JP2015520170A5 - - Google Patents
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- Publication number
- JP2015520170A5 JP2015520170A5 JP2015514227A JP2015514227A JP2015520170A5 JP 2015520170 A5 JP2015520170 A5 JP 2015520170A5 JP 2015514227 A JP2015514227 A JP 2015514227A JP 2015514227 A JP2015514227 A JP 2015514227A JP 2015520170 A5 JP2015520170 A5 JP 2015520170A5
- Authority
- JP
- Japan
- Prior art keywords
- metabolic syndrome
- hsp90
- hsp90 modulator
- modulator according
- treating
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261652023P | 2012-05-25 | 2012-05-25 | |
| US61/652,023 | 2012-05-25 | ||
| PCT/US2013/042692 WO2013177535A2 (en) | 2012-05-25 | 2013-05-24 | Methods of treating a metabolic syndrome by modulating heat shock protein (hsp) 90-beta |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2015520170A JP2015520170A (ja) | 2015-07-16 |
| JP2015520170A5 true JP2015520170A5 (https=) | 2016-07-14 |
| JP6478908B2 JP6478908B2 (ja) | 2019-03-06 |
Family
ID=49624539
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015514227A Expired - Fee Related JP6478908B2 (ja) | 2012-05-25 | 2013-05-24 | 熱ショックタンパク質(HSP)90−βを調節することによる代謝症候群の治療方法 |
Country Status (15)
| Country | Link |
|---|---|
| US (2) | US9533002B2 (https=) |
| EP (1) | EP2854865B1 (https=) |
| JP (1) | JP6478908B2 (https=) |
| KR (1) | KR20150010793A (https=) |
| CN (1) | CN104812898B (https=) |
| AU (1) | AU2013266086B2 (https=) |
| BR (1) | BR112014029301A2 (https=) |
| CA (1) | CA2874676A1 (https=) |
| EA (1) | EA201492184A1 (https=) |
| HK (1) | HK1209035A1 (https=) |
| IL (1) | IL235910A0 (https=) |
| MX (1) | MX2014014188A (https=) |
| NZ (1) | NZ702169A (https=) |
| SG (1) | SG11201407775WA (https=) |
| WO (1) | WO2013177535A2 (https=) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP6478908B2 (ja) * | 2012-05-25 | 2019-03-06 | バーグ エルエルシー | 熱ショックタンパク質(HSP)90−βを調節することによる代謝症候群の治療方法 |
| RS58010B1 (sr) | 2012-09-27 | 2019-02-28 | Childrens Medical Ct Corp | Jedinjenja za lečenje gojaznosti i postupci za njihovu upotrebu |
| CA3044998A1 (en) * | 2014-03-26 | 2015-10-01 | The Children's Medical Center Corporation | Celastrol and derivatives for the treatment of obesity |
| WO2015188198A2 (en) * | 2014-06-06 | 2015-12-10 | Berg Llc | Methods of treating a metabolic syndrome by modulating heat shock protein (hsp) 90-beta |
| JP6779867B2 (ja) * | 2014-06-13 | 2020-11-04 | ユマ セラピューティクス,インコーポレーテッド | ピリミジン化合物およびその使用方法 |
| WO2016149575A1 (en) * | 2015-03-19 | 2016-09-22 | Old Dominion University | Synergistic regulated cell death induction with hsp90 inhibitors and nanosecond pulsed electric fields |
| JP7034078B2 (ja) * | 2015-10-23 | 2022-03-11 | イーアールエックス ファーマシューティカルズ インコーポレイテッド | セラストロールの類似体 |
| CN105920018B (zh) * | 2016-06-15 | 2019-01-11 | 上海市内分泌代谢病研究所 | 雷公藤红素联合小檗碱制备治疗肥胖药物的用途 |
| CN107543929A (zh) * | 2016-06-23 | 2018-01-05 | 中国医学科学院肿瘤医院 | 基于蛋白标志物hsp90ab1诊断肺癌患者的试剂盒 |
| CN107028953A (zh) * | 2017-03-27 | 2017-08-11 | 北京大学 | 一种交感神经活性的刺激剂 |
| KR20190138871A (ko) * | 2017-04-24 | 2019-12-16 | 사무스 테라퓨틱스, 인코포레이티드 | Hsp90 저해제 경구 제형 및 관련 방법 |
