JP2015514128A5 - - Google Patents
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- Publication number
- JP2015514128A5 JP2015514128A5 JP2015505016A JP2015505016A JP2015514128A5 JP 2015514128 A5 JP2015514128 A5 JP 2015514128A5 JP 2015505016 A JP2015505016 A JP 2015505016A JP 2015505016 A JP2015505016 A JP 2015505016A JP 2015514128 A5 JP2015514128 A5 JP 2015514128A5
- Authority
- JP
- Japan
- Prior art keywords
- monomer
- lysenin
- pore
- variant
- substitution
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 102220076678 rs146651027 Human genes 0.000 claims 40
- 102220483642 Nuclear distribution protein nudE homolog 1_E84Q_mutation Human genes 0.000 claims 39
- 102200075749 rs397514044 Human genes 0.000 claims 38
- 102200101908 rs72554358 Human genes 0.000 claims 38
- 239000000178 monomer Substances 0.000 claims 26
- 101710174798 Lysenin Proteins 0.000 claims 13
- 239000011148 porous material Substances 0.000 claims 8
- 238000006467 substitution reaction Methods 0.000 claims 7
- 235000001014 amino acid Nutrition 0.000 claims 6
- 229940024606 amino acid Drugs 0.000 claims 6
- 150000001413 amino acids Chemical group 0.000 claims 6
- 239000012491 analyte Substances 0.000 claims 6
- 102000040430 polynucleotide Human genes 0.000 claims 6
- 108091033319 polynucleotide Proteins 0.000 claims 6
- 239000002157 polynucleotide Substances 0.000 claims 6
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 5
- 102220530307 Calcium-transporting ATPase type 2C member 1_E50S_mutation Human genes 0.000 claims 2
- 102220591546 Cysteine-rich hydrophobic domain-containing protein 1_E76S_mutation Human genes 0.000 claims 2
- DHMQDGOQFOQNFH-UHFFFAOYSA-N Glycine Chemical compound NCC(O)=O DHMQDGOQFOQNFH-UHFFFAOYSA-N 0.000 claims 2
- 102220539335 Prostaglandin D2 receptor 2_E71S_mutation Human genes 0.000 claims 2
- 238000005259 measurement Methods 0.000 claims 2
- 102220493937 26S proteasome complex subunit SEM1_E167A_mutation Human genes 0.000 claims 1
- 239000004475 Arginine Substances 0.000 claims 1
- DCXYFEDJOCDNAF-UHFFFAOYSA-N Asparagine Natural products OC(=O)C(N)CC(N)=O DCXYFEDJOCDNAF-UHFFFAOYSA-N 0.000 claims 1
- 102000014914 Carrier Proteins Human genes 0.000 claims 1
- 239000004471 Glycine Substances 0.000 claims 1
- QNAYBMKLOCPYGJ-REOHCLBHSA-N L-alanine Chemical compound C[C@H](N)C(O)=O QNAYBMKLOCPYGJ-REOHCLBHSA-N 0.000 claims 1
- DCXYFEDJOCDNAF-REOHCLBHSA-N L-asparagine Chemical compound OC(=O)[C@@H](N)CC(N)=O DCXYFEDJOCDNAF-REOHCLBHSA-N 0.000 claims 1
- ROHFNLRQFUQHCH-YFKPBYRVSA-N L-leucine Chemical compound CC(C)C[C@H](N)C(O)=O ROHFNLRQFUQHCH-YFKPBYRVSA-N 0.000 claims 1
- OUYCCCASQSFEME-QMMMGPOBSA-N L-tyrosine Chemical compound OC(=O)[C@@H](N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-QMMMGPOBSA-N 0.000 claims 1
- ROHFNLRQFUQHCH-UHFFFAOYSA-N Leucine Natural products CC(C)CC(N)C(O)=O ROHFNLRQFUQHCH-UHFFFAOYSA-N 0.000 claims 1
- 239000004472 Lysine Substances 0.000 claims 1
- KDXKERNSBIXSRK-UHFFFAOYSA-N Lysine Natural products NCCCCC(N)C(O)=O KDXKERNSBIXSRK-UHFFFAOYSA-N 0.000 claims 1
- 102220528081 M1-specific T cell receptor alpha chain_H58S_mutation Human genes 0.000 claims 1
- 102220520572 Osteoclast-stimulating factor 1_N48S_mutation Human genes 0.000 claims 1
