KR102307424B1 - 혈장으로부터 태아 또는 종양 메틸롬의 비침습적 결정 - Google Patents
혈장으로부터 태아 또는 종양 메틸롬의 비침습적 결정 Download PDFInfo
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- KR102307424B1 KR102307424B1 KR1020207019527A KR20207019527A KR102307424B1 KR 102307424 B1 KR102307424 B1 KR 102307424B1 KR 1020207019527 A KR1020207019527 A KR 1020207019527A KR 20207019527 A KR20207019527 A KR 20207019527A KR 102307424 B1 KR102307424 B1 KR 102307424B1
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- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
- C12Q1/6881—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for tissue or cell typing, e.g. human leukocyte antigen [HLA] probes
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- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
- C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
- C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
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- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6869—Methods for sequencing
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- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
- C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
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- G—PHYSICS
- G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
- G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
- G16B20/00—ICT specially adapted for functional genomics or proteomics, e.g. genotype-phenotype associations
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- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2523/00—Reactions characterised by treatment of reaction samples
- C12Q2523/10—Characterised by chemical treatment
- C12Q2523/125—Bisulfite(s)
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- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2535/00—Reactions characterised by the assay type for determining the identity of a nucleotide base or a sequence of oligonucleotides
- C12Q2535/122—Massive parallel sequencing
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/112—Disease subtyping, staging or classification
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/154—Methylation markers
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- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Analytical Chemistry (AREA)
- Genetics & Genomics (AREA)
- Immunology (AREA)
- Physics & Mathematics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biophysics (AREA)
- General Health & Medical Sciences (AREA)
- Biotechnology (AREA)
- Molecular Biology (AREA)
- General Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Microbiology (AREA)
- Pathology (AREA)
- Hospice & Palliative Care (AREA)
- Oncology (AREA)
- Cell Biology (AREA)
- Bioinformatics & Computational Biology (AREA)
- Evolutionary Biology (AREA)
- Medical Informatics (AREA)
- Spectroscopy & Molecular Physics (AREA)
- Theoretical Computer Science (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Apparatus Associated With Microorganisms And Enzymes (AREA)
- Ultra Sonic Daignosis Equipment (AREA)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| KR1020217030373A KR102390711B1 (ko) | 2012-09-20 | 2013-09-20 | 혈장으로부터 태아 또는 종양 메틸롬의 비침습적 결정 |
Applications Claiming Priority (8)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261703512P | 2012-09-20 | 2012-09-20 | |
| US61/703,512 | 2012-09-20 | ||
| US13/842,209 US9732390B2 (en) | 2012-09-20 | 2013-03-15 | Non-invasive determination of methylome of fetus or tumor from plasma |
| US13/842,209 | 2013-03-15 | ||
| US201361830571P | 2013-06-03 | 2013-06-03 | |
| US61/830,571 | 2013-06-03 | ||
| PCT/AU2013/001088 WO2014043763A1 (en) | 2012-09-20 | 2013-09-20 | Non-invasive determination of methylome of fetus or tumor from plasma |
| KR1020157010184A KR102148547B1 (ko) | 2012-09-20 | 2013-09-20 | 혈장으로부터 태아 또는 종양 메틸롬의 비침습적 결정 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR1020157010184A Division KR102148547B1 (ko) | 2012-09-20 | 2013-09-20 | 혈장으로부터 태아 또는 종양 메틸롬의 비침습적 결정 |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR1020217030373A Division KR102390711B1 (ko) | 2012-09-20 | 2013-09-20 | 혈장으로부터 태아 또는 종양 메틸롬의 비침습적 결정 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| KR20200085928A KR20200085928A (ko) | 2020-07-15 |
