JP2017515470A5 - - Google Patents
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- JP2017515470A5 JP2017515470A5 JP2016565168A JP2016565168A JP2017515470A5 JP 2017515470 A5 JP2017515470 A5 JP 2017515470A5 JP 2016565168 A JP2016565168 A JP 2016565168A JP 2016565168 A JP2016565168 A JP 2016565168A JP 2017515470 A5 JP2017515470 A5 JP 2017515470A5
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- JP
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- Prior art keywords
- antibody
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- antibody fragment
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- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 102000008394 Immunoglobulin Fragments Human genes 0.000 claims 19
- 108010021625 Immunoglobulin Fragments Proteins 0.000 claims 19
- 108020004707 nucleic acids Proteins 0.000 claims 8
- 150000007523 nucleic acids Chemical class 0.000 claims 8
- 102000039446 nucleic acids Human genes 0.000 claims 8
- 239000003814 drug Substances 0.000 claims 6
- 239000002773 nucleotide Substances 0.000 claims 6
- 125000003729 nucleotide group Chemical group 0.000 claims 6
- 210000003719 b-lymphocyte Anatomy 0.000 claims 5
- 239000000611 antibody drug conjugate Substances 0.000 claims 4
- 229940049595 antibody-drug conjugate Drugs 0.000 claims 4
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 4
- 208000035475 disorder Diseases 0.000 claims 4
- 230000001717 pathogenic effect Effects 0.000 claims 4
- 210000004027 cell Anatomy 0.000 claims 3
- 210000004180 plasmocyte Anatomy 0.000 claims 3
- 206010028980 Neoplasm Diseases 0.000 claims 2
- 108091028043 Nucleic acid sequence Proteins 0.000 claims 2
- 201000011510 cancer Diseases 0.000 claims 2
- 239000012634 fragment Substances 0.000 claims 2
- 210000001806 memory b lymphocyte Anatomy 0.000 claims 2
- 201000000596 systemic lupus erythematosus Diseases 0.000 claims 2
- 208000023275 Autoimmune disease Diseases 0.000 claims 1
- 208000037914 B-cell disorder Diseases 0.000 claims 1
- 208000017604 Hodgkin disease Diseases 0.000 claims 1
- 208000010747 Hodgkins lymphoma Diseases 0.000 claims 1
- 208000034578 Multiple myelomas Diseases 0.000 claims 1
- 206010035226 Plasma cell myeloma Diseases 0.000 claims 1
- 208000007452 Plasmacytoma Diseases 0.000 claims 1
- 208000033559 Waldenström macroglobulinemia Diseases 0.000 claims 1
- 238000007792 addition Methods 0.000 claims 1
- 125000003275 alpha amino acid group Chemical group 0.000 claims 1
- 150000001413 amino acids Chemical class 0.000 claims 1
- 230000001580 bacterial effect Effects 0.000 claims 1
- 230000000295 complement effect Effects 0.000 claims 1
- 230000037430 deletion Effects 0.000 claims 1
- 238000012217 deletion Methods 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 230000002068 genetic effect Effects 0.000 claims 1
- 150000004676 glycans Chemical class 0.000 claims 1
- 210000004408 hybridoma Anatomy 0.000 claims 1
- 208000026278 immune system disease Diseases 0.000 claims 1
- 230000002757 inflammatory effect Effects 0.000 claims 1
- 238000003780 insertion Methods 0.000 claims 1
- 230000037431 insertion Effects 0.000 claims 1
