JP2015525215A5 - - Google Patents
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- Publication number
- JP2015525215A5 JP2015525215A5 JP2015516217A JP2015516217A JP2015525215A5 JP 2015525215 A5 JP2015525215 A5 JP 2015525215A5 JP 2015516217 A JP2015516217 A JP 2015516217A JP 2015516217 A JP2015516217 A JP 2015516217A JP 2015525215 A5 JP2015525215 A5 JP 2015525215A5
- Authority
- JP
- Japan
- Prior art keywords
- chr
- alkyl
- och
- nhc
- compound
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 0 CC(C)(C)c1n[n](C)c(*)c1 Chemical compound CC(C)(C)c1n[n](C)c(*)c1 0.000 description 12
- WUAXWWJRNIODRY-UHFFFAOYSA-N CC(c1cc(C)n[nH]1)=O Chemical compound CC(c1cc(C)n[nH]1)=O WUAXWWJRNIODRY-UHFFFAOYSA-N 0.000 description 2
- OPTCHSMAUQAOEX-UHFFFAOYSA-N CCC(O1)=C(C)OC1=O Chemical compound CCC(O1)=C(C)OC1=O OPTCHSMAUQAOEX-UHFFFAOYSA-N 0.000 description 2
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261657229P | 2012-06-08 | 2012-06-08 | |
| US61/657,229 | 2012-06-08 | ||
| US201361773969P | 2013-03-07 | 2013-03-07 | |
| US61/773,969 | 2013-03-07 | ||
| PCT/US2013/044546 WO2013184934A1 (en) | 2012-06-08 | 2013-06-06 | Neprilysin inhibitors |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017080465A Division JP2017125063A (ja) | 2012-06-08 | 2017-04-14 | ネプリライシン阻害剤 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2015525215A JP2015525215A (ja) | 2015-09-03 |
| JP2015525215A5 true JP2015525215A5 (enExample) | 2016-06-23 |
| JP6162230B2 JP6162230B2 (ja) | 2017-07-12 |
Family
ID=48626696
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015516217A Expired - Fee Related JP6162230B2 (ja) | 2012-06-08 | 2013-06-06 | ネプリライシン阻害剤 |
| JP2017080465A Withdrawn JP2017125063A (ja) | 2012-06-08 | 2017-04-14 | ネプリライシン阻害剤 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017080465A Withdrawn JP2017125063A (ja) | 2012-06-08 | 2017-04-14 | ネプリライシン阻害剤 |
Country Status (29)
| Country | Link |
|---|---|
| US (6) | US9108934B2 (enExample) |
| EP (2) | EP2864292B1 (enExample) |
| JP (2) | JP6162230B2 (enExample) |
| KR (1) | KR102102197B1 (enExample) |
| CN (1) | CN104350042B (enExample) |
| AR (1) | AR091381A1 (enExample) |
| AU (1) | AU2013271537B2 (enExample) |
| BR (1) | BR112014030743B1 (enExample) |
| CA (1) | CA2876024C (enExample) |
| DK (1) | DK2864292T3 (enExample) |
| ES (2) | ES2700152T3 (enExample) |
| HR (1) | HRP20171037T1 (enExample) |
| HU (1) | HUE032802T2 (enExample) |
| IL (1) | IL235737B (enExample) |
| LT (1) | LT2864292T (enExample) |
| ME (1) | ME02698B (enExample) |
| MX (1) | MX356260B (enExample) |
| NZ (2) | NZ723772A (enExample) |
| PH (1) | PH12014502733B1 (enExample) |
| PL (1) | PL2864292T3 (enExample) |
| PT (1) | PT2864292T (enExample) |
| RS (1) | RS55967B1 (enExample) |
| RU (1) | RU2663618C2 (enExample) |
| SG (2) | SG10201703185VA (enExample) |
| SI (1) | SI2864292T1 (enExample) |
| SM (1) | SMT201700306T1 (enExample) |
| TW (2) | TWI644901B (enExample) |
| WO (1) | WO2013184934A1 (enExample) |
| ZA (1) | ZA201408634B (enExample) |
Families Citing this family (27)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SI2651896T1 (sl) | 2010-12-15 | 2015-11-30 | Theravance Biopharma R&D Ip, Llc | Inhibitorji neprilizina |