- 102220640643 Polyadenylate-binding protein 1_E84S_mutation Human genes 0.000 claims 1
- MTCFGRXMJLQNBG-UHFFFAOYSA-N Serine Natural products OCC(N)C(O)=O MTCFGRXMJLQNBG-UHFFFAOYSA-N 0.000 claims 1
- 102220503470 Superoxide dismutase [Cu-Zn]_H81S_mutation Human genes 0.000 claims 1
- 102220566198 Survival motor neuron protein_F70S_mutation Human genes 0.000 claims 1
- 235000004279 alanine Nutrition 0.000 claims 1
- ODKSFYDXXFIFQN-UHFFFAOYSA-N arginine Natural products OC(=O)C(N)CCCNC(N)=N ODKSFYDXXFIFQN-UHFFFAOYSA-N 0.000 claims 1
- -1 aromatic amino acids Chemical class 0.000 claims 1
- 229960001230 asparagine Drugs 0.000 claims 1
- 235000009582 asparagine Nutrition 0.000 claims 1
- 108091008324 binding proteins Proteins 0.000 claims 1
- 125000003636 chemical group Chemical group 0.000 claims 1
- 230000007423 decrease Effects 0.000 claims 1
- ZDXPYRJPNDTMRX-UHFFFAOYSA-N glutamine Natural products OC(=O)C(N)CCC(N)=O ZDXPYRJPNDTMRX-UHFFFAOYSA-N 0.000 claims 1
- 229910052739 hydrogen Inorganic materials 0.000 claims 1
- 239000001257 hydrogen Substances 0.000 claims 1
- 102220198313 rs1057519973 Human genes 0.000 claims 1
- 102200070587 rs763615602 Human genes 0.000 claims 1
- 102220072337 rs794728990 Human genes 0.000 claims 1
- 230000003335 steric effect Effects 0.000 claims 1
- OUYCCCASQSFEME-UHFFFAOYSA-N tyrosine Natural products OC(=O)C(N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-UHFFFAOYSA-N 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261622174P | 2012-04-10 | 2012-04-10 | |
| US61/622,174 | 2012-04-10 | ||
| PCT/GB2013/050667 WO2013153359A1 (en) | 2012-04-10 | 2013-03-15 | Mutant lysenin pores |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017250647A Division JP2018075025A (ja) | 2012-04-10 | 2017-12-27 | 変異体ライセニンポア |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2015514128A JP2015514128A (ja) | 2015-05-18 |
| JP2015514128A5 true JP2015514128A5 (enExample) | 2016-04-28 |
| JP6271505B2 JP6271505B2 (ja) | 2018-01-31 |
Family
ID=47915292
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015505016A Active JP6271505B2 (ja) | 2012-04-10 | 2013-03-15 | 変異体ライセニンポア |
| JP2017250647A Pending JP2018075025A (ja) | 2012-04-10 | 2017-12-27 | 変異体ライセニンポア |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017250647A Pending JP2018075025A (ja) | 2012-04-10 | 2017-12-27 | 変異体ライセニンポア |
Country Status (9)
| Country | Link |
|---|---|
| US (4) | US9777049B2 (enExample) |
| EP (2) | EP3192804B1 (enExample) |
| JP (2) | JP6271505B2 (enExample) |
| KR (1) | KR102083695B1 (enExample) |
| CN (2) | CN104350067A (enExample) |
| AU (1) | AU2013246702B2 (enExample) |
| BR (1) | BR112014025157B1 (enExample) |
| CA (1) | CA2869546C (enExample) |
| WO (1) | WO2013153359A1 (enExample) |
Families Citing this family (149)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2122344B8 (en) | 2007-02-20 | 2019-08-21 | Oxford Nanopore Technologies Limited | Lipid bilayer sensor system |
| GB0724736D0 (en) | 2007-12-19 | 2008-01-30 | Oxford Nanolabs Ltd | Formation of layers of amphiphilic molecules |
| GB0820927D0 (en) | 2008-11-14 | 2008-12-24 | Isis Innovation | Method |
