BR112018072197A2 - amplificação de emparelhamento optimizado múltiplo (moma) - pcr de tempo real para avaliar o poço fetal - Google Patents

amplificação de emparelhamento optimizado múltiplo (moma) - pcr de tempo real para avaliar o poço fetal

Info

Publication number
BR112018072197A2
BR112018072197A2 BR112018072197A BR112018072197A BR112018072197A2 BR 112018072197 A2 BR112018072197 A2 BR 112018072197A2 BR 112018072197 A BR112018072197 A BR 112018072197A BR 112018072197 A BR112018072197 A BR 112018072197A BR 112018072197 A2 BR112018072197 A2 BR 112018072197A2
Authority
BR
Brazil
Prior art keywords
moma
real time
time pcr
multiple optimized
fetal well
Prior art date
Application number
BR112018072197A
Other languages
English (en)
Inventor
Tomita Mitchell Aoy
Stamm Karl
Original Assignee
Medical College Wisconsin Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Medical College Wisconsin Inc filed Critical Medical College Wisconsin Inc
Publication of BR112018072197A2 publication Critical patent/BR112018072197A2/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6844—Nucleic acid amplification reactions
    • C12Q1/6858—Allele-specific amplification
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B20/00—ICT specially adapted for functional genomics or proteomics, e.g. genotype-phenotype associations
    • G16B20/20—Allele or variant detection, e.g. single nucleotide polymorphism [SNP] detection
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/106—Pharmacogenomics, i.e. genetic variability in individual responses to drugs and drug metabolism
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/112—Disease subtyping, staging or classification
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/16—Primer sets for multiplex assays

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Physics & Mathematics (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Biophysics (AREA)
  • Analytical Chemistry (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Immunology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Evolutionary Biology (AREA)
  • Medical Informatics (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Theoretical Computer Science (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)

Abstract

esta invenção refere-se a métodos e composições para avaliar uma quantidade de ácidos nucleicos não-nativos em uma amostra, tal como de uma paciente gestante com os ácidos dos nucleicos não-nativos sendo específico fetal. os métodos e composições aqui fornecidos podem ser utilizados para determinar o risco de uma condição, tal como uma condição fetal, em uma paciente grávida.
BR112018072197A 2016-04-29 2017-04-29 amplificação de emparelhamento optimizado múltiplo (moma) - pcr de tempo real para avaliar o poço fetal BR112018072197A2 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201662330044P 2016-04-29 2016-04-29
PCT/US2017/030292 WO2017190105A1 (en) 2016-04-29 2017-04-29 Multiplexed optimized mismatch amplification (moma)-real time pcr for assessing fetal well being

Publications (1)

Publication Number Publication Date
BR112018072197A2 true BR112018072197A2 (pt) 2019-02-12

Family

ID=60161136

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112018072197A BR112018072197A2 (pt) 2016-04-29 2017-04-29 amplificação de emparelhamento optimizado múltiplo (moma) - pcr de tempo real para avaliar o poço fetal

Country Status (11)

Country Link
US (1) US20190153525A1 (pt)
EP (1) EP3449018A4 (pt)
JP (1) JP2019514387A (pt)
CN (1) CN109661476A (pt)
AU (1) AU2017258800A1 (pt)
BR (1) BR112018072197A2 (pt)
CA (1) CA3022548A1 (pt)
EA (1) EA201892490A1 (pt)
IL (1) IL262641A (pt)
MX (1) MX2018013261A (pt)
WO (1) WO2017190105A1 (pt)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11939634B2 (en) 2010-05-18 2024-03-26 Natera, Inc. Methods for simultaneous amplification of target loci
CN103608818B (zh) 2011-02-09 2017-12-08 纳特拉公司 非侵入性产前倍性识别装置
WO2016183106A1 (en) 2015-05-11 2016-11-17 Natera, Inc. Methods and compositions for determining ploidy
US20190360033A1 (en) * 2016-11-02 2019-11-28 The Medical College Of Wisconsin, Inc. Methods for assessing risk using mismatch amplification and statistical methods
WO2018085603A1 (en) * 2016-11-02 2018-05-11 Medical College Of Wisconsin, Inc. Methods for assessing risk using total and specific cell-free dna
CN110945136A (zh) 2017-06-20 2020-03-31 威斯康星州立大学医学院 使用总无细胞dna评估移植并发症风险
WO2019200228A1 (en) 2018-04-14 2019-10-17 Natera, Inc. Methods for cancer detection and monitoring by means of personalized detection of circulating tumor dna
US11931674B2 (en) 2019-04-04 2024-03-19 Natera, Inc. Materials and methods for processing blood samples

