JP2015512927A5 - - Google Patents
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- Publication number
- JP2015512927A5 JP2015512927A5 JP2015504987A JP2015504987A JP2015512927A5 JP 2015512927 A5 JP2015512927 A5 JP 2015512927A5 JP 2015504987 A JP2015504987 A JP 2015504987A JP 2015504987 A JP2015504987 A JP 2015504987A JP 2015512927 A5 JP2015512927 A5 JP 2015512927A5
- Authority
- JP
- Japan
- Prior art keywords
- factor
- pharmaceutical composition
- blood coagulation
- composition according
- residue
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB1206628.8A GB201206628D0 (en) | 2012-04-16 | 2012-04-16 | Subcutaneous administration of PEGylated blood clotting factors |
| GB1206628.8 | 2012-04-16 | ||
| GB1213712.1 | 2012-08-01 | ||
| GBGB1213712.1A GB201213712D0 (en) | 2012-08-01 | 2012-08-01 | Modified therapeutic agents |
| GB1214985.2 | 2012-08-22 | ||
| GBGB1214985.2A GB201214985D0 (en) | 2012-08-22 | 2012-08-22 | Modified therapeutic agents |
| PCT/EP2013/057928 WO2013156488A2 (en) | 2012-04-16 | 2013-04-16 | Optimised subcutaneous therapeutic agents |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017171545A Division JP6550107B2 (ja) | 2012-04-16 | 2017-09-06 | 最適化された皮下治療薬 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2015512927A JP2015512927A (ja) | 2015-04-30 |
| JP2015512927A5 true JP2015512927A5 (enExample) | 2016-06-16 |
Family
ID=48190923
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015504987A Pending JP2015512927A (ja) | 2012-04-16 | 2013-04-16 | 最適化された皮下治療薬 |
| JP2017171545A Active JP6550107B2 (ja) | 2012-04-16 | 2017-09-06 | 最適化された皮下治療薬 |
| JP2019073048A Pending JP2019131593A (ja) | 2012-04-16 | 2019-04-05 | 最適化された皮下治療薬 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017171545A Active JP6550107B2 (ja) | 2012-04-16 | 2017-09-06 | 最適化された皮下治療薬 |
| JP2019073048A Pending JP2019131593A (ja) | 2012-04-16 | 2019-04-05 | 最適化された皮下治療薬 |
Country Status (29)
| Country | Link |
|---|---|
| US (2) | US20150086524A1 (enExample) |
| EP (1) | EP2838566A2 (enExample) |
| JP (3) | JP2015512927A (enExample) |
| KR (1) | KR102137290B1 (enExample) |
| CN (1) | CN104411335A (enExample) |
| AP (1) | AP2014008049A0 (enExample) |
| AU (3) | AU2013248296A1 (enExample) |
| BR (1) | BR112014025737A2 (enExample) |
| CA (1) | CA2869993C (enExample) |
| CL (1) | CL2014002773A1 (enExample) |
| CO (1) | CO7151496A2 (enExample) |
| CR (1) | CR20140475A (enExample) |
| EA (1) | EA033469B1 (enExample) |
| EC (1) | ECSP14023048A (enExample) |
| GB (3) | GB201910190D0 (enExample) |
| GE (1) | GEP201706716B (enExample) |
| HK (1) | HK1200695A1 (enExample) |
| IL (1) | IL235129B (enExample) |
| IN (1) | IN2014DN08598A (enExample) |
| MD (1) | MD20140123A2 (enExample) |
| MX (2) | MX2014012512A (enExample) |
| MY (1) | MY190257A (enExample) |
| NI (1) | NI201400122A (enExample) |
| NZ (1) | NZ701205A (enExample) |
| PE (1) | PE20150226A1 (enExample) |
| PH (1) | PH12014502314B1 (enExample) |
| SG (1) | SG11201406492YA (enExample) |
| WO (1) | WO2013156488A2 (enExample) |
| ZA (1) | ZA201407370B (enExample) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109498815B (zh) * | 2013-12-30 | 2022-07-22 | 江苏众红生物工程创药研究院有限公司 | 重组人激肽释放酶的化学修饰物及其应用 |
| GB201417589D0 (en) | 2014-10-06 | 2014-11-19 | Cantab Biopharmaceuticals Patents Ltd | Pharmaceutical Formulations |
| FR3034669B1 (fr) * | 2015-04-07 | 2020-02-14 | Laboratoire Francais Du Fractionnement Et Des Biotechnologies | Nouvelle utilisation du facteur von willebrand |
