MX347453B - Canalrodopsina 2 mutante. - Google Patents

Canalrodopsina 2 mutante.

Info

Publication number
MX347453B
MX347453B MX2013002591A MX2013002591A MX347453B MX 347453 B MX347453 B MX 347453B MX 2013002591 A MX2013002591 A MX 2013002591A MX 2013002591 A MX2013002591 A MX 2013002591A MX 347453 B MX347453 B MX 347453B
Authority
MX
Mexico
Prior art keywords
mutant
nucleic acid
channelrhodopsin
acid construct
channelrhodopsins
Prior art date
Application number
MX2013002591A
Other languages
English (en)
Other versions
MX2013002591A (es
Inventor
E Dempski Robert
Bamberg Ernst
Bamann Christian
Kleinlogel Sonja
Wodd Phillip
Original Assignee
Max-Planck-Gesellschaft Zur Förderung Der Wss E V
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Max-Planck-Gesellschaft Zur Förderung Der Wss E V filed Critical Max-Planck-Gesellschaft Zur Förderung Der Wss E V
Publication of MX2013002591A publication Critical patent/MX2013002591A/es
Publication of MX347453B publication Critical patent/MX347453B/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/405—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from algae
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/10—Cells modified by introduction of foreign genetic material
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6872—Intracellular protein regulatory factors and their receptors, e.g. including ion channels

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Biotechnology (AREA)
  • Zoology (AREA)
  • Cell Biology (AREA)
  • Biomedical Technology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Immunology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Microbiology (AREA)
  • Toxicology (AREA)
  • General Engineering & Computer Science (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Food Science & Technology (AREA)
  • Analytical Chemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Ophthalmology & Optometry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Plant Pathology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

La presente invención se refiere a canalrodopsinas mutantes que tienen propiedades mejoradas, constructos de ácido nucleico que codifican los mismos, vectores que lleva el constructo de ácido nucleico, a células que comprenden el constructo de ácido nucleico o vector de expresión, y sus respectivos usos.
MX2013002591A 2010-09-08 2011-09-08 Canalrodopsina 2 mutante. MX347453B (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US38079310P 2010-09-08 2010-09-08
EP10175832 2010-09-08
PCT/EP2011/065510 WO2012032103A1 (en) 2010-09-08 2011-09-08 Mutant channelrhodopsin 2

Publications (2)

Publication Number Publication Date
MX2013002591A MX2013002591A (es) 2013-07-22
MX347453B true MX347453B (es) 2017-04-27

Family

ID=42979822

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2013002591A MX347453B (es) 2010-09-08 2011-09-08 Canalrodopsina 2 mutante.

Country Status (20)

Country Link
US (1) US8748578B2 (es)
EP (1) EP2614079B1 (es)
JP (1) JP5933556B2 (es)
KR (1) KR101945962B1 (es)
CN (1) CN103261219B (es)
AU (1) AU2011298745B2 (es)
BR (1) BR112013005634A2 (es)
CA (1) CA2810757C (es)
DK (1) DK2614079T3 (es)
ES (1) ES2545992T3 (es)
HR (1) HRP20150846T1 (es)
HU (1) HUE025952T2 (es)
IL (1) IL225060A (es)
MX (1) MX347453B (es)
PL (1) PL2614079T3 (es)
PT (1) PT2614079E (es)
RU (1) RU2595384C2 (es)
SG (1) SG188409A1 (es)
SI (1) SI2614079T1 (es)
WO (1) WO2012032103A1 (es)