- 230000003993 interaction Effects 0.000 claims 1
- 210000004962 mammalian cell Anatomy 0.000 claims 1
- 150000002482 oligosaccharides Polymers 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 208000031223 plasma cell leukemia Diseases 0.000 claims 1
- 206010039073 rheumatoid arthritis Diseases 0.000 claims 1
- 238000006467 substitution reaction Methods 0.000 claims 1
- 229940124597 therapeutic agent Drugs 0.000 claims 1
- 230000005945 translocation Effects 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP14166729 | 2014-04-30 | ||
| EP14166729.5 | 2014-04-30 | ||
| PCT/EP2015/059562 WO2015166073A1 (en) | 2014-04-30 | 2015-04-30 | Humanized antibodies against cd269 (bcma) |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020142486A Division JP7189913B2 (ja) | 2014-04-30 | 2020-08-26 | Ｃｄ２６９（ｂｃｍａ）に対するヒト化抗体 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2017515470A JP2017515470A (ja) | 2017-06-15 |
| JP2017515470A5 true JP2017515470A5 (enExample) | 2018-06-07 |
| JP6755805B2 JP6755805B2 (ja) | 2020-09-16 |
Family
ID=50677985
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016565168A Active JP6755805B2 (ja) | 2014-04-30 | 2015-04-30 | Ｃｄ２６９（ｂｃｍａ）に対するヒト化抗体 |
| JP2020142486A Active JP7189913B2 (ja) | 2014-04-30 | 2020-08-26 | Ｃｄ２６９（ｂｃｍａ）に対するヒト化抗体 |
| JP2022194533A Pending JP2023025202A (ja) | 2014-04-30 | 2022-12-05 | Ｃｄ２６９（ｂｃｍａ）に対するヒト化抗体 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020142486A Active JP7189913B2 (ja) | 2014-04-30 | 2020-08-26 | Ｃｄ２６９（ｂｃｍａ）に対するヒト化抗体 |
| JP2022194533A Pending JP2023025202A (ja) | 2014-04-30 | 2022-12-05 | Ｃｄ２６９（ｂｃｍａ）に対するヒト化抗体 |
Country Status (15)
| Country | Link |
|---|---|
| US (3) | US10144782B2 (enExample) |
| EP (1) | EP3137500A1 (enExample) |
| JP (3) | JP6755805B2 (enExample) |
| KR (3) | KR102526945B1 (enExample) |
| CN (2) | CN106661109B (enExample) |
| AU (1) | AU2015254526B2 (enExample) |
| BR (1) | BR112016024546A2 (enExample) |
| IL (2) | IL303667A (enExample) |
| MX (2) | MX375800B (enExample) |
| NZ (1) | NZ725701A (enExample) |
| RU (2) | RU2749041C2 (enExample) |
| SG (1) | SG11201608415QA (enExample) |
| UA (1) | UA121031C2 (enExample) |
| WO (1) | WO2015166073A1 (enExample) |
| ZA (1) | ZA201607018B (enExample) |
Families Citing this family (82)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2914628A1 (en) | 2012-11-01 | 2015-09-09 | Max-Delbrück-Centrum für Molekulare Medizin | An antibody that binds cd269 (bcma) suitable for use in the treatment of plasma cell diseases such as multiple myeloma and autoimmune diseases |
| WO2014124280A1 (en) | 2013-02-08 | 2014-08-14 | Institute For Myeloma & Bone Cancer Research | Improved diagnostic, prognostic, and monitoring methods for multiple myeloma, chronic lymphocytic leukemia, and b-cell non-hodgkin lymphoma |
| KR102526945B1 (ko) * | 2014-04-30 | 2023-04-27 | 막스-델부뤽-센트럼 퓌어 몰레쿨라레 메디친 인 데어 헬름홀츠-게마인샤프트 | Ｃｄ269에 대한 인간화 항체 |
| US10174095B2 (en) | 2014-07-21 | 2019-01-08 | Novartis Ag | Nucleic acid encoding a humanized anti-BCMA chimeric antigen receptor |
| JP6921001B2 (ja) | 2015-04-13 | 2021-08-18 | ファイザー・インク | Ｂ細胞成熟抗原を標的にするキメラ抗原受容体 |