| WO2018235251A1 (ja) | 2017-06-23 | 2018-12-27 | 株式会社ニコン | 解析装置、解析プログラム及び解析方法 |
| CN112156188A (zh) * | 2020-11-10 | 2021-01-01 | 上海交通大学医学院附属瑞金医院 | Hsp90作为制备预防与治疗类固醇糖尿病药物的用途 |
| CN113332308A (zh) * | 2021-02-22 | 2021-09-03 | 广东省妇幼保健院 | 调控hsp90 b1表达量的制剂在制备预防或治疗多囊卵巢综合征药物中的应用 |
| CN113160983A (zh) * | 2021-04-09 | 2021-07-23 | 南京医科大学附属逸夫医院 | 一种代谢相关脂肪性肝病临床预测模型 |
Family Cites Families (57)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7078375B1 (en) | 1996-10-25 | 2006-07-18 | Peter Mose Larsen | Diabetes-mediating proteins and therapeutic uses thereof |
| US20040048256A1 (en) * | 2001-09-07 | 2004-03-11 | Agee Michele L. | Novel proteins and nucleic acids encoding same |
| EP1576124A2 (en) | 2002-10-07 | 2005-09-21 | Antigenics Inc. | Heat shock protein binding fragments of cd91, and uses thereof |
| WO2004072080A1 (en) | 2003-02-10 | 2004-08-26 | Cellular Genomics, Inc. | Certain 8-heteroaryl-6-phenyl-imidazo[1,2-a]pyrazines as modulators of hsp90 complex activity |
| GB0309637D0 (en) | 2003-04-28 | 2003-06-04 | Cancer Rec Tech Ltd | Pyrazole compounds |
| NZ546044A (en) | 2003-08-29 | 2009-09-25 | Vernalis Cambridge Ltd | Pyrimidothiophene compounds |
| US20070249540A1 (en) | 2004-05-24 | 2007-10-25 | Adonia Papathanassiu | Methods for Inhibiting Proteasome and Heat Shock Protein 90 |
| WO2006020269A2 (en) | 2004-07-19 | 2006-02-23 | University Of Rochester | Biomarkers of neurodegenerative disease |
| US20060094682A1 (en) | 2004-10-29 | 2006-05-04 | Odyssey Thera, Inc. | Kinase inhibitors for the treatment of diabetes and obesity |
| US9120774B2 (en) | 2004-11-03 | 2015-09-01 | University Of Kansas | Novobiocin analogues having modified sugar moieties |
| FR2885904B1 (fr) | 2005-05-19 | 2007-07-06 | Aventis Pharma Sa | Nouveaux derives du fluorene, compositions les contenant et utilisation |
| WO2007022042A2 (en) | 2005-08-11 | 2007-02-22 | Novartis Ag | Combinations comrising a protein kinase inhibitor being a pyrimidylaminobξnzamide compound and a hsp90 inhibitor such as 17-aag |
| US20070207950A1 (en) | 2005-12-21 | 2007-09-06 | Duke University | Methods and compositions for regulating HDAC6 activity |
| WO2007077042A1 (en) | 2006-01-06 | 2007-07-12 | Topotarget Switzerland Sa | New method for the treatment of gout or pseudogout |
| US8658633B2 (en) | 2006-02-16 | 2014-02-25 | Massachusetts Eye And Ear Infirmary | Methods and compositions for treating conditions of the eye |
| CA2645930A1 (en) | 2006-03-17 | 2007-09-27 | Crossbeta Biosciences B.V. | Methods of binding of cross-beta structures by chaperones |
| KR20090019790A (ko) | 2006-05-19 | 2009-02-25 | 더 스크립스 리서치 인스티튜트 | 단백질 미스폴딩의 치료 |
| WO2007139955A2 (en) | 2006-05-25 | 2007-12-06 | Synta Pharmaceuticals Corp. | Triazole compounds that modulate hsp90 activity |
| CA2661436A1 (en) | 2006-08-24 | 2008-02-28 | Serenex, Inc. | Isoquinoline, quinazoline and phthalazine derivatives |
| WO2008024974A1 (en) | 2006-08-24 | 2008-02-28 | Serenex, Inc. | Pyrimidine and pyrazine derivatives |
| EP2073802A1 (en) | 2006-10-12 | 2009-07-01 | Astex Therapeutics Limited | Pharmaceutical combinations |
