JP2015535209A5 - - Google Patents
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- Publication number
- JP2015535209A5 JP2015535209A5 JP2015518623A JP2015518623A JP2015535209A5 JP 2015535209 A5 JP2015535209 A5 JP 2015535209A5 JP 2015518623 A JP2015518623 A JP 2015518623A JP 2015518623 A JP2015518623 A JP 2015518623A JP 2015535209 A5 JP2015535209 A5 JP 2015535209A5
- Authority
- JP
- Japan
- Prior art keywords
- iron
- ferric
- patient
- ckd
- ferric citrate
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- XEEYBQQBJWHFJM-UHFFFAOYSA-N Iron Chemical compound [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 claims 138
- 229910052742 iron Inorganic materials 0.000 claims 69
- 208000020832 chronic kidney disease Diseases 0.000 claims 61
- 239000013589 supplement Substances 0.000 claims 43
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 claims 42
- 229960002413 ferric citrate Drugs 0.000 claims 35
- NPFOYSMITVOQOS-UHFFFAOYSA-K iron(III) citrate Chemical compound [Fe+3].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O NPFOYSMITVOQOS-UHFFFAOYSA-K 0.000 claims 35
- 210000002966 serum Anatomy 0.000 claims 16
- 201000000523 end stage renal failure Diseases 0.000 claims 12
- 239000008194 pharmaceutical composition Substances 0.000 claims 12
- 239000002552 dosage form Substances 0.000 claims 8
- 208000028208 end stage renal disease Diseases 0.000 claims 8
- OAICVXFJPJFONN-UHFFFAOYSA-N Phosphorus Chemical compound [P] OAICVXFJPJFONN-UHFFFAOYSA-N 0.000 claims 7
- 229910052698 phosphorus Inorganic materials 0.000 claims 7
- 239000011574 phosphorus Substances 0.000 claims 7
- VTLYFUHAOXGGBS-UHFFFAOYSA-N Fe3+ Chemical compound [Fe+3] VTLYFUHAOXGGBS-UHFFFAOYSA-N 0.000 claims 6
- 102000001554 Hemoglobins Human genes 0.000 claims 6
- 108010054147 Hemoglobins Proteins 0.000 claims 6
- JEIPFZHSYJVQDO-UHFFFAOYSA-N iron(III) oxide Inorganic materials O=[Fe]O[Fe]=O JEIPFZHSYJVQDO-UHFFFAOYSA-N 0.000 claims 6
- PMVSDNDAUGGCCE-TYYBGVCCSA-L Ferrous fumarate Chemical compound [Fe+2].[O-]C(=O)\C=C\C([O-])=O PMVSDNDAUGGCCE-TYYBGVCCSA-L 0.000 claims 5
- 206010022971 Iron Deficiencies Diseases 0.000 claims 5
- 102000008857 Ferritin Human genes 0.000 claims 4
- 108050000784 Ferritin Proteins 0.000 claims 4
- 238000008416 Ferritin Methods 0.000 claims 4
- 238000001990 intravenous administration Methods 0.000 claims 4
- BVKZGUZCCUSVTD-UHFFFAOYSA-M Bicarbonate Chemical compound OC([O-])=O BVKZGUZCCUSVTD-UHFFFAOYSA-M 0.000 claims 3
- 102000004338 Transferrin Human genes 0.000 claims 3
- 108090000901 Transferrin Proteins 0.000 claims 3
- 238000010521 absorption reaction Methods 0.000 claims 3
- 238000000502 dialysis Methods 0.000 claims 3
- 229940125367 erythropoiesis stimulating agent Drugs 0.000 claims 3
- 238000005534 hematocrit Methods 0.000 claims 3
- 210000000952 spleen Anatomy 0.000 claims 3
- 239000012581 transferrin Substances 0.000 claims 3
- KRKNYBCHXYNGOX-UHFFFAOYSA-K Citrate Chemical compound [O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O KRKNYBCHXYNGOX-UHFFFAOYSA-K 0.000 claims 2
- 102000008133 Iron-Binding Proteins Human genes 0.000 claims 2
- 108010035210 Iron-Binding Proteins Proteins 0.000 claims 2
- 208000007502 anemia Diseases 0.000 claims 2
- 210000004185 liver Anatomy 0.000 claims 2
- 201000004384 Alopecia Diseases 0.000 claims 1
