JP2012513982A5 - - Google Patents
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- Publication number
- JP2012513982A5 JP2012513982A5 JP2011543072A JP2011543072A JP2012513982A5 JP 2012513982 A5 JP2012513982 A5 JP 2012513982A5 JP 2011543072 A JP2011543072 A JP 2011543072A JP 2011543072 A JP2011543072 A JP 2011543072A JP 2012513982 A5 JP2012513982 A5 JP 2012513982A5
- Authority
- JP
- Japan
- Prior art keywords
- group
- optionally substituted
- alkyl group
- aromatic
- atom
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 125000004432 carbon atom Chemical group C* 0.000 claims 12
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims 11
- 125000001424 substituent group Chemical group 0.000 claims 11
- 239000003098 androgen Substances 0.000 claims 9
- 125000003118 aryl group Chemical group 0.000 claims 9
- 229910052717 sulfur Inorganic materials 0.000 claims 9
- 125000006615 aromatic heterocyclic group Chemical group 0.000 claims 7
- KAHDONZOCXSKII-NJVVDGNHSA-N kisspeptin Chemical class C([C@@H](C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](C)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CCC(N)=O)C(=O)NCC(=O)N[C@@H](C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC=1C=CC(O)=CC=1)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC=1C=CC=CC=1)C(N)=O)NC(=O)[C@H]1N(CCC1)C(=O)[C@H](C)NC(=O)[C@H](CO)NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H]1N(CCC1)C(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CO)NC(=O)CNC(=O)[C@H](CO)NC(=O)[C@H](CO)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H]1N(CCC1)C(=O)[C@H]1N(CCC1)C(=O)[C@H]1N(CCC1)C(=O)[C@H](CO)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)CN)[C@@H](C)O)C1=CN=CN1 KAHDONZOCXSKII-NJVVDGNHSA-N 0.000 claims 7
- 206010028980 Neoplasm Diseases 0.000 claims 6
- 125000000217 alkyl group Chemical group 0.000 claims 6
- 201000011510 cancer Diseases 0.000 claims 6
- 125000003917 carbamoyl group Chemical group [H]N([H])C(*)=O 0.000 claims 6
- 125000005842 heteroatom Chemical group 0.000 claims 6
- 229910052757 nitrogen Inorganic materials 0.000 claims 6
- 125000004433 nitrogen atom Chemical group N* 0.000 claims 6
- 125000004430 oxygen atom Chemical group O* 0.000 claims 6
- 125000004434 sulfur atom Chemical group 0.000 claims 6
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 claims 5
- 239000003795 chemical substances by application Substances 0.000 claims 5
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 5
- 125000000008 (C1-C10) alkyl group Chemical group 0.000 claims 4
- 229910052799 carbon Inorganic materials 0.000 claims 4
- 150000001875 compounds Chemical class 0.000 claims 4
- 229910052760 oxygen Inorganic materials 0.000 claims 4
- 229910052698 phosphorus Inorganic materials 0.000 claims 4
- 150000003839 salts Chemical class 0.000 claims 4
- 125000006273 (C1-C3) alkyl group Chemical group 0.000 claims 3
- 125000004209 (C1-C8) alkyl group Chemical group 0.000 claims 3
- 206010060862 Prostate cancer Diseases 0.000 claims 3
- 208000000236 Prostatic Neoplasms Diseases 0.000 claims 3
- 125000002029 aromatic hydrocarbon group Chemical group 0.000 claims 3
- 239000003814 drug Substances 0.000 claims 3
- 125000000623 heterocyclic group Chemical group 0.000 claims 3
