JP2011246474A5 - - Google Patents
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- Publication number
- JP2011246474A5 JP2011246474A5 JP2011151443A JP2011151443A JP2011246474A5 JP 2011246474 A5 JP2011246474 A5 JP 2011246474A5 JP 2011151443 A JP2011151443 A JP 2011151443A JP 2011151443 A JP2011151443 A JP 2011151443A JP 2011246474 A5 JP2011246474 A5 JP 2011246474A5
- Authority
- JP
- Japan
- Prior art keywords
- erythropoietin
- formulation
- combination
- modified
- epo
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 102000003951 Erythropoietin Human genes 0.000 description 27
- 108090000394 Erythropoietin Proteins 0.000 description 27
- 229940105423 erythropoietin Drugs 0.000 description 27
- OXCMYAYHXIHQOA-UHFFFAOYSA-N potassium;[2-butyl-5-chloro-3-[[4-[2-(1,2,4-triaza-3-azanidacyclopenta-1,4-dien-5-yl)phenyl]phenyl]methyl]imidazol-4-yl]methanol Chemical compound [K+].CCCCC1=NC(Cl)=C(CO)N1CC1=CC=C(C=2C(=CC=CC=2)C2=N[N-]N=N2)C=C1 OXCMYAYHXIHQOA-UHFFFAOYSA-N 0.000 description 27
- 102000001554 Hemoglobins Human genes 0.000 description 21
- 108010054147 Hemoglobins Proteins 0.000 description 21
- 238000009472 formulation Methods 0.000 description 12
- 239000000203 mixture Substances 0.000 description 12
- 239000002552 dosage form Substances 0.000 description 9
- 239000003814 drug Substances 0.000 description 9
- 238000002360 preparation method Methods 0.000 description 9
- 229940079593 drug Drugs 0.000 description 8
- INGWEZCOABYORO-UHFFFAOYSA-N 2-(furan-2-yl)-7-methyl-1h-1,8-naphthyridin-4-one Chemical class N=1C2=NC(C)=CC=C2C(O)=CC=1C1=CC=CO1 INGWEZCOABYORO-UHFFFAOYSA-N 0.000 description 4
- 239000000243 solution Substances 0.000 description 4
- 238000000034 method Methods 0.000 description 3
- XEEYBQQBJWHFJM-UHFFFAOYSA-N Iron Chemical compound [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 description 2
- 239000003708 ampul Substances 0.000 description 2
- 208000007502 anemia Diseases 0.000 description 2
- 239000003795 chemical substances by application Substances 0.000 description 2
- 208000015710 Iron-Deficiency Anemia Diseases 0.000 description 1
- 238000007796 conventional method Methods 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 239000011521 glass Substances 0.000 description 1
- 239000003978 infusion fluid Substances 0.000 description 1
- 229910052742 iron Inorganic materials 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 239000008194 pharmaceutical composition Substances 0.000 description 1
- 239000000546 pharmaceutical excipient Substances 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 230000001360 synchronised effect Effects 0.000 description 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP97110168.8 | 1997-06-21 | ||
| EP97110168A EP0885613A1 (de) | 1997-06-21 | 1997-06-21 | Verwendung von modifizierten Hämoglobinen zur Behandlung von Anämien und Kombinationspräparate umfassend Erythropoietin und modifiziertes Hämoglobin |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2007113275A Division JP2007246530A (ja) | 1997-06-21 | 2007-04-23 | エリトロポエチン及び修飾ヘモグロビンを含んでいる医薬配合製剤 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2011246474A JP2011246474A (ja) | 2011-12-08 |