| PL3988117T3 (pl) | 2015-04-13 | 2025-03-10 | Pfizer Inc. | Przeciwciała terapeutyczne i ich zastosowania |
| JP7011600B2 (ja) | 2016-01-12 | 2022-01-26 | ジェイムズ リチャード ベレンソン， | 被験体の免疫状態をモニタリングするための改善された方法 |
| US20190194338A1 (en) * | 2016-02-17 | 2019-06-27 | Seattle Genetics, Inc. | Bcma antibodies and use of same to treat cancer and immunological disorders |
| SG10202012157QA (en) | 2016-06-07 | 2021-01-28 | Max Delbrueck Centrum Fuer Molekulare Medizin Helmholtz Gemeinschaft | Chimeric antigen receptor and car-t cells that bind bcma |
| EA201891851A1 (ru) * | 2016-09-16 | 2019-04-30 | Сиэтл Дженетикс, Инк. | Антитела против bcma и их применение для лечения злокачественных новообразований и иммунологических нарушений |
| MX2019007604A (es) * | 2016-12-23 | 2019-08-16 | Heidelberg Pharma Res Gmbh | Novedoso conjugado de amanitina. |
| CN108285489A (zh) * | 2017-01-09 | 2018-07-17 | 上海恒润达生生物科技有限公司 | 靶向BCMA-BBz-tEGFR的嵌合抗原受体及其用途 |
| EP3577134A1 (en) | 2017-01-31 | 2019-12-11 | Novartis AG | Treatment of cancer using chimeric t cell receptor proteins having multiple specificities |
| CN108395478A (zh) * | 2017-02-04 | 2018-08-14 | 上海恒润达生生物科技有限公司 | 靶向bcma的嵌合抗原受体并对其双重修饰的方法及其用途 |
| CN110461335A (zh) | 2017-02-17 | 2019-11-15 | 弗雷德哈钦森癌症研究中心 | 用于治疗bcma相关癌症和自身免疫性失调的联合疗法 |
| US20200179511A1 (en) | 2017-04-28 | 2020-06-11 | Novartis Ag | Bcma-targeting agent, and combination therapy with a gamma secretase inhibitor |
| WO2018201056A1 (en) | 2017-04-28 | 2018-11-01 | Novartis Ag | Cells expressing a bcma-targeting chimeric antigen receptor, and combination therapy with a gamma secretase inhibitor |
| WO2018231944A1 (en) | 2017-06-13 | 2018-12-20 | Berenson James R | Diagnostic, prognostic, and monitoring methods for solid tumor cancers |
| WO2019035938A1 (en) | 2017-08-16 | 2019-02-21 | Elstar Therapeutics, Inc. | MULTISPECIFIC MOLECULES BINDING TO BCMA AND USES THEREOF |
| US11999802B2 (en) | 2017-10-18 | 2024-06-04 | Novartis Ag | Compositions and methods for selective protein degradation |
| SG11202004512XA (en) | 2017-11-15 | 2020-06-29 | Novartis Ag | Bcma-targeting chimeric antigen receptor, cd19-targeting chimeric antigen receptor, and combination therapies |
| CA3083949A1 (en) | 2017-11-30 | 2020-06-06 | Novartis Ag | Bcma-targeting chimeric antigen receptor, and uses thereof |
| CN112218651A (zh) | 2018-01-08 | 2021-01-12 | 诺华公司 | 用于与嵌合抗原受体疗法组合的免疫增强rna |
| US12247060B2 (en) | 2018-01-09 | 2025-03-11 | Marengo Therapeutics, Inc. | Calreticulin binding constructs and engineered T cells for the treatment of diseases |
| US20210038659A1 (en) | 2018-01-31 | 2021-02-11 | Novartis Ag | Combination therapy using a chimeric antigen receptor |
| JP7438953B2 (ja) * | 2018-02-01 | 2024-02-27 | イノベント バイオロジックス （スウツォウ） カンパニー，リミテッド | 完全ヒト化抗ｂ細胞成熟抗原（ｂｃｍａ）の単鎖抗体およびその応用 |
| EP3752203A1 (en) | 2018-02-13 | 2020-12-23 | Novartis AG | Chimeric antigen receptor therapy in combination with il-15r and il15 |
| US11401336B2 (en) * | 2018-02-21 | 2022-08-02 | Celgene Corporation | BCMA-binding antibodies and uses thereof |