| KR102307424B1 true KR102307424B1 (ko) | 2021-09-29 |
Family
ID=50340462
Family Applications (5)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR1020227013227A Active KR102587176B1 (ko) | 2012-09-20 | 2013-09-20 | 혈장으로부터 태아 또는 종양 메틸롬의 비침습적 결정 |
| KR1020237033920A Ceased KR20230145530A (ko) | 2012-09-20 | 2013-09-20 | 혈장으로부터 태아 또는 종양 메틸롬의 비침습적 결정 |
| KR1020217030373A Active KR102390711B1 (ko) | 2012-09-20 | 2013-09-20 | 혈장으로부터 태아 또는 종양 메틸롬의 비침습적 결정 |
| KR1020157010184A Active KR102148547B1 (ko) | 2012-09-20 | 2013-09-20 | 혈장으로부터 태아 또는 종양 메틸롬의 비침습적 결정 |
| KR1020207019527A Active KR102307424B1 (ko) | 2012-09-20 | 2013-09-20 | 혈장으로부터 태아 또는 종양 메틸롬의 비침습적 결정 |
Family Applications Before (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR1020227013227A Active KR102587176B1 (ko) | 2012-09-20 | 2013-09-20 | 혈장으로부터 태아 또는 종양 메틸롬의 비침습적 결정 |
| KR1020237033920A Ceased KR20230145530A (ko) | 2012-09-20 | 2013-09-20 | 혈장으로부터 태아 또는 종양 메틸롬의 비침습적 결정 |
| KR1020217030373A Active KR102390711B1 (ko) | 2012-09-20 | 2013-09-20 | 혈장으로부터 태아 또는 종양 메틸롬의 비침습적 결정 |
| KR1020157010184A Active KR102148547B1 (ko) | 2012-09-20 | 2013-09-20 | 혈장으로부터 태아 또는 종양 메틸롬의 비침습적 결정 |
Country Status (28)
| Country | Link |
|---|---|
| EP (6) | EP3839065A1 (enExample) |
| JP (6) | JP6317354B2 (enExample) |
| KR (5) | KR102587176B1 (enExample) |
| CN (2) | CN104781422B (enExample) |
| AU (5) | AU2013317708C1 (enExample) |
| BR (3) | BR112015006183B1 (enExample) |
| CA (2) | CA2884066C (enExample) |
| CY (1) | CY1124139T1 (enExample) |
| DK (4) | DK3536807T3 (enExample) |
| EA (1) | EA201500327A1 (enExample) |
| ES (4) | ES2994426T3 (enExample) |
| FI (2) | FI4056712T3 (enExample) |
| HR (3) | HRP20240210T1 (enExample) |
| HU (3) | HUE068129T2 (enExample) |
| IL (4) | IL299444B2 (enExample) |
| LT (2) | LT3354747T (enExample) |
| MX (1) | MX360034B (enExample) |
| MY (2) | MY173356A (enExample) |
| NZ (2) | NZ717423A (enExample) |
| PH (2) | PH12015500547B1 (enExample) |
| PL (4) | PL2898100T5 (enExample) |
| PT (4) | PT3536807T (enExample) |
| SG (2) | SG10201705198UA (enExample) |
| SI (1) | SI4056712T1 (enExample) |
| SM (1) | SMT202100256T1 (enExample) |
| TW (4) | TWI806621B (enExample) |
| WO (1) | WO2014043763A1 (enExample) |
| ZA (1) | ZA201501772B (enExample) |
Families Citing this family (94)
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| TWI335354B (en) | 2006-09-27 | 2011-01-01 | Univ Hong Kong Chinese | Methods for the detection of the degree of the methylation of a target dna and kits |
| US9892230B2 (en) | 2012-03-08 | 2018-02-13 | The Chinese University Of Hong Kong | Size-based analysis of fetal or tumor DNA fraction in plasma |
| US9732390B2 (en) | 2012-09-20 | 2017-08-15 | The Chinese University Of Hong Kong | Non-invasive determination of methylome of fetus or tumor from plasma |
| WO2014043763A1 (en) * | 2012-09-20 | 2014-03-27 | The Chinese University Of Hong Kong | Non-invasive determination of methylome of fetus or tumor from plasma |
| US10706957B2 (en) | 2012-09-20 | 2020-07-07 | The Chinese University Of Hong Kong | Non-invasive determination of methylome of tumor from plasma |
| US20130309666A1 (en) | 2013-01-25 | 2013-11-21 | Sequenom, Inc. | Methods and processes for non-invasive assessment of genetic variations |
| ES2685893T3 (es) * | 2013-07-30 | 2018-10-15 | Bgi Genomics Co., Limited | Método para determinar la composición de ácidos nucleicos de una mezcla de ácidos nucleicos |
| US10174375B2 (en) | 2013-09-20 | 2019-01-08 | The Chinese University Of Hong Kong | Sequencing analysis of circulating DNA to detect and monitor autoimmune diseases |
| US12054771B2 (en) * | 2014-02-18 | 2024-08-06 | Bionano Genomics, Inc. | Methods of determining nucleic acid structural information |
