma - Google Patents

Non-invasive determination of methylome of fetus or tumor from plasma Download PDF

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Publication number
AU2013317708C1
AU2013317708C1 AU2013317708A AU2013317708A AU2013317708C1 AU 2013317708 C1 AU2013317708 C1 AU 2013317708C1 AU 2013317708 A AU2013317708 A AU 2013317708A AU 2013317708 A AU2013317708 A AU 2013317708A AU 2013317708 C1 AU2013317708 C1 AU 2013317708C1
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methylation
dna
plasma
region
regions
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AU2013317708B2 (en
AU2013317708A1 (en
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Kwan Chee Chan
Wai Man Chan
Rossa Wai Kwun Chiu
Peiyong Jiang
Yuk-Ming Dennis Lo
Miu Fan Lun
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Chinese University of Hong Kong CUHK
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Chinese University of Hong Kong CUHK
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Priority claimed from US13/842,209 external-priority patent/US9732390B2/en
Application filed by Chinese University of Hong Kong CUHK filed Critical Chinese University of Hong Kong CUHK
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Priority to AU2017251832A priority Critical patent/AU2017251832B2/en
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Priority to AU2020200128A priority patent/AU2020200128B2/en
Priority to AU2022201026A priority patent/AU2022201026B2/en
Priority to AU2025205087A priority patent/AU2025205087A1/en
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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6881—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for tissue or cell typing, e.g. human leukocyte antigen [HLA] probes
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    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6869—Methods for sequencing
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    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
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    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B20/00—ICT specially adapted for functional genomics or proteomics, e.g. genotype-phenotype associations
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2523/00—Reactions characterised by treatment of reaction samples
    • C12Q2523/10—Characterised by chemical treatment
    • C12Q2523/125—Bisulfite(s)
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    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2535/00—Reactions characterised by the assay type for determining the identity of a nucleotide base or a sequence of oligonucleotides
    • C12Q2535/122—Massive parallel sequencing
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    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/112—Disease subtyping, staging or classification
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    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/154—Methylation markers

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  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
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  • Engineering & Computer Science (AREA)
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  • Hospice & Palliative Care (AREA)
  • Oncology (AREA)
  • Cell Biology (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Evolutionary Biology (AREA)
  • Medical Informatics (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Theoretical Computer Science (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Ultra Sonic Daignosis Equipment (AREA)
AU2013317708A 2012-09-20 2013-09-20 Non-invasive determination of methylome of fetus or tumor from plasma Active AU2013317708C1 (en)

Priority Applications (4)

Application Number Priority Date Filing Date Title
AU2017251832A AU2017251832B2 (en) 2012-09-20 2017-10-27 Non-invasive determination of methylome of fetus or tumor from plasma
AU2020200128A AU2020200128B2 (en) 2012-09-20 2020-01-08 Non-invasive determination of methylome of fetus or tumor from plasma
AU2022201026A AU2022201026B2 (en) 2012-09-20 2022-02-16 Non-invasive determination of methylome of fetus or tumor from plasma
AU2025205087A AU2025205087A1 (en) 2012-09-20 2025-07-03 Non-invasive determination of methylome of fetus or tumor from plasma

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US201261703512P 2012-09-20 2012-09-20
US61/703,512 2012-09-20
US13/842,209 2013-03-15
US13/842,209 US9732390B2 (en) 2012-09-20 2013-03-15 Non-invasive determination of methylome of fetus or tumor from plasma
US201361830571P 2013-06-03 2013-06-03
US61/830,571 2013-06-03
PCT/AU2013/001088 WO2014043763A1 (en) 2012-09-20 2013-09-20 Non-invasive determination of methylome of fetus or tumor from plasma

Related Child Applications (1)

Application Number Title Priority Date Filing Date
AU2017251832A Division AU2017251832B2 (en) 2012-09-20 2017-10-27 Non-invasive determination of methylome of fetus or tumor from plasma

Publications (3)

Publication Number Publication Date
AU2013317708A1 AU2013317708A1 (en) 2015-04-09
AU2013317708B2 AU2013317708B2 (en) 2017-08-03
AU2013317708C1 true AU2013317708C1 (en) 2017-11-23

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AU2013317708A Active AU2013317708C1 (en) 2012-09-20 2013-09-20 Non-invasive determination of methylome of fetus or tumor from plasma
AU2017251832A Active AU2017251832B2 (en) 2012-09-20 2017-10-27 Non-invasive determination of methylome of fetus or tumor from plasma
AU2020200128A Active AU2020200128B2 (en) 2012-09-20 2020-01-08 Non-invasive determination of methylome of fetus or tumor from plasma
AU2022201026A Active AU2022201026B2 (en) 2012-09-20 2022-02-16 Non-invasive determination of methylome of fetus or tumor from plasma
AU2025205087A Pending AU2025205087A1 (en) 2012-09-20 2025-07-03 Non-invasive determination of methylome of fetus or tumor from plasma

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AU2017251832A Active AU2017251832B2 (en) 2012-09-20 2017-10-27 Non-invasive determination of methylome of fetus or tumor from plasma
AU2020200128A Active AU2020200128B2 (en) 2012-09-20 2020-01-08 Non-invasive determination of methylome of fetus or tumor from plasma
AU2022201026A Active AU2022201026B2 (en) 2012-09-20 2022-02-16 Non-invasive determination of methylome of fetus or tumor from plasma
AU2025205087A Pending AU2025205087A1 (en) 2012-09-20 2025-07-03 Non-invasive determination of methylome of fetus or tumor from plasma

Country Status (28)

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EP (6) EP4056712B1 (enExample)
JP (6) JP6317354B2 (enExample)
KR (5) KR102587176B1 (enExample)
CN (2) CN117757932A (enExample)
AU (5) AU2013317708C1 (enExample)
BR (3) BR112015006183B1 (enExample)
CA (2) CA2884066C (enExample)
CY (1) CY1124139T1 (enExample)
DK (4) DK4056712T3 (enExample)
EA (1) EA201500327A1 (enExample)
ES (4) ES2969567T3 (enExample)
FI (2) FI4056712T3 (enExample)
HR (3) HRP20241142T1 (enExample)
HU (3) HUE053822T2 (enExample)
IL (4) IL313451A (enExample)
LT (2) LT4056712T (enExample)
MX (1) MX360034B (enExample)
MY (2) MY173356A (enExample)
NZ (2) NZ717423A (enExample)
PH (2) PH12015500547B1 (enExample)
PL (4) PL3354747T3 (enExample)
PT (4) PT3354747T (enExample)
SG (2) SG11201501927VA (enExample)
SI (1) SI4056712T1 (enExample)
SM (1) SMT202100256T1 (enExample)
TW (4) TWI707953B (enExample)
WO (1) WO2014043763A1 (enExample)
ZA (1) ZA201501772B (enExample)

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