| JP2011246474A5 true JP2011246474A5 (enExample) | 2013-11-21 |
| JP5785008B2 JP5785008B2 (ja) | 2015-09-24 |
Family
ID=8226937
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP50365599A Withdrawn JP2002504913A (ja) | 1997-06-21 | 1998-06-03 | エリトロポエチン及び修飾ヘモグロビンを含んでいる医薬配合製剤 |
| JP2007113275A Withdrawn JP2007246530A (ja) | 1997-06-21 | 2007-04-23 | エリトロポエチン及び修飾ヘモグロビンを含んでいる医薬配合製剤 |
| JP2011151443A Expired - Lifetime JP5785008B2 (ja) | 1997-06-21 | 2011-07-08 | エリトロポエチン及び修飾ヘモグロビンを含んでいる医薬配合製剤 |
Family Applications Before (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP50365599A Withdrawn JP2002504913A (ja) | 1997-06-21 | 1998-06-03 | エリトロポエチン及び修飾ヘモグロビンを含んでいる医薬配合製剤 |
| JP2007113275A Withdrawn JP2007246530A (ja) | 1997-06-21 | 2007-04-23 | エリトロポエチン及び修飾ヘモグロビンを含んでいる医薬配合製剤 |
Country Status (15)
| Country | Link |
|---|---|
| US (3) | US6440932B1 (enExample) |
| EP (2) | EP0885613A1 (enExample) |
| JP (3) | JP2002504913A (enExample) |
| KR (1) | KR100519904B1 (enExample) |
| CN (1) | CN1185010C (enExample) |
| AT (1) | ATE272405T1 (enExample) |
| AU (1) | AU743475B2 (enExample) |
| BR (1) | BR9810267A (enExample) |
| CA (1) | CA2294448C (enExample) |
| DE (1) | DE59811768D1 (enExample) |
| DK (1) | DK0996462T3 (enExample) |
| ES (1) | ES2226151T3 (enExample) |
| PT (1) | PT996462E (enExample) |
| TR (1) | TR199903192T2 (enExample) |
| WO (1) | WO1998058660A1 (enExample) |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1998041226A1 (de) * | 1997-03-18 | 1998-09-24 | Roche Diagnostics Gmbh | Pharmazeutische kombinationspräparate enthaltend erythropoietin und eisenpräparate |
| US7345019B1 (en) * | 1999-04-13 | 2008-03-18 | The Kenneth S. Warren Institute, Inc. | Modulation of excitable tissue function by peripherally administered erythropoietin |
| MEP90708A (hr) * | 2000-05-15 | 2011-12-20 | Nova farmaceutska smješa | |
| AU3323002A (en) | 2000-12-20 | 2002-07-01 | Hoffmann La Roche | Erythropoietin conjugates |
| US20030072737A1 (en) | 2000-12-29 | 2003-04-17 | Michael Brines | Tissue protective cytokines for the protection, restoration, and enhancement of responsive cells, tissues and organs |
| US7767643B2 (en) | 2000-12-29 | 2010-08-03 | The Kenneth S. Warren Institute, Inc. | Protection, restoration, and enhancement of erythropoietin-responsive cells, tissues and organs |
| DE10215315A1 (de) * | 2002-04-05 | 2003-11-20 | Aventis Behring Gmbh Intellect | Human-Transferrin zur Behandlung der Anaemia of Chronic Disease (ACD) und des funktionellen Eisenmangels |
| US7459435B2 (en) * | 2002-08-29 | 2008-12-02 | Hoffmann-La Roche Inc. | Treatment of disturbances of iron distribution |
| US7459436B2 (en) * | 2002-11-22 | 2008-12-02 | Hoffmann-La Roche Inc. | Treatment of disturbances of iron distribution |
| CN1897959A (zh) | 2003-09-29 | 2007-01-17 | 沃伦药品公司 | 用于治疗和预防脓毒病和粘连形成的组织保护细胞因子 |
| RU2273485C2 (ru) * | 2004-05-19 | 2006-04-10 | Виктор Николаевич Алейников | Железосодержащий препарат "феррал" |
| US7772182B2 (en) * | 2004-08-05 | 2010-08-10 | Alza Corporation | Stable suspension formulations of erythropoietin receptor agonists |
| CN101534847A (zh) | 2006-08-04 | 2009-09-16 | 普罗龙药品公司 | 修饰型促红细胞生成素 |
