EA201500327A1 - Неинвазивное определение метилома плода или опухоли по плазме - Google Patents
Неинвазивное определение метилома плода или опухоли по плазмеInfo
- Publication number
- EA201500327A1 EA201500327A1 EA201500327A EA201500327A EA201500327A1 EA 201500327 A1 EA201500327 A1 EA 201500327A1 EA 201500327 A EA201500327 A EA 201500327A EA 201500327 A EA201500327 A EA 201500327A EA 201500327 A1 EA201500327 A1 EA 201500327A1
- Authority
- EA
- Eurasian Patent Office
- Prior art keywords
- methylation
- fetal
- tumor
- dna
- determined
- Prior art date
Links
- 206010028980 Neoplasm Diseases 0.000 title abstract 6
- 230000001605 fetal effect Effects 0.000 title abstract 6
- 230000011987 methylation Effects 0.000 abstract 10
- 238000007069 methylation reaction Methods 0.000 abstract 10
- 238000000034 method Methods 0.000 abstract 2
- 108700028369 Alleles Proteins 0.000 abstract 1
- 201000011510 cancer Diseases 0.000 abstract 1
- 239000012634 fragment Substances 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
- C12Q1/6881—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for tissue or cell typing, e.g. human leukocyte antigen [HLA] probes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6869—Methods for sequencing
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
- C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
- C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
- C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
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- G—PHYSICS
- G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
- G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
- G16B20/00—ICT specially adapted for functional genomics or proteomics, e.g. genotype-phenotype associations
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2523/00—Reactions characterised by treatment of reaction samples
- C12Q2523/10—Characterised by chemical treatment
- C12Q2523/125—Bisulfite(s)
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2535/00—Reactions characterised by the assay type for determining the identity of a nucleotide base or a sequence of oligonucleotides
- C12Q2535/122—Massive parallel sequencing
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/112—Disease subtyping, staging or classification
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/154—Methylation markers
Landscapes
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Analytical Chemistry (AREA)
- Genetics & Genomics (AREA)
- Immunology (AREA)
- Physics & Mathematics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- General Health & Medical Sciences (AREA)
- Biotechnology (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- Microbiology (AREA)
- Pathology (AREA)
- Hospice & Palliative Care (AREA)
- Oncology (AREA)
- Cell Biology (AREA)
- Bioinformatics & Computational Biology (AREA)
- Evolutionary Biology (AREA)
- Medical Informatics (AREA)
- Spectroscopy & Molecular Physics (AREA)
- Theoretical Computer Science (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Apparatus Associated With Microorganisms And Enzymes (AREA)
- Ultra Sonic Daignosis Equipment (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261703512P | 2012-09-20 | 2012-09-20 | |
| US13/842,209 US9732390B2 (en) | 2012-09-20 | 2013-03-15 | Non-invasive determination of methylome of fetus or tumor from plasma |
| US201361830571P | 2013-06-03 | 2013-06-03 | |
| PCT/AU2013/001088 WO2014043763A1 (en) | 2012-09-20 | 2013-09-20 | Non-invasive determination of methylome of fetus or tumor from plasma |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| EA201500327A1 true EA201500327A1 (ru) | 2015-07-30 |
Family
ID=50340462