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US8926959B2 (en) 2005-07-22 2015-01-06 The Board Of Trustees Of The Leland Stanford Junior University System for optical stimulation of target cells
US9274099B2 (en) 2005-07-22 2016-03-01 The Board Of Trustees Of The Leland Stanford Junior University Screening test drugs to identify their effects on cell membrane voltage-gated ion channel
US10052497B2 (en) 2005-07-22 2018-08-21 The Board Of Trustees Of The Leland Stanford Junior University System for optical stimulation of target cells
US9238150B2 (en) 2005-07-22 2016-01-19 The Board Of Trustees Of The Leland Stanford Junior University Optical tissue interface method and apparatus for stimulating cells
EP2465925A1 (en) 2005-07-22 2012-06-20 The Board Of Trustees Of The Leland Light-activated cation channel and uses thereof
CA2685900A1 (en) 2006-05-04 2007-11-15 Wayne State University Restoration of visual responses by in vivo delivery of rhodopsin nucleic acids
WO2008086470A1 (en) 2007-01-10 2008-07-17 The Board Of Trustees Of The Leland Stanford Junior University System for optical stimulation of target cells
US8401609B2 (en) 2007-02-14 2013-03-19 The Board Of Trustees Of The Leland Stanford Junior University System, method and applications involving identification of biological circuits such as neurological characteristics
WO2008106694A2 (en) 2007-03-01 2008-09-04 The Board Of Trustees Of The Leland Stanford Junior University Systems, methods and compositions for optical stimulation of target cells
US10035027B2 (en) 2007-10-31 2018-07-31 The Board Of Trustees Of The Leland Stanford Junior University Device and method for ultrasonic neuromodulation via stereotactic frame based technique
US10434327B2 (en) 2007-10-31 2019-10-08 The Board Of Trustees Of The Leland Stanford Junior University Implantable optical stimulators
EP3165534B1 (en) 2008-04-23 2018-09-26 The Board of Trustees of The Leland Stanford Junior University Systems, methods and compositions for optical stimulation of target cells
EP2610350B1 (en) 2008-05-29 2014-12-17 The Board Of Trustees Of The Leland Stanford Junior University Cell line, system and method for optical control of secondary messengers
ES2612052T3 (es) 2008-06-17 2017-05-11 The Board Of Trustees Of The Leland Stanford Junior University Dispositivos para la estimulación óptica de células diana, utilizando un elemento de transmisión óptica
US10711242B2 (en) 2008-06-17 2020-07-14 The Board Of Trustees Of The Leland Stanford Junior University Apparatus and methods for controlling cellular development
US9101759B2 (en) 2008-07-08 2015-08-11 The Board Of Trustees Of The Leland Stanford Junior University Materials and approaches for optical stimulation of the peripheral nervous system
NZ602416A (en) 2008-11-14 2014-08-29 Univ Leland Stanford Junior Optically-based stimulation of target cells and modifications thereto
CN106011073A (zh) 2010-03-17 2016-10-12 小利兰·斯坦福大学托管委员会 光敏离子透过性分子
US9453241B2 (en) 2010-05-04 2016-09-27 Wayne State University AAV-mediated subcellular targeting of heterologous rhodopsins in retinal ganglion cells
US9992981B2 (en) 2010-11-05 2018-06-12 The Board Of Trustees Of The Leland Stanford Junior University Optogenetic control of reward-related behaviors
CN110215614A (zh) 2010-11-05 2019-09-10 斯坦福大学托管董事会 用于光遗传学方法的光的上转换
CN103384469B (zh) 2010-11-05 2016-06-15 斯坦福大学托管董事会 光控cns功能障碍
CA2816990A1 (en) * 2010-11-05 2012-05-10 The Board Of Trustees Of The Leland Stanford Junior University Stabilized step function opsin proteins and methods of using the same
EP3486253A1 (en) 2010-11-05 2019-05-22 The Board of Trustees of The Leland Stanford Junior University Light-activated chimeric opsins and methods of using the same
CA2816972C (en) 2010-11-05 2019-12-03 The Board Of Trustees Of The Leland Stanford Junior University Control and characterization of memory function
US8696722B2 (en) 2010-11-22 2014-04-15 The Board Of Trustees Of The Leland Stanford Junior University Optogenetic magnetic resonance imaging
CA3036859A1 (en) 2011-12-16 2013-06-20 The Board Of Trustees Of The Leland Stanford Junior University Opsin polypeptides and methods of use thereof
AU2013222443B2 (en) 2012-02-21 2017-12-14 Circuit Therapeutics, Inc. Compositions and methods for treating neurogenic disorders of the pelvic floor
DK2822964T3 (en) 2012-03-05 2018-12-10 Univ Wayne State IDENTIFICATION OF CHANNEL RHODOPSIN-2- (CHOP2) MUTATIONS AND METHODS OF USE
WO2014144409A1 (en) 2013-03-15 2014-09-18 The Board Of Trustees Of The Leland Stanford Junior University Optogenetic control of behavioral state
US9636380B2 (en) 2013-03-15 2017-05-02 The Board Of Trustees Of The Leland Stanford Junior University Optogenetic control of inputs to the ventral tegmental area
JP6549559B2 (ja) 2013-04-29 2019-07-24 ザ ボード オブ トラスティーズ オブ ザ レランド スタンフォード ジュニア ユニバーシティー 標的細胞における活動電位の光遺伝学的調節のための装置、システム及び方法
EP3033427A4 (en) 2013-08-14 2017-05-31 The Board Of Trustees Of The University Of the Leland Stanford Junior University Compositions and methods for controlling pain
JP6118239B2 (ja) * 2013-11-29 2017-04-19 雅敏 堀 害虫の防除方法及び防除装置
WO2015167639A1 (en) * 2014-02-07 2015-11-05 Massachusetts Institute Of Technology Blue light-activated ion channel molecules and uses thereof
WO2015142984A1 (en) * 2014-03-18 2015-09-24 Washington University Methods and compositions for red-shifted chromophore substitution for optogenetic applications
WO2015161308A1 (en) * 2014-04-18 2015-10-22 Massachusetts Institute Of Technology Mutant channelrhodopsins with altered ion selectivity
US10568516B2 (en) 2015-06-22 2020-02-25 The Board Of Trustees Of The Leland Stanford Junior University Methods and devices for imaging and/or optogenetic control of light-responsive neurons
KR102471929B1 (ko) * 2016-06-03 2022-11-28 막스-플랑크-게젤샤프트 츄어 푀르더룽 데어 비쎈샤프텐 에.파우. 크림슨의 돌연변이 광-유도성 이온 채널
KR20190020702A (ko) 2016-06-03 2019-03-04 막스-플랑크-게젤샤프트 츄어 푀르더룽 데어 비쎈샤프텐 에.파우. 채널로돕신의 돌연변이 광-유도성 이온 채널
KR102877327B1 (ko) 2016-08-29 2025-10-27 웨인 스테이트 유니버시티 개선된 광 민감성을 갖는 채널옵신 변이체에서의 돌연변이의 확인 및 이의 용도
US11180537B2 (en) 2016-11-06 2021-11-23 Nancoscope Technologies LLC Optogenetic modulation by Multi-Characteristic Opsins for vision restoration and other applications
US11294165B2 (en) 2017-03-30 2022-04-05 The Board Of Trustees Of The Leland Stanford Junior University Modular, electro-optical device for increasing the imaging field of view using time-sequential capture
WO2018189247A1 (en) * 2017-04-12 2018-10-18 MAX-PLANCK-Gesellschaft zur Förderung der Wissenschaften e.V. New optogenetic tool
CN110483645B (zh) * 2018-05-14 2023-05-12 郑州大学第一附属医院 线粒体定位质子泵型视紫红质、其突变蛋白及其应用
JP7242851B2 (ja) * 2018-07-26 2023-03-20 カウンシル・オブ・サイエンティフィック・アンド・インダストリアル・リサーチ・アン・インディアン・レジスタード・ボディ・インコーポレイテッド・アンダー・ザ・レジストレーション・オブ・ソサエティーズ・アクト・(アクト・21・オブ・1860) 子宮頸がんのグレード検出のためのスクリーニングキットおよびその調製方法
US12030917B2 (en) 2018-09-14 2024-07-09 Nagoya Institute Of Technology Photoresponsive protein and utilization thereof
CN115397991B (zh) * 2020-03-13 2024-09-20 国立大学法人名古屋工业大学 用于颜色识别的光响应性蛋白及其应用
WO2022176754A1 (ja) * 2021-02-18 2022-08-25 国立大学法人名古屋工業大学 青色光もしくは藍色光応答性タンパク質及びその利用
EP4223768A1 (en) 2022-02-04 2023-08-09 Georg-August-Universität Göttingen Stiftung Öffentlichen Rechts, Universitätsmedizin Novel mutant bacteriorhodopsin-like-channelrhodopsin ion channel
WO2024092248A1 (en) * 2022-10-28 2024-05-02 The Board Of Trustees Of The Leland Stanford Junior University Enhanced light gated potassium selective channelrhodopsin

