BR112014029301A2 - métodos de tratamento de síndrome metabólica através de modulação da proteína choque térmico (hsp) 90-beta - Google Patents

métodos de tratamento de síndrome metabólica através de modulação da proteína choque térmico (hsp) 90-beta

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Publication number
BR112014029301A2
BR112014029301A2 BR112014029301A BR112014029301A BR112014029301A2 BR 112014029301 A2 BR112014029301 A2 BR 112014029301A2 BR 112014029301 A BR112014029301 A BR 112014029301A BR 112014029301 A BR112014029301 A BR 112014029301A BR 112014029301 A2 BR112014029301 A2 BR 112014029301A2
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Brazil
Prior art keywords
metabolic syndrome
methods
hsp
beta
heat shock
Prior art date
Application number
BR112014029301A
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English (en)
Inventor
Jing Enxuan
Niven Narain Rajin
Sarangarajan Rangaprasad
K Vishnudas Vivek
Original Assignee
Berg Llc
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Application filed by Berg Llc filed Critical Berg Llc
Publication of BR112014029301A2 publication Critical patent/BR112014029301A2/pt

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Abstract

resumo patente de invenção: "métodos de tratamento de síndrome metabólica através de modulação da proteína choque térmico (hsp) 90-beta". a presente invenção refere-se a métodos de tratamento de síndrome metabólica com inibidores de hsp90, em particular inibidores de hsp90ß. a invenção fornece métodos de diagnóstico e monitoramento de síndrome metabólica usando o nível de expressão e atividade de hsp90, particularmente hsp90ß.
BR112014029301A 2012-05-25 2013-05-24 métodos de tratamento de síndrome metabólica através de modulação da proteína choque térmico (hsp) 90-beta BR112014029301A2 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201261652023P 2012-05-25 2012-05-25
PCT/US2013/042692 WO2013177535A2 (en) 2012-05-25 2013-05-24 Methods of treating a metabolic syndrome by modulating heat shock protein (hsp) 90-beta

Publications (1)

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BR112014029301A2 true BR112014029301A2 (pt) 2017-07-25

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BR112014029301A BR112014029301A2 (pt) 2012-05-25 2013-05-24 métodos de tratamento de síndrome metabólica através de modulação da proteína choque térmico (hsp) 90-beta

Country Status (15)

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US (2) US9533002B2 (pt)
EP (1) EP2854865B1 (pt)
JP (1) JP6478908B2 (pt)
KR (1) KR20150010793A (pt)
CN (1) CN104812898B (pt)
AU (1) AU2013266086B2 (pt)
BR (1) BR112014029301A2 (pt)
CA (1) CA2874676A1 (pt)
EA (1) EA201492184A1 (pt)
HK (1) HK1209035A1 (pt)
IL (1) IL235910A0 (pt)
MX (1) MX2014014188A (pt)
NZ (1) NZ702169A (pt)
SG (1) SG11201407775WA (pt)
WO (1) WO2013177535A2 (pt)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9533002B2 (en) * 2012-05-25 2017-01-03 Berg Llc Methods of treating a metabolic syndrome by modulating heat shock protein (HSP) 90-β
LT2900230T (lt) 2012-09-27 2019-01-10 The Children`S Medical Center Corporation Junginiai, skirti nutukimo gydymui ir jų panaudojimo būdai
ES2813424T3 (es) * 2014-03-26 2021-03-23 Childrens Medical Ct Corp Derivados de celastrol para el tratamiento de la obesidad
WO2015188198A2 (en) * 2014-06-06 2015-12-10 Berg Llc Methods of treating a metabolic syndrome by modulating heat shock protein (hsp) 90-beta
CA2952230C (en) * 2014-06-13 2023-03-21 Yuma Therapeutics, Inc. Pyrimidine compounds and methods using the same
US20180110978A1 (en) * 2015-03-19 2018-04-26 Old Dominion University Research Foundation Synergistic regulated cell death induction with hsp90 inhibitors and nanosecond pulsed electric fields
US10662218B2 (en) * 2015-10-23 2020-05-26 Erx Pharmaceuticals, Inc. Analogs of celastrol
CN105920018B (zh) * 2016-06-15 2019-01-11 上海市内分泌代谢病研究所 雷公藤红素联合小檗碱制备治疗肥胖药物的用途
CN107543929A (zh) * 2016-06-23 2018-01-05 中国医学科学院肿瘤医院 基于蛋白标志物hsp90ab1诊断肺癌患者的试剂盒
CN107028953A (zh) * 2017-03-27 2017-08-11 北京大学 一种交感神经活性的刺激剂
SG10201913562VA (en) * 2017-04-24 2020-03-30 Samus Therapeutics Inc Hsp90 inhibitor oral formulations and related methods
US11379983B2 (en) 2017-06-23 2022-07-05 Nikon Corporation Analysis device, analysis program, and analysis method
CN112156188A (zh) * 2020-11-10 2021-01-01 上海交通大学医学院附属瑞金医院 Hsp90作为制备预防与治疗类固醇糖尿病药物的用途
CN113332308A (zh) * 2021-02-22 2021-09-03 广东省妇幼保健院 调控hsp90 b1表达量的制剂在制备预防或治疗多囊卵巢综合征药物中的应用
CN113160983A (zh) * 2021-04-09 2021-07-23 南京医科大学附属逸夫医院 一种代谢相关脂肪性肝病临床预测模型