| CN103261168B (zh) | 2010-12-15 | 2015-08-05 | 施万生物制药研发Ip有限责任公司 | 脑啡肽酶抑制剂 |
| US8449890B2 (en) | 2011-02-17 | 2013-05-28 | Theravance, Inc. | Neprilysin inhibitors |
| AU2012217615B2 (en) | 2011-02-17 | 2016-09-29 | Theravance Biopharma R&D Ip, Llc | Substituted aminobutyric derivatives as neprilysin inhibitors |
| ES2653215T3 (es) | 2011-05-31 | 2018-02-06 | Theravance Biopharma R&D Ip, Llc | Inhibidores de neprilisina |
| TWI560172B (en) | 2011-11-02 | 2016-12-01 | Theravance Biopharma R&D Ip Llc | Neprilysin inhibitors |
| LT2864292T (lt) | 2012-06-08 | 2017-07-10 | Theravance Biopharma R&D Ip, Llc | Neprilizino inhibitoriai |
| ES2710932T3 (es) | 2012-06-08 | 2019-04-29 | Theravance Biopharma R&D Ip Llc | Inhibidores de neprilisina |
| US9126956B2 (en) | 2012-08-08 | 2015-09-08 | Theravance Biopharma R&D Ip, Llc | Neprilysin inhibitors |
| HUE034210T2 (hu) | 2013-03-05 | 2018-02-28 | Theravance Biopharma R&D Ip Llc | Neprilizininhibitorok |
| EP3099668B1 (en) | 2014-01-30 | 2022-05-04 | Theravance Biopharma R&D IP, LLC | 5-biphenyl-4-heteroarylcarbonylamino-pentanoic acid derivatives as neprilysin inhibitors |
| MX2016009760A (es) | 2014-01-30 | 2016-11-08 | Theravance Biopharma R&D Ip Llc | Inhibidores de neprilisina. |
| CN105338467B (zh) * | 2014-08-07 | 2019-04-02 | 电信科学技术研究院 | 一种设备到设备通信中数据接收方法、发送方法及设备 |
| CN104592163B (zh) * | 2015-01-08 | 2016-08-24 | 爱斯特（成都）生物制药有限公司 | 一种手性2-苯基吡咯烷的合成方法 |
| WO2016130650A1 (en) | 2015-02-11 | 2016-08-18 | Theravance Biopharma R&D Ip, Llc | (2s, 4r)-5-(5'-chloro-2'-fluorobiphenyl-4-yl)-2-ethoxyoxalylamino)-2-hydroxymethyl-2-methylpentanoic acid as neprilysin inhibitor |
| RU2715241C2 (ru) | 2015-02-19 | 2020-02-26 | ТЕРЕВАНС БАЙОФАРМА Ар энд Ди АйПи, ЭлЭлСи | (2r,4r)-5-(5′-хлор-2′-фторбифенил-4-ил)-2-гидрокси-4-[(5-метилоксазол-2-карбонил)амино]пентановая кислота |
| KR102671166B1 (ko) * | 2015-12-14 | 2024-05-31 | 막스-플랑크-게젤샤프트 츄어 푀르더룽 데어 비쎈샤프텐 에.파우. | 3,5-디페닐-디아졸 화합물의 수용성 유도체 |
| TWI731943B (zh) | 2016-03-08 | 2021-07-01 | 美商施萬生物製藥研發Ｉｐ有限責任公司 | 結晶型（2s，4r）－5－（5’－氯－2’－氟－［1，1’－聯苯］－4－基）－2－（乙氧基甲基）－4－（3－羥基異㗁唑－5－甲醯胺基）－2－甲基戊酸及其用途 |
| CN107071636B (zh) * | 2016-12-29 | 2019-12-31 | 北京小鸟听听科技有限公司 | 对带麦克风的设备的去混响控制方法和装置 |
| JP6580097B2 (ja) | 2017-09-05 | 2019-09-25 | 株式会社東芝 | 面発光量子カスケードレーザ |
| UY38072A (es) | 2018-02-07 | 2019-10-01 | Novartis Ag | Compuestos derivados de éster butanoico sustituido con bisfenilo como inhibidores de nep, composiciones y combinaciones de los mismos |
| WO2020110008A1 (en) | 2018-11-27 | 2020-06-04 | Novartis Ag | Cyclic pentamer compounds as proprotein convertase subtilisin/kexin type 9 (pcsk9) inhibitors for the treatment of metabolic disorder |
| JP7657151B2 (ja) | 2018-11-27 | 2025-04-04 | ノバルティス アーゲー | 代謝性障害の処置のためのプロタンパク質コンバターゼスブチリシン／ケキシン９型（ｐｃｓｋ９）阻害剤としての環状ペプチド |
| UY38485A (es) | 2018-11-27 | 2020-06-30 | Novartis Ag | Compuestos tetrámeros cíclicos como inhibidores de proproteína convertasa subtilisina/kexina tipo 9 (pcsk9), método de tratamiento, uso y su preparación |
