EA201500327A1 - Неинвазивное определение метилома плода или опухоли по плазме - Google Patents

Неинвазивное определение метилома плода или опухоли по плазме

Info

Publication number
EA201500327A1
EA201500327A1 EA201500327A EA201500327A EA201500327A1 EA 201500327 A1 EA201500327 A1 EA 201500327A1 EA 201500327 A EA201500327 A EA 201500327A EA 201500327 A EA201500327 A EA 201500327A EA 201500327 A1 EA201500327 A1 EA 201500327A1
Authority
EA
Eurasian Patent Office
Prior art keywords
methylation
fetal
tumor
dna
determined
Prior art date
Application number
EA201500327A
Other languages
English (en)
Russian (ru)
Inventor
Росса Вай Квун Чиу
Кван Чи Чань
Юйк-Мин Деннис Ло
Мю Фань Лунь
Пэйюн Цзян
Вай Мань Чань
Original Assignee
Те Чайниз Юниверсити Ов Гонконг
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=50340462&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=EA201500327(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority claimed from US13/842,209 external-priority patent/US9732390B2/en
Application filed by Те Чайниз Юниверсити Ов Гонконг filed Critical Те Чайниз Юниверсити Ов Гонконг
Publication of EA201500327A1 publication Critical patent/EA201500327A1/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6881—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for tissue or cell typing, e.g. human leukocyte antigen [HLA] probes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6869—Methods for sequencing
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B20/00—ICT specially adapted for functional genomics or proteomics, e.g. genotype-phenotype associations
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2523/00—Reactions characterised by treatment of reaction samples
    • C12Q2523/10—Characterised by chemical treatment
    • C12Q2523/125—Bisulfite(s)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2535/00—Reactions characterised by the assay type for determining the identity of a nucleotide base or a sequence of oligonucleotides
    • C12Q2535/122—Massive parallel sequencing
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/112—Disease subtyping, staging or classification
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/154—Methylation markers

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Analytical Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Immunology (AREA)
  • Physics & Mathematics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Pathology (AREA)
  • Hospice & Palliative Care (AREA)
  • Oncology (AREA)
  • Cell Biology (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Evolutionary Biology (AREA)
  • Medical Informatics (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Theoretical Computer Science (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Ultra Sonic Daignosis Equipment (AREA)
EA201500327A 2012-09-20 2013-09-20 Неинвазивное определение метилома плода или опухоли по плазме EA201500327A1 (ru)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US201261703512P 2012-09-20 2012-09-20
US13/842,209 US9732390B2 (en) 2012-09-20 2013-03-15 Non-invasive determination of methylome of fetus or tumor from plasma
US201361830571P 2013-06-03 2013-06-03
PCT/AU2013/001088 WO2014043763A1 (en) 2012-09-20 2013-09-20 Non-invasive determination of methylome of fetus or tumor from plasma

Publications (1)

Publication Number Publication Date
EA201500327A1 true EA201500327A1 (ru) 2015-07-30

Family

ID=50340462

Family Applications (1)

Application Number Title Priority Date Filing Date
EA201500327A EA201500327A1 (ru) 2012-09-20 2013-09-20 Неинвазивное определение метилома плода или опухоли по плазме

Country Status (28)

Country Link
EP (6) EP3536807B1 (enExample)
JP (6) JP6317354B2 (enExample)
KR (5) KR102390711B1 (enExample)
CN (2) CN117757932A (enExample)
AU (5) AU2013317708C1 (enExample)
BR (3) BR112015006183B1 (enExample)
CA (2) CA2884066C (enExample)
CY (1) CY1124139T1 (enExample)
DK (4) DK3536807T3 (enExample)
EA (1) EA201500327A1 (enExample)
ES (4) ES2862726T3 (enExample)
FI (2) FI3536807T3 (enExample)
HR (3) HRP20240210T1 (enExample)
HU (3) HUE053822T2 (enExample)
IL (4) IL299444B2 (enExample)
LT (2) LT3354747T (enExample)
MX (1) MX360034B (enExample)
MY (2) MY187444A (enExample)
NZ (2) NZ717423A (enExample)
PH (2) PH12022552061A1 (enExample)
PL (4) PL3536807T3 (enExample)
PT (4) PT3354747T (enExample)
SG (2) SG11201501927VA (enExample)
SI (1) SI4056712T1 (enExample)
SM (1) SMT202100256T1 (enExample)
TW (4) TWI806621B (enExample)
WO (1) WO2014043763A1 (enExample)
ZA (1) ZA201501772B (enExample)

