JP2017515470A5 - - Google Patents
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- JP2017515470A5 JP2017515470A5 JP2016565168A JP2016565168A JP2017515470A5 JP 2017515470 A5 JP2017515470 A5 JP 2017515470A5 JP 2016565168 A JP2016565168 A JP 2016565168A JP 2016565168 A JP2016565168 A JP 2016565168A JP 2017515470 A5 JP2017515470 A5 JP 2017515470A5
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- Japan
- Prior art keywords
- antibody
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- 102000008394 Immunoglobulin Fragments Human genes 0.000 claims 19
- 108010021625 Immunoglobulin Fragments Proteins 0.000 claims 19
- 108020004707 nucleic acids Proteins 0.000 claims 8
- 150000007523 nucleic acids Chemical class 0.000 claims 8
- 102000039446 nucleic acids Human genes 0.000 claims 8
- 239000003814 drug Substances 0.000 claims 6
- 239000002773 nucleotide Substances 0.000 claims 6
- 125000003729 nucleotide group Chemical group 0.000 claims 6
- 210000003719 b-lymphocyte Anatomy 0.000 claims 5
- 239000000611 antibody drug conjugate Substances 0.000 claims 4
- 229940049595 antibody-drug conjugate Drugs 0.000 claims 4
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 4
- 208000035475 disorder Diseases 0.000 claims 4
- 230000001717 pathogenic effect Effects 0.000 claims 4
- 210000004027 cell Anatomy 0.000 claims 3
- 210000004180 plasmocyte Anatomy 0.000 claims 3
- 206010028980 Neoplasm Diseases 0.000 claims 2
- 108091028043 Nucleic acid sequence Proteins 0.000 claims 2
- 201000011510 cancer Diseases 0.000 claims 2
- 239000012634 fragment Substances 0.000 claims 2
- 210000001806 memory b lymphocyte Anatomy 0.000 claims 2
- 201000000596 systemic lupus erythematosus Diseases 0.000 claims 2
- 208000023275 Autoimmune disease Diseases 0.000 claims 1
- 208000037914 B-cell disorder Diseases 0.000 claims 1
- 208000017604 Hodgkin disease Diseases 0.000 claims 1
- 208000010747 Hodgkins lymphoma Diseases 0.000 claims 1
- 208000034578 Multiple myelomas Diseases 0.000 claims 1
- 206010035226 Plasma cell myeloma Diseases 0.000 claims 1
- 208000007452 Plasmacytoma Diseases 0.000 claims 1
- 208000033559 Waldenström macroglobulinemia Diseases 0.000 claims 1
- 238000007792 addition Methods 0.000 claims 1
- 125000003275 alpha amino acid group Chemical group 0.000 claims 1
- 150000001413 amino acids Chemical class 0.000 claims 1
- 230000001580 bacterial effect Effects 0.000 claims 1
- 230000000295 complement effect Effects 0.000 claims 1
- 230000037430 deletion Effects 0.000 claims 1
- 238000012217 deletion Methods 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 230000002068 genetic effect Effects 0.000 claims 1
- 150000004676 glycans Chemical class 0.000 claims 1
- 210000004408 hybridoma Anatomy 0.000 claims 1
- 208000026278 immune system disease Diseases 0.000 claims 1
- 230000002757 inflammatory effect Effects 0.000 claims 1
- 238000003780 insertion Methods 0.000 claims 1
