JP2015515490A5 - - Google Patents

Info

Publication number

JP2015515490A5

JP2015515490A5 JP2015507659A JP2015507659A JP2015515490A5 JP 2015515490 A5 JP2015515490 A5 JP 2015515490A5 JP 2015507659 A JP2015507659 A JP 2015507659A JP 2015507659 A JP2015507659 A JP 2015507659A JP 2015515490 A5 JP2015515490 A5 JP 2015515490A5

Authority

JP

Japan

Prior art keywords

amino acid

seq

acid sequence

antibody

heavy chain

Prior art date

2013-04-26

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Granted

Links

• Espacenet
• Global Dossier
• Discuss

• 125000003275 alpha amino acid group Chemical group 0.000 claims 49
• 150000001413 amino acids Chemical class 0.000 claims 41
• 239000012634 fragment Substances 0.000 claims 23
• 239000002773 nucleotide Substances 0.000 claims 10
• 125000003729 nucleotide group Chemical group 0.000 claims 10
• 101000650590 Homo sapiens Roundabout homolog 4 Proteins 0.000 claims 5
• 201000010099 disease Diseases 0.000 claims 5
• 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 5
• 239000008194 pharmaceutical composition Substances 0.000 claims 5
• 102100027701 Roundabout homolog 4 Human genes 0.000 claims 4
• FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 3
• 230000002491 angiogenic effect Effects 0.000 claims 3
• 210000004027 cell Anatomy 0.000 claims 3
• 206010012689 Diabetic retinopathy Diseases 0.000 claims 2
• 208000010412 Glaucoma Diseases 0.000 claims 2
• 208000001344 Macular Edema Diseases 0.000 claims 2
• 206010025415 Macular oedema Diseases 0.000 claims 2
• 206010038934 Retinopathy proliferative Diseases 0.000 claims 2
• 239000004480 active ingredient Substances 0.000 claims 2
• 230000033115 angiogenesis Effects 0.000 claims 2
• 230000010595 endothelial cell migration Effects 0.000 claims 2
• 238000000338 in vitro Methods 0.000 claims 2
• 238000001727 in vivo Methods 0.000 claims 2
• 230000002401 inhibitory effect Effects 0.000 claims 2
• 201000010230 macular retinal edema Diseases 0.000 claims 2
• 238000004519 manufacturing process Methods 0.000 claims 2
• 201000003142 neovascular glaucoma Diseases 0.000 claims 2
• 108090000623 proteins and genes Proteins 0.000 claims 2
• 102000004169 proteins and genes Human genes 0.000 claims 2
• 210000003556 vascular endothelial cell Anatomy 0.000 claims 2
• VEEGZPWAAPPXRB-BJMVGYQFSA-N (3e)-3-(1h-imidazol-5-ylmethylidene)-1h-indol-2-one Chemical compound O=C1NC2=CC=CC=C2\C1=C/C1=CN=CN1 VEEGZPWAAPPXRB-BJMVGYQFSA-N 0.000 claims 1
• 201000001320 Atherosclerosis Diseases 0.000 claims 1
• 208000008589 Obesity Diseases 0.000 claims 1
• 201000004681 Psoriasis Diseases 0.000 claims 1
• 101150050515 Robo4 gene Proteins 0.000 claims 1
• 206010040047 Sepsis Diseases 0.000 claims 1
• 208000000208 Wet Macular Degeneration Diseases 0.000 claims 1
• 208000038016 acute inflammation Diseases 0.000 claims 1
• 230000006022 acute inflammation Effects 0.000 claims 1
• 206010064930 age-related macular degeneration Diseases 0.000 claims 1
• 229940121369 angiogenesis inhibitor Drugs 0.000 claims 1
• 239000004037 angiogenesis inhibitor Substances 0.000 claims 1
• 201000011510 cancer Diseases 0.000 claims 1
• 239000003795 chemical substances by application Substances 0.000 claims 1
• 208000037976 chronic inflammation Diseases 0.000 claims 1
• 230000006020 chronic inflammation Effects 0.000 claims 1
• 238000012258 culturing Methods 0.000 claims 1
• 201000011066 hemangioma Diseases 0.000 claims 1
• 102000049707 human ROBO4 Human genes 0.000 claims 1
• 208000002780 macular degeneration Diseases 0.000 claims 1
• 238000000034 method Methods 0.000 claims 1
• 235000020824 obesity Nutrition 0.000 claims 1
• 230000002265 prevention Effects 0.000 claims 1
• 230000000069 prophylactic effect Effects 0.000 claims 1
• 206010039073 rheumatoid arthritis Diseases 0.000 claims 1
• 230000001225 therapeutic effect Effects 0.000 claims 1