Families Citing this family (94)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101153336B (zh) 2006-09-27 2011-09-07 香港中文大学 检测dna甲基化程度的方法和试剂盒
US9892230B2 (en) 2012-03-08 2018-02-13 The Chinese University Of Hong Kong Size-based analysis of fetal or tumor DNA fraction in plasma
US9732390B2 (en) 2012-09-20 2017-08-15 The Chinese University Of Hong Kong Non-invasive determination of methylome of fetus or tumor from plasma
BR112015006183B1 (pt) 2012-09-20 2022-04-26 The Chinese University Of Hong Kong Métodos para analisar uma amostra biológica de um organismo, para determinar um primeiro perfil de metilação de uma amostra biológica de um organismo, para detecção de uma anormalidade cromossômica de uma amostra biológica de um organismo e para estimar um nível de metilação do dna em uma amostra biológica de um organismo, produto de computador, e, kit para análise de dna fetal
US10706957B2 (en) 2012-09-20 2020-07-07 The Chinese University Of Hong Kong Non-invasive determination of methylome of tumor from plasma
US20130309666A1 (en) 2013-01-25 2013-11-21 Sequenom, Inc. Methods and processes for non-invasive assessment of genetic variations
WO2015013885A1 (zh) * 2013-07-30 2015-02-05 深圳华大基因科技有限公司 确定核酸混合物中核酸组成的方法
US10174375B2 (en) 2013-09-20 2019-01-08 The Chinese University Of Hong Kong Sequencing analysis of circulating DNA to detect and monitor autoimmune diseases
WO2015126840A1 (en) * 2014-02-18 2015-08-27 Bionano Genomics, Inc. Improved methods of determining nucleic acid structural information
EP3561075A1 (en) * 2014-04-21 2019-10-30 Natera, Inc. Detecting mutations in tumour biopsies and cell-free samples
US12492429B2 (en) 2014-04-21 2025-12-09 Natera, Inc. Detecting mutations and ploidy in chromosomal segments
EP2942400A1 (en) 2014-05-09 2015-11-11 Lifecodexx AG Multiplex detection of DNA that originates from a specific cell-type
CA2985134A1 (en) 2014-05-09 2015-11-12 Sebastian Gromminger Detection of dna that originates from a specific cell-type and related methods
TWI727156B (zh) * 2014-07-18 2021-05-11 香港中文大學 Ｄｎａ混合物中之組織甲基化模式分析
WO2016010401A1 (ko) * 2014-07-18 2016-01-21 에스케이텔레콘 주식회사 산모의 혈청 dna를 이용한 태아의 단일유전자 유전변이의 예측방법
EP4358097A1 (en) 2014-07-25 2024-04-24 University of Washington Methods of determining tissues and/or cell types giving rise to cell-free dna, and methods of identifying a disease or disorder using same
EP4574996B1 (en) 2014-12-31 2025-11-05 Guardant Health, Inc. Detection and treatment of disease exhibiting disease cell heterogeneity and systems and methods for communicating test results
US10364467B2 (en) * 2015-01-13 2019-07-30 The Chinese University Of Hong Kong Using size and number aberrations in plasma DNA for detecting cancer
ES2908347T3 (es) 2015-02-10 2022-04-28 Univ Hong Kong Chinese Detección de mutaciones para cribado de cáncer y análisis fetal
WO2017012544A1 (en) * 2015-07-20 2017-01-26 The Chinese University Of Hong Kong Methylation pattern analysis of haplotypes in tissues in dna mixture
