JP2012530073A5 - - Google Patents

Info

Publication number

JP2012530073A5

JP2012530073A5 JP2012515290A JP2012515290A JP2012530073A5 JP 2012530073 A5 JP2012530073 A5 JP 2012530073A5 JP 2012515290 A JP2012515290 A JP 2012515290A JP 2012515290 A JP2012515290 A JP 2012515290A JP 2012530073 A5 JP2012530073 A5 JP 2012530073A5

Authority

JP

Japan

Prior art keywords

seq

peptide

compound

peptidomimetic

amino acid

Prior art date

2010-06-18

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Pending

Links

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• 108090000765 processed proteins & peptides Proteins 0.000 claims 14
• 239000000816 peptidomimetic Substances 0.000 claims 13
• 150000001875 compounds Chemical class 0.000 claims 12
• 108090000790 Enzymes Proteins 0.000 claims 8
• 102000004190 Enzymes Human genes 0.000 claims 8
• 125000003275 alpha amino acid group Chemical group 0.000 claims 7
• 230000001580 bacterial effect Effects 0.000 claims 7
• 239000008194 pharmaceutical composition Substances 0.000 claims 7
• FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 5
• 150000001768 cations Chemical class 0.000 claims 4
• 238000000034 method Methods 0.000 claims 4
• 208000028169 periodontal disease Diseases 0.000 claims 4
• 230000000694 effects Effects 0.000 claims 3
• 230000002401 inhibitory effect Effects 0.000 claims 3
• 238000006467 substitution reaction Methods 0.000 claims 3
• 108091020100 Gingipain Cysteine Endopeptidases Proteins 0.000 claims 2
• HCHKCACWOHOZIP-UHFFFAOYSA-N Zinc Chemical compound [Zn] HCHKCACWOHOZIP-UHFFFAOYSA-N 0.000 claims 2
• 239000003937 drug carrier Substances 0.000 claims 2
• 239000011701 zinc Substances 0.000 claims 2
• 229910052725 zinc Inorganic materials 0.000 claims 2
• 241000605862 Porphyromonas gingivalis Species 0.000 claims 1
• 239000005018 casein Substances 0.000 claims 1
• BECPQYXYKAMYBN-UHFFFAOYSA-N casein, tech. Chemical compound NCCCCC(C(O)=O)N=C(O)C(CC(O)=O)N=C(O)C(CCC(O)=N)N=C(O)C(CC(C)C)N=C(O)C(CCC(O)=O)N=C(O)C(CC(O)=O)N=C(O)C(CCC(O)=O)N=C(O)C(C(C)O)N=C(O)C(CCC(O)=N)N=C(O)C(CCC(O)=N)N=C(O)C(CCC(O)=N)N=C(O)C(CCC(O)=O)N=C(O)C(CCC(O)=O)N=C(O)C(COP(O)(O)=O)N=C(O)C(CCC(O)=N)N=C(O)C(N)CC1=CC=CC=C1 BECPQYXYKAMYBN-UHFFFAOYSA-N 0.000 claims 1
• 235000021240 caseins Nutrition 0.000 claims 1
• 239000003814 drug Substances 0.000 claims 1
• 239000012634 fragment Substances 0.000 claims 1
• 239000000203 mixture Substances 0.000 claims 1