JP2007521333A5 - - Google Patents
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- JP2007521333A5 JP2007521333A5 JP2006545433A JP2006545433A JP2007521333A5 JP 2007521333 A5 JP2007521333 A5 JP 2007521333A5 JP 2006545433 A JP2006545433 A JP 2006545433A JP 2006545433 A JP2006545433 A JP 2006545433A JP 2007521333 A5 JP2007521333 A5 JP 2007521333A5
- Authority
- JP
- Japan
- Prior art keywords
- pharmaceutical composition
- agonist
- composition according
- disorder
- signaling pathway
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
- 239000008194 pharmaceutical composition Substances 0.000 claims 47
- 239000000556 agonist Substances 0.000 claims 35
- 230000008410 smoothened signaling pathway Effects 0.000 claims 12
- 241000124008 Mammalia Species 0.000 claims 9
- 108091030071 RNAI Proteins 0.000 claims 8
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 8
- 230000009368 gene silencing by RNA Effects 0.000 claims 8
- 229920001184 polypeptide Polymers 0.000 claims 7
- 102000004196 processed proteins & peptides Human genes 0.000 claims 7
- 108090000765 processed proteins & peptides Proteins 0.000 claims 7
- 208000024827 Alzheimer disease Diseases 0.000 claims 6
- 102000000017 Patched Receptors Human genes 0.000 claims 6
- 108010069873 Patched Receptors Proteins 0.000 claims 6
- 230000002159 abnormal effect Effects 0.000 claims 5
- 230000003542 behavioural effect Effects 0.000 claims 5
- 210000003169 central nervous system Anatomy 0.000 claims 5
- 208000019901 Anxiety disease Diseases 0.000 claims 4
- 125000003275 alpha amino acid group Chemical group 0.000 claims 4
- 239000004480 active ingredient Substances 0.000 claims 3
- 208000010877 cognitive disease Diseases 0.000 claims 3
- 239000012634 fragment Substances 0.000 claims 3
- 238000011321 prophylaxis Methods 0.000 claims 3
- 230000011664 signaling Effects 0.000 claims 3
- 208000006096 Attention Deficit Disorder with Hyperactivity Diseases 0.000 claims 2
- 208000036864 Attention deficit/hyperactivity disease Diseases 0.000 claims 2
- 229940094659 Dopamine reuptake inhibitor Drugs 0.000 claims 2
- 208000021384 Obsessive-Compulsive disease Diseases 0.000 claims 2
- 102000013380 Smoothened Receptor Human genes 0.000 claims 2
- 108010090739 Smoothened Receptor Proteins 0.000 claims 2
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 claims 2
- 230000036506 anxiety Effects 0.000 claims 2
- 230000003920 cognitive function Effects 0.000 claims 2
- 239000000221 dopamine uptake inhibitor Substances 0.000 claims 2
- 230000002708 enhancing effect Effects 0.000 claims 2
- 239000004615 ingredient Substances 0.000 claims 2
- 230000007074 memory dysfunction Effects 0.000 claims 2
- 208000019906 panic disease Diseases 0.000 claims 2
- 239000000546 pharmaceutical excipient Substances 0.000 claims 2
- 108091033319 polynucleotide Proteins 0.000 claims 2
- 102000040430 polynucleotide Human genes 0.000 claims 2
- 239000002157 polynucleotide Substances 0.000 claims 2
- 208000011580 syndromic disease Diseases 0.000 claims 2
- 238000005406 washing Methods 0.000 claims 2
- 208000017194 Affective disease Diseases 0.000 claims 1
- 208000028698 Cognitive impairment Diseases 0.000 claims 1
- 208000027534 Emotional disease Diseases 0.000 claims 1
- 208000019022 Mood disease Diseases 0.000 claims 1
- 108020004459 Small interfering RNA Proteins 0.000 claims 1
- 208000027418 Wounds and injury Diseases 0.000 claims 1
- 230000003213 activating effect Effects 0.000 claims 1
- 230000003302 anti-idiotype Effects 0.000 claims 1
- 230000001149 cognitive effect Effects 0.000 claims 1