EP4279612B1 (en) * 2015-07-23 2025-07-02 The Chinese University of Hong Kong Analysis of fragmentation patterns of cell-free dna
CA2995422A1 (en) 2015-08-12 2017-02-16 The Chinese University Of Hong Kong Single-molecule sequencing of plasma dna
CN108026576B (zh) 2015-09-22 2022-06-28 香港中文大学 通过母亲血浆dna的浅深度测序准确定量胎儿dna分数
US10260088B2 (en) * 2015-10-30 2019-04-16 New England Biolabs, Inc. Compositions and methods for analyzing modified nucleotides
CN108368548A (zh) * 2015-11-09 2018-08-03 普罗格尼迪公司 用于确定dna分子的来源的方法
EP3168309B8 (en) 2015-11-10 2020-06-03 Eurofins LifeCodexx GmbH Detection of foetal chromosomal aneuploidies using dna regions that are differentially methylated between the foetus and the pregnant female
AU2016370835B2 (en) 2015-12-17 2020-02-13 Illumina, Inc. Distinguishing methylation levels in complex biological samples
CN116640847A (zh) * 2016-02-02 2023-08-25 夸登特健康公司 癌症进化检测和诊断
US11514289B1 (en) 2016-03-09 2022-11-29 Freenome Holdings, Inc. Generating machine learning models using genetic data
EP4425178A3 (en) 2016-05-03 2024-12-18 University Health Network Methods of capturing cell-free methylated dna and uses of same
WO2017201606A1 (en) * 2016-05-04 2017-11-30 Queen's University At Kingston Cell-free detection of methylated tumour dna
SG11201810544WA (en) 2016-05-30 2018-12-28 Univ Hong Kong Chinese Detecting hematological disorders using cell-free dna in blood
WO2017218908A2 (en) * 2016-06-16 2017-12-21 The Johns Hopkins University Methods and system for epigenetic analysis
US11999998B2 (en) 2016-08-24 2024-06-04 Center For Excellence In Molecular Cell Science, Chinese Academy Of Sciences Modification of 5-methylcytosine catalyzed by Cmd1 enzyme and application thereof
EP3529377B1 (en) 2016-10-19 2023-04-05 The Chinese University Of Hong Kong Gestational age assessment by methylation and size profiling of maternal plasma dna
WO2018081130A1 (en) 2016-10-24 2018-05-03 The Chinese University Of Hong Kong Methods and systems for tumor detection
JP2020503003A (ja) * 2016-11-30 2020-01-30 ザ チャイニーズ ユニバーシティ オブ ホンコン 尿および他のサンプルにおける無細胞ｄｎａの分析
WO2018112100A2 (en) * 2016-12-13 2018-06-21 Bellwether Bio, Inc. Determining a physiological condition in an individual by analyzing cell-free dna fragment endpoints in a biological sample
BR112019014208A2 (pt) * 2017-01-11 2020-03-17 Quest Diagnostics Investments Llc Métodos para detectar diagnóstico falso-positivo de aneuploidia cromossômica em um feto e para detectar diagnóstico aneuploidiadiagnóstico de aneuploidia cromossômica falso-positiva em um feto.
PL3575407T3 (pl) * 2017-01-24 2024-07-29 Bgi Genomics Co., Ltd. Sposób oznaczania udziału frakcji bezkomórkowych kwasów nukleinowych z wcześniej określonego źródła w próbce biologicznej
AU2018212272B2 (en) 2017-01-25 2022-04-28 Grail, Inc. Diagnostic applications using nucleic acid fragments
CN107247873B (zh) * 2017-03-29 2020-04-14 电子科技大学 一种差异甲基化位点识别方法
CN111417731A (zh) * 2017-05-12 2020-07-14 哈佛学院校长同事会 通用早期癌症诊断