| AR067537A1 (es) | 2007-07-17 | 2009-10-14 | Hoffmann La Roche | Purificacion de polipeptidos pegilados |
| CL2008002054A1 (es) * | 2007-07-17 | 2009-05-29 | Hoffmann La Roche | Metodo para la regeneracion de una columna de cromatografia de intercambio cationico despues de la elusion de eritropoyetina monopeguilada y metodo para obtener una eritropoyetina monopeguilada, incorporando el metodo de regeneracion de la columna de intercambio cationico. |
| SMT202000649T1 (it) | 2015-11-23 | 2021-01-05 | Bristol Myers Squibb Co | Sistemi di additivi per l'uso nella pegilazione di proteine |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IL77081A (en) | 1984-12-04 | 1999-10-28 | Genetics Inst | Dna sequence encoding human erythropoietin process for the preparation thereof and a pharmaceutical composition of human erythropoietin |
| US4826811A (en) * | 1986-06-20 | 1989-05-02 | Northfield Laboratories, Inc. | Acellular red blood cell substitute |
| JP2858752B2 (ja) * | 1987-04-10 | 1999-02-17 | オーソ・フアーマシユーチカル・コーポレーシヨン | 正常な哺乳動物のヘマトクリツト値の増大方法 |
| JPH03112934A (ja) * | 1989-09-27 | 1991-05-14 | Mitsubishi Kasei Corp | 圧縮成型可能な粉体組成物 |
| US5631219A (en) * | 1994-03-08 | 1997-05-20 | Somatogen, Inc. | Method of stimulating hematopoiesis with hemoglobin |
| JPH09507867A (ja) * | 1994-11-17 | 1997-08-12 | バクスター、インターナショナル、インコーポレイテッド | 血液透析におけるヘモグロビン療法 |
| DE19535571A1 (de) | 1995-09-14 | 1997-03-20 | Boehringer Mannheim Gmbh | Pharmazeutische Kombinationspräparate und deren Verwendung zur Behandlung von Hämodialysepatienten |
| WO1998008537A1 (en) * | 1996-08-27 | 1998-03-05 | Hemosol Inc. | Enhanced stimulation of erythropoiesis |
-
1997
- 1997-06-21 EP EP97110168A patent/EP0885613A1/de not_active Withdrawn
-
1998
- 1998-06-03 US US09/446,378 patent/US6440932B1/en not_active Expired - Lifetime
- 1998-06-03 JP JP50365599A patent/JP2002504913A/ja not_active Withdrawn
- 1998-06-03 KR KR10-1999-7012111A patent/KR100519904B1/ko not_active Expired - Fee Related
- 1998-06-03 WO PCT/EP1998/003299 patent/WO1998058660A1/de not_active Ceased
- 1998-06-03 PT PT98930785T patent/PT996462E/pt unknown
- 1998-06-03 CA CA002294448A patent/CA2294448C/en not_active Expired - Lifetime
- 1998-06-03 ES ES98930785T patent/ES2226151T3/es not_active Expired - Lifetime
- 1998-06-03 AT AT98930785T patent/ATE272405T1/de active
- 1998-06-03 TR TR1999/03192T patent/TR199903192T2/xx unknown
- 1998-06-03 DE DE59811768T patent/DE59811768D1/de not_active Expired - Lifetime
- 1998-06-03 CN CNB988064324A patent/CN1185010C/zh not_active Expired - Lifetime
- 1998-06-03 BR BR9810267-2A patent/BR9810267A/pt not_active Application Discontinuation
- 1998-06-03 AU AU81098/98A patent/AU743475B2/en not_active Expired
- 1998-06-03 EP EP98930785A patent/EP0996462B1/de not_active Expired - Lifetime
- 1998-06-03 DK DK98930785T patent/DK0996462T3/da active
-
2002
- 2002-05-08 US US10/140,682 patent/US20020160956A1/en not_active Abandoned
-
2005
- 2005-03-28 US US11/091,876 patent/US20050197281A1/en not_active Abandoned
-
2007
- 2007-04-23 JP JP2007113275A patent/JP2007246530A/ja not_active Withdrawn
-
2011
- 2011-07-08 JP JP2011151443A patent/JP5785008B2/ja not_active Expired - Lifetime
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