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| EA201500327A EA201500327A1 (ru) | 2012-09-20 | 2013-09-20 | Неинвазивное определение метилома плода или опухоли по плазме |
Country Status (28)
| Country | Link |
|---|---|
| EP (6) | EP3536807B1 (enExample) |
| JP (6) | JP6317354B2 (enExample) |
| KR (5) | KR102307424B1 (enExample) |
| CN (2) | CN117757932A (enExample) |
| AU (5) | AU2013317708C1 (enExample) |
| BR (3) | BR122021021823B1 (enExample) |
| CA (2) | CA2884066C (enExample) |
| CY (1) | CY1124139T1 (enExample) |
| DK (4) | DK4056712T3 (enExample) |
| EA (1) | EA201500327A1 (enExample) |
| ES (5) | ES3060911T3 (enExample) |
| FI (2) | FI3536807T3 (enExample) |
| HR (3) | HRP20240210T1 (enExample) |
| HU (3) | HUE053822T2 (enExample) |
| IL (4) | IL313451A (enExample) |
| LT (2) | LT3354747T (enExample) |
| MX (1) | MX360034B (enExample) |
| MY (2) | MY187444A (enExample) |
| NZ (2) | NZ717423A (enExample) |
| PH (2) | PH12022552061A1 (enExample) |
| PL (5) | PL4056712T3 (enExample) |
| PT (4) | PT4056712T (enExample) |
| SG (2) | SG11201501927VA (enExample) |
| SI (1) | SI4056712T1 (enExample) |
| SM (1) | SMT202100256T1 (enExample) |
| TW (6) | TWI784258B (enExample) |
| WO (1) | WO2014043763A1 (enExample) |
| ZA (1) | ZA201501772B (enExample) |
Families Citing this family (98)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101153336B (zh) | 2006-09-27 | 2011-09-07 | 香港中文大学 | 检测dna甲基化程度的方法和试剂盒 |
| US9892230B2 (en) | 2012-03-08 | 2018-02-13 | The Chinese University Of Hong Kong | Size-based analysis of fetal or tumor DNA fraction in plasma |
| US10706957B2 (en) | 2012-09-20 | 2020-07-07 | The Chinese University Of Hong Kong | Non-invasive determination of methylome of tumor from plasma |
| HUE053822T2 (hu) | 2012-09-20 | 2021-07-28 | Univ Hong Kong Chinese | Nem invazív módszer daganat metilom meghatározása plazmából |
| US9732390B2 (en) | 2012-09-20 | 2017-08-15 | The Chinese University Of Hong Kong | Non-invasive determination of methylome of fetus or tumor from plasma |
| US20130309666A1 (en) | 2013-01-25 | 2013-11-21 | Sequenom, Inc. | Methods and processes for non-invasive assessment of genetic variations |
| ES2685893T3 (es) * | 2013-07-30 | 2018-10-15 | Bgi Genomics Co., Limited | Método para determinar la composición de ácidos nucleicos de una mezcla de ácidos nucleicos |
| US10174375B2 (en) * | 2013-09-20 | 2019-01-08 | The Chinese University Of Hong Kong | Sequencing analysis of circulating DNA to detect and monitor autoimmune diseases |
| WO2015126840A1 (en) * | 2014-02-18 | 2015-08-27 | Bionano Genomics, Inc. | Improved methods of determining nucleic acid structural information |
| US12492429B2 (en) | 2014-04-21 | 2025-12-09 | Natera, Inc. | Detecting mutations and ploidy in chromosomal segments |
| RU2717641C2 (ru) * | 2014-04-21 | 2020-03-24 | Натера, Инк. | Обнаружение мутаций и плоидности в хромосомных сегментах |
| EP2942400A1 (en) | 2014-05-09 | 2015-11-11 | Lifecodexx AG | Multiplex detection of DNA that originates from a specific cell-type |
| US10801067B2 (en) | 2014-05-09 | 2020-10-13 | Eurofins Lifecodexx Gmbh | Detection of DNA that originates from a specific cell-type and related methods |
| TWI758011B (zh) | 2014-07-18 | 2022-03-11 | 香港中文大學 | Ｄｎａ混合物中之組織甲基化模式分析 |
| WO2016010401A1 (ko) * | 2014-07-18 | 2016-01-21 | 에스케이텔레콘 주식회사 | 산모의 혈청 dna를 이용한 태아의 단일유전자 유전변이의 예측방법 |
| CN107002122B (zh) | 2014-07-25 | 2023-09-19 | 华盛顿大学 | 确定导致无细胞dna的产生的组织和/或细胞类型的方法以及使用其鉴定疾病或紊乱的方法 |
| WO2016109452A1 (en) | 2014-12-31 | 2016-07-07 | Guardant Health , Inc. | Detection and treatment of disease exhibiting disease cell heterogeneity and systems and methods for communicating test results |
