JP2015535233A - ガレクチン−３のガラクトシド阻害剤及び肺線維症のためのその使用 - Google Patents

ガレクチン−３のガラクトシド阻害剤及び肺線維症のためのその使用 Download PDF

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Publication number
JP2015535233A
JP2015535233A JP2015538502A JP2015538502A JP2015535233A JP 2015535233 A JP2015535233 A JP 2015535233A JP 2015538502 A JP2015538502 A JP 2015538502A JP 2015538502 A JP2015538502 A JP 2015538502A JP 2015535233 A JP2015535233 A JP 2015535233A
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Prior art keywords
compound
nebulizer
formula
galectin
composition according
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Pending
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JP2015538502A
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English (en)
Japanese (ja)
Inventor
ニルソン，ウルフ
レフレル，ホーコン
ヘンダーソン，ニール
セシ，タリク
マッキノン，アリソン
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ガレクト・バイオテック・エイビイ
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Priority claimed from CA2794066A external-priority patent/CA2794066C/en
Priority claimed from US13/832,672 external-priority patent/US9243021B2/en
Application filed by ガレクト・バイオテック・エイビイ filed Critical ガレクト・バイオテック・エイビイ
Publication of JP2015535233A publication Critical patent/JP2015535233A/ja
Pending legal-status Critical Current

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/7056—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing five-membered rings with nitrogen as a ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/007—Pulmonary tract; Aromatherapy
    • A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
    • A61K9/0075—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy for inhalation via a dry powder inhaler [DPI], e.g. comprising micronized drug mixed with lactose carrier particles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/007—Pulmonary tract; Aromatherapy
    • A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
    • A61K9/0078—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy for inhalation via a nebulizer such as a jet nebulizer, ultrasonic nebulizer, e.g. in the form of aqueous drug solutions or dispersions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M11/00—Sprayers or atomisers specially adapted for therapeutic purposes
    • A61M11/005—Sprayers or atomisers specially adapted for therapeutic purposes using ultrasonics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
    • A61M15/0001—Details of inhalators; Constructional features thereof
    • A61M15/0005—Details of inhalators; Constructional features thereof with means for agitating the medicament
    • A61M15/001—Details of inhalators; Constructional features thereof with means for agitating the medicament using ultrasonic means
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
    • A61M15/0085—Inhalators using ultrasonics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
    • A61M15/0065—Inhalators with dosage or measuring devices
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2202/00—Special media to be introduced, removed or treated
    • A61M2202/06—Solids
    • A61M2202/064—Powder

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Pulmonology (AREA)
  • Epidemiology (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Anesthesiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Otolaryngology (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Dispersion Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
JP2015538502A 2012-10-31 2013-10-30 ガレクチン−３のガラクトシド阻害剤及び肺線維症のためのその使用 Pending JP2015535233A (ja)

Applications Claiming Priority (9)

Application Number Priority Date Filing Date Title
US201261720641P 2012-10-31 2012-10-31
CA2794066 2012-10-31
CA2794066A CA2794066C (en) 2012-10-31 2012-10-31 Galactoside inhibitor of galectins
US61/720,641 2012-10-31
CA2795793 2012-11-15
CA2795753A CA2795753A1 (en) 2012-10-31 2012-11-15 Novel galactoside inhibitor of galectins
US13/832,672 2013-03-15
US13/832,672 US9243021B2 (en) 2012-10-31 2013-03-15 Galactoside inhibitor of galectins
PCT/EP2013/072691 WO2014067986A1 (en) 2012-10-31 2013-10-30 Galactoside inhibitor of galectin-3 and its use for treating pulmonary fibrosis

Publications (1)

Publication Number Publication Date
JP2015535233A true JP2015535233A (ja) 2015-12-10

Family

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Family Applications (1)

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JP2015538502A Pending JP2015535233A (ja) 2012-10-31 2013-10-30 ガレクチン−３のガラクトシド阻害剤及び肺線維症のためのその使用

Country Status (7)

Country Link
EP (2) EP3278805A1 (member.php)
JP (1) JP2015535233A (member.php)
CN (1) CN104755088A (member.php)
CA (1) CA2884802A1 (member.php)
ES (1) ES2817888T3 (member.php)
IN (1) IN2015DN02573A (member.php)
WO (1) WO2014067986A1 (member.php)

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* Cited by examiner, † Cited by third party
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JP2018537469A (ja) * 2015-12-18 2018-12-20 ガレクト・バイオテック・エイビイ 結晶多形とプロセス
JP2021523951A (ja) * 2018-05-17 2021-09-09 アクチュエイト セラピューティクス、インク． グリコーゲンシンターゼキナーゼ３型β阻害剤による特発性肺線維症の治療
JP2021527102A (ja) * 2018-06-15 2021-10-11 ブリストル−マイヤーズ スクイブ カンパニーＢｒｉｓｔｏｌ−Ｍｙｅｒｓ Ｓｑｕｉｂｂ Ｃｏｍｐａｎｙ ガレクチン−３抑制剤を模したテトラヒドロピラン系チオ二糖類