| GB0620259D0 (en) * | 2006-10-12 | 2006-11-22 | Astex Therapeutics Ltd | Pharmaceutical compounds |
| JP5518478B2 (ja) | 2006-10-12 | 2014-06-11 | アステックス、セラピューティックス、リミテッド | 医薬化合物 |
| GB0622084D0 (en) | 2006-11-06 | 2006-12-13 | Chroma Therapeutics Ltd | Inhibitors of HSP90 |
| BRPI0718562A2 (pt) | 2006-11-09 | 2014-04-08 | Biotica Tech Ltd | Composto, processo para preparar e para gerar análogo de macbecina, análogo de macbecina, composição farmacêutica, uso do análogo de macbecina, e, cepa engenheirada. |
| EP2121957A4 (en) | 2007-01-26 | 2010-11-10 | Kosan Biosciences Inc | MACROLACTAMES OBTAINED BY MODIFIED BIOSYNTHESIS |
| KR101313804B1 (ko) | 2007-03-20 | 2013-10-01 | 쿠리스 인코퍼레이션 | Hsp90 억제제로서의 융합된 아미노 피리딘 |
| GB2449293A (en) | 2007-05-17 | 2008-11-19 | Evotec | Compounds having Hsp90 inhibitory activity |
| EP2164865A2 (en) | 2007-06-13 | 2010-03-24 | Hochschule Mannheim | Compounds for the modulation of huntingtin aggregation, methods and means for identifying such compounds |
| IL184671A0 (en) | 2007-07-17 | 2008-12-29 | Hadasit Med Res Service | Substances directed to heparanase c-terminal domain-or substance derived therefrom and uses thereof as modulators of heparanas biological activities |
| DE102007041116A1 (de) | 2007-08-30 | 2009-03-05 | Merck Patent Gmbh | 1,3-Dihydro-isoindolderivate |
| TW200920357A (en) | 2007-09-10 | 2009-05-16 | Curis Inc | HSP90 inhibitors containing a zinc binding moiety |
| EP2060565A1 (en) | 2007-11-16 | 2009-05-20 | 4Sc Ag | Novel bifunctional compounds which inhibit protein kinases and histone deacetylases |
| WO2009067245A2 (en) | 2007-11-20 | 2009-05-28 | University Of Florida Research Foundation, Inc. | Compositions and methods for tissue repair |
| JP5582783B2 (ja) | 2007-12-28 | 2014-09-03 | 武田薬品工業株式会社 | 細胞保護剤のスクリーニング方法 |
| HRP20191953T8 (hr) | 2008-03-07 | 2021-06-25 | Aziende Chimiche Riunite Angelini Francesco A.C.R.A.F. S.P.A. | DERIVATI 1-BENZIL-3-HIDROKSIMETILINDAZOLA I NJIHOVA UPORABA U LIJEČENJU BOLESTI KOJE SE BAZIRAJU NA EKSPRESIJI MCP-1, CX3CR1 i P40 |
| WO2009114470A2 (en) | 2008-03-10 | 2009-09-17 | Curis, Inc. | Tetrahydroindole and tetrahdyroindazole as hsp90 inhibitors containing a zinc binding moiety |
| EP2100879A1 (en) | 2008-03-13 | 2009-09-16 | 4Sc Ag | Novel N-substituted tetrahydroisoquinoline/isoindoline hydroxamic acid compounds |
| BRPI0822354B1 (pt) | 2008-05-19 | 2020-11-10 | Hewlett Packard Development Company, L.P | método para suportar login de pré-boot em sistemas de computador, mídia legível por computador e sistema de computador |
| JP5767965B2 (ja) * | 2008-06-10 | 2015-08-26 | プレキシコン インコーポレーテッドPlexxikon Inc. | キナーゼを調節する5h−ピロロ[2,3−b]ピラジン誘導体、およびその適応症 |
| WO2010014617A1 (en) | 2008-07-28 | 2010-02-04 | University Of Kansas | Heat shock protein 90 inhibitor dosing methods |
| CN102112481A (zh) | 2008-08-04 | 2011-06-29 | 帝斯曼知识产权资产管理有限公司 | 使用过氧化氢或过酸由鼠尾草酸生产鼠尾草酚的方法 |
| WO2010019965A1 (en) | 2008-08-15 | 2010-02-18 | The Board Of Trustees Of The Leland Stanford Junior University | Compositions and methods for modulating epsilon protein kinase c-mediated cytoprotection |