| WO2019178362A1 (en) | 2018-03-14 | 2019-09-19 | Elstar Therapeutics, Inc. | Multifunctional molecules that bind to calreticulin and uses thereof |
| KR20250151605A (ko) | 2018-06-01 | 2025-10-21 | 노파르티스 아게 | Bcma에 대한 결합 분자 및 이의 용도 |
| JP7438988B2 (ja) | 2018-06-13 | 2024-02-27 | ノバルティス アーゲー | Ｂｃｍａキメラ抗原受容体及びその使用 |
| WO2020004934A1 (ko) * | 2018-06-26 | 2020-01-02 | 에이비엘바이오 주식회사 | 항-bcma 항체 및 그 용도 |
| CA3105448A1 (en) | 2018-07-03 | 2020-01-09 | Elstar Therapeutics, Inc. | Anti-tcr antibody molecules and uses thereof |
| TWI838389B (zh) | 2018-07-19 | 2024-04-11 | 美商再生元醫藥公司 | 雙特異性抗-BCMAｘ抗-CD3抗體及其用途 |
| EA202190315A1 (ru) | 2018-07-19 | 2021-04-16 | Ридженерон Фармасьютикалз, Инк. | Химерные антигенные рецепторы со специфичностью к bcma и их применение |
| EP3844265A2 (en) | 2018-08-31 | 2021-07-07 | Novartis AG | Methods of making chimeric antigen receptor-expressing cells |
| EP3844267B1 (en) | 2018-08-31 | 2025-06-25 | Novartis AG | Methods of making chimeric antigen receptor-expressing cells |
| LT3749338T (lt) | 2019-01-16 | 2024-08-12 | Caribou Biosciences, Inc. | Humanizuoti bcma antikūnai ir bcma-car-t ląstelės |
| EP3927744A1 (en) | 2019-02-21 | 2021-12-29 | Marengo Therapeutics, Inc. | Multifunctional molecules that bind to t cell related cancer cells and uses thereof |
| GB2597851B (en) | 2019-02-21 | 2024-05-29 | Marengo Therapeutics Inc | Antibody molecules that bind to NKP30 and uses thereof |
| EP3930763A1 (en) | 2019-02-25 | 2022-01-05 | Novartis AG | Mesoporous silica particles compositions for viral delivery |
| US20230074800A1 (en) | 2019-03-21 | 2023-03-09 | Novartis Ag | Car-t cell therapies with enhanced efficacy |
| US20220168389A1 (en) | 2019-04-12 | 2022-06-02 | Novartis Ag | Methods of making chimeric antigen receptor-expressing cells |
| EP3959320A1 (en) | 2019-04-24 | 2022-03-02 | Novartis AG | Compositions and methods for selective protein degradation |
| CA3134918A1 (en) * | 2019-05-03 | 2020-11-12 | John Lee | Anti-bcma antibody conjugate, compositions comprising the same, and methods of making and using the same |
| TWI905099B (zh) | 2019-05-21 | 2025-11-21 | 瑞士商諾華公司 | Cd19 結合分子及其用途 |
| US12540190B2 (en) | 2019-07-30 | 2026-02-03 | Shanghai Hansoh Biomedical Co., Ltd. | Anti-BCMA antibody, antigen-binding fragment thereof and medical use thereof |
| EP4272837A3 (en) * | 2019-08-02 | 2024-02-28 | Fundacio de Recerca Clinic Barcelona-Institut d'Investigacions Biomèdiques August Pi I Sunyer | Car t-cells against bcma for the treatment of multiple myeloma |
| WO2021062281A2 (en) * | 2019-09-25 | 2021-04-01 | Fate Therapeutics, Inc. | Multi-targeting effector cells and use thereof |
| WO2021068761A1 (zh) * | 2019-10-10 | 2021-04-15 | 苏州亲为药业有限公司 | 靶向bcma的具有人猴交叉的人源化单克隆抗体 |
| CN114761037A (zh) | 2019-11-26 | 2022-07-15 | 诺华股份有限公司 | 结合bcma和cd19的嵌合抗原受体及其用途 |
| BR112022011964A2 (pt) * | 2019-12-17 | 2022-09-06 | Shenzhen Feipeng Biological Therapy Co Ltd | Anticorpo de ligação a bcma e uso do mesmo |
| EP4084823A4 (en) | 2020-01-03 | 2024-05-15 | Marengo Therapeutics, Inc. | ANTI-TCR ANTIBODY MOLECULES AND THEIR USES |
| KR20220146530A (ko) | 2020-02-27 | 2022-11-01 | 노파르티스 아게 | 키메라 항원 수용체-발현 세포의 제조 방법 |