| EP2391732B1 (en) | 2009-01-30 | 2015-05-27 | Oxford Nanopore Technologies Limited | Methods using adaptors for nucleic acid constructs in transmembrane sequencing |
| GB0905140D0 (en) | 2009-03-25 | 2009-05-06 | Isis Innovation | Method |
| BR112013020411B1 (pt) | 2011-02-11 | 2021-09-08 | Oxford Nanopore Technologies Limited | Monômero de msp mutante, construto, polinucleotídeo, poro, kit e aparelho para caracterizar uma sequência de ácido nucleico alvo, e, método para caracterizar uma sequência de ácido nucleico alvo |
| SG10201604316WA (en) | 2011-05-27 | 2016-07-28 | Oxford Nanopore Tech Ltd | Coupling method |
| KR20140050067A (ko) | 2011-07-25 | 2014-04-28 | 옥스포드 나노포어 테크놀로지즈 리미티드 | 막횡단 포어를 사용한 이중 가닥 폴리뉴클레오티드 서열분석을 위한 헤어핀 루프 방법 |
| EP3663412B1 (en) | 2011-09-23 | 2022-03-09 | Oxford Nanopore Technologies PLC | Analysis of a polymer comprising polymer units by means of translocation through a nanopore |
| CN104039979B (zh) | 2011-10-21 | 2016-08-24 | 牛津纳米孔技术公司 | 使用孔和Hel308解旋酶表征目标多核苷酸的酶方法 |
| CA2861808C (en) | 2011-12-29 | 2021-02-23 | Oxford Nanopore Technologies Limited | Enzyme method |
| GB201202519D0 (en) | 2012-02-13 | 2012-03-28 | Oxford Nanopore Tech Ltd | Apparatus for supporting an array of layers of amphiphilic molecules and method of forming an array of layers of amphiphilic molecules |
| CA2864035C (en) | 2012-02-15 | 2021-05-18 | Oxford Nanopore Technologies Limited | A method for determining the presence of an analyte using an aptamer |
| EP3736339B1 (en) | 2012-02-16 | 2022-07-27 | Oxford Nanopore Technologies plc | Analysis of measurements of a polymer |
| WO2013153359A1 (en) | 2012-04-10 | 2013-10-17 | Oxford Nanopore Technologies Limited | Mutant lysenin pores |
| US11155860B2 (en) | 2012-07-19 | 2021-10-26 | Oxford Nanopore Technologies Ltd. | SSB method |
| CA2879355C (en) | 2012-07-19 | 2021-09-21 | Oxford Nanopore Technologies Limited | Helicase construct and its use in characterising polynucleotides |
| AU2013291763B2 (en) | 2012-07-19 | 2019-06-20 | Oxford Nanopore Technologies Limited | Modified helicases |
| WO2014041337A1 (en) | 2012-09-14 | 2014-03-20 | Oxford Nanopore Technologies Limited | Sample preparation method |
| GB201313121D0 (en) | 2013-07-23 | 2013-09-04 | Oxford Nanopore Tech Ltd | Array of volumes of polar medium |
| WO2014072703A1 (en) | 2012-11-06 | 2014-05-15 | Oxford Nanopore Technologies Limited | Quadruplex method |
| GB201222928D0 (en) | 2012-12-19 | 2013-01-30 | Oxford Nanopore Tech Ltd | Analysis of a polynucleotide |
| GB201314695D0 (en) | 2013-08-16 | 2013-10-02 | Oxford Nanopore Tech Ltd | Method |
| GB201318465D0 (en) | 2013-10-18 | 2013-12-04 | Oxford Nanopore Tech Ltd | Method |
| CA2901545C (en) | 2013-03-08 | 2019-10-08 | Oxford Nanopore Technologies Limited | Use of spacer elements in a nucleic acid to control movement of a helicase |
| GB201313477D0 (en) | 2013-07-29 | 2013-09-11 | Univ Leuven Kath | Nanopore biosensors for detection of proteins and nucleic acids |
| GB201406151D0 (en) | 2014-04-04 | 2014-05-21 | Oxford Nanopore Tech Ltd | Method |
| EP3575410A3 (en) | 2013-10-18 | 2020-03-04 | Oxford Nanopore Technologies Limited | Modified enzymes |
| ES2735015T3 (es) | 2013-11-26 | 2019-12-13 | Illumina Inc | Composiciones y métodos para secuenciar polinucleótidos |