- 208000019505 Deglutition disease Diseases 0.000 claims 1
- 208000007519 Plummer-Vinson syndrome Diseases 0.000 claims 1
- 208000005793 Restless legs syndrome Diseases 0.000 claims 1
- 206010040664 Sideropenic dysphagia Diseases 0.000 claims 1
- 239000003173 antianemic agent Substances 0.000 claims 1
- 210000004369 blood Anatomy 0.000 claims 1
- 239000008280 blood Substances 0.000 claims 1
- 239000003795 chemical substances by application Substances 0.000 claims 1
- 230000001186 cumulative effect Effects 0.000 claims 1
- 208000002173 dizziness Diseases 0.000 claims 1
- 230000037406 food intake Effects 0.000 claims 1
- 238000001631 haemodialysis Methods 0.000 claims 1
- 208000024963 hair loss Diseases 0.000 claims 1
- 230000003676 hair loss Effects 0.000 claims 1
- 230000000322 hemodialysis Effects 0.000 claims 1
- 230000002440 hepatic effect Effects 0.000 claims 1
- 208000026278 immune system disease Diseases 0.000 claims 1
- 238000000707 layer-by-layer assembly Methods 0.000 claims 1
- 238000012423 maintenance Methods 0.000 claims 1
- 235000012054 meals Nutrition 0.000 claims 1
- 235000011888 snacks Nutrition 0.000 claims 1
- 230000009469 supplementation Effects 0.000 claims 1
- 208000024891 symptom Diseases 0.000 claims 1
Applications Claiming Priority (9)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261662565P | 2012-06-21 | 2012-06-21 | |
| US61/662,565 | 2012-06-21 | ||
| US201361757229P | 2013-01-28 | 2013-01-28 | |
| US61/757,229 | 2013-01-28 | ||
| US201361800618P | 2013-03-15 | 2013-03-15 | |
| US201361801050P | 2013-03-15 | 2013-03-15 | |
| US61/801,050 | 2013-03-15 | ||
| US61/800,618 | 2013-03-15 | ||
| PCT/US2013/047134 WO2013192565A2 (en) | 2012-06-21 | 2013-06-21 | Use of ferric citrate in the treatment of chronic kidney disease patients |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018075243A Division JP2018138562A (ja) | 2012-06-21 | 2018-04-10 | 慢性腎臓病患者の治療におけるクエン酸第二鉄の使用 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2015535209A JP2015535209A (ja) | 2015-12-10 |
| JP2015535209A5 true JP2015535209A5 (enExample) | 2016-08-12 |
Family
ID=49769729
Family Applications (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015518623A Pending JP2015535209A (ja) | 2012-06-21 | 2013-06-21 | 慢性腎臓病患者の治療におけるクエン酸第二鉄の使用 |
| JP2018075243A Pending JP2018138562A (ja) | 2012-06-21 | 2018-04-10 | 慢性腎臓病患者の治療におけるクエン酸第二鉄の使用 |
| JP2020029756A Pending JP2020100638A (ja) | 2012-06-21 | 2020-02-25 | 慢性腎臓病患者の治療におけるクエン酸第二鉄の使用 |
| JP2022019167A Pending JP2022070945A (ja) | 2012-06-21 | 2022-02-10 | 慢性腎臓病患者の治療におけるクエン酸第二鉄の使用 |
Family Applications After (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018075243A Pending JP2018138562A (ja) | 2012-06-21 | 2018-04-10 | 慢性腎臓病患者の治療におけるクエン酸第二鉄の使用 |
| JP2020029756A Pending JP2020100638A (ja) | 2012-06-21 | 2020-02-25 | 慢性腎臓病患者の治療におけるクエン酸第二鉄の使用 |
| JP2022019167A Pending JP2022070945A (ja) | 2012-06-21 | 2022-02-10 | 慢性腎臓病患者の治療におけるクエン酸第二鉄の使用 |
Country Status (19)
| Country | Link |
|---|---|
| US (3) | US20130345303A1 (enExample) |
| EP (3) | EP4335436A3 (enExample) |
| JP (4) | JP2015535209A (enExample) |
| KR (2) | KR20200103855A (enExample) |
| CN (2) | CN113244209A (enExample) |
| AU (2) | AU2013278000A1 (enExample) |
| BR (1) | BR112014032049A2 (enExample) |
| CA (1) | CA2876982A1 (enExample) |