- 230000037431 insertion Effects 0.000 claims 1
- 230000003993 interaction Effects 0.000 claims 1
- 210000004962 mammalian cell Anatomy 0.000 claims 1
- 150000002482 oligosaccharides Polymers 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 208000031223 plasma cell leukemia Diseases 0.000 claims 1
- 206010039073 rheumatoid arthritis Diseases 0.000 claims 1
- 238000006467 substitution reaction Methods 0.000 claims 1
- 229940124597 therapeutic agent Drugs 0.000 claims 1
- 230000005945 translocation Effects 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP14166729.5 | 2014-04-30 | ||
| EP14166729 | 2014-04-30 | ||
| PCT/EP2015/059562 WO2015166073A1 (en) | 2014-04-30 | 2015-04-30 | Humanized antibodies against cd269 (bcma) |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020142486A Division JP7189913B2 (ja) | 2014-04-30 | 2020-08-26 | Ｃｄ２６９（ｂｃｍａ）に対するヒト化抗体 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2017515470A JP2017515470A (ja) | 2017-06-15 |
| JP2017515470A5 true JP2017515470A5 (enExample) | 2018-06-07 |
| JP6755805B2 JP6755805B2 (ja) | 2020-09-16 |
Family
ID=50677985
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016565168A Active JP6755805B2 (ja) | 2014-04-30 | 2015-04-30 | Ｃｄ２６９（ｂｃｍａ）に対するヒト化抗体 |
| JP2020142486A Active JP7189913B2 (ja) | 2014-04-30 | 2020-08-26 | Ｃｄ２６９（ｂｃｍａ）に対するヒト化抗体 |
| JP2022194533A Pending JP2023025202A (ja) | 2014-04-30 | 2022-12-05 | Ｃｄ２６９（ｂｃｍａ）に対するヒト化抗体 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020142486A Active JP7189913B2 (ja) | 2014-04-30 | 2020-08-26 | Ｃｄ２６９（ｂｃｍａ）に対するヒト化抗体 |
| JP2022194533A Pending JP2023025202A (ja) | 2014-04-30 | 2022-12-05 | Ｃｄ２６９（ｂｃｍａ）に対するヒト化抗体 |
Country Status (15)
| Country | Link |
|---|---|
| US (3) | US10144782B2 (enExample) |
| EP (1) | EP3137500A1 (enExample) |
| JP (3) | JP6755805B2 (enExample) |
| KR (3) | KR102526945B1 (enExample) |
| CN (2) | CN113491776B (enExample) |
| AU (1) | AU2015254526B2 (enExample) |
| BR (1) | BR112016024546A2 (enExample) |
| IL (2) | IL303667A (enExample) |
| MX (2) | MX375800B (enExample) |
| NZ (1) | NZ725701A (enExample) |
| RU (2) | RU2021115081A (enExample) |
| SG (1) | SG11201608415QA (enExample) |
| UA (1) | UA121031C2 (enExample) |
| WO (1) | WO2015166073A1 (enExample) |
| ZA (1) | ZA201607018B (enExample) |
Families Citing this family (81)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2914628A1 (en) | 2012-11-01 | 2015-09-09 | Max-Delbrück-Centrum für Molekulare Medizin | An antibody that binds cd269 (bcma) suitable for use in the treatment of plasma cell diseases such as multiple myeloma and autoimmune diseases |
| EP2954330A4 (en) | 2013-02-08 | 2016-08-31 | Inst Myeloma & Bone Cancer Res | IMPROVED DIAGNOSTIC, PROGNOSTIC AND MONITORING PROCEDURES FOR MULTIPLE MYELOMA, CHRONIC LYMPHATIC LEUKEMIA AND NON-HODGKIN B CELL LYMPHOMA |
| KR102526945B1 (ko) * | 2014-04-30 | 2023-04-27 | 막스-델부뤽-센트럼 퓌어 몰레쿨라레 메디친 인 데어 헬름홀츠-게마인샤프트 | Ｃｄ269에 대한 인간화 항체 |