- 229940124597 therapeutic agent Drugs 0.000 claims 3
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 claims 2
- 125000003275 alpha amino acid group Chemical group 0.000 claims 2
- 125000003277 amino group Chemical group 0.000 claims 2
- 150000001721 carbon Chemical class 0.000 claims 2
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims 2
- 125000006165 cyclic alkyl group Chemical group 0.000 claims 2
- 125000004122 cyclic group Chemical group 0.000 claims 2
- 125000005915 C6-C14 aryl group Chemical group 0.000 claims 1
- 125000002252 acyl group Chemical group 0.000 claims 1
- 125000000539 amino acid group Chemical group 0.000 claims 1
- 125000003710 aryl alkyl group Chemical group 0.000 claims 1
- 210000004899 c-terminal region Anatomy 0.000 claims 1
- 125000003739 carbamimidoyl group Chemical group C(N)(=N)* 0.000 claims 1
- -1 glyoxyloyl group Chemical group 0.000 claims 1
- 125000002795 guanidino group Chemical group C(N)(=N)N* 0.000 claims 1
- 230000002265 prevention Effects 0.000 claims 1
- 230000003449 preventive effect Effects 0.000 claims 1
- 230000000069 prophylactic effect Effects 0.000 claims 1
- 125000000213 sulfino group Chemical group [H]OS(*)=O 0.000 claims 1
- 125000003396 thiol group Chemical group [H]S* 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US20388708P | 2008-12-29 | 2008-12-29 | |
| US61/203,887 | 2008-12-29 | ||
| PCT/JP2009/071919 WO2010076896A1 (en) | 2008-12-29 | 2009-12-28 | Prophylactic/therapeutic agent for cancer |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2012513982A JP2012513982A (ja) | 2012-06-21 |
| JP2012513982A5 true JP2012513982A5 (enExample) | 2013-01-31 |
Family
ID=42025816
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011543072A Pending JP2012513982A (ja) | 2008-12-29 | 2009-12-28 | 癌の予防・治療剤 |
Country Status (26)
| Country | Link |
|---|---|
| US (1) | US20110312898A1 (enExample) |
| EP (1) | EP2379053A1 (enExample) |
| JP (1) | JP2012513982A (enExample) |
| KR (1) | KR20110111420A (enExample) |
| CN (1) | CN102333520B (enExample) |
| AR (1) | AR074918A1 (enExample) |
| AU (1) | AU2009334235A1 (enExample) |
| BR (1) | BRPI0923663A2 (enExample) |
| CA (1) | CA2748517A1 (enExample) |
| CL (1) | CL2011001519A1 (enExample) |
| CO (1) | CO6382105A2 (enExample) |
| CR (1) | CR20110374A (enExample) |
| DO (1) | DOP2011000163A (enExample) |
| EA (1) | EA019738B1 (enExample) |
| EC (1) | ECSP11011166A (enExample) |
| GE (1) | GEP20146001B (enExample) |
| IL (1) | IL212913A0 (enExample) |
| MA (1) | MA32935B1 (enExample) |
| MX (1) | MX2011006170A (enExample) |
| NZ (1) | NZ593381A (enExample) |
| PE (1) | PE20110939A1 (enExample) |
| TN (1) | TN2011000250A1 (enExample) |
| TW (1) | TW201029660A (enExample) |
| UY (1) | UY32367A (enExample) |
| WO (1) | WO2010076896A1 (enExample) |
| ZA (1) | ZA201103627B (enExample) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2009139298A1 (ja) * | 2008-04-30 | 2009-11-19 | 国立大学法人京都大学 | メタスチン誘導体およびその用途 |
| MA33910B1 (fr) * | 2009-12-22 | 2013-01-02 | Takeda Pharmaceutcal Company Ltd | Formulation à libération prolongée |
| TW201204378A (en) * | 2010-06-25 | 2012-02-01 | Takeda Pharmaceutical | Sustained-release formulation |
| JP6253146B2 (ja) * | 2014-02-04 | 2017-12-27 | 国立大学法人山口大学 | 新規なペプチド誘導体及びこれを含有する医薬 |
