JP2012524725A5 - - Google Patents
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- Publication number
- JP2012524725A5 JP2012524725A5 JP2012506297A JP2012506297A JP2012524725A5 JP 2012524725 A5 JP2012524725 A5 JP 2012524725A5 JP 2012506297 A JP2012506297 A JP 2012506297A JP 2012506297 A JP2012506297 A JP 2012506297A JP 2012524725 A5 JP2012524725 A5 JP 2012524725A5
- Authority
- JP
- Japan
- Prior art keywords
- klk1
- seq
- pharmaceutical composition
- polypeptide
- disease
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 101710176219 Kallikrein-1 Proteins 0.000 claims 30
- 102000057032 Tissue Kallikreins Human genes 0.000 claims 30
- 229920001184 polypeptide Polymers 0.000 claims 15
- 102000004196 processed proteins & peptides Human genes 0.000 claims 15
- 108090000765 processed proteins & peptides Proteins 0.000 claims 15
- 239000008194 pharmaceutical composition Substances 0.000 claims 13
- 208000023105 Huntington disease Diseases 0.000 claims 11
- 208000024891 symptom Diseases 0.000 claims 10
- 239000012634 fragment Substances 0.000 claims 5
- 101100453988 Homo sapiens KLK1 gene Proteins 0.000 claims 4
- 208000025069 Juvenile Huntington disease Diseases 0.000 claims 4
- 239000003814 drug Substances 0.000 claims 3
- 229940079593 drug Drugs 0.000 claims 3
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 2
- 241000283690 Bos taurus Species 0.000 claims 2
- 101100453989 Macaca fascicularis KLK1 gene Proteins 0.000 claims 2
- 101001050269 Mus musculus Kallikrein 1-related peptidase b1 Proteins 0.000 claims 2
- 241000283973 Oryctolagus cuniculus Species 0.000 claims 2
- 241001504519 Papio ursinus Species 0.000 claims 2
- 241001494479 Pecora Species 0.000 claims 2
- 241000288961 Saguinus imperator Species 0.000 claims 2
- 150000001875 compounds Chemical class 0.000 claims 2
- RCRODHONKLSMIF-UHFFFAOYSA-N isosuberenol Natural products O1C(=O)C=CC2=C1C=C(OC)C(CC(O)C(C)=C)=C2 RCRODHONKLSMIF-UHFFFAOYSA-N 0.000 claims 2
- 230000001225 therapeutic effect Effects 0.000 claims 2
- 238000004519 manufacturing process Methods 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US17157909P | 2009-04-22 | 2009-04-22 | |
| US61/171,579 | 2009-04-22 | ||
| PCT/CA2010/000575 WO2010121361A1 (en) | 2009-04-22 | 2010-04-22 | Tissue kallikrein for the treatment of huntington's disease |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2012524725A JP2012524725A (ja) | 2012-10-18 |
| JP2012524725A5 true JP2012524725A5 (enExample) | 2013-05-30 |
Family
ID=43010630
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012506297A Pending JP2012524725A (ja) | 2009-04-22 | 2010-04-22 | ハンチントン病を治療するための組織カリクレイン |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US20120225051A1 (enExample) |
| EP (1) | EP2421554A4 (enExample) |
| JP (1) | JP2012524725A (enExample) |
| CN (1) | CN102458454A (enExample) |
| CA (1) | CA2759490A1 (enExample) |
| WO (1) | WO2010121361A1 (enExample) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8501695B2 (en) | 2007-07-20 | 2013-08-06 | Diamedica, Inc. | Tissue kallikrein for the treatment of diseases associated with amyloid protein |
| US20130315891A1 (en) * | 2012-05-25 | 2013-11-28 | Matthew Charles | Formulations of human tissue kallikrein-1 for parenteral delivery and related methods |
| CA2880085C (en) | 2012-06-04 | 2021-09-07 | Diamedica Inc. | Human tissue kallikrein 1 glycosylation isoforms |
| WO2015109107A1 (en) * | 2014-01-15 | 2015-07-23 | Cal Poly Pomona Foundation, Inc. | Treatment and diagnosis of huntington's disease |
| EP3592377A4 (en) | 2017-03-09 | 2021-02-17 | Diamedica Inc. | TISSUE KALLICREIN DOSAGE FORMS 1 |
| CN116549619A (zh) * | 2022-01-28 | 2023-08-08 | 江苏众红生物工程创药研究院有限公司 | 激肽原酶及其衍生物在治疗vci、psci或csvd中的应用 |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2001056532A2 (en) * | 2000-02-04 | 2001-08-09 | The Scripps Research Institute | Neuroprotective, antithrombotic and anti-inflammatory uses of activated protein c (apc) |
| EP1664790A2 (en) * | 2003-08-30 | 2006-06-07 | Bayer HealthCare AG | Diagnostics and therapeutics for diseases associated with kallikrein 8 (klk8) |
| WO2005022146A2 (en) * | 2003-08-30 | 2005-03-10 | Bayer Healthcare Ag | Diagnostics and therapeutics for diseases associated with kallikrein 13 (klk13) |
| US8501695B2 (en) * | 2007-07-20 | 2013-08-06 | Diamedica, Inc. | Tissue kallikrein for the treatment of diseases associated with amyloid protein |
-
2010
- 2010-04-22 US US13/265,357 patent/US20120225051A1/en not_active Abandoned
- 2010-04-22 CN CN2010800275339A patent/CN102458454A/zh active Pending
- 2010-04-22 JP JP2012506297A patent/JP2012524725A/ja active Pending
- 2010-04-22 CA CA2759490A patent/CA2759490A1/en not_active Abandoned
- 2010-04-22 EP EP10766547A patent/EP2421554A4/en not_active Withdrawn
- 2010-04-22 WO PCT/CA2010/000575 patent/WO2010121361A1/en not_active Ceased
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