| DK (1) | DK3730136T3 (enExample) |
| EA (1) | EA201590062A1 (enExample) |
| ES (2) | ES2796254T3 (enExample) |
| FR (1) | FR25C1043I1 (enExample) |
| HK (1) | HK1214503A1 (enExample) |
| IL (1) | IL236356A0 (enExample) |
| MX (1) | MX2014015615A (enExample) |
| NO (1) | NO2025048I1 (enExample) |
| PL (1) | PL3730136T3 (enExample) |
| SG (2) | SG11201408521WA (enExample) |
| WO (1) | WO2013192565A2 (enExample) |
Families Citing this family (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR20120046753A (ko) | 2009-07-21 | 2012-05-10 | 케릭스 바이오파마슈티컬스 인코포레이티드 | 구연산철 투여형태 |
| TWI653043B (zh) * | 2012-12-20 | 2019-03-11 | 瑞士商伊蘭科動物健康公司 | 新用途 |
| KR102633597B1 (ko) | 2013-06-05 | 2024-02-06 | 트리시다, 인크. | 경구 투여를 위한 양성자-결합 중합체 |
| ES2856261T3 (es) * | 2013-10-01 | 2021-09-27 | Fresenius Medical Care Deutschland Gmbh | Método y aparatos para determinar una pérdida diaria de hierro de un paciente |
| CN105873583A (zh) * | 2013-11-04 | 2016-08-17 | 凯克斯生物制药公司 | 用于降低慢性肾病患者的心力衰竭的枸橼酸铁 |
| WO2015110968A1 (en) * | 2014-01-23 | 2015-07-30 | Lupin Limited | Pharmaceutical grade ferric citrate and method for its production |
| EP3157516A4 (en) | 2014-06-22 | 2017-12-13 | Dexcel Pharma Technologies Ltd. | Pharmaceutical compositions comprising ferric citrate and methods for the production thereof |
| IL322207A (en) | 2014-12-10 | 2025-09-01 | Tricida Inc | Proton-binding polymers for oral administration |
| CN107530310A (zh) * | 2015-03-04 | 2018-01-02 | 凯克斯生物制药公司 | 柠檬酸铁在治疗缺铁性贫血中的用途 |
| CN104688706B (zh) * | 2015-04-01 | 2017-07-14 | 成都欣捷高新技术开发有限公司 | 一种高载药量、快速溶出的枸橼酸铁组合物及其制备方法 |
| WO2016162794A1 (en) * | 2015-04-08 | 2016-10-13 | Leiutis Pharmaceuticals Pvt Ltd | Pharmaceutical compositions of ferric citrate |
| WO2016162888A1 (en) * | 2015-04-09 | 2016-10-13 | Actavis Group Ptc Ehf. | Process for preparing pharmaceutical grade ferric citrate |
| IL262660B2 (en) | 2016-05-06 | 2024-04-01 | Tricida Inc | Compositions for and method of treating acid-base disorders |
| US20210085711A1 (en) | 2017-09-19 | 2021-03-25 | Japan Tobacco Inc. | Use of ferric citrate in prevention and/or treatment of iron-deficiency anemia in hypermenorrhea patient and/or patient suffering from hypermenorrhea-associated gynecologic disease |
| IL319146A (en) | 2017-11-03 | 2025-04-01 | Tricida Inc | Compositions for and method of treating acid-base disorders |
| WO2019236639A1 (en) * | 2018-06-04 | 2019-12-12 | Tricida, Inc. | Method of treating acid-base disorders |
| MX2021004640A (es) | 2018-10-29 | 2021-05-28 | Pharmacosmos Holding As | Tratamiento de la deficiencia de hierro con carboximaltosa ferrica. |
| WO2022150623A1 (en) | 2021-01-08 | 2022-07-14 | Akebia Therapeutics, Inc. | Compounds and composition for the treatment of anemia |
| EP4347022A1 (en) | 2021-05-27 | 2024-04-10 | Keryx Biopharmaceuticals, Inc. | Pediatric formulations of ferric citrate |
| CN115024495B (zh) * | 2022-06-27 | 2024-03-22 | 北京金康普食品科技有限公司 | 改善肾病患者钙磷代谢的营养组合物及其应用 |
| WO2025181559A1 (en) * | 2024-02-29 | 2025-09-04 | Sloiron, Inc. | Methods for determining the amount of encapsulated and free iron in a sample |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1230118A (zh) * | 1996-07-19 | 1999-09-29 | 日研化学株式会社 | 高磷血症治疗剂 |
| US5753706A (en) * | 1996-12-16 | 1998-05-19 | Hsu; Chen Hsing | Methods for treating renal failure |