US12031184B2 (en) 2017-07-12 2024-07-09 University Health Network Cancer detection and classification using methylome analysis
US12227737B2 (en) 2017-07-12 2025-02-18 University Health Network Cancer detection and classification using methylome analysis
CN118782138A (zh) * 2017-07-12 2024-10-15 安德股份有限公司 模式识别系统
CN111051536A (zh) 2017-07-26 2020-04-21 香港中文大学 利用不含细胞的病毒核酸改善癌症筛选
WO2019055819A1 (en) 2017-09-14 2019-03-21 Grail, Inc. METHODS FOR PREPARING A SEQUENCING LIBRARY FROM SINGLE STRANDED DNA
US11851650B2 (en) 2017-09-28 2023-12-26 Grail, Llc Enrichment of short nucleic acid fragments in sequencing library preparation
US11168356B2 (en) * 2017-11-02 2021-11-09 The Chinese University Of Hong Kong Using nucleic acid size range for noninvasive cancer detection
TW202434742A (zh) 2018-03-13 2024-09-01 美商格瑞爾有限責任公司 異常片段偵測及分類
KR20210023804A (ko) * 2018-03-15 2021-03-04 그레일, 인코포레이티드. 조직 특이적 메틸화 마커
CN119753091A (zh) 2018-04-02 2025-04-04 格里尔公司 用于扩增与癌症相关联的cfDNA分子的化验板
AU2019253118B2 (en) * 2018-04-13 2024-02-22 Freenome Holdings, Inc. Machine learning implementation for multi-analyte assay of biological samples
EP3781709A4 (en) * 2018-04-16 2022-11-30 Grail, LLC Systems and methods for determining tumor fraction in cell-free nucleic acid
WO2019209884A1 (en) 2018-04-23 2019-10-31 Grail, Inc. Methods and systems for screening for conditions
US11932899B2 (en) * 2018-06-07 2024-03-19 10X Genomics, Inc. Methods and systems for characterizing nucleic acid molecules
CN109448789A (zh) * 2018-09-17 2019-03-08 上海派森诺生物科技股份有限公司 一种基于perl语言的种群特异SNP位点的自动化分析方法
WO2020069350A1 (en) 2018-09-27 2020-04-02 Grail, Inc. Methylation markers and targeted methylation probe panel
CN109295230A (zh) * 2018-10-24 2019-02-01 福建翊善生物科技有限公司 一种基于ctDNA的多基因联合突变检测评估肿瘤动态变化的方法
CN114901818B (zh) 2018-11-21 2025-01-10 安捷伦科技有限公司 靶向核酸文库形成的方法
ES2968457T3 (es) * 2018-12-19 2024-05-09 Univ Hong Kong Chinese Características de los extremos del ADN extracelular circulante
US12234514B2 (en) 2018-12-21 2025-02-25 Grail, Inc. Source of origin deconvolution based on methylation fragments in cell-free DNA samples
WO2020163410A1 (en) 2019-02-05 2020-08-13 Grail, Inc. Detecting cancer, cancer tissue of origin, and/or a cancer cell type
EP4485464A3 (en) 2019-02-05 2025-02-19 Grail, Inc. Detecting cancer, cancer tissue of origin, and/or a cancer cell type
TWI874374B (zh) 2019-03-25 2025-03-01 香港中文大學 確定循環核酸之線性及環狀形式
US11773450B2 (en) 2019-04-03 2023-10-03 Grail, Llc Methylation-based false positive duplicate marking reduction
US20220243263A1 (en) * 2019-05-03 2022-08-04 Cornell University Markers for identifying and quantifying of nucleic acid sequence mutation, expression, splice variant, translocation, copy number, or methylation changes
CA3147613A1 (en) * 2019-08-19 2021-02-25 Chang-Seok Ki Method for detecting chromosomal abnormality by using information about distance between nucleic acid fragments
KR102452413B1 (ko) * 2019-08-19 2022-10-11 주식회사 지씨지놈 핵산 단편간 거리 정보를 이용한 염색체 이상 검출 방법