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Also Published As

Publication number Publication date
WO2012032103A1 (en) 2012-03-15
AU2011298745B2 (en) 2015-05-07
PL2614079T3 (pl) 2016-01-29
US20130281379A1 (en) 2013-10-24
SI2614079T1 (sl) 2015-10-30
KR101945962B1 (ko) 2019-02-08
JP5933556B2 (ja) 2016-06-15
ES2545992T3 (es) 2015-09-17
BR112013005634A2 (pt) 2017-06-27
JP2013544494A (ja) 2013-12-19
AU2011298745A1 (en) 2013-03-21
MX2013002591A (es) 2013-07-22
US8748578B2 (en) 2014-06-10
CA2810757C (en) 2020-06-09
DK2614079T3 (en) 2015-08-10
PT2614079E (pt) 2015-10-06
KR20130108335A (ko) 2013-10-02
SG188409A1 (en) 2013-04-30
CN103261219B (zh) 2017-05-17
CA2810757A1 (en) 2012-03-15
EP2614079A1 (en) 2013-07-17
RU2595384C2 (ru) 2016-08-27
EP2614079B1 (en) 2015-07-15
HUE025952T2 (en) 2016-04-28
CN103261219A (zh) 2013-08-21
HRP20150846T1 (hr) 2015-09-11
IL225060A (en) 2016-10-31
RU2013115454A (ru) 2014-10-20

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