MX2013002591A - Canalrodopsina 2 mutante. - Google Patents
Canalrodopsina 2 mutante.Info
- Publication number
- MX2013002591A MX2013002591A MX2013002591A MX2013002591A MX2013002591A MX 2013002591 A MX2013002591 A MX 2013002591A MX 2013002591 A MX2013002591 A MX 2013002591A MX 2013002591 A MX2013002591 A MX 2013002591A MX 2013002591 A MX2013002591 A MX 2013002591A
- Authority
- MX
- Mexico
- Prior art keywords
- mutant
- nucleic acid
- channelrhodopsin
- acid construct
- channelrhodopsins
- Prior art date
Links
- 108010035848 Channelrhodopsins Proteins 0.000 title abstract 2
- 150000007523 nucleic acids Chemical class 0.000 abstract 3
- 102000039446 nucleic acids Human genes 0.000 abstract 3
- 108020004707 nucleic acids Proteins 0.000 abstract 3
- 239000013604 expression vector Substances 0.000 abstract 2
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/405—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from algae
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/10—Cells modified by introduction of foreign genetic material
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6872—Intracellular protein regulatory factors and their receptors, e.g. including ion channels
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Medicinal Chemistry (AREA)
- Biotechnology (AREA)
- Zoology (AREA)
- Cell Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biomedical Technology (AREA)
- Biophysics (AREA)
- Immunology (AREA)
- Gastroenterology & Hepatology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Wood Science & Technology (AREA)
- Microbiology (AREA)
- Toxicology (AREA)
- General Engineering & Computer Science (AREA)
- Urology & Nephrology (AREA)
- Hematology (AREA)
- Physics & Mathematics (AREA)
- Analytical Chemistry (AREA)
- Food Science & Technology (AREA)
- General Physics & Mathematics (AREA)
- Pathology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Plant Pathology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Ophthalmology & Optometry (AREA)
- Public Health (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Abstract
La invención se relaciona con canalrodopsinas mutantes que tienen propiedades mejoradas, constructos de ácido nucleico que codifican los mismos, vectores de expresión que portan el constructo de ácido nucleico, células que comprenden el constructo de ácido nucleico o vector de expresión y sus usos respectivos.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US38079310P | 2010-09-08 | 2010-09-08 | |
EP10175832 | 2010-09-08 | ||
PCT/EP2011/065510 WO2012032103A1 (en) | 2010-09-08 | 2011-09-08 | Mutant channelrhodopsin 2 |
Publications (2)
Publication Number | Publication Date |
---|---|
MX2013002591A true MX2013002591A (es) | 2013-07-22 |
MX347453B MX347453B (es) | 2017-04-27 |
Family
ID=42979822
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2013002591A MX347453B (es) | 2010-09-08 | 2011-09-08 | Canalrodopsina 2 mutante. |
Country Status (20)
Country | Link |
---|---|
US (1) | US8748578B2 (es) |
EP (1) | EP2614079B1 (es) |
JP (1) | JP5933556B2 (es) |
KR (1) | KR101945962B1 (es) |
CN (1) | CN103261219B (es) |
AU (1) | AU2011298745B2 (es) |
BR (1) | BR112013005634A2 (es) |
CA (1) | CA2810757C (es) |
DK (1) | DK2614079T3 (es) |
ES (1) | ES2545992T3 (es) |
HR (1) | HRP20150846T1 (es) |
HU (1) | HUE025952T2 (es) |
IL (1) | IL225060A (es) |
MX (1) | MX347453B (es) |
PL (1) | PL2614079T3 (es) |
PT (1) | PT2614079E (es) |
RU (1) | RU2595384C2 (es) |
SG (1) | SG188409A1 (es) |