- 230000006378 damage Effects 0.000 claims 1
- 230000007812 deficiency Effects 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 230000006870 function Effects 0.000 claims 1
- 230000002401 inhibitory effect Effects 0.000 claims 1
- 238000002347 injection Methods 0.000 claims 1
- 239000007924 injection Substances 0.000 claims 1
- 208000014674 injury Diseases 0.000 claims 1
- 230000003993 interaction Effects 0.000 claims 1
- 230000006386 memory function Effects 0.000 claims 1
- 206010027175 memory impairment Diseases 0.000 claims 1
- 210000004898 n-terminal fragment Anatomy 0.000 claims 1
- 108020004707 nucleic acids Proteins 0.000 claims 1
- 102000039446 nucleic acids Human genes 0.000 claims 1
- 150000007523 nucleic acids Chemical class 0.000 claims 1
- 239000002773 nucleotide Substances 0.000 claims 1
- 125000003729 nucleotide group Chemical group 0.000 claims 1
- 238000007911 parenteral administration Methods 0.000 claims 1
- 238000002360 preparation method Methods 0.000 claims 1
- 108090000623 proteins and genes Proteins 0.000 claims 1
- 102000005962 receptors Human genes 0.000 claims 1
- 108020003175 receptors Proteins 0.000 claims 1
- 239000011780 sodium chloride Substances 0.000 claims 1
- 239000001509 sodium citrate Substances 0.000 claims 1
- NLJMYIDDQXHKNR-UHFFFAOYSA-K sodium citrate Chemical compound O.O.[Na+].[Na+].[Na+].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O NLJMYIDDQXHKNR-UHFFFAOYSA-K 0.000 claims 1
- 208000024891 symptom Diseases 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US53120103P | 2003-12-19 | 2003-12-19 | |
| PCT/US2004/042271 WO2005061002A2 (en) | 2003-12-19 | 2004-12-15 | Composition and methods for modulating cns activity |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2007521333A JP2007521333A (ja) | 2007-08-02 |
| JP2007521333A5 true JP2007521333A5 (enExample) | 2008-01-17 |
Family
ID=34710209
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2006545433A Withdrawn JP2007521333A (ja) | 2003-12-19 | 2004-12-15 | 中枢神経系の活動を調節するための組成物および方法 |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US20050203014A1 (enExample) |
| EP (1) | EP1694353A2 (enExample) |
| JP (1) | JP2007521333A (enExample) |
| CN (1) | CN1917897A (enExample) |
| AU (1) | AU2004305582A1 (enExample) |
| BR (1) | BRPI0417491A (enExample) |
| CA (1) | CA2547338A1 (enExample) |
| MX (1) | MXPA06006659A (enExample) |
| WO (1) | WO2005061002A2 (enExample) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20040224302A1 (en) * | 2002-07-16 | 2004-11-11 | Thomas Jessel | Systems and methods for screening for modulators of neural differentiation |
| US7390659B2 (en) | 2002-07-16 | 2008-06-24 | The Trustees Of Columbia University In The City Of New York | Methods for inducing differentiation of embryonic stem cells and uses thereof |
| US7632679B2 (en) * | 2002-07-16 | 2009-12-15 | The Trustees Of Columbia University In The City Of New York | Systems and methods for screening for modulators of neural differentiation |
| WO2007028770A1 (en) * | 2005-09-05 | 2007-03-15 | Neurosearch A/S | Monoamine neurotransmitter re-uptake inhibitors for neuroprotection in patients suffering from an advanced stage of a mental disease |
| WO2008020864A2 (en) * | 2005-11-14 | 2008-02-21 | The Trustees Of Columbia University In The City Of New York | Imaging correlates of neurogenesis with mri |
| US9765297B2 (en) * | 2007-04-13 | 2017-09-19 | The Trustees Of Columbia University In The City Of New York | Stem cell-based culture system for drug development |