| US20180169297A1 (en) * | 2015-06-12 | 2018-06-21 | Laboratoire Français Du Fractionnement Et Des Biotechnologies | Injectable composition of factor vii and fillers |
| GB201518172D0 (en) | 2015-10-14 | 2015-11-25 | Cantab Biopharmaceuticals Patents Ltd | Colloidal particles for use in medicine |
| GB201518170D0 (en) | 2015-10-14 | 2015-11-25 | Cantab Biopharmaceuticals Patents Ltd | Colloidal particles for subcutaneous administration with intravenous administration of therapeutic agent |
| GB201518171D0 (en) | 2015-10-14 | 2015-11-25 | Cantab Biopharmaceuticals Patents Ltd | Colloidal particles for topical administration with therapeutic agent |
| CN109998994B (zh) * | 2018-02-13 | 2021-12-07 | 四川大学 | 包含药物的柔性脂质体及其制备方法 |
| WO2021165226A1 (en) | 2020-02-17 | 2021-08-26 | Biotest Ag | Subcutaneous administration of factor viii |
| US20230236199A1 (en) * | 2020-04-23 | 2023-07-27 | Eli Lilly And Company | Subcutaneous absorption and bioavailability of antibodies |
Family Cites Families (58)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1479268A (en) | 1973-07-05 | 1977-07-13 | Beecham Group Ltd | Pharmaceutical compositions |
| US4179337A (en) | 1973-07-20 | 1979-12-18 | Davis Frank F | Non-immunogenic polypeptides |
| CH596313A5 (enExample) | 1975-05-30 | 1978-03-15 | Battelle Memorial Institute | |
| US4414147A (en) | 1981-04-17 | 1983-11-08 | Massachusetts Institute Of Technology | Methods of decreasing the hydrophobicity of fibroblast and other interferons |
| US4496689A (en) | 1983-12-27 | 1985-01-29 | Miles Laboratories, Inc. | Covalently attached complex of alpha-1-proteinase inhibitor with a water soluble polymer |
| DE3676670D1 (de) | 1985-06-26 | 1991-02-07 | Cetus Corp | Solubilisierung von proteinen fuer pharmazeutische zusammensetzungen mittels polymerkonjugierung. |
| AU5858690A (en) * | 1989-06-14 | 1991-01-08 | Cetus Corporation | Polymer/antibiotic conjugate |
| AU5098193A (en) | 1992-09-01 | 1994-03-29 | Berlex Laboratories, Inc. | Glycolation of glycosylated macromolecules |
| CA2145407C (en) | 1992-09-28 | 2009-09-22 | Louis A. Carpino | New reagents for peptide couplings |
| US5621039A (en) * | 1993-06-08 | 1997-04-15 | Hallahan; Terrence W. | Factor IX- polymeric conjugates |
| IL113010A (en) | 1994-03-31 | 1999-10-28 | Pharmacia & Upjohn Ab | Pharmaceutical formulation comprising factor viii with an activity of at least 500iu/ml and an enhancer for improved subcutaneous intramuscular or intradermal administration |
| JPH0892294A (ja) * | 1994-09-29 | 1996-04-09 | Teijin Ltd | ヒト活性化プロテインc誘導体 |
| US5693609A (en) | 1994-11-17 | 1997-12-02 | Eli Lilly And Company | Acylated insulin analogs |
| CA2177644A1 (en) * | 1995-05-31 | 1996-12-01 | Peter D. Senter | Polymeric prodrugs for beta-lactamase and uses thereof |
| SE9503380D0 (sv) * | 1995-09-29 | 1995-09-29 | Pharmacia Ab | Protein derivatives |
| EP0921817B1 (en) | 1997-01-29 | 2001-03-28 | PolyMASC Pharmaceuticals plc | Pegylation process |
| AU2605099A (en) * | 1998-02-25 | 1999-09-15 | Micrologix Biotech, Inc. | Indolicidin and cationic peptides conjugated with polymers |
| WO2001058935A2 (en) * | 2000-02-11 | 2001-08-16 | Maxygen Aps | FACTOR VII OR VIIa-LIKE MOLECULES |
| AU2001256148A1 (en) | 2000-05-03 | 2001-11-12 | Novo-Nordisk A/S | Subcutaneous administration of coagulation factor vii |
| US20030211094A1 (en) * | 2001-06-26 | 2003-11-13 | Nelsestuen Gary L. | High molecular weight derivatives of vitamin k-dependent polypeptides |
| MXPA04012496A (es) | 2002-06-21 | 2005-09-12 | Novo Nordisk Healthcare Ag | Glicoformos del factor vii pegilados. |