GB201915469D0 (en) 2019-10-24 2019-12-11 Univ London Cancer detection methods
EP4066245A1 (en) * 2019-11-27 2022-10-05 Grail, LLC Systems and methods for evaluating longitudinal biological feature data
EP4534690A3 (en) 2020-01-31 2025-07-23 Agilent Technologies, Inc. Systems and methods for targeted nucleic acid capture
US20210247378A1 (en) * 2020-02-10 2021-08-12 Palogen, Inc. Nanopore device and methods of detecting and classifying charged particles using same
US11211147B2 (en) 2020-02-18 2021-12-28 Tempus Labs, Inc. Estimation of circulating tumor fraction using off-target reads of targeted-panel sequencing
US11475981B2 (en) 2020-02-18 2022-10-18 Tempus Labs, Inc. Methods and systems for dynamic variant thresholding in a liquid biopsy assay
US11211144B2 (en) 2020-02-18 2021-12-28 Tempus Labs, Inc. Methods and systems for refining copy number variation in a liquid biopsy assay
US20210292845A1 (en) * 2020-02-28 2021-09-23 Grail, Inc. Identifying methylation patterns that discriminate or indicate a cancer condition
CN112662764A (zh) * 2020-03-17 2021-04-16 博尔诚（北京）科技有限公司 一种检测11种癌症的探针组合物
RU2738675C1 (ru) * 2020-07-28 2020-12-15 Федеральное государственное автономное образовательное учреждение высшего образования "Белгородский государственный национальный исследовательский университет" (НИУ "БелГУ") Способ прогнозирования риска развития преэклампсии у женщин без отягощенного семейного анамнеза с учетом генетических факторов
US20240026453A1 (en) * 2020-11-19 2024-01-25 Nucleix Ltd. Detecting methylation changes in dna samples using restriction enzymes and high throughput sequencing
WO2022133315A1 (en) * 2020-12-17 2022-06-23 President And Fellows Of Harvard College Methods of cancer detection using extraembryonically methylated cpg islands
CN112813148A (zh) * 2021-02-02 2021-05-18 博淼生物科技（北京）有限公司 飞行时间质谱检测5-羟甲基胞嘧啶的方法
EP4409468A4 (en) * 2021-09-28 2025-08-13 Act Genomics Ip Ltd APPARATUS AND METHODS FOR SELECTING METHYLATION BIOMARKERS
KR20230059423A (ko) * 2021-10-26 2023-05-03 주식회사 지씨지놈 메틸화된 무세포 핵산을 이용한 암 진단 및 암 종 예측방법
US20230138633A1 (en) * 2021-11-04 2023-05-04 Universal Diagnostics, S.L. Systems and methods for preparing biological samples for genetic sequencing
WO2023147783A1 (en) 2022-02-07 2023-08-10 Centre For Novostics Limited Fragmentation for measuring methylation and disease
WO2023164017A2 (en) * 2022-02-22 2023-08-31 Flagship Pioneering Innovations Vi, Llc Intra-individual analysis for presence of health conditions
CN115064211B (zh) * 2022-08-15 2023-01-24 臻和(北京)生物科技有限公司 一种基于全基因组甲基化测序的ctDNA预测方法及装置
CN115612723B (zh) * 2022-09-26 2023-07-14 广州女娲生命科技有限公司 植入前胚胎的筛选方法
WO2024203348A1 (ja) * 2023-03-31 2024-10-03 ソニーグループ株式会社 腫瘍の解析方法、腫瘍の解析システム、及び腫瘍の解析データ生成方法
CN118737268A (zh) * 2023-05-04 2024-10-01 杭州圣庭医疗科技有限公司 一种鉴定肿瘤组织来源的试剂盒的数据分析方法
CN117025753A (zh) * 2023-08-15 2023-11-10 广州女娲生命科技有限公司 检测染色体变异的方法和装置
CN117079822B (zh) * 2023-10-17 2024-01-02 北京大学第三医院（北京大学第三临床医学院） 一种妊娠早中期四因子预测胎儿脑损伤的系统