| EP3097210B2 (en) | 2014-01-22 | 2022-04-20 | Oxford Nanopore Technologies Limited | Method for attaching one or more polynucleotide binding proteins to a target polynucleotide |
| GB201406155D0 (en) | 2014-04-04 | 2014-05-21 | Oxford Nanopore Tech Ltd | Method |
| US10359395B2 (en) | 2014-02-19 | 2019-07-23 | University Of Washington | Nanopore-based analysis of protein characteristics |
| GB201403096D0 (en) | 2014-02-21 | 2014-04-09 | Oxford Nanopore Tech Ltd | Sample preparation method |
| US10337060B2 (en) | 2014-04-04 | 2019-07-02 | Oxford Nanopore Technologies Ltd. | Method for characterising a double stranded nucleic acid using a nano-pore and anchor molecules at both ends of said nucleic acid |
| US10443097B2 (en) | 2014-05-02 | 2019-10-15 | Oxford Nanopore Technologies Ltd. | Method of improving the movement of a target polynucleotide with respect to a transmembrane pore |
| GB201417712D0 (en) | 2014-10-07 | 2014-11-19 | Oxford Nanopore Tech Ltd | Method |
| CA3221500A1 (en) | 2014-06-03 | 2015-12-10 | Illumina, Inc. | Compositions, systems, and methods for detecting events using tethers anchored to or adjacent to nanopores |
| WO2016014822A1 (en) * | 2014-07-25 | 2016-01-28 | Ge Healthcare Uk Limited | Screening and monitoring the progression of type 2 diabetes by the molecular identification of gut flora using fta as a faecal collection device |
| CN119899249A (zh) * | 2014-09-01 | 2025-04-29 | 弗拉芒区生物技术研究所 | 突变csgg孔 |
| US10266885B2 (en) | 2014-10-07 | 2019-04-23 | Oxford Nanopore Technologies Ltd. | Mutant pores |
| GB201418159D0 (en) | 2014-10-14 | 2014-11-26 | Oxford Nanopore Tech Ltd | Method |
| EP3971300B1 (en) | 2014-10-16 | 2024-06-05 | Oxford Nanopore Technologies plc | Sorting of polymers |
| WO2016059436A1 (en) | 2014-10-17 | 2016-04-21 | Oxford Nanopore Technologies Limited | Method for nanopore rna characterisation |
| GB201418469D0 (en) | 2014-10-17 | 2014-12-03 | Oxford Nanopore Tech Ltd | Method |
| US10794895B2 (en) | 2015-02-05 | 2020-10-06 | President And Fellows Of Harvard College | Nanopore sensor including fluidic passage |
| GB201502809D0 (en) | 2015-02-19 | 2015-04-08 | Oxford Nanopore Tech Ltd | Mutant pore |
| GB201502810D0 (en) | 2015-02-19 | 2015-04-08 | Oxford Nanopore Tech Ltd | Method |
| CN107735686B (zh) | 2015-04-14 | 2021-06-11 | 鲁汶天主教大学 | 具有内部蛋白质衔接子的纳米孔 |
| GB201508003D0 (en) | 2015-05-11 | 2015-06-24 | Oxford Nanopore Tech Ltd | Apparatus and methods for measuring an electrical current |
| GB201508669D0 (en) | 2015-05-20 | 2015-07-01 | Oxford Nanopore Tech Ltd | Methods and apparatus for forming apertures in a solid state membrane using dielectric breakdown |
| EP4495255A3 (en) | 2015-06-03 | 2025-04-09 | Illumina Inc. | Systems and methods for sequencing polynucleotides using tethers anchored to polymerases adjacent to nanopores |
| CN109072295B (zh) | 2015-12-08 | 2022-05-31 | 鲁汶大学研究与发展中心 | 修饰的纳米孔，包含其的组合物及其应用 |
| JP6579948B2 (ja) * | 2015-12-24 | 2019-09-25 | 株式会社日立ハイテクノロジーズ | 生体ポリマを分析するための測定試薬及び分析デバイス |
| KR102222191B1 (ko) | 2016-03-02 | 2021-03-02 | 옥스포드 나노포어 테크놀로지즈 리미티드 | 돌연변이체 기공 |
| CN118272512A (zh) | 2016-04-06 | 2024-07-02 | 牛津纳米孔科技公开有限公司 | 突变体孔 |
| GB201609221D0 (en) | 2016-05-25 | 2016-07-06 | Oxford Nanopore Tech Ltd | Method |