| BR112017001183A2 (pt) | 2014-07-21 | 2017-11-28 | Novartis Ag | tratamento de câncer usando receptor de antígeno quimérico anti-bcma humanizado |
| DK3283520T3 (da) | 2015-04-13 | 2020-07-20 | Pfizer | Kimæriske antigenreceptorer målrettet b-celle- modningsantigen |
| JP6913025B2 (ja) | 2015-04-13 | 2021-08-04 | ファイザー・インク | 治療抗体およびその使用 |
| JP7011600B2 (ja) | 2016-01-12 | 2022-01-26 | ジェイムズ リチャード ベレンソン， | 被験体の免疫状態をモニタリングするための改善された方法 |
| MA44254A (fr) * | 2016-02-17 | 2018-12-26 | Seattle Genetics Inc | Anticorps bcma et leur utilisation pour traiter le cancer et les troubles immunologiques |
| AU2017276706B2 (en) * | 2016-06-07 | 2024-08-15 | Max-Delbrück-Centrum Für Molekulare Medizin In Der Helmholtz-Gemeinschaft | Chimeric antigen receptor and CAR-T cells that bind BCMA |
| EA201891851A1 (ru) * | 2016-09-16 | 2019-04-30 | Сиэтл Дженетикс, Инк. | Антитела против bcma и их применение для лечения злокачественных новообразований и иммунологических нарушений |
| JP7038717B2 (ja) | 2016-12-23 | 2022-03-18 | ハイデルベルク ファルマ リサーチ ゲゼルシャフト ミット ベシュレンクテル ハフツング | アマニチン抗体コンジュゲート |
| CN108285489A (zh) * | 2017-01-09 | 2018-07-17 | 上海恒润达生生物科技有限公司 | 靶向BCMA-BBz-tEGFR的嵌合抗原受体及其用途 |
| CN110582509A (zh) | 2017-01-31 | 2019-12-17 | 诺华股份有限公司 | 使用具有多特异性的嵌合t细胞受体蛋白治疗癌症 |
| CN108395478A (zh) * | 2017-02-04 | 2018-08-14 | 上海恒润达生生物科技有限公司 | 靶向bcma的嵌合抗原受体并对其双重修饰的方法及其用途 |
| CN117357638A (zh) | 2017-02-17 | 2024-01-09 | 弗雷德哈钦森癌症中心 | 用于治疗bcma相关癌症和自身免疫性失调的联合疗法 |
| US20200179511A1 (en) | 2017-04-28 | 2020-06-11 | Novartis Ag | Bcma-targeting agent, and combination therapy with a gamma secretase inhibitor |
| US20200055948A1 (en) | 2017-04-28 | 2020-02-20 | Novartis Ag | Cells expressing a bcma-targeting chimeric antigen receptor, and combination therapy with a gamma secretase inhibitor |
| EP3639028B1 (en) | 2017-06-13 | 2025-10-15 | Onco Tracker, Inc. | Diagnostic, prognostic, and monitoring methods for breast cancer |
| WO2019035938A1 (en) | 2017-08-16 | 2019-02-21 | Elstar Therapeutics, Inc. | MULTISPECIFIC MOLECULES BINDING TO BCMA AND USES THEREOF |
| US11999802B2 (en) | 2017-10-18 | 2024-06-04 | Novartis Ag | Compositions and methods for selective protein degradation |
| CN111787938A (zh) | 2017-11-15 | 2020-10-16 | 诺华股份有限公司 | 靶向bcma的嵌合抗原受体、靶向cd19的嵌合抗原受体及组合疗法 |
| RU2020121458A (ru) | 2017-11-30 | 2021-12-30 | Новартис Аг | Химерный антигенный рецептор, нацеливающийся на bcma, и его пути применения |
| CN112218651A (zh) | 2018-01-08 | 2021-01-12 | 诺华公司 | 用于与嵌合抗原受体疗法组合的免疫增强rna |
| US12247060B2 (en) | 2018-01-09 | 2025-03-11 | Marengo Therapeutics, Inc. | Calreticulin binding constructs and engineered T cells for the treatment of diseases |
| US20210038659A1 (en) | 2018-01-31 | 2021-02-11 | Novartis Ag | Combination therapy using a chimeric antigen receptor |
| AU2019214183B2 (en) * | 2018-02-01 | 2022-04-07 | Innovent Biologics (Suzhou) Co., Ltd. | Fully human anti-B cell maturation antigen (BCMA) single chain variable fragment, and application thereof |