Family Cites Families (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6927028B2 (en) 2001-08-31 2005-08-09 Chinese University Of Hong Kong Non-invasive methods for detecting non-host DNA in a host using epigenetic differences between the host and non-host DNA
ES2253461T3 (es) 2002-03-05 2006-06-01 Epigenomics Ag Procedimiento y dispositivo para la determinacion de la especificidad del tejido y del adn que flota libre en tejidos corporales.
AU2003294315A1 (en) * 2002-11-19 2004-06-15 Amgen Inc. Amplified genes involved in cancer
US20060183128A1 (en) † 2003-08-12 2006-08-17 Epigenomics Ag Methods and compositions for differentiating tissues for cell types using epigenetic markers
DE10348407A1 (de) 2003-10-17 2005-05-19 Widschwendter, Martin, Prof. Prognostische und diagnostische Marker für Zell-proliferative Erkrankungen von Brustgeweben
CA2559209C (en) * 2004-03-08 2016-06-07 Rubicon Genomics, Inc. Methods and compositions for generating and amplifying dna libraries for sensitive detection and analysis of dna methylation
AU2006251937A1 (en) 2005-05-27 2006-11-30 John Wayne Cancer Institute Use of free circulating DNA for diagnosis, prognosis, and treatment of cancer
US7754428B2 (en) * 2006-05-03 2010-07-13 The Chinese University Of Hong Kong Fetal methylation markers
US7901884B2 (en) * 2006-05-03 2011-03-08 The Chinese University Of Hong Kong Markers for prenatal diagnosis and monitoring
CN101153336B (zh) * 2006-09-27 2011-09-07 香港中文大学 检测dna甲基化程度的方法和试剂盒
WO2008155549A2 (en) 2007-06-19 2008-12-24 Oncomethylome Sciences Sa Improved urine sample collecting and processing
KR102458210B1 (ko) 2007-07-23 2022-10-24 더 차이니즈 유니버시티 오브 홍콩 핵산 서열 불균형의 결정
JP4347372B2 (ja) 2007-08-10 2009-10-21 トヨタ自動車株式会社 静電塗装装置
US20110028333A1 (en) * 2009-05-01 2011-02-03 Brown University Diagnosing, prognosing, and early detection of cancers by dna methylation profiling
US8563242B2 (en) * 2009-08-11 2013-10-22 The Chinese University Of Hong Kong Method for detecting chromosomal aneuploidy
CA2775671A1 (en) † 2009-10-02 2011-04-07 Centre For Addiction And Mental Health Method for analysis of dna methylation profiles of cell-free circulating dna in bodily fluids
LT3783110T (lt) * 2009-11-05 2023-01-25 The Chinese University Of Hong Kong Vaisiaus genomo analizė iš motinos biologinio mėginio
US8620593B2 (en) 2009-11-06 2013-12-31 The Chinese University Of Hong Kong Size-based genomic analysis
US10662474B2 (en) † 2010-01-19 2020-05-26 Verinata Health, Inc. Identification of polymorphic sequences in mixtures of genomic DNA by whole genome sequencing
CN102892899A (zh) * 2010-01-26 2013-01-23 Nipd遗传学有限公司 无创产前诊断胎儿非整倍体性的方法和组合物
CA3007805C (en) † 2010-04-29 2019-11-26 The Regents Of The University Of California Pathway recognition algorithm using data integration on genomic models (paradigm)
GB201007944D0 (en) 2010-05-12 2010-06-30 Univ Aberystwyth Methods
EP2576832B1 (en) 2010-05-25 2016-05-04 The Johns Hopkins University Compositions and methods for detecting a neoplasia
WO2012012703A2 (en) * 2010-07-23 2012-01-26 Esoterix Genetic Laboratories, Llc Identification of differentially represented fetal or maternal genomic regions and uses thereof
SG10201505723UA (en) * 2010-07-23 2015-09-29 Harvard College Methods for detecting signatures of disease or conditions in bodily fluids
WO2012031329A1 (en) † 2010-09-10 2012-03-15 Murdoch Childrens Research Institute Assay for detection and monitoring of cancer
EA038374B1 (ru) † 2010-11-30 2021-08-17 Те Чайниз Юниверсити Ов Гонконг Способ анализа биологического образца организма для выявления хромосомных делеций или амплификаций, ассоциированных с раком
BR112015006183B1 (pt) 2012-09-20 2022-04-26 The Chinese University Of Hong Kong Métodos para analisar uma amostra biológica de um organismo, para determinar um primeiro perfil de metilação de uma amostra biológica de um organismo, para detecção de uma anormalidade cromossômica de uma amostra biológica de um organismo e para estimar um nível de metilação do dna em uma amostra biológica de um organismo, produto de computador, e, kit para análise de dna fetal