| EP3464616B1 (en) | 2016-05-25 | 2022-05-04 | Oxford Nanopore Technologies plc | Method |
| GB201609220D0 (en) | 2016-05-25 | 2016-07-06 | Oxford Nanopore Tech Ltd | Method |
| GB201611770D0 (en) | 2016-07-06 | 2016-08-17 | Oxford Nanopore Tech | Microfluidic device |
| GB201616590D0 (en) | 2016-09-29 | 2016-11-16 | Oxford Nanopore Technologies Limited | Method |
| GB201617886D0 (en) | 2016-10-21 | 2016-12-07 | Oxford Nanopore Technologies Limited | Method |
| GB201619930D0 (en) | 2016-11-24 | 2017-01-11 | Oxford Nanopore Tech | Apparatus and methods for controlling insertion of a membrane channel into a membrane |
| GB201620450D0 (en) | 2016-12-01 | 2017-01-18 | Oxford Nanopore Tech Ltd | Method |
| CA3053086A1 (en) | 2017-02-10 | 2018-08-16 | Oxford Nanopore Technologies Limited | Modified nanopores, compositions comprising the same, and uses thereof |
| WO2018152050A1 (en) | 2017-02-14 | 2018-08-23 | Axbio Inc. | Apparatus and methods for continuous diagnostics of macromolecules |
| GB201707140D0 (en) | 2017-05-04 | 2017-06-21 | Oxford Nanopore Tech Ltd | Method |
| GB201707122D0 (en) | 2017-05-04 | 2017-06-21 | Oxford Nanopore Tech Ltd | Pore |
| GB201707138D0 (en) | 2017-05-04 | 2017-06-21 | Oxford Nanopore Tech Ltd | Machine learning analysis of nanopore measurements |
| EP3645552B1 (en) | 2017-06-30 | 2023-06-28 | Vib Vzw | Novel protein pores |
| GB2568895B (en) | 2017-11-29 | 2021-10-27 | Oxford Nanopore Tech Ltd | Microfluidic device |
| GB2569630B (en) | 2017-12-21 | 2022-10-12 | Sharp Life Science Eu Ltd | Droplet Interfaces in Electro-wetting Devices |
| GB201801768D0 (en) | 2018-02-02 | 2018-03-21 | Oxford Nanopore Tech Ltd | Synthesis method |
| GB201807793D0 (en) | 2018-05-14 | 2018-06-27 | Oxford Nanopore Tech Ltd | Method |
| GB201808556D0 (en) | 2018-05-24 | 2018-07-11 | Oxford Nanopore Tech Ltd | Method |
| EP3801901A1 (en) | 2018-05-24 | 2021-04-14 | Oxford Nanopore Technologies Limited | Droplet interfaces in electro-wetting devices |
| GB2574048B (en) | 2018-05-24 | 2021-06-16 | Oxford Nanopore Tech Ltd | Nanopore sensor component with electrostatic discharge protection |
| GB201809323D0 (en) | 2018-06-06 | 2018-07-25 | Oxford Nanopore Tech Ltd | Method |
| GB201814369D0 (en) | 2018-09-04 | 2018-10-17 | Oxford Nanopore Tech Ltd | Method for determining a polymersequence |
| JP7499761B2 (ja) | 2018-11-08 | 2024-06-14 | オックスフォード ナノポール テクノロジーズ ピーエルシー | 細孔 |
| GB201818216D0 (en) | 2018-11-08 | 2018-12-26 | Oxford Nanopore Tech Ltd | Pore |
| WO2020109800A1 (en) | 2018-11-28 | 2020-06-04 | Oxford Nanopore Technologies Ltd. | Sensing system and method of operation |
| GB201819378D0 (en) | 2018-11-28 | 2019-01-09 | Oxford Nanopore Tech Ltd | Analysis of nanopore signal using a machine-learning technique |
| GB201821155D0 (en) | 2018-12-21 | 2019-02-06 | Oxford Nanopore Tech Ltd | Method |
| WO2020183172A1 (en) | 2019-03-12 | 2020-09-17 | Oxford Nanopore Technologies Inc. | Nanopore sensing device and methods of operation and of forming it |
| GB2580988B (en) | 2019-03-19 | 2022-04-13 | Oxford Nanopore Tech Ltd | Current measurement apparatus, molecular entity sensing apparatus, method of measuring a current, method of sensing a molecular entity |