| US8969081B2 (en) * | 2008-12-10 | 2015-03-03 | The Trustees Of Columbia University In The City Of New York | Caudal motor neuron derived from embryonic stem cells under conditions essentially free of any retinoid |
| FR2966733B1 (fr) * | 2010-10-29 | 2012-12-14 | Centre Nat Rech Scient | Nouvelles strategies therapeutiques impliquant la voie de signalisation hedgehog |
| CN104740633A (zh) * | 2013-12-26 | 2015-07-01 | 中国科学院上海生命科学研究院 | Shh信号通路特异性抑制剂的应用 |
| JP6193176B2 (ja) * | 2014-05-12 | 2017-09-06 | ライオン株式会社 | 活力及び／又は集中力向上剤 |
| CN111551729B (zh) * | 2020-04-27 | 2021-02-09 | 浙江正熙生物技术股份有限公司 | 藻红蛋白免疫荧光探针制备方法 |
Family Cites Families (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6610656B1 (en) * | 1993-12-30 | 2003-08-26 | President And Fellows Of Harvard College | Method of promoting chondrocyte differentiation with hedgehog related polypeptides |
| US5789543A (en) * | 1993-12-30 | 1998-08-04 | President And Fellows Of Harvard College | Vertebrate embryonic pattern-inducing proteins and uses related thereto |
| US6271363B1 (en) * | 1993-12-30 | 2001-08-07 | President & Fellows Of Harvard College | Nucleic acids encoding hedgehog proteins |
| US6165747A (en) * | 1993-12-30 | 2000-12-26 | President & Fellows Of Harvard College | Nucleic acids encoding hedgehog proteins |
| US6261786B1 (en) * | 1993-12-30 | 2001-07-17 | Imperial Cancer Res. Technology | Screening assays for hedgehog agonists and antagonists |
| JP3776454B2 (ja) * | 1994-10-07 | 2006-05-17 | ザ ボード オブ トラスティーズ オブ ザ リーランド スタンフォード ジュニア ユニバーシティ | パッチド遺伝子及びそれらの使用 |
| US6429354B1 (en) * | 1994-10-07 | 2002-08-06 | The Board Of Trustees Of The Leland Stanford Junior University | Patched genes and uses related thereto |
| US6027882A (en) * | 1994-10-07 | 2000-02-22 | The Regents Of The University Of California | Patched genes and their use for diagnostics |
| US7144997B2 (en) * | 1997-07-24 | 2006-12-05 | Curis, Inc. | Vertebrate embryonic patterning-inducing proteins, compositions and uses related therto |
| US6897297B1 (en) * | 1997-12-03 | 2005-05-24 | Curis, Inc. | Hydrophobically-modified protein compositions and methods |
| WO2000035948A1 (en) * | 1998-12-03 | 2000-06-22 | Biogen, Inc. | Methods and compositions for treating disorders involving excitotoxicity |
| EP1743903A2 (en) * | 1998-12-03 | 2007-01-17 | Curis, Inc. | Methods and compositions for treating disorders involving excitotoxicity |
| WO2001046227A2 (en) * | 1999-12-21 | 2001-06-28 | University Of Zurich | 'dispatched' polypeptides |
| US6683192B2 (en) * | 2000-03-30 | 2004-01-27 | Curis, Inc. | Small organic molecule regulators of cell proliferation |
| AU2001259252A1 (en) * | 2000-04-28 | 2001-11-12 | Curis, Inc. | Neuroprotective compositions |
| EP1353665A4 (en) * | 2000-12-21 | 2004-05-06 | Mclean Hospital Corp | Treatment of depression |
| US20060078499A1 (en) * | 2003-12-01 | 2006-04-13 | Rene Hen | Use of hedgehog agonist to treat depression |
-
2004
- 2004-12-15 WO PCT/US2004/042271 patent/WO2005061002A2/en not_active Ceased
- 2004-12-15 CN CNA200480041838XA patent/CN1917897A/zh active Pending
- 2004-12-15 JP JP2006545433A patent/JP2007521333A/ja not_active Withdrawn
- 2004-12-15 MX MXPA06006659A patent/MXPA06006659A/es not_active Application Discontinuation
- 2004-12-15 BR BRPI0417491-7A patent/BRPI0417491A/pt not_active IP Right Cessation
- 2004-12-15 AU AU2004305582A patent/AU2004305582A1/en not_active Abandoned
- 2004-12-15 CA CA002547338A patent/CA2547338A1/en not_active Abandoned
- 2004-12-15 EP EP04814451A patent/EP1694353A2/en not_active Withdrawn
- 2004-12-20 US US11/018,739 patent/US20050203014A1/en not_active Abandoned
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