Family Cites Families (57)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7078375B1 (en) * 1996-10-25 2006-07-18 Peter Mose Larsen Diabetes-mediating proteins and therapeutic uses thereof
US20040048256A1 (en) 2001-09-07 2004-03-11 Agee Michele L. Novel proteins and nucleic acids encoding same
AU2003287048A1 (en) 2002-10-07 2004-05-04 Antigenics, Inc. Heat shock protein binding fragments of cd91, and uses thereof
US7160885B2 (en) 2003-02-10 2007-01-09 Cgi Pharmaceuticals, Inc. Certain 6, 8-(heteroaryl or aryl) disubstituted imidazo[1,2-a]pyrazines as modulators of Hsp90 complex activity
GB0309637D0 (en) 2003-04-28 2003-06-04 Cancer Rec Tech Ltd Pyrazole compounds
KR101139314B1 (ko) 2003-08-29 2012-04-26 베르날리스(캠브리지)리미티드 피리미도티오펜 화합물
WO2005115431A2 (en) 2004-05-24 2005-12-08 Adonia Papathanassiu Methods for inhibiting proteasome and heat shock protein 90
JP2008506415A (ja) * 2004-07-19 2008-03-06 ユニバーシティー オブ ロチェスター 神経変性疾患の生物マーカー
US20060094682A1 (en) 2004-10-29 2006-05-04 Odyssey Thera, Inc. Kinase inhibitors for the treatment of diabetes and obesity
US9120774B2 (en) 2004-11-03 2015-09-01 University Of Kansas Novobiocin analogues having modified sugar moieties
FR2885904B1 (fr) 2005-05-19 2007-07-06 Aventis Pharma Sa Nouveaux derives du fluorene, compositions les contenant et utilisation
WO2007022042A2 (en) 2005-08-11 2007-02-22 Novartis Ag Combinations comrising a protein kinase inhibitor being a pyrimidylaminobξnzamide compound and a hsp90 inhibitor such as 17-aag
US20070207950A1 (en) 2005-12-21 2007-09-06 Duke University Methods and compositions for regulating HDAC6 activity
WO2007077042A1 (en) 2006-01-06 2007-07-12 Topotarget Switzerland Sa New method for the treatment of gout or pseudogout
WO2007097839A2 (en) 2006-02-16 2007-08-30 Massachusetts Eye And Ear Infirmary Ansamycin analogs or heat shock 90 inhibitors in combination with pdt treatin conditions of the eye
WO2007108675A1 (en) 2006-03-17 2007-09-27 Crossbeta Biosciences B.V. Methods of binding of cross-beta structures by chaperones
WO2007137239A2 (en) 2006-05-19 2007-11-29 The Scripps Research Institute Treatment of protein misfolding
JP5441690B2 (ja) 2006-05-25 2014-03-12 シンタ ファーマシューティカルズ コーポレーション Ｈｓｐ９０活性を調節するトリアゾール化合物
CA2661436A1 (en) 2006-08-24 2008-02-28 Serenex, Inc. Isoquinoline, quinazoline and phthalazine derivatives
WO2008024974A1 (en) 2006-08-24 2008-02-28 Serenex, Inc. Pyrimidine and pyrazine derivatives
JP5518478B2 (ja) 2006-10-12 2014-06-11 アステックス、セラピューティックス、リミテッド 医薬化合物
JP5721949B2 (ja) 2006-10-12 2015-05-20 アステックス、セラピューティックス、リミテッドＡｓｔｅｘ Ｔｈｅｒａｐｅｕｔｉｃｓ Ｌｉｍｉｔｅｄ 複合薬剤
GB0620259D0 (en) * 2006-10-12 2006-11-22 Astex Therapeutics Ltd Pharmaceutical compounds
GB0622084D0 (en) 2006-11-06 2006-12-13 Chroma Therapeutics Ltd Inhibitors of HSP90
AU2007319015A1 (en) 2006-11-09 2008-05-15 Biotica Technology Limited 18, 21-didesoxymacbecin derivatives for the treatment of cancer
WO2008094438A1 (en) 2007-01-26 2008-08-07 Kosan Biosciences Incorporated Macrolactams by engineered biosynthesis
NZ579635A (en) 2007-03-20 2011-07-29 Curis Inc Fused amino pyridine as hsp90 inhibitors
GB2449293A (en) 2007-05-17 2008-11-19 Evotec Compounds having Hsp90 inhibitory activity
EP2164865A2 (en) 2007-06-13 2010-03-24 Hochschule Mannheim Compounds for the modulation of huntingtin aggregation, methods and means for identifying such compounds
IL184671A0 (en) 2007-07-17 2008-12-29 Hadasit Med Res Service Substances directed to heparanase c-terminal domain-or substance derived therefrom and uses thereof as modulators of heparanas biological activities