| CN110093399A (zh) * | 2019-04-22 | 2019-08-06 | 武汉大学 | 一种利用二磷酸尿嘧啶脱氧核苷酸检测核酸中腺嘌呤n6位发生甲基化修饰的方法 |
| GB201907246D0 (en) | 2019-05-22 | 2019-07-03 | Oxford Nanopore Tech Ltd | Method |
| GB201907243D0 (en) | 2019-05-22 | 2019-07-03 | Oxford Nanopore Tech Ltd | Sensing interactions between molecular entities and nanapores |
| GB201907244D0 (en) | 2019-05-22 | 2019-07-03 | Oxford Nanopore Tech Ltd | Method |
| GB201915480D0 (en) | 2019-10-25 | 2019-12-11 | Oxford Nanopore Tech Ltd | Improved nanopore sensing device, components and method of manufacture |
| GB201917060D0 (en) | 2019-11-22 | 2020-01-08 | Oxford Nanopore Tech Ltd | Method |
| WO2021111125A1 (en) | 2019-12-02 | 2021-06-10 | Oxford Nanopore Technologies Limited | Method of characterising a target polypeptide using a nanopore |
| GB201917742D0 (en) | 2019-12-04 | 2020-01-15 | Oxford Nanopore Tech Ltd | Method |
| GB202004944D0 (en) | 2020-04-03 | 2020-05-20 | King S College London | Method |
| GB202016874D0 (en) | 2020-10-23 | 2020-12-09 | Oxford Nanopore Tech Ltd | Nanopore support structure and manufacture thereof |
| GB202009349D0 (en) | 2020-06-18 | 2020-08-05 | Oxford Nanopore Tech Ltd | Method |
| US20240076729A9 (en) | 2020-06-18 | 2024-03-07 | Oxford Nanopore Technologies Plc | Method |
| EP4168582B1 (en) | 2020-06-18 | 2025-11-19 | Oxford Nanopore Technologies plc | A method of selectively characterising a polynucleotide using a detector |
| CN115989410A (zh) | 2020-07-17 | 2023-04-18 | 牛津纳米孔科技公开有限公司 | 纳米孔感测装置 |
| WO2022020461A1 (en) | 2020-07-22 | 2022-01-27 | Oxford Nanopore Technologies Inc. | Solid state nanopore formation |
| WO2022069022A1 (en) | 2020-09-29 | 2022-04-07 | Ecole Polytechnique Federale De Lausanne (Epfl) | Systems and methods for digital information decoding and data storage in hybrid macromolecules |
| GB202015993D0 (en) | 2020-10-08 | 2020-11-25 | Oxford Nanopore Tech Ltd | Method |
| CN117255945A (zh) | 2021-03-31 | 2023-12-19 | 伊鲁米纳公司 | 纳米孔传感器装置 |
| GB202107192D0 (en) | 2021-05-19 | 2021-06-30 | Oxford Nanopore Tech Ltd | Method |
| US20240240248A1 (en) | 2021-05-19 | 2024-07-18 | Oxford Nanopore Technologies Plc | Methods for complement strand sequencing |
| GB202107354D0 (en) | 2021-05-24 | 2021-07-07 | Oxford Nanopore Tech Ltd | Method |
| GB2610380A (en) | 2021-08-23 | 2023-03-08 | Cambridge Entpr Ltd | Nucleic acid detection |
| GB202112235D0 (en) | 2021-08-26 | 2021-10-13 | Oxford Nanopore Tech Ltd | Nanopore |
| WO2023049682A1 (en) | 2021-09-22 | 2023-03-30 | Illumina, Inc. | Sequencing polynucleotides using nanopores |
| GB202113935D0 (en) | 2021-09-29 | 2021-11-10 | Cambridge Entpr Ltd | Nucleic acid characterisation |
| WO2023081031A1 (en) | 2021-11-08 | 2023-05-11 | Illumina, Inc. | Identifying nucleotides using changes in impedance between electrodes |
| EP4441744A1 (en) | 2021-11-29 | 2024-10-09 | Oxford Nanopore Technologies Ltd. | Nanopore measurement signal analysis |
| GB202118906D0 (en) | 2021-12-23 | 2022-02-09 | Oxford Nanopore Tech Ltd | Method |
| GB202118908D0 (en) | 2021-12-23 | 2022-02-09 | Oxford Nanopore Tech Ltd | Method |
| WO2023187081A1 (en) | 2022-03-31 | 2023-10-05 | Illumina Cambridge Limited | Methods for inserting nanopores into polymeric membranes using chaotropic solvents |