| US11419917B2 (en) * | 2020-04-07 | 2022-08-23 | Drora Shevy | Treatment for SARS-CoV-2 and other coronaviruses |
| WO2023084449A1 (en) | 2021-11-12 | 2023-05-19 | Novartis Ag | Diaminocyclopentylpyridine derivatives for the treatment of a disease or disorder |
| KR102485499B1 (ko) * | 2022-07-15 | 2023-01-09 | 오가노이드사이언스 주식회사 | 신장 질환의 치료 또는 예방용 조성물 |
Family Cites Families (46)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4189604A (en) | 1975-07-22 | 1980-02-19 | Zaidan Hojin Biseibutsu Kagaku Kenkyu Kai | Bestatin |
| US4206232A (en) | 1976-05-10 | 1980-06-03 | E. R. Squibb & Sons, Inc. | Relieving hypertension with carboxyalkylacylamino acids |
| IL58849A (en) | 1978-12-11 | 1983-03-31 | Merck & Co Inc | Carboxyalkyl dipeptides and derivatives thereof,their preparation and pharmaceutical compositions containing them |
| FR2480747A1 (fr) | 1980-04-17 | 1981-10-23 | Roques Bernard | Derives d'acides amines et leur application therapeutique |
| US4906615A (en) | 1980-12-18 | 1990-03-06 | Schering Corporation | Substituted dipeptides as inhibitors of enkephalinases |
| US4722810A (en) | 1984-08-16 | 1988-02-02 | E. R. Squibb & Sons, Inc. | Enkephalinase inhibitors |
| US4939261A (en) | 1984-06-08 | 1990-07-03 | Ciba-Geigy Corporation | N-substituted butyramide derivatives useful for treatment of conditions responsive to inhibition of enkephalinase |
| EP0225292A3 (en) | 1985-12-06 | 1988-11-30 | Ciba-Geigy Ag | Certain n-substituted butyramide derivatives |
| US4929641B1 (en) | 1988-05-11 | 1994-08-30 | Schering Corp | Mercapto-acylamino acid antihypertensives |
| KR880007441A (ko) | 1986-12-11 | 1988-08-27 | 알렌 제이.스피겔 | 스피로-치환된 글루타르아미드 이뇨제 |
| FR2623498B1 (fr) | 1987-11-24 | 1990-04-06 | Bioprojet Soc Civ | Nouveaux composes enantiomeres derives d'amino-acides, leur procede de preparation et leurs applications therapeutiques |
| GB8820844D0 (en) | 1988-09-05 | 1988-10-05 | Pfizer Ltd | Therapeutic agents |
| US5599951A (en) | 1989-09-15 | 1997-02-04 | Societe Civile Bioprojet | Amino acid derivatives, the process for their preparation and their applications to therapy |
| US5294632A (en) | 1991-05-01 | 1994-03-15 | Ciba-Geigy Corporation | Phosphono/biaryl substituted dipetide derivatives |
| US5155100A (en) | 1991-05-01 | 1992-10-13 | Ciba-Geigy Corporation | Phosphono/biaryl substituted dipeptide derivatives |
| US5217996A (en) | 1992-01-22 | 1993-06-08 | Ciba-Geigy Corporation | Biaryl substituted 4-amino-butyric acid amides |
| US5508272A (en) | 1993-06-15 | 1996-04-16 | Bristol-Myers Squibb Company | Compounds containing a fused bicycle ring and processes therefor |
| DE19510566A1 (de) | 1995-03-23 | 1996-09-26 | Kali Chemie Pharma Gmbh | Benzazepin-, Benzoxazepin- und Benzothiazepin-N-essigsäurederivate sowie Verfahren zu ihrer Herstellung und diese Verbindungen enthaltende Arzneimittel |
| AU5687396A (en) | 1995-04-21 | 1996-11-07 | Novarits Ag | N-aroylamino acid amides as endothelin inhibitors |
| US6660756B2 (en) | 2001-03-28 | 2003-12-09 | Pfizer Inc. | N-phenpropylcyclopentyl-substituted glutaramide derivatives as inhibitors of neutral endopeptidase |