Also Published As

Publication number Publication date
AU2017251832B2 (en) 2019-10-10
SI4056712T1 (sl) 2024-10-30
EP2898100B2 (en) 2023-05-10
TWI806621B (zh) 2023-06-21
EP2898100B1 (en) 2017-11-22
TWI640634B (zh) 2018-11-11
KR20230145530A (ko) 2023-10-17
AU2025205087A1 (en) 2025-07-24
KR20220065034A (ko) 2022-05-19
TWI707953B (zh) 2020-10-21
HUE053822T2 (hu) 2021-07-28
BR112015006183B1 (pt) 2022-04-26
DK2898100T3 (en) 2018-02-26
PL2898100T3 (pl) 2018-06-29
DK3536807T3 (da) 2024-02-05
ZA201501772B (en) 2016-10-26
PH12015500547B1 (en) 2024-05-17
BR122021021823B1 (pt) 2023-04-25
EP2898100A1 (en) 2015-07-29
JP2018121644A (ja) 2018-08-09
IL268512B2 (en) 2023-06-01
LT3354747T (lt) 2021-04-12
WO2014043763A1 (en) 2014-03-27
JP7594817B2 (ja) 2024-12-05
AU2013317708C1 (en) 2017-11-23
BR122021021825B1 (pt) 2022-05-24
KR102587176B1 (ko) 2023-10-06
HK1257868A1 (en) 2019-11-01
KR102307424B1 (ko) 2021-09-29
LT4056712T (lt) 2024-09-10
JP6317354B2 (ja) 2018-04-25
CN117757932A (zh) 2024-03-26
PT3536807T (pt) 2024-02-01
ES2665273T5 (es) 2023-10-02
PL3536807T3 (pl) 2024-05-06
CN104781422A (zh) 2015-07-15
PT2898100T (pt) 2018-02-26
NZ706269A (en) 2016-08-26
EP3354747A1 (en) 2018-08-01
DK4056712T3 (da) 2024-08-26
PH12022552061A1 (en) 2024-03-11
PT3354747T (pt) 2021-05-07
SG10201705198UA (en) 2017-07-28
CA2884066A1 (en) 2014-03-27
HUE066054T2 (hu) 2024-07-28
ES2994426T3 (en) 2025-01-23
EP3839065A1 (en) 2021-06-23
TW201418474A (zh) 2014-05-16
PL4056712T3 (pl) 2024-12-02
JP6985753B2 (ja) 2021-12-22
CA3122779A1 (en) 2014-03-27
KR20210120124A (ko) 2021-10-06
PH12015500547A1 (en) 2015-05-04
EP4056712B1 (en) 2024-07-31
KR20150082228A (ko) 2015-07-15
FI3536807T3 (fi) 2024-02-01
TW202043483A (zh) 2020-12-01
EP3536807A1 (en) 2019-09-11
IL299444B1 (en) 2024-07-01
ES2969567T3 (es) 2024-05-21
JP2020108400A (ja) 2020-07-16
DK3354747T3 (da) 2021-04-19
HUE068129T2 (hu) 2024-12-28
ES2862726T3 (es) 2021-10-07
JP6683752B2 (ja) 2020-04-22
KR102390711B1 (ko) 2022-04-26
PT4056712T (pt) 2024-08-08
ES2665273T3 (es) 2018-04-25
BR112015006183A2 (pt) 2017-07-04
AU2020200128B2 (en) 2021-11-18
EP4335929A2 (en) 2024-03-13
HK1206797A1 (en) 2016-01-15
AU2022201026B2 (en) 2025-04-03
PL2898100T5 (pl) 2023-11-06
AU2013317708A1 (en) 2015-04-09
TW202334438A (zh) 2023-09-01
IL268512A (en) 2019-09-26
HRP20241142T1 (hr) 2024-11-22
JP2024009833A (ja) 2024-01-23
EP2898100A4 (en) 2016-05-11
KR102148547B1 (ko) 2020-08-26
TWI784258B (zh) 2022-11-21
IL237495B (en) 2019-09-26
KR20200085928A (ko) 2020-07-15
TW201907013A (zh) 2019-02-16
MY173356A (en) 2020-01-21
EP3536807B1 (en) 2023-11-29
IL313451A (en) 2024-08-01
DK2898100T4 (da) 2023-07-24
MY187444A (en) 2021-09-22
SG11201501927VA (en) 2015-04-29
PL3354747T3 (pl) 2021-07-26
CN104781422B (zh) 2023-12-26
FI4056712T3 (fi) 2024-08-29
EP3354747B1 (en) 2021-02-17
HK1207124A1 (en) 2016-01-22
CY1124139T1 (el) 2022-05-27
AU2017251832A1 (en) 2017-11-16
IL299444A (en) 2023-02-01
EP4056712A1 (en) 2022-09-14
MX360034B (es) 2018-10-19
AU2020200128A1 (en) 2020-01-30
SMT202100256T1 (it) 2021-05-07
MX2015003571A (es) 2015-06-22
JP2015536639A (ja) 2015-12-24
IL237495A0 (en) 2015-04-30
NZ717423A (en) 2017-08-25
AU2013317708B2 (en) 2017-08-03
IL299444B2 (en) 2024-11-01
JP2022031753A (ja) 2022-02-22
AU2022201026A1 (en) 2022-03-10
EP2898100B9 (en) 2023-08-02
CA2884066C (en) 2021-08-10
HRP20240210T1 (hr) 2024-05-10
TW202305145A (zh) 2023-02-01
JP2025026936A (ja) 2025-02-26
HRP20210716T1 (hr) 2021-06-11
EP4335929A3 (en) 2024-05-29