DE102007041116A1 (de) 2007-08-30 2009-03-05 Merck Patent Gmbh 1,3-Dihydro-isoindolderivate
TW200920357A (en) 2007-09-10 2009-05-16 Curis Inc HSP90 inhibitors containing a zinc binding moiety
EP2060565A1 (en) 2007-11-16 2009-05-20 4Sc Ag Novel bifunctional compounds which inhibit protein kinases and histone deacetylases
US20110218143A1 (en) 2007-11-20 2011-09-08 University Of Florida Research Foundation Compositions and methods for tissue repair
JP5582783B2 (ja) 2007-12-28 2014-09-03 武田薬品工業株式会社 細胞保護剤のスクリーニング方法
US8461194B2 (en) * 2008-03-07 2013-06-11 Aziende Chimiche Riunite Angelini Francesco A. C. R. A. F. S. P. A. 1-benzyl-3-hydroxymethylindazole derivatives and use thereof in the treatment of diseases based on the expression of MCP-1, CX3CR1 and P40
WO2009114470A2 (en) 2008-03-10 2009-09-17 Curis, Inc. Tetrahydroindole and tetrahdyroindazole as hsp90 inhibitors containing a zinc binding moiety
EP2100879A1 (en) 2008-03-13 2009-09-16 4Sc Ag Novel N-substituted tetrahydroisoquinoline/isoindoline hydroxamic acid compounds
KR101446377B1 (ko) 2008-05-19 2014-10-01 휴렛-팩커드 디벨롭먼트 컴퍼니, 엘.피. 프리부트 로그인의 지원 방법 및 시스템
JP5767965B2 (ja) 2008-06-10 2015-08-26 プレキシコン インコーポレーテッドＰｌｅｘｘｉｋｏｎ Ｉｎｃ． キナーゼを調節する５ｈ−ピロロ［２，３−ｂ］ピラジン誘導体、およびその適応症
WO2010014617A1 (en) 2008-07-28 2010-02-04 University Of Kansas Heat shock protein 90 inhibitor dosing methods
CN102112481A (zh) 2008-08-04 2011-06-29 帝斯曼知识产权资产管理有限公司 使用过氧化氢或过酸由鼠尾草酸生产鼠尾草酚的方法
WO2010019965A1 (en) 2008-08-15 2010-02-18 The Board Of Trustees Of The Leland Stanford Junior University Compositions and methods for modulating epsilon protein kinase c-mediated cytoprotection
US20110230551A1 (en) 2008-09-15 2011-09-22 Leslie Gunatilaka Withaferin a analogs and uses thereof
CA2744937C (en) 2008-11-28 2017-02-28 Novartis Ag Pharmaceutical combination comprising a hsp 90 inhibitor and a mtor inhibitor
TW201102391A (en) 2009-03-31 2011-01-16 Biogen Idec Inc Certain substituted pyrimidines, pharmaceutical compositions thereof, and methods for their use
CA2786777A1 (en) * 2010-01-07 2011-07-14 Akron Molecules Gmbh Obesity small molecules
US20110201587A1 (en) * 2010-02-16 2011-08-18 Bio Holding, Inc. Hsp90 inhibitors and methods of use
KR101392086B1 (ko) 2010-02-17 2014-05-07 일동제약주식회사 신규 5각 헤테로 고리 유도체 및 그 제조방법
CA2697887A1 (en) 2010-03-12 2011-09-12 Institut De Recherches Cliniques De Montreal Modulating and/or detecting activation induced deaminase and methods of use thereof
US9062072B2 (en) 2010-04-20 2015-06-23 Emory University Inhibitors of HIF and angiogenesis
CA2825599C (en) 2011-02-01 2021-07-13 The Board Of Trustees Of The University Of Illinois 4-methyl-n-hydroxybenzamide compounds as histone deacetylase (hdac) inhibitors
US8598339B2 (en) 2011-02-01 2013-12-03 University Of Kansas Withanolide isolated from Physalis longifolia and analogs and methods of use thereof
WO2012139010A1 (en) 2011-04-08 2012-10-11 University Of Kansas Grp94 inhibitors
WO2013015661A2 (en) 2011-07-28 2013-01-31 Ildong Pharm Co.,Ltd. Novel prodrugs of 5-(2,4-dihydroxy-5-isopropylphenyl)-n-ethyl-4-(5-methyl1-1,2,4-oxadiazol-3-yl)isoxazole-3-carboxamide
US9533002B2 (en) * 2012-05-25 2017-01-03 Berg Llc Methods of treating a metabolic syndrome by modulating heat shock protein (HSP) 90-β
CN102772399A (zh) * 2012-08-16 2012-11-14 厦门大学 藤黄酸作为5`-amp激活的蛋白激酶激动剂的用途

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