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US9243021B2 (en) 2012-10-31 2016-01-26 Galecto Biotech Ab Galactoside inhibitor of galectins
EP2620443A1 (en) 2012-01-25 2013-07-31 Galecto Biotech AB Novel galactoside inhibitors of galectins
ES2784873T3 (es) 2014-07-09 2020-10-01 Galecto Biotech Ab Novedoso inhibidor galactósido híbrido de galectinas
ES2776255T3 (es) 2015-01-16 2020-07-29 Galecto Biotech Ab Novedoso inhibidor de galactósido de galectinas
EP3250581B1 (en) 2015-01-30 2021-01-20 Galecto Biotech AB Alpha-d-galactoside inhibitors of galectins
CA2983198C (en) 2015-05-12 2022-07-19 Galecto Biotech Ab Once-daily treatment of pulmonary fibrosis
JP6915956B2 (ja) * 2015-05-15 2021-08-11 ガレクト・バイオテック・エイビイ 肺線維症の１日１回の治療
US10799522B2 (en) * 2015-07-27 2020-10-13 Wayne State University Compositions and methods relating to galectin detection
WO2017080973A1 (en) 2015-11-09 2017-05-18 Galecto Biotech Ab 1,1 '-sulfanediyl-di-beta-d-galactopyranosides as inhibitors of galectins
US20190367552A1 (en) * 2016-03-04 2019-12-05 Galectin Sciences, Llc Selenogalactoside compounds for the prevention and treatment of diseases associated with galectin and the use thereof
US10889610B2 (en) 2016-07-12 2021-01-12 Galecto Biotech Ab Alpha-D-galactoside inhibitors of galectins
CN109563120B (zh) * 2016-07-12 2022-12-02 格莱克特生物技术公司 半乳糖凝集素的α-D-半乳糖苷抑制剂
AU2018265571B2 (en) 2017-05-12 2022-09-29 Galectin Sciences, Llc Compounds for the prevention and treatment of diseases and the use thereof
WO2019067702A1 (en) 2017-09-27 2019-04-04 Bristol-Myers Squibb Company INHIBITORS WITH SMALL MOLECULES OF GALECTIN-3
US11072626B2 (en) 2017-10-11 2021-07-27 Bristol-Myers Squibb Company Small molecule inhibitors of Galectin-3
CA3085356A1 (en) 2017-12-29 2019-07-04 Glycomimetics, Inc. Heterobifunctional inhibitors of e-selectin and galectin-3
WO2019137971A1 (en) 2018-01-10 2019-07-18 Galecto Biotech Ab Novel galactoside inhibitor of galectins
CN112672765A (zh) * 2018-06-29 2021-04-16 格莱科斯生物医药公司 结合物
JP2022508720A (ja) 2018-10-15 2022-01-19 ガレクト バイオテック エービー ガレクチンのガラクトシド阻害剤
WO2020078807A1 (en) 2018-10-15 2020-04-23 Galecto Biotech Ab Prodrug of galactoside inhibitors of galectins
EP3883946A1 (en) 2018-11-21 2021-09-29 Galecto Biotech AB Alpha-d-galactoside inhibitors of galectins
KR20210100139A (ko) 2018-12-06 2021-08-13 브리스톨-마이어스 스큅 컴퍼니 갈렉틴-3의 소분자 억제제
CA3122321A1 (en) 2018-12-27 2020-07-02 Glycomimetics, Inc. Galectin-3 inhibiting c-glycosides
US11845771B2 (en) 2018-12-27 2023-12-19 Glycomimetics, Inc. Heterobifunctional inhibitors of E-selectin and galectin-3
EP3947407B1 (en) 2019-03-26 2024-06-12 Bristol-Myers Squibb Company Small molecule inhibitors of galectin-3
US12269819B2 (en) 2019-04-10 2025-04-08 Bristol-Myers Squibb Company Small molecule inhibitors of Galectin-3
CA3138668A1 (en) 2019-06-14 2020-12-17 Denis Giguere Synthesis of 3-azido-3-deoxy-d-galactopyranose
CA3144551A1 (en) 2019-06-24 2020-12-30 Galecto Biotech Ab Large scale process of 3,3'-dideoxy-3,3'-bis-[4-(3-fluorophenyl)-1h-1,2,3-triazol-1-yl]-1,1'-sulfanediyl-di-beta-d-galactopyranoside