SI (1) | SI2614079T1 (es) |
WO (1) | WO2012032103A1 (es) |
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US8906360B2 (en) | 2005-07-22 | 2014-12-09 | The Board Of Trustees Of The Leland Stanford Junior University | Light-activated cation channel and uses thereof |
US9238150B2 (en) | 2005-07-22 | 2016-01-19 | The Board Of Trustees Of The Leland Stanford Junior University | Optical tissue interface method and apparatus for stimulating cells |
US8926959B2 (en) | 2005-07-22 | 2015-01-06 | The Board Of Trustees Of The Leland Stanford Junior University | System for optical stimulation of target cells |
US9274099B2 (en) | 2005-07-22 | 2016-03-01 | The Board Of Trustees Of The Leland Stanford Junior University | Screening test drugs to identify their effects on cell membrane voltage-gated ion channel |
US10052497B2 (en) | 2005-07-22 | 2018-08-21 | The Board Of Trustees Of The Leland Stanford Junior University | System for optical stimulation of target cells |
CN101484005A (zh) | 2006-05-04 | 2009-07-15 | 韦恩州立大学 | 通过向体内递送视紫红质核酸恢复视觉响应 |
WO2008086470A1 (en) | 2007-01-10 | 2008-07-17 | The Board Of Trustees Of The Leland Stanford Junior University | System for optical stimulation of target cells |
US8401609B2 (en) | 2007-02-14 | 2013-03-19 | The Board Of Trustees Of The Leland Stanford Junior University | System, method and applications involving identification of biological circuits such as neurological characteristics |
WO2008106694A2 (en) | 2007-03-01 | 2008-09-04 | The Board Of Trustees Of The Leland Stanford Junior University | Systems, methods and compositions for optical stimulation of target cells |
US10035027B2 (en) | 2007-10-31 | 2018-07-31 | The Board Of Trustees Of The Leland Stanford Junior University | Device and method for ultrasonic neuromodulation via stereotactic frame based technique |
US10434327B2 (en) | 2007-10-31 | 2019-10-08 | The Board Of Trustees Of The Leland Stanford Junior University | Implantable optical stimulators |
MY169771A (en) | 2008-04-23 | 2019-05-15 | Univ Leland Stanford Junior | Systems, methods and compositions for optical stimulation of target cells |
CA2726128C (en) | 2008-05-29 | 2016-10-18 | The Board Of Trustees Of The Leland Stanford Junior University | Cell line, system and method for optical control of secondary messengers |
AU2009260029B2 (en) | 2008-06-17 | 2016-03-17 | The Board Of Trustees Of The Leland Stanford Junior University | Methods, systems and devices for optical stimulation of target cells using an optical transmission element |
MY162929A (en) | 2008-06-17 | 2017-07-31 | Univ Leland Stanford Junior | Apparatus and methods for controlling cellular development |
US9101759B2 (en) | 2008-07-08 | 2015-08-11 | The Board Of Trustees Of The Leland Stanford Junior University | Materials and approaches for optical stimulation of the peripheral nervous system |
NZ602416A (en) | 2008-11-14 | 2014-08-29 | Univ Leland Stanford Junior | Optically-based stimulation of target cells and modifications thereto |
AU2011227131B2 (en) | 2010-03-17 | 2014-11-13 | The Board Of Trustees Of The Leland Stanford Junior University | Light-sensitive ion-passing molecules |
US9453241B2 (en) | 2010-05-04 | 2016-09-27 | Wayne State University | AAV-mediated subcellular targeting of heterologous rhodopsins in retinal ganglion cells |
AU2011323226B2 (en) | 2010-11-05 | 2015-03-12 | The Board Of Trustees Of The Leland Stanford Junior University | Light-activated chimeric opsins and methods of using the same |