| AU2015249846B2 (en) * | 2014-04-21 | 2021-07-22 | Natera, Inc. | Detecting mutations and ploidy in chromosomal segments |
| US12492429B2 (en) | 2014-04-21 | 2025-12-09 | Natera, Inc. | Detecting mutations and ploidy in chromosomal segments |
| EP2942400A1 (en) | 2014-05-09 | 2015-11-11 | Lifecodexx AG | Multiplex detection of DNA that originates from a specific cell-type |
| EP3521454A1 (en) | 2014-05-09 | 2019-08-07 | LifeCodexx AG | Detection of dna that originates from a specific cell-type and related methods |
| WO2016010401A1 (ko) * | 2014-07-18 | 2016-01-21 | 에스케이텔레콘 주식회사 | 산모의 혈청 dna를 이용한 태아의 단일유전자 유전변이의 예측방법 |
| TWI727156B (zh) * | 2014-07-18 | 2021-05-11 | 香港中文大學 | Dna混合物中之組織甲基化模式分析 |
| WO2016015058A2 (en) | 2014-07-25 | 2016-01-28 | University Of Washington | Methods of determining tissues and/or cell types giving rise to cell-free dna, and methods of identifying a disease or disorder using same |
| ES3017068T3 (en) * | 2014-12-31 | 2025-05-12 | Guardant Health Inc | Detection and treatment of disease exhibiting disease cell heterogeneity and systems and methods for communicating test results |
| US10364467B2 (en) | 2015-01-13 | 2019-07-30 | The Chinese University Of Hong Kong | Using size and number aberrations in plasma DNA for detecting cancer |
| SG11201706529TA (en) | 2015-02-10 | 2017-09-28 | Univ Hong Kong Chinese | Detecting mutations for cancer screening and fetal analysis |
| EP3325663B1 (en) | 2015-07-20 | 2020-08-19 | The Chinese University Of Hong Kong | Methylation pattern analysis of haplotypes in tissues in dna mixture |
| DK3325664T3 (da) | 2015-07-23 | 2022-03-07 | Univ Hong Kong Chinese | Analyse af fragmenteringsmønstre for cellefrit DNA |
| TWI793586B (zh) | 2015-08-12 | 2023-02-21 | 香港中文大學 | 血漿dna之單分子定序 |
| TWI858334B (zh) | 2015-09-22 | 2024-10-11 | 香港中文大學 | 藉由母體血漿dna之淺深度測序以準確定量胎兒dna含量 |
| US10260088B2 (en) * | 2015-10-30 | 2019-04-16 | New England Biolabs, Inc. | Compositions and methods for analyzing modified nucleotides |
| EP4180532A1 (en) * | 2015-11-09 | 2023-05-17 | Roche Molecular Systems, Inc. | Methods for determining the origin of dna molecules |
| HUE050491T2 (hu) | 2015-11-10 | 2020-12-28 | Eurofins Lifecodexx Gmbh | Magzati kromoszomális aneuploidiák kimutatása olyan DNS régiókat alkalmazva, amelyek különbözõképpen vannak metilezve a magzat és a terhes nõstény között |
| US11319593B2 (en) | 2015-12-17 | 2022-05-03 | Illumina, Inc. | Distinguishing methylation levels in complex biological samples |
| SG11201806609TA (en) * | 2016-02-02 | 2018-09-27 | Guardant Health Inc | Cancer evolution detection and diagnostic |
| US11514289B1 (en) | 2016-03-09 | 2022-11-29 | Freenome Holdings, Inc. | Generating machine learning models using genetic data |
| EP4425178A3 (en) * | 2016-05-03 | 2024-12-18 | University Health Network | Methods of capturing cell-free methylated dna and uses of same |
| US12300356B2 (en) | 2016-05-04 | 2025-05-13 | Queen's University At Kingston | Cell-free detection of methylated tumour DNA |
| IL262953B2 (en) | 2016-05-30 | 2023-11-01 | Univ Hong Kong Chinese | Detection of hematological disorders using cell-free DNA in blood |
| AU2017285496B2 (en) * | 2016-06-16 | 2023-02-23 | The Johns Hopkins University | Methods and system for epigenetic analysis |
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| WO2018072705A1 (en) * | 2016-10-19 | 2018-04-26 | The Chinese University Of Hong Kong | Gestational age assessment by methylation and size profiling of maternal plasma dna |
| TWI797095B (zh) | 2016-10-24 | 2023-04-01 | 美商格瑞爾有限責任公司 | 腫瘤檢測之方法及系統 |
| US11435339B2 (en) | 2016-11-30 | 2022-09-06 | The Chinese University Of Hong Kong | Analysis of cell-free DNA in urine |
| EP3555311B1 (en) * | 2016-12-13 | 2024-06-26 | Bellwether Bio, Inc. | Determining a physiological condition in an individual by analyzing cell-free dna fragment endpoints in a biological sample |
| US20200255896A1 (en) * | 2017-01-11 | 2020-08-13 | Quest Diagnostics Investments Llc | Method for non-invasive prenatal screening for aneuploidy |
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