| GB0119305D0 (en) | 2001-04-12 | 2001-10-03 | Aventis Pharma Gmbh | Mercaptoacetylamide derivatives,a process for their preparation and their use |
| BR0314898A (pt) * | 2002-11-19 | 2005-08-02 | Galderma Res & Dev | Compostos, composição cosmética, uso cosmético de uma composição, uso de um composto e composição farmacêutica |
| WO2006027680A1 (en) | 2004-09-10 | 2006-03-16 | Pfizer Limited | 3-(1-carbamoylcyclohexyl) propionic acid derivatives as inhibitors of neutral endopeptidase enzyme |
| AR057882A1 (es) | 2005-11-09 | 2007-12-26 | Novartis Ag | Compuestos de accion doble de bloqueadores del receptor de angiotensina e inhibidores de endopeptidasa neutra |
| WO2007106708A2 (en) | 2006-03-10 | 2007-09-20 | Novartis Ag | Combinations of the angiotensin ii antagonist valsartan and the nep inhibitor daglutril |
| ES2602566T3 (es) * | 2007-01-12 | 2017-02-21 | Novartis Ag | Proceso para preparar ácido 5-bifenil-4-amino-2-metil pentanoico |
| TWI448284B (zh) | 2007-04-24 | 2014-08-11 | Theravance Inc | 雙效抗高血壓劑 |
| AR070176A1 (es) | 2008-01-17 | 2010-03-17 | Novartis Ag | Procesos de sintesis de inhibidores de nep, compuestos intermediarios y uso de los mismos en la sintesis |
| US20120150643A1 (en) * | 2010-12-14 | 2012-06-14 | Moneyhoney Llc | System and method for processing remainder amounts of money from gift cards |
| CA2763565A1 (en) | 2009-05-28 | 2010-12-02 | Novartis Ag | Substituted aminobutyric derivatives as neprilysin inhibitors |
| PL2435409T3 (pl) | 2009-05-28 | 2015-01-30 | Novartis Ag | Podstawione pochodne aminopropionowe jako inhibitory neprylizyny |
| JO2967B1 (en) | 2009-11-20 | 2016-03-15 | نوفارتس ايه جي | Acetic acid derivatives of carbamoyl methyl amino are substituted as new NEP inhibitors |
| ES2550485T3 (es) | 2010-01-22 | 2015-11-10 | Novartis Ag | Intermedios de inhibidores de la endopeptidasa neutra y método de preparación de los mismos |
| US8993631B2 (en) | 2010-11-16 | 2015-03-31 | Novartis Ag | Method of treating contrast-induced nephropathy |
| US8673974B2 (en) | 2010-11-16 | 2014-03-18 | Novartis Ag | Substituted amino bisphenyl pentanoic acid derivatives as NEP inhibitors |
| CN103261168B (zh) | 2010-12-15 | 2015-08-05 | 施万生物制药研发Ip有限责任公司 | 脑啡肽酶抑制剂 |
| SI2651896T1 (sl) * | 2010-12-15 | 2015-11-30 | Theravance Biopharma R&D Ip, Llc | Inhibitorji neprilizina |
| US8449890B2 (en) | 2011-02-17 | 2013-05-28 | Theravance, Inc. | Neprilysin inhibitors |
| AU2012217615B2 (en) * | 2011-02-17 | 2016-09-29 | Theravance Biopharma R&D Ip, Llc | Substituted aminobutyric derivatives as neprilysin inhibitors |
| CA2835281A1 (en) | 2011-05-31 | 2012-12-06 | Theravance, Inc. | Neprilysin inhibitors |
| ES2699773T3 (es) | 2011-05-31 | 2019-02-12 | Theravance Biopharma R&D Ip Llc | Inhibidores de neprilisina |
| ES2653215T3 (es) | 2011-05-31 | 2018-02-06 | Theravance Biopharma R&D Ip, Llc | Inhibidores de neprilisina |
| TWI560172B (en) | 2011-11-02 | 2016-12-01 | Theravance Biopharma R&D Ip Llc | Neprilysin inhibitors |
| CA2871292A1 (en) | 2012-05-31 | 2013-12-05 | Theravance Biopharma R&D Ip, Llc | Nitric oxide donor neprilysin inhibitors |