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1599608A4 (en) * 2003-03-05 2007-07-18 Genetic Technologies Ltd Identification of fetal DNA and fetal cell marker in maternal plasma or serum
DK2351858T3 (da) * 2006-02-28 2015-04-07 Univ Louisville Res Found Påvisning af føtale kromosomabnormiteter ved anvendelse af tandem-enkeltnukleotid-polymorfismer
UA115321C2 (uk) * 2011-12-16 2017-10-25 Басф Агрокемікал Продактс Б.В. Спосіб та комплект для аналізу ahasl генів у рослин
WO2014143989A1 (en) * 2013-03-15 2014-09-18 Medical College Of Wisconsin, Inc. Fetal well being surveillance using fetal specific cell free dna
WO2015178978A2 (en) * 2014-02-14 2015-11-26 The Board Of Regents Of The University Of Texas System Strand exchange hairpin primers that give high allelic discrimination
EP3289102A1 (en) * 2015-04-30 2018-03-07 Medical College of Wisconsin, Inc. Multiplexed optimized mismatch amplification (moma)-real time pcr for assessing cell-free dna

Also Published As

Publication number Publication date
EA201892490A1 (ru) 2019-07-31
WO2017190105A1 (en) 2017-11-02
MX2018013261A (es) 2019-04-22
EP3449018A4 (en) 2019-11-06
JP2019514387A (ja) 2019-06-06
EP3449018A1 (en) 2019-03-06
AU2017258800A1 (en) 2018-12-20
IL262641A (en) 2018-12-31
US20190153525A1 (en) 2019-05-23
CA3022548A1 (en) 2017-11-02
CN109661476A (zh) 2019-04-19

Similar Documents

Publication Publication Date Title
BR112018072197A2 (pt) amplificação de emparelhamento optimizado múltiplo (moma) - pcr de tempo real para avaliar o poço fetal
BR112018072196A2 (pt) amplificação de incompatibilidade otimizada multiplexadas (moma) - número do alvo
BR112017023232A2 (pt) pcr em tempo real da amplificação da ligação imperfeita diversificada otimizada (moma) para a avaliação do dna livre de células
BR112018072195A2 (pt) amplificação de incompatibilidade otimizada multiplexado (moma) - pcr de tempo real para avaliar o câncer
BR112017008082A2 (pt) composições e métodos para detectar um vírus de rna
BR112018074979A2 (pt) composições de limpeza que compreendem enzimas
MX2019005199A (es) Métodos para evaluar el riesgo usando and libre de células total y específico.
BR112018069849A2 (pt) kit, dispositivo e método para a detecção de câncer pancreático precoce ou de lesão precursora do câncer pancreático
BR112016026950A2 (pt) composições de rnai para angiotensinogênio (agt) e métodos de uso das mesmas
BR112016019940A2 (pt) edição de genoma sem nucleases
BR112017012222A2 (pt) métodos para derivar um biomarcador de assinatura gênica e para tratar um paciente que tem um tumor, método e sistema para testar uma amostra de tumor removida de um paciente, e, kit.
WO2015195949A3 (en) Methods, compositions, and devices for rapid analysis of biological markers
DK4026917T5 (da) Fremgangsmåde og kit til bestemmelse af cellers eller vævs død eller dna's vævs- eller celleoprindelse ved dna-methyleringsanalyse
AR080009A1 (es) Alteracion genomica objetivo utilizando nucleasas de dedos de zinc
IN2014DN08831A (pt)
BR112016027475A2 (pt) kit, dispositivo e método para a detecção de câncer pancreático
SA518392005B1 (ar) تحديد خصائص التسلسل العميق للأورام
AR105618A1 (es) Metilación del promotor del ligando al receptor de muerte programada (pd-l1) en cáncer
BR112016022407A2 (pt) composições e métodos relacionados ao diagnóstico do câncer de próstata
BR112017016880A2 (pt) métodos de avaliação genômica em gado
WO2015185672A3 (en) New markers for the assessment of an increased risk for mortality
BR112017019841A2 (pt) técnica de análise de amostra de tecido
DOP2019000298A (es) Métodos para la determinación del género de embriones aviares en huevos sin eclosionar y medios de los mismos.
BR112016024622A2 (pt) composições e métodos para melhorar e/ou prever a amplificação de dna
BR112016025971A2 (pt) ?grelhador?

Legal Events

Date Code Title Description
B350 Update of information on the portal [chapter 15.35 patent gazette]
B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

Free format text: REFERENTE A 5A ANUIDADE.

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: EM VIRTUDE DO ARQUIVAMENTO PUBLICADO NA RPI 2668 DE 22-02-2022 E CONSIDERANDO AUSENCIA DE MANIFESTACAO DENTRO DOS PRAZOS LEGAIS, INFORMO QUE CABE SER MANTIDO O ARQUIVAMENTO DO PEDIDO DE PATENTE, CONFORME O DISPOSTO NO ARTIGO 12, DA RESOLUCAO 113/2013.