Similar Documents

Publication Publication Date Title
EA201500327A1 (ru) Неинвазивное определение метилома плода или опухоли по плазме
Vachon et al. Common breast cancer susceptibility variants in LSP1 and RAD51L1 are associated with mammographic density measures that predict breast cancer risk
WO2013132305A8 (en) Size-based analysis of fetal dna fraction in maternal plasma
WO2015048665A3 (en) Method to estimate the age of tissues and cell types based on epigenetic markers
EP4484572A3 (en) Identification and use of circulating nucleic acid tumor markers
CO7151491A2 (es) Método para la identificación del origen de un cancer de origen primario desconocido
MY205940A (en) Gestational age assessment by methylation and size profiling of maternal plasma dna
MX2017014381A (es) Metodos terapeuticos y diagnosticos para cancer.
EA201500027A1 (ru) Мутационный анализ днк в плазме для детектирования рака
EA201491371A1 (ru) Соединение пиразинкарбоксамида
EP4246144A3 (en) Compositions and methods for screening mutations in thyroid cancer
NZ748624A (en) Methods of selecting an individual who will benefit from treatment with a telomerase inhibitor using a formalin fixed paraffin embedded (ffpe) biological sample of solid tumor cancer cells
AU2015308620A8 (en) Early lung cancer detection by DNA methylation phenotyping of sputum-derived cells
CA2977439C (en) MICRORNA-BASED METHOD FOR EVALUATING THE PROGNOSIS OF A PATIENT WITH PROSTATE CANCER
BR112016024143A2 (pt) tratamento de câncer
PH12020551982A1 (en) Tumor marker, methylation detection reagent, kit and use thereof
BR112015019425A2 (pt) Métodos e kits para identificar e ajustar desvio no sequenciamento de amostras de polinucleotídeos
AU2013231230A8 (en) Method for selecting or identifying a subject for V1B antagonist therapy
MX382589B (es) Determinación no invasiva del metiloma fetal o de tumor de plasma.
WO2016018524A8 (en) E2f4 signature for use in diagnosing and treating breast and bladder cancer
WO2019103421A3 (ko) 유전자의 cpg 메틸화 변화를 이용한 간암의 예후 또는 위험도를 평가하는 방법
BR102015015096A2 (pt) método de detecção in vitro de câncer de tireoide em um paciente, método in vitro de diferenciação entre câncer de tireoide e tecido de tireoide normal ou de lesões benignas de tireoide, uso de um conjunto de genes, método de obtenção de dados para direcionamento do tratamento do cancer de tireoide, kit laboratorial e dispositivo para classificar uma amostra biológica de glândula tireoide como maligna ou benigna
CA2863358A1 (en) Methods and compositions for determining virus susceptibility to non-nucleoside reverse transcriptase inhibitors
RU2014128454A (ru) Способ определения вероятности рецидивирования рака молочной железы
EA201690354A1 (ru) Уровни экспрессии иммуноглобулинов в качестве биологического маркера для реакции на ингибитор протеасом