| WO2010030395A2 (en) | 2008-09-15 | 2010-03-18 | Whitehead Institute For Biomedical Research | Withaferin a analogs and uses thereof |
| MA32934B1 (fr) | 2008-11-28 | 2012-01-02 | Novartis Ag | Combinaisons inhibitrices hsp90 |
| WO2010117425A1 (en) | 2009-03-31 | 2010-10-14 | Biogen Idec Ma Inc. | Certain substituted pyrimidines, pharmaceutical compositions thereof, and methods for their use |
| WO2011083150A2 (en) * | 2010-01-07 | 2011-07-14 | Akron Molecules Gmbh | Obesity small molecules |
| US20110201587A1 (en) * | 2010-02-16 | 2011-08-18 | Bio Holding, Inc. | Hsp90 inhibitors and methods of use |
| JP2013519727A (ja) | 2010-02-17 | 2013-05-30 | イルドン ファーム シーオー.,エルティーディー. | 新規の5員複素環誘導体及びその製造方法 |
| CA2697887A1 (en) | 2010-03-12 | 2011-09-12 | Institut De Recherches Cliniques De Montreal | Modulating and/or detecting activation induced deaminase and methods of use thereof |
| US9062072B2 (en) | 2010-04-20 | 2015-06-23 | Emory University | Inhibitors of HIF and angiogenesis |
| WO2012106393A2 (en) | 2011-02-01 | 2012-08-09 | University Of Kansas | Withanolide isolated from physalis longifolia and analogs and methods of use thereof |
| AU2012212323A1 (en) | 2011-02-01 | 2013-09-12 | The Board Of Trustees Of The University Of Illinois | HDAC inhibitors and therapeutic methods using the same |
| US8685966B2 (en) | 2011-04-08 | 2014-04-01 | University Of Kansas | GRP94 inhibitors |
| WO2013015661A2 (en) | 2011-07-28 | 2013-01-31 | Ildong Pharm Co.,Ltd. | Novel prodrugs of 5-(2,4-dihydroxy-5-isopropylphenyl)-n-ethyl-4-(5-methyl1-1,2,4-oxadiazol-3-yl)isoxazole-3-carboxamide |
| JP6478908B2 (ja) * | 2012-05-25 | 2019-03-06 | バーグ エルエルシー | 熱ショックタンパク質(HSP)90−βを調節することによる代謝症候群の治療方法 |
| CN102772399A (zh) * | 2012-08-16 | 2012-11-14 | 厦门大学 | 藤黄酸作为5`-amp激活的蛋白激酶激动剂的用途 |
-
2013
- 2013-05-24 JP JP2015514227A patent/JP6478908B2/ja not_active Expired - Fee Related
- 2013-05-24 CN CN201380039309.5A patent/CN104812898B/zh not_active Expired - Fee Related
- 2013-05-24 EP EP13793158.0A patent/EP2854865B1/en active Active
- 2013-05-24 CA CA2874676A patent/CA2874676A1/en not_active Abandoned
- 2013-05-24 KR KR1020147035410A patent/KR20150010793A/ko not_active Withdrawn
- 2013-05-24 MX MX2014014188A patent/MX2014014188A/es unknown
- 2013-05-24 HK HK15109711.2A patent/HK1209035A1/xx unknown
- 2013-05-24 BR BR112014029301A patent/BR112014029301A2/pt not_active IP Right Cessation
- 2013-05-24 US US13/902,354 patent/US9533002B2/en not_active Expired - Fee Related
- 2013-05-24 EA EA201492184A patent/EA201492184A1/ru unknown
- 2013-05-24 SG SG11201407775WA patent/SG11201407775WA/en unknown
- 2013-05-24 WO PCT/US2013/042692 patent/WO2013177535A2/en not_active Ceased
- 2013-05-24 AU AU2013266086A patent/AU2013266086B2/en not_active Ceased
- 2013-05-24 NZ NZ702169A patent/NZ702169A/en not_active IP Right Cessation
-
2014
- 2014-11-25 IL IL235910A patent/IL235910A0/en unknown
-
2016
- 2016-11-21 US US15/357,915 patent/US20170166891A1/en not_active Abandoned
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