| TWI335218B (en) * | 2003-02-19 | 2011-01-01 | Panion & Bf Biotech Inc | Ferric organic compounds, uses thereof and methods of making same |
| US8093423B2 (en) | 2003-02-19 | 2012-01-10 | Globoasia, Llc | Pharmaceutical-grade ferric organic compounds, uses thereof and method of making same |
| CN1600302A (zh) * | 2003-09-22 | 2005-03-30 | 宝龄富锦生技股份有限公司 | 含有柠檬酸铁的医药组合物以及药用级柠檬酸铁及其制法和含有药用级柠檬酸铁的膳食营养品 |
| US20060134227A1 (en) * | 2004-12-22 | 2006-06-22 | Bortz Jonathan D | Compositions including iron |
| NZ566743A (en) | 2005-08-18 | 2010-07-30 | Globoasia Llc | Pharmaceutical-grade ferric organic compounds, uses thereof and methods of making same |
| WO2007081744A2 (en) * | 2006-01-06 | 2007-07-19 | Luitpold Pharmaceuticals, Inc. | Methods and compositions for administration of iron |
| EP1978808B1 (en) * | 2006-01-30 | 2018-08-29 | Panion & BF Biotech Inc. | Ferric citrate for reversing, preventing, delaying or stabilizing soft tissue calcification |
| KR20120046753A (ko) * | 2009-07-21 | 2012-05-10 | 케릭스 바이오파마슈티컬스 인코포레이티드 | 구연산철 투여형태 |
-
2013
- 2013-06-21 SG SG11201408521WA patent/SG11201408521WA/en unknown
- 2013-06-21 US US13/924,332 patent/US20130345303A1/en not_active Abandoned
- 2013-06-21 ES ES13807102T patent/ES2796254T3/es active Active
- 2013-06-21 BR BR112014032049A patent/BR112014032049A2/pt not_active IP Right Cessation
- 2013-06-21 JP JP2015518623A patent/JP2015535209A/ja active Pending
- 2013-06-21 DK DK20163104.1T patent/DK3730136T3/da active
- 2013-06-21 CN CN202110644193.4A patent/CN113244209A/zh active Pending
- 2013-06-21 AU AU2013278000A patent/AU2013278000A1/en not_active Abandoned
- 2013-06-21 CA CA2876982A patent/CA2876982A1/en not_active Abandoned
- 2013-06-21 KR KR1020207024260A patent/KR20200103855A/ko not_active Ceased
- 2013-06-21 CN CN201380044271.0A patent/CN104884055A/zh active Pending
- 2013-06-21 EP EP23219273.2A patent/EP4335436A3/en not_active Withdrawn
- 2013-06-21 ES ES20163104T patent/ES2970050T3/es active Active
- 2013-06-21 SG SG10201805177PA patent/SG10201805177PA/en unknown
- 2013-06-21 HK HK16102352.0A patent/HK1214503A1/zh unknown
- 2013-06-21 EP EP20163104.1A patent/EP3730136B1/en active Active
- 2013-06-21 MX MX2014015615A patent/MX2014015615A/es unknown
- 2013-06-21 PL PL20163104.1T patent/PL3730136T3/pl unknown
- 2013-06-21 KR KR1020157001458A patent/KR102150135B1/ko active Active
- 2013-06-21 EA EA201590062A patent/EA201590062A1/ru unknown
- 2013-06-21 EP EP13807102.2A patent/EP2863906B1/en active Active
- 2013-06-21 WO PCT/US2013/047134 patent/WO2013192565A2/en not_active Ceased
-
2014
- 2014-04-25 US US14/262,465 patent/US20140234416A1/en not_active Abandoned
- 2014-10-24 US US14/523,656 patent/US20150079168A1/en not_active Abandoned
- 2014-12-18 IL IL236356A patent/IL236356A0/en unknown
-
2018
- 2018-04-10 JP JP2018075243A patent/JP2018138562A/ja active Pending
- 2018-05-08 AU AU2018203205A patent/AU2018203205B2/en not_active Ceased
-
2020
- 2020-02-25 JP JP2020029756A patent/JP2020100638A/ja active Pending
-
2022
- 2022-02-10 JP JP2022019167A patent/JP2022070945A/ja active Pending
-
2025
- 2025-11-06 NO NO2025048C patent/NO2025048I1/no unknown
- 2025-11-18 FR FR25C1043C patent/FR25C1043I1/fr active Active
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