JP2015535289A5 - - Google Patents
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- JP2015535289A5 JP2015535289A5 JP2015540796A JP2015540796A JP2015535289A5 JP 2015535289 A5 JP2015535289 A5 JP 2015535289A5 JP 2015540796 A JP2015540796 A JP 2015540796A JP 2015540796 A JP2015540796 A JP 2015540796A JP 2015535289 A5 JP2015535289 A5 JP 2015535289A5
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- PURKAOJPTOLRMP-UHFFFAOYSA-N CC(C)(C)c(cc(C(C)(C)C)c(O)c1)c1NC(C1=CNc2ccccc2C1=O)=O Chemical compound CC(C)(C)c(cc(C(C)(C)C)c(O)c1)c1NC(C1=CNc2ccccc2C1=O)=O PURKAOJPTOLRMP-UHFFFAOYSA-N 0.000 description 1
Applications Claiming Priority (11)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261721622P | 2012-11-02 | 2012-11-02 | |
| US61/721,622 | 2012-11-02 | ||
| US201261728328P | 2012-11-20 | 2012-11-20 | |
| US61/728,328 | 2012-11-20 | ||
| US201361770668P | 2013-02-28 | 2013-02-28 | |
| US61/770,668 | 2013-02-28 | ||
| US201361824005P | 2013-05-16 | 2013-05-16 | |
| US61/824,005 | 2013-05-16 | ||
| US201361840668P | 2013-06-28 | 2013-06-28 | |
| US61/840,668 | 2013-06-28 | ||
| PCT/US2013/067952 WO2014071122A1 (en) | 2012-11-02 | 2013-11-01 | Pharmaceutical compositions for the treatment of cftr mediated diseases |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018038741A Division JP2018090626A (ja) | 2012-11-02 | 2018-03-05 | Ｃｆｔｒが媒介する疾患の処置のための医薬組成物 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2015535289A JP2015535289A (ja) | 2015-12-10 |
| JP2015535289A5 true JP2015535289A5 (OSRAM) | 2016-12-15 |
| JP6302923B2 JP6302923B2 (ja) | 2018-03-28 |
Family
ID=50628072
Family Applications (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015540796A Active JP6302923B2 (ja) | 2012-11-02 | 2013-11-01 | Ｃｆｔｒが媒介する疾患の処置のための医薬組成物 |
| JP2018038741A Withdrawn JP2018090626A (ja) | 2012-11-02 | 2018-03-05 | Ｃｆｔｒが媒介する疾患の処置のための医薬組成物 |
| JP2019087813A Active JP7003085B2 (ja) | 2012-11-02 | 2019-05-07 | Ｃｆｔｒが媒介する疾患の処置のための医薬組成物 |
| JP2021214209A Pending JP2022034069A (ja) | 2012-11-02 | 2021-12-28 | Ｃｆｔｒが媒介する疾患の処置のための医薬組成物 |
Family Applications After (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018038741A Withdrawn JP2018090626A (ja) | 2012-11-02 | 2018-03-05 | Ｃｆｔｒが媒介する疾患の処置のための医薬組成物 |
| JP2019087813A Active JP7003085B2 (ja) | 2012-11-02 | 2019-05-07 | Ｃｆｔｒが媒介する疾患の処置のための医薬組成物 |
| JP2021214209A Pending JP2022034069A (ja) | 2012-11-02 | 2021-12-28 | Ｃｆｔｒが媒介する疾患の処置のための医薬組成物 |
Country Status (30)
| Country | Link |
|---|---|
| US (4) | US20140163068A1 (OSRAM) |
| EP (3) | EP2914248B2 (OSRAM) |
| JP (4) | JP6302923B2 (OSRAM) |
| KR (1) | KR102396897B1 (OSRAM) |
| CN (2) | CN104869982A (OSRAM) |
| AR (1) | AR093340A1 (OSRAM) |
| AU (4) | AU2013337730B2 (OSRAM) |
| BR (1) | BR112015009913B1 (OSRAM) |
| CA (1) | CA2890106C (OSRAM) |
| CL (1) | CL2015001148A1 (OSRAM) |
| CY (1) | CY1121070T1 (OSRAM) |
| DK (2) | DK2914248T4 (OSRAM) |
| ES (2) | ES2694290T5 (OSRAM) |
| FI (2) | FI3470063T3 (OSRAM) |
| HR (2) | HRP20250100T1 (OSRAM) |
| HU (2) | HUE070382T2 (OSRAM) |
| IL (2) | IL283276B2 (OSRAM) |
| LT (2) | LT3470063T (OSRAM) |
| MX (2) | MX368353B (OSRAM) |
| NZ (2) | NZ708474A (OSRAM) |
| PL (2) | PL3470063T3 (OSRAM) |
| PT (2) | PT3470063T (OSRAM) |
| RS (2) | RS57831B2 (OSRAM) |
| SG (3) | SG10201703452PA (OSRAM) |
| SI (2) | SI2914248T2 (OSRAM) |
| SM (2) | SMT202500078T1 (OSRAM) |
| TR (1) | TR201815218T4 (OSRAM) |
| TW (2) | TW201422253A (OSRAM) |
| UA (2) | UA117464C2 (OSRAM) |
| WO (1) | WO2014071122A1 (OSRAM) |
Families Citing this family (96)