| CN1671420A (zh) * | 2002-06-21 | 2005-09-21 | 诺和诺德医疗保健公司 | Peg化因子ⅶ糖型 |
| AU2004215912B2 (en) * | 2003-02-26 | 2009-03-26 | Nektar Therapeutics | Polymer-factor VIII moiety conjugates |
| CA2521784C (en) * | 2003-04-08 | 2012-03-27 | Yeda Research And Development Co. Ltd. | Reversible pegylated drugs |
| US20130137157A1 (en) * | 2003-04-09 | 2013-05-30 | Novo Nordisk A/S | Glycopegylated factor vii and factor viia |
| GB0316294D0 (en) | 2003-07-11 | 2003-08-13 | Polytherics Ltd | Conjugated biological molecules and their preparation |
| US20060198819A1 (en) | 2003-08-08 | 2006-09-07 | Novo Nordisk Healthcare A/G | Use of galactose oxidase for selective chemical conjugation of protractor molecules to proteins of therapeutic interest |
| AU2005219090B2 (en) | 2004-03-04 | 2008-01-10 | Eisai R&D Management Co., Ltd | Composition containing benzamidine derivative and method for stabilizing benzamidine derivative |
| US7579444B2 (en) * | 2004-06-30 | 2009-08-25 | Nektar Therapeutics Al, Corporation | Polymer-factor IX moiety conjugates |
| US20090176967A1 (en) | 2004-08-02 | 2009-07-09 | Novo Nordisk Healthcare A/G | Conjugation of FVII |
| EP1891231A4 (en) | 2005-05-25 | 2011-06-22 | Novo Nordisk As | GLYCOPEGYLATED FACTOR IX |
| WO2006134173A2 (en) | 2005-06-17 | 2006-12-21 | Novo Nordisk Health Care Ag | Selective reduction and derivatization of engineered proteins comprising at least one non-native cysteine |
| JP2009515508A (ja) * | 2005-08-19 | 2009-04-16 | ネオス テクノロジーズ インコーポレイテッド | グリコpeg化因子viiおよび因子viia |
| NZ572050A (en) | 2006-03-31 | 2011-09-30 | Baxter Int | Factor VIII conjugated to polyethylene glycol |
| ES2531934T3 (es) | 2006-09-01 | 2015-03-20 | Novo Nordisk Health Care Ag | Glicoproteínas modificadas |
| CN105838699A (zh) | 2006-12-15 | 2016-08-10 | 巴克斯艾尔塔公司 | 具有延长的体内半衰期的因子VIIa-聚唾液酸结合物 |
| JP5702066B2 (ja) * | 2006-12-27 | 2015-04-15 | ネクター セラピューティクス | 解離可能な連結を有するフォンウィルブランド因子および第viii因子のポリマー共役体 |
| EP2099475B1 (en) * | 2007-01-03 | 2016-08-24 | Novo Nordisk Health Care AG | Subcutaneous administration of coagulation factor viia-related polypeptides |
| WO2008119815A1 (en) * | 2007-04-02 | 2008-10-09 | Novo Nordisk A/S | Subcutaneous administration of coagulation factor ix |
| NZ579985A (en) | 2007-04-13 | 2012-02-24 | Catalyst Biosciences Inc | Modified factor vii polypetides and uses thereof |
| EP2014299A1 (en) | 2007-07-11 | 2009-01-14 | Novo Nordisk A/S | Subcutaneous administration of coagulation factor VII |
| EP2209494B1 (en) | 2007-10-09 | 2016-07-20 | Polytherics Limited | Novel conjugated proteins and peptides |
| EP2209801B1 (en) | 2007-10-16 | 2013-01-16 | Pharmacyclics, Inc. | Manufacture, compositions and uses of coagulationfactor viia modulator |
| ES2476690T3 (es) | 2008-02-27 | 2014-07-15 | Novo Nordisk A/S | Moléculas conjugadas del Factor VIII |
| TWI538916B (zh) | 2008-04-11 | 2016-06-21 | 介控生化科技公司 | 經修飾的因子vii多肽和其用途 |
| WO2009140015A2 (en) * | 2008-04-16 | 2009-11-19 | Bayer Healthcare Llc | Site-directed modification of factor ix |
| EP2280734B1 (en) * | 2008-04-24 | 2014-02-26 | Cantab Biopharmaceuticals Patents Limited | Factor ix conjugates with extended half-lives |
| WO2009141433A1 (en) * | 2008-05-23 | 2009-11-26 | Novo Nordisk Health Care Ag | Low viscosity compositions comprising a pegylated gla-domain containing protein |
| JP5622117B2 (ja) | 2008-07-21 | 2014-11-12 | ポリテリクスリミテッド | 生体分子を接合するための新規な試薬及び方法 |
| US8143347B2 (en) * | 2008-10-15 | 2012-03-27 | Baxter International Inc. | Pegylation of recombinant blood coagulation factors in the presence of bound antibodies |