| US10364467B2 (en) | 2015-01-13 | 2019-07-30 | The Chinese University Of Hong Kong | Using size and number aberrations in plasma DNA for detecting cancer |
| DK3256605T3 (da) * | 2015-02-10 | 2022-03-14 | Univ Hong Kong Chinese | Påvisning af mutationer til cancerscreening og føtal analyse |
| WO2017012544A1 (en) * | 2015-07-20 | 2017-01-26 | The Chinese University Of Hong Kong | Methylation pattern analysis of haplotypes in tissues in dna mixture |
| US10453556B2 (en) * | 2015-07-23 | 2019-10-22 | The Chinese University Of Hong Kong | Analysis of fragmentation patterns of cell-free DNA |
| US11319586B2 (en) | 2015-08-12 | 2022-05-03 | The Chinese University Of Hong Kong | Single-molecule sequencing of plasma DNA |
| MY199897A (en) | 2015-09-22 | 2023-11-28 | Univ Hong Kong Chinese | Accurate quantification of fetal dna fraction by shallow-depth sequencing of maternal plasma dna |
| US10260088B2 (en) * | 2015-10-30 | 2019-04-16 | New England Biolabs, Inc. | Compositions and methods for analyzing modified nucleotides |
| EP4180532A1 (en) * | 2015-11-09 | 2023-05-17 | Roche Molecular Systems, Inc. | Methods for determining the origin of dna molecules |
| HUE050491T2 (hu) | 2015-11-10 | 2020-12-28 | Eurofins Lifecodexx Gmbh | Magzati kromoszomális aneuploidiák kimutatása olyan DNS régiókat alkalmazva, amelyek különbözõképpen vannak metilezve a magzat és a terhes nõstény között |
| CA3168463A1 (en) * | 2015-12-17 | 2017-06-22 | Illumina, Inc. | Distinguishing methylation levels in complex biological samples |
| EP4779643A2 (en) * | 2016-02-02 | 2026-07-22 | Guardant Health, Inc. | Cancer evolution detection and diagnostic |
| US11514289B1 (en) | 2016-03-09 | 2022-11-29 | Freenome Holdings, Inc. | Generating machine learning models using genetic data |
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| US11078475B2 (en) | 2016-05-03 | 2021-08-03 | Sinai Health System | Methods of capturing cell-free methylated DNA and uses of same |
| CA3023335A1 (en) * | 2016-05-04 | 2017-11-30 | Queen's University At Kingston | Cell-free detection of methylated tumour dna |
| CN115161390B (zh) | 2016-05-30 | 2025-12-05 | 香港中文大学 | 使用血液中的无细胞dna检测血液病症 |
| WO2017218908A2 (en) * | 2016-06-16 | 2017-12-21 | The Johns Hopkins University | Methods and system for epigenetic analysis |
| CN107779485B (zh) * | 2016-08-24 | 2022-03-18 | 中国科学院分子细胞科学卓越创新中心 | Cmd1酶催化的5-甲基胞嘧啶核酸的新修饰及其应用 |
| EP4209598A1 (en) | 2016-10-19 | 2023-07-12 | The Chinese University of Hong Kong | Gestational age assessment by methylation and size profiling of maternal plasma dna |
| TWI797095B (zh) | 2016-10-24 | 2023-04-01 | 美商格瑞爾有限責任公司 | 腫瘤檢測之方法及系統 |
| IL266347B2 (en) * | 2016-11-30 | 2025-01-01 | Univ Hong Kong Chinese | Analysis of cell-free DNA in urine and other samples |
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| WO2018137685A1 (en) | 2017-01-25 | 2018-08-02 | The Chinese University Of Hong Kong | Diagnostic applications using nucleic acid fragments |
| CN107247873B (zh) * | 2017-03-29 | 2020-04-14 | 电子科技大学 | 一种差异甲基化位点识别方法 |
| CN111417731A (zh) * | 2017-05-12 | 2020-07-14 | 哈佛学院校长同事会 | 通用早期癌症诊断 |
| US12227737B2 (en) | 2017-07-12 | 2025-02-18 | University Health Network | Cancer detection and classification using methylome analysis |
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| WO2019020057A1 (en) | 2017-07-26 | 2019-01-31 | The Chinese University Of Hong Kong | ENHANCING CANCER SCREENING WITH ACELLULAR VIRAL NUCLEIC ACIDS |
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| US11168356B2 (en) | 2017-11-02 | 2021-11-09 | The Chinese University Of Hong Kong | Using nucleic acid size range for noninvasive cancer detection |
| CN111989407B (zh) | 2018-03-13 | 2024-10-29 | 格里尔公司 | 异常的片段检测及分类 |
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