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| EP1912983B1 (en) | 2005-08-11 | 2011-06-08 | Vertex Pharmaceuticals, Inc. | Modulators of cystic fibrosis transmembrane conductance regulator |
| KR101331768B1 (ko) | 2005-11-08 | 2013-11-22 | 버텍스 파마슈티칼스 인코포레이티드 | Ａｔｐ 결합 카세트 수송체의 헤테로사이클릭 조정제 |
| CA2635581C (en) | 2005-12-28 | 2017-02-28 | Vertex Pharmaceuticals Incorporated | Solid forms of n-[2,4-bis(1,1-dimethylethyl)-5-hydroxyphenyl]-1,4-dihydro-4-oxoquinoline-3-carboxamide |
| US7645789B2 (en) | 2006-04-07 | 2010-01-12 | Vertex Pharmaceuticals Incorporated | Indole derivatives as CFTR modulators |
| PL2674428T3 (pl) | 2006-04-07 | 2017-01-31 | Vertex Pharmaceuticals Incorporated | Modulatory transporterów z kasetą wiążącą ATP |
| USRE50453E1 (en) | 2006-04-07 | 2025-06-10 | Vertex Pharmaceuticals Incorporated | Indole derivatives as CFTR modulators |
| US10022352B2 (en) | 2006-04-07 | 2018-07-17 | Vertex Pharmaceuticals Incorporated | Modulators of ATP-binding cassette transporters |
| US8563573B2 (en) | 2007-11-02 | 2013-10-22 | Vertex Pharmaceuticals Incorporated | Azaindole derivatives as CFTR modulators |
| CA2686838C (en) | 2007-05-09 | 2017-03-14 | Vertex Pharmaceuticals Incorporated | Modulators of cftr |
| AU2008302598B2 (en) | 2007-08-24 | 2014-07-17 | Vertex Pharmaceuticals Incorporated | Isothiazolopyridinones useful for the treatment of (inter alia) Cystic Fibrosis |
| SI2578571T1 (sl) | 2007-11-16 | 2016-01-29 | Vertex Pharmaceuticals Incorporated | Izokinolinski modulatorji prenašalcev z atp-vezavno kaseto |
| DK2639223T3 (en) | 2007-12-07 | 2017-06-19 | Vertex Pharma | Process for Preparation of Cycloalkylcarboxiamido-pyridine Benzoic Acids |
| HRP20170241T2 (hr) | 2007-12-07 | 2023-03-17 | Vertex Pharmaceuticals Incorporated | Čvrsti oblici 3-(6-(1-(2,2-difluorobenzo[d][1,3]dioksol-5-il)ciklopropankarboksamido)-3-metilpiridin-2-il)benzojeve kiseline |
| US20100036130A1 (en) | 2007-12-07 | 2010-02-11 | Vertex Pharmaceuticals Incorporated | Processes for producing cycloalkylcarboxamido-pyridine benzoic acids |
| NZ736561A (en) | 2008-02-28 | 2018-02-23 | Vertex Pharma | Heteroaryl derivatives as cftr modulators |
| US20100074949A1 (en) | 2008-08-13 | 2010-03-25 | William Rowe | Pharmaceutical composition and administration thereof |
| US12458635B2 (en) | 2008-08-13 | 2025-11-04 | Vertex Pharmaceuticals Incorporated | Pharmaceutical composition and administrations thereof |
| PL2408750T3 (pl) | 2009-03-20 | 2016-02-29 | Vertex Pharma | Sposób otrzymywania modulatorów błonowego regulatora przewodnictwa swoistego dla mukowiscydozy |
| US8802868B2 (en) | 2010-03-25 | 2014-08-12 | Vertex Pharmaceuticals Incorporated | Solid forms of (R)-1(2,2-difluorobenzo[D][1,3]dioxo1-5-yl)-N-(1-(2,3-dihydroxypropyl-6-fluoro-2-(1-hydroxy-2-methylpropan2-yl)-1H-Indol-5-yl)-Cyclopropanecarboxamide |
| DK3150198T3 (da) | 2010-04-07 | 2021-11-01 | Vertex Pharma | Farmaceutiske sammensætninger af 3-(6-(1-(2,2-difluorbenzo[d][1,3]dioxol-5-yl)-cyclopropancarboxamido)-3-methylpyriodin-2-yl)benzoesyre og indgivelse deraf |
| RS54783B1 (sr) | 2010-04-07 | 2016-10-31 | Vertex Pharma | Čvrste forme 3-(6-(1-(2,2-difluorobenzo[d][1,3]dioksol-5-il)ciklopropankarboksiamido)-3-metilpiridin-2-il)benzoeve kiseline |
| CA2797118C (en) | 2010-04-22 | 2021-03-30 | Vertex Pharmaceuticals Incorporated | Process of producing cycloalkylcarboxamido-indole compounds |
| HUE047354T2 (hu) | 2011-05-18 | 2020-04-28 | Vertex Pharmaceuticals Europe Ltd | Ivacaftor deuterizált származékai |