CA2816968C (en) | 2010-11-05 | 2019-11-26 | The Board Of Trustees Of The Leland Stanford Junior University | Optically-controlled cns dysfunction |
CA2816976C (en) | 2010-11-05 | 2019-12-03 | The Board Of Trustees Of The Leland Standford Junior University | Optogenetic control of reward-related behaviors |
CN110215614A (zh) | 2010-11-05 | 2019-09-10 | 斯坦福大学托管董事会 | 用于光遗传学方法的光的上转换 |
CA2816972C (en) | 2010-11-05 | 2019-12-03 | The Board Of Trustees Of The Leland Stanford Junior University | Control and characterization of memory function |
JP6002140B2 (ja) * | 2010-11-05 | 2016-10-05 | ザ ボード オブ トラスティーズ オブ ザ レランド スタンフォード ジュニア ユニバーシティー | 安定化階段関数オプシンタンパク質及びその使用方法 |
US8696722B2 (en) | 2010-11-22 | 2014-04-15 | The Board Of Trustees Of The Leland Stanford Junior University | Optogenetic magnetic resonance imaging |
JP6406581B2 (ja) | 2011-12-16 | 2018-10-17 | ザ ボード オブ トラスティーズ オブ ザ レランド スタンフォード ジュニア ユニバーシティー | オプシンポリペプチドおよびその使用法 |
CA2865296A1 (en) | 2012-02-21 | 2013-08-29 | Karl A. DEISSEROTH | Compositions and methods for treating neurogenic disorders of the pelvic floor |
HUE040487T2 (hu) * | 2012-03-05 | 2019-03-28 | Univ Wayne State | Csatornarodopszin-2 (CHOP2) mutációk azonosítása és alkalmazási eljárások |
US9636380B2 (en) | 2013-03-15 | 2017-05-02 | The Board Of Trustees Of The Leland Stanford Junior University | Optogenetic control of inputs to the ventral tegmental area |
ES2742492T3 (es) | 2013-03-15 | 2020-02-14 | Univ Leland Stanford Junior | Control optogenético del estado conductual |
CN105431046B (zh) | 2013-04-29 | 2020-04-17 | 小利兰·斯坦福大学托管委员会 | 用于靶细胞中的动作电位的光遗传学调节的装置、系统和方法 |
CA2921221A1 (en) | 2013-08-14 | 2015-02-19 | The Board Of Trustees Of The Leland Stanford Junior University | Compositions and methods for controlling pain |
JP6118239B2 (ja) * | 2013-11-29 | 2017-04-19 | 雅敏 堀 | 害虫の防除方法及び防除装置 |
EP3102290A1 (en) * | 2014-02-07 | 2016-12-14 | Massachusetts Institute Of Technology | Blue light-activated ion channel molecules and uses thereof |
US10047130B2 (en) | 2014-03-18 | 2018-08-14 | Washington University | Methods and compositions for red-shifted chromophore substitution for optogenetic applications |
US10590181B2 (en) | 2014-04-18 | 2020-03-17 | Massachusetts Institute Of Technology | Mutant channelrhodopsins with altered ion selectivity |
WO2016209654A1 (en) | 2015-06-22 | 2016-12-29 | The Board Of Trustees Of The Leland Stanford Junior University | Methods and devices for imaging and/or optogenetic control of light-responsive neurons |
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JP2019522469A (ja) * | 2016-06-03 | 2019-08-15 | マックス−プランク−ゲゼルシャフト ツア フェルデルンク デア ヴィッセンシャフテン エー.ファウ. | チャネルロドプシンの変異型光誘導性イオンチャネル |
JP6779546B2 (ja) * | 2016-11-06 | 2020-11-04 | ナノスコープ テクノロジーズ エルエルシーNanoscope Technologies Llc | 視力回復のための多特性オプシンによる光遺伝学的調節及びその別の用途 |
US11294165B2 (en) | 2017-03-30 | 2022-04-05 | The Board Of Trustees Of The Leland Stanford Junior University | Modular, electro-optical device for increasing the imaging field of view using time-sequential capture |
EP3609518A1 (en) * | 2017-04-12 | 2020-02-19 | Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. | New optogenetic tool |
CN110483645B (zh) * | 2018-05-14 | 2023-05-12 | 郑州大学第一附属医院 | 线粒体定位质子泵型视紫红质、其突变蛋白及其应用 |
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CN115397991A (zh) * | 2020-03-13 | 2022-11-25 | 国立大学法人名古屋工业大学 | 用于颜色识别的光响应性蛋白及其应用 |
WO2022176754A1 (ja) * | 2021-02-18 | 2022-08-25 | 国立大学法人名古屋工業大学 | 青色光もしくは藍色光応答性タンパク質及びその利用 |
