EA201170715A1 - Вектор, содержащий множественные гомологичные нуклеотидные последовательности - Google Patents

Вектор, содержащий множественные гомологичные нуклеотидные последовательности

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Publication number
EA201170715A1
EA201170715A1 EA201170715A EA201170715A EA201170715A1 EA 201170715 A1 EA201170715 A1 EA 201170715A1 EA 201170715 A EA201170715 A EA 201170715A EA 201170715 A EA201170715 A EA 201170715A EA 201170715 A1 EA201170715 A1 EA 201170715A1
Authority
EA
Eurasian Patent Office
Prior art keywords
nucleotide sequences
homological
nucleotide sequence
vector containing
containing multiple
Prior art date
Application number
EA201170715A
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English (en)
Other versions
EA024749B1 (ru
Inventor
Робин Штайгервальд
Original Assignee
Бавариан Нордик А/С
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
Application filed by Бавариан Нордик А/С filed Critical Бавариан Нордик А/С
Publication of EA201170715A1 publication Critical patent/EA201170715A1/ru
Publication of EA024749B1 publication Critical patent/EA024749B1/ru

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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C12N15/86—Viral vectors
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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
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    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
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    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Biomedical Technology (AREA)
  • General Engineering & Computer Science (AREA)
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  • Medicinal Chemistry (AREA)
  • Cell Biology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Изобретение относится к векторам, содержащим две или более гомологичных нуклеотидных последовательностей, и к способам их получения. Изобретение затрагивает замещение оснований в гомологичных нуклеотидных последовательностях на отличающиеся основания, таким образом, чтобы не изменять кодируемую аминокислотную последовательность. Изобретение делает возможным снижение внутримолекулярной рекомбинации между гомологичными нуклеотидными последовательностями, в особенности в клетках млекопитающих. Изобретение также относится к нуклеотидным последовательностям, содержащим замещенные основания.
EA201170715A 2008-11-21 2009-11-20 Экспрессионный вектор со сниженным уровнем внутримолекулярной рекомбинации, содержащий гомологичные или гетерологичные нуклеотидные последовательности EA024749B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US11667208P 2008-11-21 2008-11-21
PCT/EP2009/008275 WO2010057650A1 (en) 2008-11-21 2009-11-20 Vector comprising multiple homologous nucleotide sequences

Publications (2)

Publication Number Publication Date
EA201170715A1 true EA201170715A1 (ru) 2012-03-30
EA024749B1 EA024749B1 (ru) 2016-10-31

Family

ID=40547753

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Application Number Title Priority Date Filing Date
EA201170715A EA024749B1 (ru) 2008-11-21 2009-11-20 Экспрессионный вектор со сниженным уровнем внутримолекулярной рекомбинации, содержащий гомологичные или гетерологичные нуклеотидные последовательности

Country Status (18)

Country Link
US (4) US8999637B2 (ru)
EP (1) EP2352834B1 (ru)
JP (2) JP2012509073A (ru)
KR (1) KR101702956B1 (ru)
CN (2) CN102325888B (ru)
AU (1) AU2009317517B2 (ru)
CA (1) CA2742247C (ru)
DK (1) DK2352834T3 (ru)
EA (1) EA024749B1 (ru)
ES (1) ES2618103T3 (ru)
HK (1) HK1160884A1 (ru)
IL (1) IL211498A (ru)
MX (1) MX2011005171A (ru)
MY (1) MY161849A (ru)
NZ (2) NZ591662A (ru)
UA (1) UA105193C2 (ru)
WO (1) WO2010057650A1 (ru)
ZA (1) ZA201306331B (ru)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9463236B2 (en) 2011-08-29 2016-10-11 Tokushima University RSV mucosal vaccine
KR20240010758A (ko) 2012-04-12 2024-01-24 더 트러스티스 오브 더 유니버시티 오브 펜실베니아 필로바이러스 공통 항원, 이로부터 제조된 핵산 구조체 및 백신, 및 이를 사용하는 방법
KR102435054B1 (ko) 2012-08-01 2022-08-22 버베리안 노딕 에이/에스 재조합 변형된 백시니아 바이러스 앙카라(ankara) (mva) 호흡기 신시티알 바이러스(rsv) 백신
US20140099445A1 (en) 2012-10-09 2014-04-10 University Of Massachusetts Method for producing a film having a nano-structure on the surface of the film
JPWO2014097762A1 (ja) * 2012-12-20 2017-01-12 国立大学法人 熊本大学 高病原性トリインフルエンザに対する抗体
EP3068896B1 (en) * 2013-11-12 2018-08-08 Life Technologies Corporation Reagents and methods for sequencing
US10561722B2 (en) * 2014-09-03 2020-02-18 Bavarian Nordic A/S Methods and compositions for enhancing immune responses
SG10201901735XA (en) 2014-09-03 2019-03-28 Bavarian Nordic As Recombinant modified vaccinia virus ankara (mva) filovirus vaccine
MY183072A (en) * 2014-09-03 2021-02-10 Bavarian Nordic As Methods and compositions for inducing protective immunity against filovirus infection
FR3042121A1 (fr) 2015-10-08 2017-04-14 Jean-Marc Limacher Composition anti-tumorale
WO2018011768A1 (en) 2016-07-15 2018-01-18 Janssen Vaccines And Prevention B.V. Methods and compositions for inducing protective immunity against a marburg virus infection
EP3606553A1 (en) 2017-04-06 2020-02-12 Janssen Vaccines & Prevention B.V. Mva-bn and ad26.zebov or ad26.filo prime-boost regimen