| EA201700154A1 (ru) * | 2014-10-20 | 2017-08-31 | Товарищество С Ограниченной Ответственностью "Фармацевтическая Компания "Ромат" | Фармацевтический состав лечебно-профилактического действия и способ его приготовления |
| MA46353A (fr) | 2016-09-30 | 2019-08-07 | Myovant Sciences Gmbh | Méthodes de traitement de l'infertilité féminine |
| WO2024206577A1 (en) * | 2023-03-28 | 2024-10-03 | Radionetics Oncology, Inc. | Kisspeptin receptor (kiss1r) targeted therapeutics and uses thereof |
| WO2025217074A1 (en) | 2024-04-08 | 2025-10-16 | Radionetics Oncology, Inc. | Kisspeptin receptor (kiss1r) targeted therapeutics and uses thereof |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2511858A1 (en) | 2002-12-26 | 2004-07-29 | Takeda Pharmaceutical Company Limited | Metastin derivative and use thereof |
| US6800611B2 (en) * | 2003-01-06 | 2004-10-05 | Takeda Chemical Industries, Ltd. | Metastin derivatives and their use |
| US7625869B2 (en) * | 2004-06-25 | 2009-12-01 | Takeda Pharmaceutical Company Limited | Metastin derivatives and use thereof |
| CN1972959A (zh) * | 2004-06-25 | 2007-05-30 | 武田药品工业株式会社 | 转移素衍生物及其用途 |
| AR058584A1 (es) * | 2005-12-22 | 2008-02-13 | Takeda Pharmaceutical | Derivados de metastina y uso de los mismos |
-
2009
- 2009-12-28 PE PE2011001293A patent/PE20110939A1/es not_active Application Discontinuation
- 2009-12-28 EP EP09801574A patent/EP2379053A1/en not_active Withdrawn
- 2009-12-28 US US13/142,414 patent/US20110312898A1/en not_active Abandoned
- 2009-12-28 JP JP2011543072A patent/JP2012513982A/ja active Pending
- 2009-12-28 KR KR1020117017317A patent/KR20110111420A/ko not_active Withdrawn
- 2009-12-28 MX MX2011006170A patent/MX2011006170A/es not_active Application Discontinuation
- 2009-12-28 EA EA201100882A patent/EA019738B1/ru not_active IP Right Cessation
- 2009-12-28 GE GEAP200912275A patent/GEP20146001B/en unknown
- 2009-12-28 AR ARP090105129A patent/AR074918A1/es not_active Application Discontinuation
- 2009-12-28 BR BRPI0923663A patent/BRPI0923663A2/pt not_active IP Right Cessation
- 2009-12-28 CN CN2009801575361A patent/CN102333520B/zh not_active Expired - Fee Related
- 2009-12-28 UY UY0001032367A patent/UY32367A/es not_active Application Discontinuation
- 2009-12-28 WO PCT/JP2009/071919 patent/WO2010076896A1/en not_active Ceased
- 2009-12-28 CA CA2748517A patent/CA2748517A1/en not_active Abandoned
- 2009-12-28 NZ NZ593381A patent/NZ593381A/xx not_active IP Right Cessation
- 2009-12-28 TW TW098145251A patent/TW201029660A/zh unknown
- 2009-12-28 AU AU2009334235A patent/AU2009334235A1/en not_active Abandoned
- 2009-12-28 MA MA33959A patent/MA32935B1/fr unknown
-
2011
- 2011-05-16 IL IL212913A patent/IL212913A0/en unknown
- 2011-05-17 ZA ZA2011/03627A patent/ZA201103627B/en unknown
- 2011-05-17 TN TN2011000250A patent/TN2011000250A1/fr unknown
- 2011-05-31 DO DO2011000163A patent/DOP2011000163A/es unknown
- 2011-06-20 CL CL2011001519A patent/CL2011001519A1/es unknown
- 2011-06-23 CO CO11078830A patent/CO6382105A2/es not_active Application Discontinuation
- 2011-06-29 EC EC2011011166A patent/ECSP11011166A/es unknown
- 2011-06-29 CR CR20110374A patent/CR20110374A/es not_active Application Discontinuation
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