EP4223768A1 (en) | 2022-02-04 | 2023-08-09 | Georg-August-Universität Göttingen Stiftung Öffentlichen Rechts, Universitätsmedizin | Novel mutant bacteriorhodopsin-like-channelrhodopsin ion channel |
WO2024092248A1 (en) * | 2022-10-28 | 2024-05-02 | The Board Of Trustees Of The Leland Stanford Junior University | Enhanced light gated potassium selective channelrhodopsin |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP2112501A1 (de) | 1998-02-05 | 2009-10-28 | Novartis Ag | Verfahren und Vorrichtung zur Lumineszenzmessung |
DE10216005A1 (de) | 2002-04-11 | 2003-10-30 | Max Planck Gesellschaft | Verwendung von biologischen Photorezeptoren als direkt lichtgesteuerte Ionenkanäle |
CN101484005A (zh) * | 2006-05-04 | 2009-07-15 | 韦恩州立大学 | 通过向体内递送视紫红质核酸恢复视觉响应 |
DE102008020152B4 (de) * | 2008-04-22 | 2012-04-05 | MAX-PLANCK-Gesellschaft zur Förderung der Wissenschaften e.V. | Verwendung von biologischen Photorezeptoren als direkt lichtgesteuerte Ionenkanäle |
NZ602416A (en) * | 2008-11-14 | 2014-08-29 | Univ Leland Stanford Junior | Optically-based stimulation of target cells and modifications thereto |
-
2011
- 2011-09-08 DK DK11760432.2T patent/DK2614079T3/en active
- 2011-09-08 SG SG2013016332A patent/SG188409A1/en unknown
- 2011-09-08 WO PCT/EP2011/065510 patent/WO2012032103A1/en active Application Filing
- 2011-09-08 ES ES11760432.2T patent/ES2545992T3/es active Active
- 2011-09-08 PT PT117604322T patent/PT2614079E/pt unknown
- 2011-09-08 CN CN201180052156.9A patent/CN103261219B/zh active Active
- 2011-09-08 JP JP2013527595A patent/JP5933556B2/ja active Active
- 2011-09-08 AU AU2011298745A patent/AU2011298745B2/en active Active
- 2011-09-08 US US13/821,353 patent/US8748578B2/en active Active
- 2011-09-08 KR KR1020137008660A patent/KR101945962B1/ko active IP Right Grant
- 2011-09-08 BR BR112013005634A patent/BR112013005634A2/pt not_active Application Discontinuation
- 2011-09-08 RU RU2013115454/10A patent/RU2595384C2/ru active
- 2011-09-08 EP EP11760432.2A patent/EP2614079B1/en active Active
- 2011-09-08 MX MX2013002591A patent/MX347453B/es active IP Right Grant
- 2011-09-08 CA CA2810757A patent/CA2810757C/en active Active
- 2011-09-08 PL PL11760432T patent/PL2614079T3/pl unknown
- 2011-09-08 SI SI201130552T patent/SI2614079T1/sl unknown
- 2011-09-08 HU HUE11760432A patent/HUE025952T2/en unknown
-
2013
- 2013-03-05 IL IL225060A patent/IL225060A/en active IP Right Grant
-
2015
- 2015-08-10 HR HRP20150846TT patent/HRP20150846T1/hr unknown
Also Published As
Publication number | Publication date |
---|---|
CA2810757A1 (en) | 2012-03-15 |
US20130281379A1 (en) | 2013-10-24 |
JP5933556B2 (ja) | 2016-06-15 |
PT2614079E (pt) | 2015-10-06 |
KR20130108335A (ko) | 2013-10-02 |
KR101945962B1 (ko) | 2019-02-08 |
RU2595384C2 (ru) | 2016-08-27 |
BR112013005634A2 (pt) | 2017-06-27 |
CA2810757C (en) | 2020-06-09 |
DK2614079T3 (en) | 2015-08-10 |
EP2614079B1 (en) | 2015-07-15 |
EP2614079A1 (en) | 2013-07-17 |
HUE025952T2 (en) | 2016-04-28 |
CN103261219B (zh) | 2017-05-17 |
SI2614079T1 (sl) | 2015-10-30 |
CN103261219A (zh) | 2013-08-21 |
PL2614079T3 (pl) | 2016-01-29 |
AU2011298745B2 (en) | 2015-05-07 |
SG188409A1 (en) | 2013-04-30 |
IL225060A (en) | 2016-10-31 |
MX347453B (es) | 2017-04-27 |
ES2545992T3 (es) | 2015-09-17 |
HRP20150846T1 (hr) | 2015-09-11 |
JP2013544494A (ja) | 2013-12-19 |
US8748578B2 (en) | 2014-06-10 |
RU2013115454A (ru) | 2014-10-20 |
WO2012032103A1 (en) | 2012-03-15 |
AU2011298745A1 (en) | 2013-03-21 |
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