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE69031735T2 (de) 1989-04-18 1998-03-12 Applied Biotechnology Inc Erzeugung von hybrid-genen und proteinen durch rekombination mittels viren
DE19629828A1 (de) * 1996-07-24 1998-01-29 Bayer Ag Carbanilide
FR2774699B1 (fr) * 1997-11-17 2003-10-03 Rhone Poulenc Rorer Sa Methode de reduction des evenements de recombinaison homologue
CN101397574A (zh) 2001-12-04 2009-04-01 巴法里安诺迪克有限公司 黄病毒ns1亚单位疫苗
US7501127B2 (en) 2002-05-16 2009-03-10 Bavarian Nordic A/S Intergenic regions as novel sites for insertion of HIV DNA sequences in the genome of Modified Vaccinia virus Ankara
CN102703393A (zh) * 2002-05-16 2012-10-03 巴法里安诺迪克有限公司 表达插入痘病毒基因组中的同源基因的重组痘病毒
NZ540156A (en) 2002-11-25 2006-11-30 Bavarian Nordic As Stable recombinant poxvirus harbouring at least two expression cassettes that are not naturally part of the poxviral genome, such as the cowpox virus A-type inclusion (ATI) promoters
NZ592082A (en) 2008-11-27 2013-03-28 Bavarian Nordic As Promoters for recombinant viral expression

Also Published As

Publication number Publication date
EP2352834A1 (en) 2011-08-10
WO2010057650A1 (en) 2010-05-27
NZ602322A (en) 2013-12-20
UA105193C2 (ru) 2014-04-25
US11225673B2 (en) 2022-01-18
US20110236976A1 (en) 2011-09-29
NZ591662A (en) 2012-10-26
EA024749B1 (ru) 2016-10-31
KR20110105780A (ko) 2011-09-27
JP2012509073A (ja) 2012-04-19
US9540660B2 (en) 2017-01-10
US10072274B2 (en) 2018-09-11
US8999637B2 (en) 2015-04-07
MX2011005171A (es) 2011-05-30
MY161849A (en) 2017-05-15
CN102325888B (zh) 2016-09-07
HK1160884A1 (zh) 2012-08-17
CN106318978A (zh) 2017-01-11
IL211498A0 (en) 2011-05-31
JP6316227B2 (ja) 2018-04-25
ES2618103T3 (es) 2017-06-20
AU2009317517A1 (en) 2010-05-27
US20190055582A1 (en) 2019-02-21
IL211498A (en) 2016-06-30
CN106318978B (zh) 2020-06-23
US20170211098A1 (en) 2017-07-27
CA2742247C (en) 2017-07-04
CN102325888A (zh) 2012-01-18
EP2352834B1 (en) 2016-12-21
JP2015128443A (ja) 2015-07-16
ZA201306331B (en) 2016-07-27
KR101702956B1 (ko) 2017-02-06
CA2742247A1 (en) 2010-05-27
AU2009317517B2 (en) 2014-12-04
DK2352834T3 (en) 2017-03-13
US20160017369A1 (en) 2016-01-21

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