JP2015535002A5 - - Google Patents
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- JP2015535002A5 JP2015535002A5 JP2015540135A JP2015540135A JP2015535002A5 JP 2015535002 A5 JP2015535002 A5 JP 2015535002A5 JP 2015540135 A JP2015540135 A JP 2015540135A JP 2015540135 A JP2015540135 A JP 2015540135A JP 2015535002 A5 JP2015535002 A5 JP 2015535002A5
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- 102000008394 Immunoglobulin Fragments Human genes 0.000 claims 39
- 108010021625 Immunoglobulin Fragments Proteins 0.000 claims 39
- 239000012634 fragment Substances 0.000 claims 12
- 150000007523 nucleic acids Chemical class 0.000 claims 8
- 102000039446 nucleic acids Human genes 0.000 claims 8
- 108020004707 nucleic acids Proteins 0.000 claims 8
- 239000002773 nucleotide Substances 0.000 claims 8
- 125000003729 nucleotide group Chemical group 0.000 claims 8
- 210000003719 b-lymphocyte Anatomy 0.000 claims 6
- 206010028980 Neoplasm Diseases 0.000 claims 4
- 201000011510 cancer Diseases 0.000 claims 4
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 4
- 230000001717 pathogenic effect Effects 0.000 claims 4
- 210000004027 cell Anatomy 0.000 claims 3
- 239000003795 chemical substances by application Substances 0.000 claims 3
- 201000010099 disease Diseases 0.000 claims 3
- 239000003814 drug Substances 0.000 claims 3
- 210000004180 plasmocyte Anatomy 0.000 claims 3
- 208000023275 Autoimmune disease Diseases 0.000 claims 2
- 201000000596 systemic lupus erythematosus Diseases 0.000 claims 2
- 208000017604 Hodgkin disease Diseases 0.000 claims 1
- 208000010747 Hodgkins lymphoma Diseases 0.000 claims 1
- 208000034578 Multiple myelomas Diseases 0.000 claims 1
- 206010035226 Plasma cell myeloma Diseases 0.000 claims 1
- 208000007452 Plasmacytoma Diseases 0.000 claims 1
- 208000033559 Waldenström macroglobulinemia Diseases 0.000 claims 1
- 238000007792 addition Methods 0.000 claims 1
- 125000003275 alpha amino acid group Chemical group 0.000 claims 1
- 125000000539 amino acid group Chemical group 0.000 claims 1
- 150000001413 amino acids Chemical class 0.000 claims 1
- 230000001580 bacterial effect Effects 0.000 claims 1
- 238000006243 chemical reaction Methods 0.000 claims 1
- 230000000295 complement effect Effects 0.000 claims 1
- 230000037430 deletion Effects 0.000 claims 1
- 238000012217 deletion Methods 0.000 claims 1
- 208000035475 disorder Diseases 0.000 claims 1
- 229940079593 drug Drugs 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 230000002068 genetic effect Effects 0.000 claims 1
- 150000004676 glycans Chemical class 0.000 claims 1
- 230000002757 inflammatory effect Effects 0.000 claims 1
- 230000037431 insertion Effects 0.000 claims 1
- 238000003780 insertion Methods 0.000 claims 1
- 230000003993 interaction Effects 0.000 claims 1
- 210000004962 mammalian cell Anatomy 0.000 claims 1
- 210000001806 memory b lymphocyte Anatomy 0.000 claims 1
- 150000002482 oligosaccharides Polymers 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 208000031223 plasma cell leukemia Diseases 0.000 claims 1
- 229920001282 polysaccharide Polymers 0.000 claims 1
- 239000005017 polysaccharide Substances 0.000 claims 1
- 206010039073 rheumatoid arthritis Diseases 0.000 claims 1
- 238000006467 substitution reaction Methods 0.000 claims 1
- 229940124597 therapeutic agent Drugs 0.000 claims 1
- 230000017105 transposition Effects 0.000 claims 1
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP12190970.9 | 2012-11-01 | ||
| EP12190970 | 2012-11-01 | ||
| EP13156091.4 | 2013-02-21 | ||
| EP13156091 | 2013-02-21 | ||
| EP13180548.3 | 2013-08-15 | ||
| EP13180548 | 2013-08-15 | ||
| PCT/EP2013/072857 WO2014068079A1 (en) | 2012-11-01 | 2013-11-01 | An antibody that binds cd269 (bcma) suitable for use in the treatment of plasma cell diseases such as multiple myeloma and autoimmune diseases |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020015980A Division JP2020078319A (ja) | 2012-11-01 | 2020-02-03 | Ｃｄ２６９（ｂｃｍａ）に対する抗体 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2015535002A JP2015535002A (ja) | 2015-12-07 |
| JP2015535002A5 true JP2015535002A5 (enExample) | 2016-12-15 |
| JP6694712B2 JP6694712B2 (ja) | 2020-05-20 |
