JP2014505734A5 - - Google Patents

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Publication number
JP2014505734A5
JP2014505734A5 JP2013554588A JP2013554588A JP2014505734A5 JP 2014505734 A5 JP2014505734 A5 JP 2014505734A5 JP 2013554588 A JP2013554588 A JP 2013554588A JP 2013554588 A JP2013554588 A JP 2013554588A JP 2014505734 A5 JP2014505734 A5 JP 2014505734A5
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JP
Japan
Prior art keywords
alkylene
alkyl
compound according
halo
benzyl
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Granted
Application number
JP2013554588A
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English (en)
Japanese (ja)
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JP5959066B2 (ja
JP2014505734A (ja
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Priority claimed from PCT/US2012/025369 external-priority patent/WO2012154249A1/en
Publication of JP2014505734A publication Critical patent/JP2014505734A/ja
Publication of JP2014505734A5 publication Critical patent/JP2014505734A5/ja
Application granted granted Critical
Publication of JP5959066B2 publication Critical patent/JP5959066B2/ja
Expired - Fee Related legal-status Critical Current
Anticipated expiration legal-status Critical

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JP2013554588A 2011-02-17 2012-02-16 ネプリライシン阻害剤としての置換アミノ酪酸誘導体 Expired - Fee Related JP5959066B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201161443828P 2011-02-17 2011-02-17
US61/443,828 2011-02-17
PCT/US2012/025369 WO2012154249A1 (en) 2011-02-17 2012-02-16 Substituted aminobutyric derivatives as neprilysin inhibitors

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2015246947A Division JP2016094453A (ja) 2011-02-17 2015-12-18 ネプリライシン阻害剤としての置換アミノ酪酸誘導体

Publications (3)

Publication Number Publication Date
JP2014505734A JP2014505734A (ja) 2014-03-06
JP2014505734A5 true JP2014505734A5 (enExample) 2015-04-02
JP5959066B2 JP5959066B2 (ja) 2016-08-02

Family

ID=45814662

Family Applications (2)

Application Number Title Priority Date Filing Date
JP2013554588A Expired - Fee Related JP5959066B2 (ja) 2011-02-17 2012-02-16 ネプリライシン阻害剤としての置換アミノ酪酸誘導体
JP2015246947A Withdrawn JP2016094453A (ja) 2011-02-17 2015-12-18 ネプリライシン阻害剤としての置換アミノ酪酸誘導体

Family Applications After (1)

Application Number Title Priority Date Filing Date
JP2015246947A Withdrawn JP2016094453A (ja) 2011-02-17 2015-12-18 ネプリライシン阻害剤としての置換アミノ酪酸誘導体

Country Status (5)

Country Link
US (5) US8449890B2 (enExample)
EP (1) EP2675792B1 (enExample)
JP (2) JP5959066B2 (enExample)
ES (1) ES2564275T3 (enExample)
WO (1) WO2012154249A1 (enExample)

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SG176010A1 (en) 2009-05-28 2011-12-29 Novartis Ag Substituted aminobutyric derivatives as neprilysin inhibitors
NZ611528A (en) 2010-12-15 2015-06-26 Theravance Biopharma R & D Ip Llc Neprilysin inhibitors
US8586536B2 (en) 2010-12-15 2013-11-19 Theravance, Inc. Neprilysin inhibitors
US8449890B2 (en) 2011-02-17 2013-05-28 Theravance, Inc. Neprilysin inhibitors
CA2825737C (en) * 2011-02-17 2018-11-13 Theravance, Inc. Substituted aminobutyric derivatives as neprilysin inhibitors
CA2835220A1 (en) 2011-05-31 2012-12-06 Theravance, Inc. Neprilysin inhibitors
US8513244B2 (en) 2011-05-31 2013-08-20 Theravance, Inc. Neprilysin inhibitors
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EP2858650B1 (en) * 2012-06-08 2018-11-14 Theravance Biopharma R&D IP, LLC Neprilysin inhibitors
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US9585882B2 (en) * 2014-01-30 2017-03-07 Theravance Biopharma R&D Ip, Llc Neprilysin inhibitors
ES2923002T3 (es) 2015-02-11 2022-09-22 Theravance Biopharma R&D Ip Llc Acido (2S,4R)-5-(5'-cloro-2'-fluorobifenil-4-il)-4-(etoxioxailamino)-2-hidroximetil-2-metilpentanoico como inhibidor de la neprilisina
RU2715241C2 (ru) 2015-02-19 2020-02-26 ТЕРЕВАНС БАЙОФАРМА Ар энд Ди АйПи, ЭлЭлСи (2r,4r)-5-(5′-хлор-2′-фторбифенил-4-ил)-2-гидрокси-4-[(5-метилоксазол-2-карбонил)амино]пентановая кислота
PT3408260T (pt) 2016-03-08 2021-07-23 Theravance Biopharma R&D Ip Llc Ácido (2s,4r)-5-(5¿-cloro-2¿-fluoro-[1,1¿-bifenil]-4-il)-2- (etoximetil)-4-(3-hidroxi-isoxazole-5-carboxamido)-2- metilpentanoico cristalino e suas utilizações
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CN111479819B (zh) * 2017-12-15 2024-06-14 中外制药株式会社 制备肽的方法和处理碱的方法
EP3735398B1 (en) 2018-01-03 2022-02-16 Ecolab Usa Inc. Benzotriazole derivatives as corrosion inhibitors
UY38072A (es) 2018-02-07 2019-10-01 Novartis Ag Compuestos derivados de éster butanoico sustituido con bisfenilo como inhibidores de nep, composiciones y combinaciones de los mismos

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SG176010A1 (en) * 2009-05-28 2011-12-29 Novartis Ag Substituted aminobutyric derivatives as neprilysin inhibitors
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NZ611528A (en) * 2010-12-15 2015-06-26 Theravance Biopharma R & D Ip Llc Neprilysin inhibitors
US8586536B2 (en) 2010-12-15 2013-11-19 Theravance, Inc. Neprilysin inhibitors
CA2825737C (en) * 2011-02-17 2018-11-13 Theravance, Inc. Substituted aminobutyric derivatives as neprilysin inhibitors
US8449890B2 (en) 2011-02-17 2013-05-28 Theravance, Inc. Neprilysin inhibitors
US8513244B2 (en) 2011-05-31 2013-08-20 Theravance, Inc. Neprilysin inhibitors
CA2835220A1 (en) 2011-05-31 2012-12-06 Theravance, Inc. Neprilysin inhibitors
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TWI560172B (en) 2011-11-02 2016-12-01 Theravance Biopharma R&D Ip Llc Neprilysin inhibitors
US9045443B2 (en) 2012-05-31 2015-06-02 Theravance Biopharma R&D Ip, Llc Nitric oxide donor neprilysin inhibitors
JP6162230B2 (ja) 2012-06-08 2017-07-12 セラヴァンス バイオファーマ アール＆ディー アイピー， エルエルシー ネプリライシン阻害剤
EP2858650B1 (en) 2012-06-08 2018-11-14 Theravance Biopharma R&D IP, LLC Neprilysin inhibitors
AU2013299642B2 (en) 2012-08-08 2017-06-08 Theravance Biopharma R&D Ip, Llc Neprilysin inhibitors
EP2964616B1 (en) 2013-03-05 2017-05-03 Theravance Biopharma R&D IP, LLC Neprilysin inhibitors

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