WO2021001538A1 (en) 2019-07-03 2021-01-07 Galecto Biotech Ab Novel galactoside inhibitor of galectins
CN114555620A (zh) 2019-07-03 2022-05-27 格莱克特生物技术公司 半乳糖凝集素的新型半乳糖苷抑制剂
US12441755B2 (en) 2019-07-05 2025-10-14 Galecto Biotech Ab Galactoside inhibitor of galectins
CA3147078A1 (en) 2019-08-09 2021-02-18 Martin Bolli (2-acetamidyl)thio-beta-d-galactopyranoside derivatives
CN114206893A (zh) 2019-08-09 2022-03-18 爱杜西亚药品有限公司 (杂)芳基-甲基-硫代-β-D-吡喃半乳糖苷衍生物
JP7604457B2 (ja) 2019-08-15 2024-12-23 イドルシア・ファーマシューティカルズ・リミテッド ２－ヒドロキシシクロアルカン－１－カルバモイル誘導体
RS65294B1 (sr) 2019-08-29 2024-04-30 Idorsia Pharmaceuticals Ltd Derivati alfa-d-galaktopiranozida
WO2021123506A1 (en) 2019-12-18 2021-06-24 Glykos Biomedical Oy Stabile conjugate
WO2021195020A1 (en) * 2020-03-23 2021-09-30 G3 Pharmaceuticals, Inc. Methods and compositions for preventing and treating fibrosis resulting from a coronavirus infection
JP2023519952A (ja) 2020-03-31 2023-05-15 ガレクト バイオテック エービー １，２，４，６－テトラ－ｏ－アセチル－３－アジド－３－デオキシ－ｄ－ガラクトピラノシドを調製するための大規模方法
EP4146646A1 (en) 2020-05-05 2023-03-15 Bristol-Myers Squibb Company Small molecule inhibitors of galectin-3
JP7677995B2 (ja) 2020-05-11 2025-05-15 ブリストル－マイヤーズ スクイブ カンパニー ガレクチン－３の低分子阻害剤
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JP2023547241A (ja) 2020-11-02 2023-11-09 イドーシア ファーマシューティカルズ リミテッド ガレクチン－３を阻害する２－ヒドロキシシクロアルカン－１－カルバモイル誘導体
KR20230145111A (ko) 2021-02-09 2023-10-17 이도르시아 파마슈티컬스 리미티드 히드록시헤테로시클로알칸-카르바모일 유도체
IL305581A (en) 2021-03-03 2023-10-01 Idorsia Pharmaceuticals Ltd Triazolyl-methyl-converted alpha-D-galactopyranoside histories
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Cited By (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2018537469A (ja) * 2015-12-18 2018-12-20 ガレクト・バイオテック・エイビイ 結晶多形とプロセス
JP2021105029A (ja) * 2015-12-18 2021-07-26 ガレクト・バイオテック・エイビイ 結晶多形とプロセス
JP2021191777A (ja) * 2015-12-18 2021-12-16 ガレクト・バイオテック・エイビイ 結晶多形および医薬組成物
JP7254130B2 (ja) 2015-12-18 2023-04-07 ガレクト・バイオテック・エイビイ 結晶多形および医薬組成物
JP2021523951A (ja) * 2018-05-17 2021-09-09 アクチュエイト セラピューティクス、インク． グリコーゲンシンターゼキナーゼ３型β阻害剤による特発性肺線維症の治療
JP7471660B2 (ja) 2018-05-17 2024-04-22 アクチュエイト セラピューティクス インク． グリコーゲンシンターゼキナーゼ３型β阻害剤による特発性肺線維症の治療
JP2024069221A (ja) * 2018-05-17 2024-05-21 アクチュエイト セラピューティクス インク． グリコーゲンシンターゼキナーゼ３型β阻害剤による特発性肺線維症の治療
US12083098B2 (en) 2018-05-17 2024-09-10 Actuate Therapeutics Inc. Treatment of idiopathic pulmonary fibrosis with glycogen synthase kinase 3 form β inhibitors
JP2021527102A (ja) * 2018-06-15 2021-10-11 ブリストル−マイヤーズ スクイブ カンパニーＢｒｉｓｔｏｌ−Ｍｙｅｒｓ Ｓｑｕｉｂｂ Ｃｏｍｐａｎｙ ガレクチン−３抑制剤を模したテトラヒドロピラン系チオ二糖類
JP7190513B2 (ja) 2018-06-15 2022-12-15 ブリストル－マイヤーズ スクイブ カンパニー ガレクチン－３抑制剤を模したテトラヒドロピラン系チオ二糖類

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Publication number Publication date
ES2817888T3 (es) 2021-04-08
CN104755088A (zh) 2015-07-01
WO2014067986A8 (en) 2016-04-14
IN2015DN02573A (member.php) 2015-09-11
EP3278805A1 (en) 2018-02-07
WO2014067986A1 (en) 2014-05-08
EP2914269B1 (en) 2020-07-29
EP2914269A1 (en) 2015-09-09
CA2884802A1 (en) 2014-05-08

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