Family
ID=49552346
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015540135A Active JP6694712B2 (ja) | 2012-11-01 | 2013-11-01 | Ｃｄ２６９（ｂｃｍａ）に対する抗体 |
| JP2020015980A Pending JP2020078319A (ja) | 2012-11-01 | 2020-02-03 | Ｃｄ２６９（ｂｃｍａ）に対する抗体 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020015980A Pending JP2020078319A (ja) | 2012-11-01 | 2020-02-03 | Ｃｄ２６９（ｂｃｍａ）に対する抗体 |
Country Status (7)
| Country | Link |
|---|---|
| US (3) | US10189906B2 (enExample) |
| EP (2) | EP2914628A1 (enExample) |
| JP (2) | JP6694712B2 (enExample) |
| AU (1) | AU2013340799B2 (enExample) |
| CA (1) | CA2889764C (enExample) |
| ES (1) | ES2937015T3 (enExample) |
| WO (1) | WO2014068079A1 (enExample) |
Families Citing this family (98)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2914628A1 (en) * | 2012-11-01 | 2015-09-09 | Max-Delbrück-Centrum für Molekulare Medizin | An antibody that binds cd269 (bcma) suitable for use in the treatment of plasma cell diseases such as multiple myeloma and autoimmune diseases |
| PL2953972T3 (pl) | 2013-02-05 | 2021-03-08 | Engmab Sàrl | Metoda wyboru przeciwciał przeciwko bcma |
| WO2014124280A1 (en) | 2013-02-08 | 2014-08-14 | Institute For Myeloma & Bone Cancer Research | Improved diagnostic, prognostic, and monitoring methods for multiple myeloma, chronic lymphocytic leukemia, and b-cell non-hodgkin lymphoma |
| KR102526945B1 (ko) * | 2014-04-30 | 2023-04-27 | 막스-델부뤽-센트럼 퓌어 몰레쿨라레 메디친 인 데어 헬름홀츠-게마인샤프트 | Ｃｄ269에 대한 인간화 항체 |
| WO2016014565A2 (en) | 2014-07-21 | 2016-01-28 | Novartis Ag | Treatment of cancer using humanized anti-bcma chimeric antigen receptor |
| CN107109420A (zh) | 2014-07-21 | 2017-08-29 | 诺华股份有限公司 | 使用cll－1嵌合抗原受体的癌症治疗 |
| US9616114B1 (en) | 2014-09-18 | 2017-04-11 | David Gordon Bermudes | Modified bacteria having improved pharmacokinetics and tumor colonization enhancing antitumor activity |
| ES3012402T3 (en) | 2015-04-13 | 2025-04-09 | Pfizer | Therapeutic antibodies and their uses |
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| US12048718B2 (en) | 2016-06-07 | 2024-07-30 | Max-Delbrück-Centrum für Molekulare Medizin in der Helmholtz-Geminschaft | Chimeric antigen receptor and CAR-T cells that bind BCMA |
| UA126384C2 (uk) | 2016-09-14 | 2022-09-28 | Тенеобіо, Інк. | Антитіло, яке зв'язує cd3 |
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| CN110945026B (zh) * | 2017-06-20 | 2024-03-19 | 特纳奥尼股份有限公司 | 仅有重链的抗bcma抗体 |
| CN111107874A (zh) | 2017-09-14 | 2020-05-05 | 葛兰素史密斯克莱知识产权发展有限公司 | 用于癌症的组合治疗 |
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| JP7438953B2 (ja) * | 2018-02-01 | 2024-02-27 | イノベント バイオロジックス （スウツォウ） カンパニー，リミテッド | 完全ヒト化抗ｂ細胞成熟抗原（ｂｃｍａ）の単鎖抗体およびその応用 |
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| CN112566643A (zh) | 2018-06-12 | 2021-03-26 | 加利福尼亚大学董事会 | 用于治疗癌症的单链双特异性嵌合抗原受体 |
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| PH12013502421A1 (en) | 2011-05-27 | 2014-01-06 | Glaxo Group Ltd | Bcma (cd269/tnfrsf17) -binding proteins |
| EP2914628A1 (en) * | 2012-11-01 | 2015-09-09 | Max-Delbrück-Centrum für Molekulare Medizin | An antibody that binds cd269 (bcma) suitable for use in the treatment of plasma cell diseases such as multiple myeloma and autoimmune diseases |
| KR102526945B1 (ko) | 2014-04-30 | 2023-04-27 | 막스-델부뤽-센트럼 퓌어 몰레쿨라레 메디친 인 데어 헬름홀츠-게마인샤프트 | Ｃｄ269에 대한 인간화 항체 |
-
2013
- 2013-11-01 EP EP13788724.6A patent/EP2914628A1/en not_active Withdrawn
- 2013-11-01 EP EP19155984.8A patent/EP3508503B1/en active Active
- 2013-11-01 CA CA2889764A patent/CA2889764C/en active Active
- 2013-11-01 WO PCT/EP2013/072857 patent/WO2014068079A1/en not_active Ceased
- 2013-11-01 JP JP2015540135A patent/JP6694712B2/ja active Active
- 2013-11-01 ES ES19155984T patent/ES2937015T3/es active Active
- 2013-11-01 US US14/440,165 patent/US10189906B2/en active Active
- 2013-11-01 AU AU2013340799A patent/AU2013340799B2/en active Active
-
2018
- 2018-12-13 US US16/219,379 patent/US10745486B2/en active Active
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2020
- 2020-02-03 JP JP2020015980A patent/JP2020078319A/ja active Pending
- 2020-07-08 US US16/923,726 patent/US11667722B2/en active Active
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