| BR112022016633A2 (pt) | 2020-02-27 | 2022-12-13 | Novartis Ag | Métodos para produzir células que expressam receptor de antígeno quimérico |
| CN113637073B (zh) * | 2020-05-11 | 2024-04-12 | 上海赛比曼生物科技有限公司 | Bcma抗体及其制备和应用 |
| TWI901692B (zh) | 2020-06-05 | 2025-10-21 | 日商衛材R&D企管股份有限公司 | 抗ｂｃｍａ抗體-藥物軛合物及其使用方法 |
| KR20230024967A (ko) | 2020-06-11 | 2023-02-21 | 노파르티스 아게 | Zbtb32 억제제 및 이의 용도 |
| EP4202047A4 (en) * | 2020-08-20 | 2024-09-18 | Chia Tai Tianqing Pharmaceutical Group Co., Ltd. | UNIQUE VARIABLE STRUCTURAL DOMAIN FOR BCMA BINDING AND ANTIGEN BINDING MOLECULE |
| WO2022040586A2 (en) | 2020-08-21 | 2022-02-24 | Novartis Ag | Compositions and methods for in vivo generation of car expressing cells |
| AU2021357841A1 (en) | 2020-10-08 | 2023-06-15 | Affimed Gmbh | Trispecific binders |
| US20240344058A1 (en) | 2020-10-30 | 2024-10-17 | Vor Biopharma Inc. | Compositions and methods for bcma modification |
| CN112614596B (zh) * | 2020-12-22 | 2023-01-10 | 厦门承葛生物科技有限公司 | 一种肠道菌群移植治疗溃疡性结肠炎的供受体配型方法 |
| KR20240004462A (ko) | 2021-04-08 | 2024-01-11 | 마렝고 테라퓨틱스, 인크. | Tcr에 결합하는 다기능성 분자 및 이의 용도 |
| AU2022267891A1 (en) | 2021-04-27 | 2023-11-09 | Novartis Ag | Viral vector production system |
| CN117396231A (zh) | 2021-04-30 | 2024-01-12 | 新基公司 | 使用抗BCMA抗体药物缀合物（ADC）与γ分泌酶抑制剂（GSI）的组合的组合疗法 |
| JP2024529381A (ja) | 2021-07-30 | 2024-08-06 | アフィメド ゲーエムベーハー | デュプレックスボディ |
| WO2023019226A1 (en) | 2021-08-11 | 2023-02-16 | Sana Biotechnology, Inc. | Genetically modified cells for allogeneic cell therapy |
| KR20240073006A (ko) | 2021-08-11 | 2024-05-24 | 사나 바이오테크놀로지, 인크. | 동종이계 세포 요법을 위한 유전자 변형된 1차 세포 |
| AU2022325231A1 (en) | 2021-08-11 | 2024-02-08 | Sana Biotechnology, Inc. | Genetically modified cells for allogeneic cell therapy to reduce complement-mediated inflammatory reactions |
| AU2022325955A1 (en) | 2021-08-11 | 2024-02-08 | Sana Biotechnology, Inc. | Genetically modified cells for allogeneic cell therapy to reduce instant blood mediated inflammatory reactions |
| WO2023021477A1 (en) | 2021-08-20 | 2023-02-23 | Novartis Ag | Methods of making chimeric antigen receptor–expressing cells |
| KR20240099382A (ko) | 2021-11-03 | 2024-06-28 | 아피메트 게엠베하 | 이중특이적 cd16a 결합제 |
| AU2023220128A1 (en) | 2022-02-17 | 2024-08-22 | Sana Biotechnology, Inc. | Engineered cd47 proteins and uses thereof |
| WO2023215725A1 (en) | 2022-05-02 | 2023-11-09 | Fred Hutchinson Cancer Center | Compositions and methods for cellular immunotherapy |
| WO2024089639A1 (en) | 2022-10-26 | 2024-05-02 | Novartis Ag | Lentiviral formulations |
| WO2024097311A2 (en) | 2022-11-02 | 2024-05-10 | Sana Biotechnology, Inc. | Hypoimmunogenic mail cells, methods of making and methods of using same |
| TW202440636A (zh) | 2023-03-21 | 2024-10-16 | 美商傳記５５有限公司 | Ｃｄ１９／ｃｄ３８多特異性抗體 |
| WO2025043172A1 (en) | 2023-08-23 | 2025-02-27 | Sana Biotechnology, Inc. | Modified cd47 proteins and their uses |
| WO2025101820A1 (en) | 2023-11-08 | 2025-05-15 | Fred Hutchinson Cancer Center | Compositions and methods for cellular immunotherapy |
| WO2025217258A1 (en) * | 2024-04-09 | 2025-10-16 | The Rockefeller University | Nptx1 antibodies |