| HUE039906T2 (hu) * | 2008-10-17 | 2019-02-28 | Baxalta GmbH | Alacsony fokú vízben oldható polimer tartalmú módosított vérfaktorok |
| US20120121613A1 (en) * | 2009-01-19 | 2012-05-17 | Bayer Healthcare Llc | Protein conjugate having an endopeptidase- cleavable bioprotective moiety |
| EP2459224B1 (en) * | 2009-07-27 | 2016-06-01 | Baxalta GmbH | Blood coagulation protein conjugates |
| EP2536753B1 (en) * | 2010-02-16 | 2017-12-20 | Novo Nordisk A/S | Factor viii molecules with reduced vwf binding |
| GB201007357D0 (en) | 2010-04-30 | 2010-06-16 | Leverton Licence Holdings Ltd | Conjugated factor VIII |
| GB201007356D0 (en) * | 2010-04-30 | 2010-06-16 | Leverton Licence Holdings Ltd | Conjugated factor VIIa |
| PL2598172T3 (pl) * | 2010-07-30 | 2019-09-30 | Baxalta GmbH | Katalizatory nukleofilowe do wiązania oksymowego |
| WO2012088123A1 (en) * | 2010-12-22 | 2012-06-28 | Nektar Therapeutics | Polymer-factor vii moiety conjugates |
-
2013
- 2013-04-16 EP EP13719043.5A patent/EP2838566A2/en active Pending
- 2013-04-16 BR BR112014025737A patent/BR112014025737A2/pt not_active Application Discontinuation
- 2013-04-16 PE PE2014001639A patent/PE20150226A1/es active IP Right Grant
- 2013-04-16 GE GEAP201313632A patent/GEP201706716B/en unknown
- 2013-04-16 EA EA201491702A patent/EA033469B1/ru unknown
- 2013-04-16 HK HK15100881.5A patent/HK1200695A1/xx unknown
- 2013-04-16 JP JP2015504987A patent/JP2015512927A/ja active Pending
- 2013-04-16 IL IL235129A patent/IL235129B/en unknown
- 2013-04-16 GB GBGB1910190.6A patent/GB201910190D0/en not_active Ceased
- 2013-04-16 NZ NZ701205A patent/NZ701205A/en not_active IP Right Cessation
- 2013-04-16 CN CN201380027958.3A patent/CN104411335A/zh active Pending
- 2013-04-16 AU AU2013248296A patent/AU2013248296A1/en not_active Abandoned
- 2013-04-16 MX MX2014012512A patent/MX2014012512A/es unknown
- 2013-04-16 CA CA2869993A patent/CA2869993C/en active Active
- 2013-04-16 WO PCT/EP2013/057928 patent/WO2013156488A2/en not_active Ceased
- 2013-04-16 SG SG11201406492YA patent/SG11201406492YA/en unknown
- 2013-04-16 IN IN8598DEN2014 patent/IN2014DN08598A/en unknown
- 2013-04-16 GB GB1418864.3A patent/GB2516388A/en not_active Withdrawn
- 2013-04-16 US US14/394,437 patent/US20150086524A1/en not_active Abandoned
- 2013-04-16 MD MD20140123A patent/MD20140123A2/ro unknown
- 2013-04-16 AP AP2014008049A patent/AP2014008049A0/xx unknown
- 2013-04-16 GB GBGB1910184.9A patent/GB201910184D0/en not_active Ceased
- 2013-04-16 KR KR1020147031042A patent/KR102137290B1/ko active Active
- 2013-04-16 MY MYPI2014002900A patent/MY190257A/en unknown
-
2014
- 2014-10-10 ZA ZA2014/07370A patent/ZA201407370B/en unknown
- 2014-10-14 CR CR20140475A patent/CR20140475A/es unknown
- 2014-10-15 CL CL2014002773A patent/CL2014002773A1/es unknown
- 2014-10-15 PH PH12014502314A patent/PH12014502314B1/en unknown
- 2014-10-15 NI NI201400122A patent/NI201400122A/es unknown
- 2014-10-16 MX MX2020014208A patent/MX2020014208A/es unknown
- 2014-10-16 EC ECIEPI201423048A patent/ECSP14023048A/es unknown
- 2014-11-14 CO CO14252826A patent/CO7151496A2/es unknown
-
2017
- 2017-08-30 US US15/691,090 patent/US11351112B2/en active Active
- 2017-09-06 JP JP2017171545A patent/JP6550107B2/ja active Active
-
2018
- 2018-01-05 AU AU2018200111A patent/AU2018200111B2/en not_active Ceased
-
2019
- 2019-04-05 JP JP2019073048A patent/JP2019131593A/ja active Pending
-
2020
- 2020-02-06 AU AU2020200842A patent/AU2020200842A1/en not_active Abandoned
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