| WO2019160956A1 (en) | 2018-02-13 | 2019-08-22 | Novartis Ag | Chimeric antigen receptor therapy in combination with il-15r and il15 |
| KR20200123155A (ko) * | 2018-02-21 | 2020-10-28 | 셀진 코포레이션 | Bcma-결합 항체 및 이의 용도 |
| WO2019178362A1 (en) | 2018-03-14 | 2019-09-19 | Elstar Therapeutics, Inc. | Multifunctional molecules that bind to calreticulin and uses thereof |
| PE20210320A1 (es) | 2018-06-01 | 2021-02-16 | Novartis Ag | Moleculas de union contra bcma y usos de las mismas |
| JP7438988B2 (ja) | 2018-06-13 | 2024-02-27 | ノバルティス アーゲー | Ｂｃｍａキメラ抗原受容体及びその使用 |
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| CA3105448A1 (en) | 2018-07-03 | 2020-01-09 | Elstar Therapeutics, Inc. | Anti-tcr antibody molecules and uses thereof |
| TWI838389B (zh) | 2018-07-19 | 2024-04-11 | 美商再生元醫藥公司 | 雙特異性抗-BCMAｘ抗-CD3抗體及其用途 |
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| CN112074279B (zh) | 2019-01-16 | 2024-01-26 | 卡里布生物科学公司 | 人源化bcma抗体和bcma-car-t细胞 |
| CN119039441A (zh) | 2019-02-21 | 2024-11-29 | 马伦戈治疗公司 | 与nkp30结合的抗体分子及其用途 |
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| JP7631211B2 (ja) | 2019-02-25 | 2025-02-18 | ノバルティス アーゲー | ウイルス送達のためのメソポーラスシリカ粒子組成物 |
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| EP3959320A1 (en) | 2019-04-24 | 2022-03-02 | Novartis AG | Compositions and methods for selective protein degradation |
| EP3962946A1 (en) * | 2019-05-03 | 2022-03-09 | Celgene Corporation | Anti-bcma antibody conjugate, compositions comprising the same, and methods of making and using the same |
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| AU2020322588A1 (en) * | 2019-07-30 | 2022-02-03 | Jiangsu Hansoh Pharmaceutical Group Co., Ltd. | Anti-BCMA antibody, antigen-binding fragment thereof and medical use thereof |
| JP7729561B2 (ja) * | 2019-08-02 | 2025-08-26 | フンダシオ・クリニック・ペル・ア・ラ・レセルカ・ビオメディカ | 多発性骨髄腫治療用の抗ｂｃｍａ ｃａｒ ｔ細胞 |
| MX2022003414A (es) * | 2019-09-25 | 2022-04-18 | Fate Therapeutics Inc | Celulas efectoras con multiples objetivos y uso de las mismas. |
| CN112646032B (zh) | 2019-10-10 | 2025-08-05 | 再凌生物医药(香港)有限公司 | 靶向bcma的具有人猴交叉的人源化单克隆抗体 |
| JP7714545B2 (ja) | 2019-11-26 | 2025-07-29 | ノバルティス アーゲー | キメラ抗原受容体及びその使用 |
| BR112022011964A2 (pt) * | 2019-12-17 | 2022-09-06 | Shenzhen Feipeng Biological Therapy Co Ltd | Anticorpo de ligação a bcma e uso do mesmo |
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| KR20220146530A (ko) | 2020-02-27 | 2022-11-01 | 노파르티스 아게 | 키메라 항원 수용체-발현 세포의 제조 방법 |
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| CN113637073B (zh) * | 2020-05-11 | 2024-04-12 | 上海赛比曼生物科技有限公司 | Bcma抗体及其制备和应用 |
| JP7791843B2 (ja) | 2020-06-05 | 2025-12-24 | エーザイ・アール・アンド・ディー・マネジメント株式会社 | 抗ｂｃｍａ抗体－薬物コンジュゲート及び使用方法 |
| EP4165169A1 (en) | 2020-06-11 | 2023-04-19 | Novartis AG | Zbtb32 inhibitors and uses thereof |
| CN115715325A (zh) * | 2020-08-20 | 2023-02-24 | 正大天晴药业集团股份有限公司 | 结合bcma的单可变结构域及抗原结合分子 |