| WO2026050572A2 (en) | 2024-08-29 | 2026-03-05 | Marengo Therapeutics, Inc. | Multifunctional molecules binding to tcr and uses thereof |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2002066516A2 (en) | 2001-02-20 | 2002-08-29 | Zymogenetics, Inc. | Antibodies that bind both bcma and taci |
| AR039067A1 (es) * | 2001-11-09 | 2005-02-09 | Pfizer Prod Inc | Anticuerpos para cd40 |
| CN1305905C (zh) | 2002-03-22 | 2007-03-21 | Aprogen株式会社 | 人源化抗体及其制备方法 |
| CA2609269C (en) * | 2005-05-26 | 2014-08-05 | Seattle Genetics, Inc. | Humanized anti-cd40 antibodies and their methods of use |
| US9382327B2 (en) * | 2006-10-10 | 2016-07-05 | Vaccinex, Inc. | Anti-CD20 antibodies and methods of use |
| WO2009070767A2 (en) * | 2007-11-28 | 2009-06-04 | Whitehead Institute For Biomedical Research | Systemic instigation systems to study tumor growth or metastasis |
| WO2010014629A1 (en) * | 2008-07-28 | 2010-02-04 | Trubion Pharmaceuticals, Inc. | Multi-specific binding proteins targeting b cell disorders |
| AU2010224160A1 (en) | 2009-03-10 | 2011-09-22 | Biogen Idec Ma Inc. | Anti-BCMA antibodies |
| KR20110126748A (ko) | 2009-04-07 | 2011-11-23 | 로슈 글리카트 아게 | 이중특이적 항-ｅｒｂｂ-1/항-ｃ-ｍｅｔ 항체 |
| EP2640750A1 (en) | 2010-11-16 | 2013-09-25 | Boehringer Ingelheim International GmbH | Agents and methods for treating diseases that correlate with bcma expression |
| US20130101599A1 (en) * | 2011-04-21 | 2013-04-25 | Boehringer Ingelheim International Gmbh | Bcma-based stratification and therapy for multiple myeloma patients |
| SG194176A1 (en) * | 2011-05-27 | 2013-12-30 | Glaxo Group Ltd | Bcma (cd269/tnfrsf17) -binding proteins |
| EP2914628A1 (en) * | 2012-11-01 | 2015-09-09 | Max-Delbrück-Centrum für Molekulare Medizin | An antibody that binds cd269 (bcma) suitable for use in the treatment of plasma cell diseases such as multiple myeloma and autoimmune diseases |
| KR102526945B1 (ko) * | 2014-04-30 | 2023-04-27 | 막스-델부뤽-센트럼 퓌어 몰레쿨라레 메디친 인 데어 헬름홀츠-게마인샤프트 | Ｃｄ269에 대한 인간화 항체 |
-
2015
- 2015-04-30 KR KR1020227018383A patent/KR102526945B1/ko active Active
- 2015-04-30 EP EP15720954.5A patent/EP3137500A1/en active Pending
- 2015-04-30 UA UAA201612087A patent/UA121031C2/uk unknown
- 2015-04-30 RU RU2016146486A patent/RU2749041C2/ru active
- 2015-04-30 US US15/306,438 patent/US10144782B2/en active Active
- 2015-04-30 MX MX2016013767A patent/MX375800B/es active IP Right Grant
- 2015-04-30 IL IL303667A patent/IL303667A/en unknown
- 2015-04-30 KR KR1020167033409A patent/KR102405492B1/ko active Active
- 2015-04-30 NZ NZ725701A patent/NZ725701A/en unknown
- 2015-04-30 KR KR1020237013978A patent/KR102632731B1/ko active Active
- 2015-04-30 WO PCT/EP2015/059562 patent/WO2015166073A1/en not_active Ceased
- 2015-04-30 JP JP2016565168A patent/JP6755805B2/ja active Active
- 2015-04-30 AU AU2015254526A patent/AU2015254526B2/en active Active
- 2015-04-30 RU RU2021115081A patent/RU2021115081A/ru unknown
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- 2015-04-30 CN CN201580021693.5A patent/CN106661109B/zh active Active
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