| WO2023187106A1 (en) | 2022-03-31 | 2023-10-05 | Illumina Cambridge Limited | Barriers including cross-linked amphiphilic molecules, and methods of making the same |
| CN118973693A (zh) | 2022-03-31 | 2024-11-15 | 伊鲁米纳公司 | 包括用于dna测序的生物纳米孔的屏障、由具有端基和/或中间基团的共聚物制成的该屏障、以及制造该屏障的方法 |
| JP2025513682A (ja) | 2022-03-31 | 2025-04-30 | イルミナ インコーポレイテッド | ジブロック又はトリブロックコポリマーを使用するバリアを含むナノポアデバイス、及びその作製方法 |
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| US10443097B2 (en) | 2014-05-02 | 2019-10-15 | Oxford Nanopore Technologies Ltd. | Method of improving the movement of a target polynucleotide with respect to a transmembrane pore |
| FR3023394B1 (fr) | 2014-07-02 | 2017-12-29 | Adn Access Data Networks | Dispositif permettant de faciliter l'enseignement de la langue amharique et d'en normaliser l'ecriture |
| CN119899249A (zh) | 2014-09-01 | 2025-04-29 | 弗拉芒区生物技术研究所 | 突变csgg孔 |
| US10266885B2 (en) | 2014-10-07 | 2019-04-23 | Oxford Nanopore Technologies Ltd. | Mutant pores |
| WO2016059436A1 (en) | 2014-10-17 | 2016-04-21 | Oxford Nanopore Technologies Limited | Method for nanopore rna characterisation |
| GB201502809D0 (en) | 2015-02-19 | 2015-04-08 | Oxford Nanopore Tech Ltd | Mutant pore |
| GB201502810D0 (en) | 2015-02-19 | 2015-04-08 | Oxford Nanopore Tech Ltd | Method |
| CN107735686B (zh) | 2015-04-14 | 2021-06-11 | 鲁汶天主教大学 | 具有内部蛋白质衔接子的纳米孔 |
| CN109072295B (zh) | 2015-12-08 | 2022-05-31 | 鲁汶大学研究与发展中心 | 修饰的纳米孔，包含其的组合物及其应用 |
| KR102222191B1 (ko) | 2016-03-02 | 2021-03-02 | 옥스포드 나노포어 테크놀로지즈 리미티드 | 돌연변이체 기공 |
| CN118272512A (zh) | 2016-04-06 | 2024-07-02 | 牛津纳米孔科技公开有限公司 | 突变体孔 |
| GB201707122D0 (en) | 2017-05-04 | 2017-06-21 | Oxford Nanopore Tech Ltd | Pore |
| EP3645552B1 (en) | 2017-06-30 | 2023-06-28 | Vib Vzw | Novel protein pores |
| JP7499761B2 (ja) | 2018-11-08 | 2024-06-14 | オックスフォード ナノポール テクノロジーズ ピーエルシー | 細孔 |
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2013
- 2013-03-15 WO PCT/GB2013/050667 patent/WO2013153359A1/en not_active Ceased
- 2013-03-15 CN CN201380030527.2A patent/CN104350067A/zh active Pending
- 2013-03-15 EP EP17157441.1A patent/EP3192804B1/en active Active
- 2013-03-15 EP EP13711464.1A patent/EP2836506B1/en active Active
- 2013-03-15 AU AU2013246702A patent/AU2013246702B2/en active Active
- 2013-03-15 US US14/391,660 patent/US9777049B2/en active Active
- 2013-03-15 BR BR112014025157-6A patent/BR112014025157B1/pt active IP Right Grant
- 2013-03-15 KR KR1020147031143A patent/KR102083695B1/ko active Active
- 2013-03-15 CA CA2869546A patent/CA2869546C/en active Active
- 2013-03-15 JP JP2015505016A patent/JP6271505B2/ja active Active
- 2013-03-15 CN CN202011579254.5A patent/CN112646019B/zh active Active
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2017
- 2017-08-31 US US15/692,498 patent/US10882889B2/en active Active
- 2017-12-27 JP JP2017250647A patent/JP2018075025A/ja active Pending
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2020
- 2020-12-01 US US17/108,536 patent/US11845780B2/en active Active
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2023
- 2023-11-08 US US18/504,590 patent/US12258375B2/en active Active
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