JP2014505734A5 - - Google Patents

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Publication number
JP2014505734A5
JP2014505734A5 JP2013554588A JP2013554588A JP2014505734A5 JP 2014505734 A5 JP2014505734 A5 JP 2014505734A5 JP 2013554588 A JP2013554588 A JP 2013554588A JP 2013554588 A JP2013554588 A JP 2013554588A JP 2014505734 A5 JP2014505734 A5 JP 2014505734A5
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JP
Japan
Prior art keywords
alkylene
alkyl
compound according
halo
benzyl
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JP2013554588A
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English (en)
Japanese (ja)
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JP2014505734A (ja
JP5959066B2 (ja
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Priority claimed from PCT/US2012/025369 external-priority patent/WO2012154249A1/en
Publication of JP2014505734A publication Critical patent/JP2014505734A/ja
Publication of JP2014505734A5 publication Critical patent/JP2014505734A5/ja
Application granted granted Critical
Publication of JP5959066B2 publication Critical patent/JP5959066B2/ja
Expired - Fee Related legal-status Critical Current
Anticipated expiration legal-status Critical

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JP2013554588A 2011-02-17 2012-02-16 ネプリライシン阻害剤としての置換アミノ酪酸誘導体 Expired - Fee Related JP5959066B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201161443828P 2011-02-17 2011-02-17
US61/443,828 2011-02-17
PCT/US2012/025369 WO2012154249A1 (en) 2011-02-17 2012-02-16 Substituted aminobutyric derivatives as neprilysin inhibitors

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2015246947A Division JP2016094453A (ja) 2011-02-17 2015-12-18 ネプリライシン阻害剤としての置換アミノ酪酸誘導体

Publications (3)

Publication Number Publication Date
JP2014505734A JP2014505734A (ja) 2014-03-06
JP2014505734A5 true JP2014505734A5 (enExample) 2015-04-02
JP5959066B2 JP5959066B2 (ja) 2016-08-02

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ID=45814662

Family Applications (2)

Application Number Title Priority Date Filing Date
JP2013554588A Expired - Fee Related JP5959066B2 (ja) 2011-02-17 2012-02-16 ネプリライシン阻害剤としての置換アミノ酪酸誘導体
JP2015246947A Withdrawn JP2016094453A (ja) 2011-02-17 2015-12-18 ネプリライシン阻害剤としての置換アミノ酪酸誘導体

Family Applications After (1)

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JP2015246947A Withdrawn JP2016094453A (ja) 2011-02-17 2015-12-18 ネプリライシン阻害剤としての置換アミノ酪酸誘導体

Country Status (5)

Country Link
US (5) US8449890B2 (enExample)
EP (1) EP2675792B1 (enExample)
JP (2) JP5959066B2 (enExample)
ES (1) ES2564275T3 (enExample)
WO (1) WO2012154249A1 (enExample)

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EP2651896B1 (en) 2010-12-15 2015-08-12 Theravance Biopharma R&D IP, LLC Neprilysin inhibitors
WO2012154249A1 (en) 2011-02-17 2012-11-15 Theravance, Inc. Substituted aminobutyric derivatives as neprilysin inhibitors
CN103380119B (zh) 2011-02-17 2016-02-17 施万生物制药研发Ip有限责任公司 作为脑啡肽酶抑制剂的经取代的氨基丁酸衍生物
US9499487B2 (en) 2011-05-31 2016-11-22 Theravance Biopharma R&D Ip, Llc Neprilysin inhibitors
CN103596928B (zh) 2011-05-31 2017-02-15 施万生物制药研发Ip有限责任公司 脑啡肽酶抑制剂
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HUE034210T2 (hu) 2013-03-05 2018-02-28 Theravance Biopharma R&D Ip Llc Neprilizininhibitorok
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LT3259255T (lt) 2015-02-19 2021-04-26 Theravance Biopharma R&D Ip, Llc (2r,4r)-5-(5`-chlor-2`-fluorbifenil-4-il)-2-hidroksi-4-[(5-metiloksazol-2-karbonil)amino]pentano rūgštis
KR20220035991A (ko) 2016-03-08 2022-03-22 세라밴스 바이오파마 알앤디 아이피, 엘엘씨 (2s,4r)-5-(5'-클로로-2'-플루오로-[1,1'-비페닐]-4-일)-2-(에톡시메틸)-4-(3-히드록시이속사졸-5-카르복사미도)-2-메틸펜탄산 결정 및 그 용도
CN106905348B (zh) * 2017-02-13 2018-12-04 牡丹江医学院 一种预防和治疗急性肾损伤的药物及其制备方法和用途
CN111479819B (zh) * 2017-12-15 2024-06-14 中外制药株式会社 制备肽的方法和处理碱的方法
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UY38072A (es) 2018-02-07 2019-10-01 Novartis Ag Compuestos derivados de éster butanoico sustituido con bisfenilo como inhibidores de nep, composiciones y combinaciones de los mismos

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JP5420761B2 (ja) * 2009-05-28 2014-02-19 ノバルティス アーゲー ネプリリシン阻害剤としての置換アミノプロピオン酸誘導体
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SG191175A1 (en) * 2010-12-15 2013-07-31 Theravance Inc Neprilysin inhibitors
EP2651896B1 (en) 2010-12-15 2015-08-12 Theravance Biopharma R&D IP, LLC Neprilysin inhibitors
CN103380119B (zh) * 2011-02-17 2016-02-17 施万生物制药研发Ip有限责任公司 作为脑啡肽酶抑制剂的经取代的氨基丁酸衍生物
WO2012154249A1 (en) 2011-02-17 2012-11-15 Theravance, Inc. Substituted aminobutyric derivatives as neprilysin inhibitors
US9499487B2 (en) 2011-05-31 2016-11-22 Theravance Biopharma R&D Ip, Llc Neprilysin inhibitors
CN103596928B (zh) 2011-05-31 2017-02-15 施万生物制药研发Ip有限责任公司 脑啡肽酶抑制剂
CA2835281A1 (en) 2011-05-31 2012-12-06 Theravance, Inc. Neprilysin inhibitors
TWI560172B (en) 2011-11-02 2016-12-01 Theravance Biopharma R&D Ip Llc Neprilysin inhibitors
CA2871292A1 (en) 2012-05-31 2013-12-05 Theravance Biopharma R&D Ip, Llc Nitric oxide donor neprilysin inhibitors
ES2710932T3 (es) 2012-06-08 2019-04-29 Theravance Biopharma R&D Ip Llc Inhibidores de neprilisina
BR112014030743B1 (pt) 2012-06-08 2022-09-06 Theravance Biopharma R&D Ip, Llc Composto inibidor de neprilisina, processo para a preparação do referido composto, composição farmacêutica e uso do referido composto
KR102104954B1 (ko) 2012-08-08 2020-04-27 세라밴스 바이오파마 알앤디 아이피, 엘엘씨 네프릴리신 억제제
HUE034210T2 (hu) 2013-03-05 2018-02-28 Theravance Biopharma R&D Ip Llc Neprilizininhibitorok

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