WO2019103421A3 - 유전자의 cpg 메틸화 변화를 이용한 간암의 예후 또는 위험도를 평가하는 방법 - Google Patents
유전자의 cpg 메틸화 변화를 이용한 간암의 예후 또는 위험도를 평가하는 방법 Download PDFInfo
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- WO2019103421A3 WO2019103421A3 PCT/KR2018/014207 KR2018014207W WO2019103421A3 WO 2019103421 A3 WO2019103421 A3 WO 2019103421A3 KR 2018014207 W KR2018014207 W KR 2018014207W WO 2019103421 A3 WO2019103421 A3 WO 2019103421A3
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- liver cancer
- gene
- risk stratification
- cpg methylation
- assessing prognosis
- Prior art date
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
- C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
- C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
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- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Pathology (AREA)
- Analytical Chemistry (AREA)
- Zoology (AREA)
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- Wood Science & Technology (AREA)
- Physics & Mathematics (AREA)
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- Biochemistry (AREA)
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- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
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Abstract
본 발명은 정상 및 혈액 조직에서 낮은 메틸화 수준을 보이나 암 조직에서만 높은 메틸화 수준을 보이는 하나 이상의 CpG 부위의 메틸화 수준을 측정하여 정상 조직이 섞여 있는 임상 검체를 이용하여 간암의 예후 또는 위험도를 평가하는 방법에 관한 것이다.
Priority Applications (8)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| SG11202004795RA SG11202004795RA (en) | 2017-11-22 | 2018-11-19 | Method for assessing prognosis or risk stratification of liver cancer by using cpg methylation variation in gene |
| EP22196985.0A EP4180540A1 (en) | 2017-11-22 | 2018-11-19 | Method for assessing prognosis or risk stratification of liver cancer by using cpg methylation variation in gene |
| US16/766,504 US20210147943A1 (en) | 2017-11-22 | 2018-11-19 | Method for assessing prognosis or risk stratification of liver cancer by using cpg methylation variation in gene |
| JP2020546257A JP7306723B2 (ja) | 2017-11-22 | 2018-11-19 | 遺伝子のｃｐｇメチル化変化を用いた肝癌の予後または危険度を評価する方法 |
| EP18881098.0A EP3715474A4 (en) | 2017-11-22 | 2018-11-19 | METHOD FOR PROGNOSTIC ASSESSMENT OR RISK STRATIFICATION OF LIVER CANCER USING CPG METHYLATION VARIATION IN A GENE |
| CN201880075735.7A CN111386352B (zh) | 2017-11-22 | 2018-11-19 | 利用基因的cpg甲基化变化评估肝癌的预后或者风险的方法 |
| US17/728,240 US20220259676A1 (en) | 2017-11-22 | 2022-04-25 | Method for assessing prognosis or risk stratification of liver cancer by using cpg methylation variation in gene |
| JP2022129672A JP7452894B2 (ja) | 2017-11-22 | 2022-08-16 | 遺伝子のｃｐｇメチル化変化を用いた肝癌の予後または危険度を評価する方法 |
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| KR20170156527 | 2017-11-22 | ||
| KR10-2017-0156527 | 2017-11-22 | ||
| KR10-2018-0137644 | 2018-11-09 | ||
| KR1020180137644A KR102052089B1 (ko) | 2017-11-22 | 2018-11-09 | 유전자의 CpG 메틸화 변화를 이용한 간암의 위험도를 평가하는 방법 |