| LT2864292T (lt) | 2012-06-08 | 2017-07-10 | Theravance Biopharma R&D Ip, Llc | Neprilizino inhibitoriai |
| RU2715241C2 (ru) * | 2015-02-19 | 2020-02-26 | ТЕРЕВАНС БАЙОФАРМА Ар энд Ди АйПи, ЭлЭлСи | (2r,4r)-5-(5′-хлор-2′-фторбифенил-4-ил)-2-гидрокси-4-[(5-метилоксазол-2-карбонил)амино]пентановая кислота |
-
2013
- 2013-06-06 LT LTEP13729232.2T patent/LT2864292T/lt unknown
- 2013-06-06 NZ NZ723772A patent/NZ723772A/en not_active IP Right Cessation
- 2013-06-06 EP EP13729232.2A patent/EP2864292B1/en active Active
- 2013-06-06 WO PCT/US2013/044546 patent/WO2013184934A1/en not_active Ceased
- 2013-06-06 RS RS20170515A patent/RS55967B1/sr unknown
- 2013-06-06 US US13/911,819 patent/US9108934B2/en active Active
- 2013-06-06 ES ES17160870T patent/ES2700152T3/es active Active
- 2013-06-06 EP EP17160870.6A patent/EP3199517B1/en active Active
- 2013-06-06 BR BR112014030743-1A patent/BR112014030743B1/pt not_active IP Right Cessation
- 2013-06-06 CN CN201380030259.4A patent/CN104350042B/zh not_active Expired - Fee Related
- 2013-06-06 ME MEP-2017-121A patent/ME02698B/me unknown
- 2013-06-06 KR KR1020157000506A patent/KR102102197B1/ko active Active
- 2013-06-06 DK DK13729232.2T patent/DK2864292T3/en active
- 2013-06-06 SI SI201330690A patent/SI2864292T1/sl unknown
- 2013-06-06 SG SG10201703185VA patent/SG10201703185VA/en unknown
- 2013-06-06 ES ES13729232.2T patent/ES2632600T3/es active Active
- 2013-06-06 HR HRP20171037TT patent/HRP20171037T1/hr unknown
- 2013-06-06 CA CA2876024A patent/CA2876024C/en active Active
- 2013-06-06 MX MX2014014918A patent/MX356260B/es active IP Right Grant
- 2013-06-06 SM SM20170306T patent/SMT201700306T1/it unknown
- 2013-06-06 HU HUE13729232A patent/HUE032802T2/hu unknown
- 2013-06-06 JP JP2015516217A patent/JP6162230B2/ja not_active Expired - Fee Related
- 2013-06-06 PT PT137292322T patent/PT2864292T/pt unknown
- 2013-06-06 RU RU2014153578A patent/RU2663618C2/ru active
- 2013-06-06 AU AU2013271537A patent/AU2013271537B2/en not_active Ceased
- 2013-06-06 NZ NZ702749A patent/NZ702749A/en not_active IP Right Cessation
- 2013-06-06 SG SG11201408094YA patent/SG11201408094YA/en unknown
- 2013-06-06 PL PL13729232T patent/PL2864292T3/pl unknown
- 2013-06-07 AR ARP130102017 patent/AR091381A1/es active IP Right Grant
- 2013-06-07 TW TW106111422A patent/TWI644901B/zh not_active IP Right Cessation
- 2013-06-07 TW TW102120448A patent/TWI583671B/zh not_active IP Right Cessation
-
2014
- 2014-11-17 IL IL235737A patent/IL235737B/en active IP Right Grant
- 2014-11-24 ZA ZA2014/08634A patent/ZA201408634B/en unknown
- 2014-12-05 PH PH12014502733A patent/PH12014502733B1/en unknown
-
2015
- 2015-07-07 US US14/792,810 patent/US9670140B2/en not_active Expired - Fee Related
-
2017
- 2017-04-14 JP JP2017080465A patent/JP2017125063A/ja not_active Withdrawn
- 2017-04-28 US US15/581,327 patent/US9884807B2/en not_active Expired - Fee Related
- 2017-12-15 US US15/843,427 patent/US10315984B2/en active Active
-
2019
- 2019-04-24 US US16/392,920 patent/US10829438B2/en active Active
-
2020
- 2020-10-05 US US16/948,872 patent/US11174219B2/en not_active Expired - Fee Related
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