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| CN112614596B (zh) * | 2020-12-22 | 2023-01-10 | 厦门承葛生物科技有限公司 | 一种肠道菌群移植治疗溃疡性结肠炎的供受体配型方法 |
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Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2301971A1 (en) | 2001-02-20 | 2011-03-30 | ZymoGenetics, L.L.C. | Antibodies that bind both BCMA and TACI |
| AR039067A1 (es) * | 2001-11-09 | 2005-02-09 | Pfizer Prod Inc | Anticuerpos para cd40 |
| KR100708398B1 (ko) | 2002-03-22 | 2007-04-18 | (주) 에이프로젠 | 인간화 항체 및 이의 제조방법 |
| BRPI0610470A2 (pt) * | 2005-05-26 | 2010-06-22 | Seattle Genetics Inc | anticorpo isolado ou fragmento de ligação a antìgeno que especificamente se liga a cd40 humano, kit, composição farmacêutica, e, polinucleotìdeo isolado |
| US9382327B2 (en) * | 2006-10-10 | 2016-07-05 | Vaccinex, Inc. | Anti-CD20 antibodies and methods of use |
| WO2009070767A2 (en) * | 2007-11-28 | 2009-06-04 | Whitehead Institute For Biomedical Research | Systemic instigation systems to study tumor growth or metastasis |
| US20110158995A1 (en) * | 2008-07-28 | 2011-06-30 | Renault S.A.S | Multi-Specific Binding Proteins Targeting B Cell Disorders |
| MX2011009430A (es) | 2009-03-10 | 2011-11-18 | Biogen Idec Inc | Anticuerpos anti-bcma. |
| EP2417164A1 (en) | 2009-04-07 | 2012-02-15 | Roche Glycart AG | Bispecific anti-erbb-2/anti-c-met antibodies |
| US20130273055A1 (en) | 2010-11-16 | 2013-10-17 | Eric Borges | Agents and methods for treating diseases that correlate with bcma expression |
| US20130101599A1 (en) * | 2011-04-21 | 2013-04-25 | Boehringer Ingelheim International Gmbh | Bcma-based stratification and therapy for multiple myeloma patients |
| EP3693394A1 (en) | 2011-05-27 | 2020-08-12 | Glaxo Group Limited | Antigen binding proteins |
| EP2914628A1 (en) | 2012-11-01 | 2015-09-09 | Max-Delbrück-Centrum für Molekulare Medizin | An antibody that binds cd269 (bcma) suitable for use in the treatment of plasma cell diseases such as multiple myeloma and autoimmune diseases |
| KR102526945B1 (ko) * | 2014-04-30 | 2023-04-27 | 막스-델부뤽-센트럼 퓌어 몰레쿨라레 메디친 인 데어 헬름홀츠-게마인샤프트 | Ｃｄ269에 대한 인간화 항체 |
-
2015
- 2015-04-30 KR KR1020227018383A patent/KR102526945B1/ko active Active
- 2015-04-30 RU RU2021115081A patent/RU2021115081A/ru unknown
- 2015-04-30 IL IL303667A patent/IL303667A/en unknown
- 2015-04-30 SG SG11201608415QA patent/SG11201608415QA/en unknown
- 2015-04-30 US US15/306,438 patent/US10144782B2/en active Active
- 2015-04-30 WO PCT/EP2015/059562 patent/WO2015166073A1/en not_active Ceased
- 2015-04-30 CN CN202110761923.9A patent/CN113491776B/zh active Active
- 2015-04-30 UA UAA201612087A patent/UA121031C2/uk unknown
- 2015-04-30 IL IL248257A patent/IL248257B2/en unknown
- 2015-04-30 NZ NZ725701A patent/NZ725701A/en unknown
- 2015-04-30 EP EP15720954.5A patent/EP3137500A1/en active Pending
- 2015-04-30 MX MX2016013767A patent/MX375800B/es active IP Right Grant
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