Related Child Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| US16/766,504 A-371-Of-International US20210147943A1 (en) | 2017-11-22 | 2018-11-19 | Method for assessing prognosis or risk stratification of liver cancer by using cpg methylation variation in gene |
| US17/728,240 Continuation US20220259676A1 (en) | 2017-11-22 | 2022-04-25 | Method for assessing prognosis or risk stratification of liver cancer by using cpg methylation variation in gene |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| WO2019103421A2 WO2019103421A2 (ko) | 2019-05-31 |
| WO2019103421A3 true WO2019103421A3 (ko) | 2019-07-18 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PCT/KR2018/014207 WO2019103421A2 (ko) | 2017-11-22 | 2018-11-19 | 유전자의 cpg 메틸화 변화를 이용한 간암의 예후 또는 위험도를 평가하는 방법 |
Country Status (1)
| Country | Link |
|---|---|
| WO (1) | WO2019103421A2 (ko) |
Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR20100041937A (ko) * | 2008-10-15 | 2010-04-23 | 재단법인서울대학교산학협력재단 | 암 전이 억제 물질의 스크리닝 방법 |
| US20120101023A1 (en) * | 2009-04-20 | 2012-04-26 | Erasmus University Medical Center Rotterdam | Method of diagnosing bladder cancer |
| KR101198046B1 (ko) * | 2009-12-11 | 2012-11-07 | 한국생명공학연구원 | ＴＴＰ 프로모터 내 특정 단일 ＣｐＧ 부위의 후생유전학적 지표를 이용한 암 발병／예후 진단 및 이의 조절을 통한 암 치료기술 |
| KR20130103110A (ko) * | 2012-03-09 | 2013-09-23 | (주)지노믹트리 | 간암 특이적 과메틸화 ＣｐＧ 서열을 이용한 간암의 검출방법 |
| WO2016097120A1 (en) * | 2014-12-18 | 2016-06-23 | Hospital Clínic De Barcelona | Method for the prognosis of hepatocellular carcinoma |
| KR20170071724A (ko) * | 2015-12-16 | 2017-06-26 | 연세대학교 산학협력단 | 간암 발생 특이적 유전자 발현에 관여하는 유전자 구조 내 cpg 섬의 dna 메틸화 변이를 이용한 간암의 예측 또는 진단 방법 |
-
2018
- 2018-11-19 WO PCT/KR2018/014207 patent/WO2019103421A2/ko unknown
Patent Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR20100041937A (ko) * | 2008-10-15 | 2010-04-23 | 재단법인서울대학교산학협력재단 | 암 전이 억제 물질의 스크리닝 방법 |
| US20120101023A1 (en) * | 2009-04-20 | 2012-04-26 | Erasmus University Medical Center Rotterdam | Method of diagnosing bladder cancer |
| KR101198046B1 (ko) * | 2009-12-11 | 2012-11-07 | 한국생명공학연구원 | ＴＴＰ 프로모터 내 특정 단일 ＣｐＧ 부위의 후생유전학적 지표를 이용한 암 발병／예후 진단 및 이의 조절을 통한 암 치료기술 |
| KR20130103110A (ko) * | 2012-03-09 | 2013-09-23 | (주)지노믹트리 | 간암 특이적 과메틸화 ＣｐＧ 서열을 이용한 간암의 검출방법 |
| WO2016097120A1 (en) * | 2014-12-18 | 2016-06-23 | Hospital Clínic De Barcelona | Method for the prognosis of hepatocellular carcinoma |
| KR20170071724A (ko) * | 2015-12-16 | 2017-06-26 | 연세대학교 산학협력단 | 간암 발생 특이적 유전자 발현에 관여하는 유전자 구조 내 cpg 섬의 dna 메틸화 변이를 이용한 간암의 예측 또는 진단 방법 |
Non-Patent Citations (2)
| Title |
|---|
| RICHARDSON, K. S.: "The emerging role of the COP9 signalosome in cancer", MOLECULAR CANCER RESEARCH, vol. 3, no. 12, December 2005 (2005-12-01), pages 645 - 653, XP055625020 * |
| VILLANUEVA, A.: "DNA methylation-based prognosis and epidrivers in hepatocellular carcinoma", HEPATOLOGY, vol. 6 1, no. 6, June 2015 (2015-06-01), pages 1945 - 1956, XP055450673 * |
Also Published As
| Publication number | Publication date |
|---|---|
| WO2019103421A2 (ko) | 2019-05-31 |
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