| MX357328B (es) | 2011-11-08 | 2018-07-05 | Vertex Pharma | Moduladores de trasportadores de casete enlazante de atp. |
| NZ627750A (en) | 2012-01-06 | 2016-11-25 | Abide Therapeutics Inc | Carbamate compounds and of making and using same |
| AU2013226076B2 (en) | 2012-02-27 | 2017-11-16 | Vertex Pharmaceuticals Incorporated | Pharmaceutical composition and administration thereof |
| EP2872122A1 (en) | 2012-07-16 | 2015-05-20 | Vertex Pharmaceuticals Incorporated | Pharmaceutical compositions of (r)-1-(2,2-diflurorbenzo[d][1,3]dioxol-5-yl)-n-(1-(2,3-dihydroxypropyl)-6-fluoro-2-(1-hydroxy-2-methylpropan-2-yl)-1h-indol-5-yl) cyclopropanecarboxamide and administration thereof |
| SMT202500078T1 (it) * | 2012-11-02 | 2025-03-12 | Vertex Pharma | Composizioni farmaceutiche per il trattamento di malattie mediate da cftr |
| US9303918B2 (en) * | 2013-03-15 | 2016-04-05 | Monosol Rx, Llc | Process for drying a wet film with control of loss on drying |
| WO2014176553A1 (en) * | 2013-04-26 | 2014-10-30 | Vertex Pharmaceuticals Incorporated | Correctors acting through msd1 of cftr protein |
| RU2718044C2 (ru) * | 2013-11-12 | 2020-03-30 | Вертекс Фармасьютикалз Инкорпорейтед | Способ получения фармацевтических композиций для лечения опосредованных cftr заболеваний |
| RS62140B1 (sr) | 2014-04-15 | 2021-08-31 | Vertex Pharma | Farmaceutske kompozicije za lečenje bolesti posredovanih transmembranskim regulatorom provodljivosti cistične fibroze |
| IL313498A (en) | 2014-10-06 | 2024-08-01 | Vertex Pharma | Modulators of the cystic fibrosis transmembrane conductance regulator |
| KR20170063954A (ko) | 2014-10-07 | 2017-06-08 | 버텍스 파마슈티칼스 인코포레이티드 | 낭성 섬유증 막횡단 전도도 조절자의 조정제의 공-결정 |
| HRP20211194T1 (hr) | 2014-11-18 | 2021-10-29 | Vertex Pharmaceuticals Inc. | Postupak za provođenje testova velike propusnosti putem tekućinske kromatografije visoke djelotvornosti |
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| HK1258473A1 (zh) | 2015-09-25 | 2019-11-15 | Vertex Pharmaceuticals (Europe) Limited | 氘代cftr增效剂 |
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| EP3436446B1 (en) | 2016-03-31 | 2023-06-07 | Vertex Pharmaceuticals Incorporated | Modulators of cystic fibrosis transmembrane conductance regulator |
| US10206915B2 (en) | 2016-04-25 | 2019-02-19 | Druggability Technologies Ip Holdco Limited | Complexes of Ivacaftor and its salts and derivatives, process for the preparation thereof and pharmaceutical compositions containing them |
| HUP1600271A2 (hu) | 2016-04-25 | 2017-10-30 | Druggability Tech Ip Holdco Ltd | Ivacaftor és Lumacaftor sóinak és származékainak komplexei, eljárás azok elõállítására és azok gyógyszerészetileg elfogadható készítményei |
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| TWI867024B (zh) | 2019-08-14 | 2024-12-21 | 美商維泰克斯製藥公司 | 囊腫纖維化跨膜傳導調節蛋白之調節劑 |
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| KR20230004622A (ko) | 2020-04-21 | 2023-01-06 | 하. 룬드벡 아크티에셀스카브 | 모노아실글리세롤 리파제 억제제의 합성 |
| WO2022194399A1 (en) | 2020-07-13 | 2022-09-22 | Idorsia Pharmaceuticals Ltd | Macrocycles as cftr modulators |
| CR20230120A (es) | 2020-08-07 | 2023-09-01 | Vertex Pharma | Moduladores del regulador de la conductancia transmembrana de la fibrosis quística |
| US20230373974A1 (en) | 2020-10-07 | 2023-11-23 | Vertex Pharmaceuticals Incorporated | Modulators of cystic fibrosis transmembrane conductance regulator |
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| CN119947720A (zh) | 2022-05-16 | 2025-05-06 | 弗特克斯药品有限公司 | 治疗囊性纤维化的方法 |
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