JP2012525391A5 - - Google Patents

Info

Publication number

JP2012525391A5

JP2012525391A5 JP2012508570A JP2012508570A JP2012525391A5 JP 2012525391 A5 JP2012525391 A5 JP 2012525391A5 JP 2012508570 A JP2012508570 A JP 2012508570A JP 2012508570 A JP2012508570 A JP 2012508570A JP 2012525391 A5 JP2012525391 A5 JP 2012525391A5

Authority

JP

Japan

Prior art keywords

glycopeptide antibiotic

glycopeptide

binds

administration

bacterial infection

Prior art date

2010-04-26

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Pending

Links

• Espacenet
• Global Dossier
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• 239000003910 polypeptide antibiotic agent Substances 0.000 claims 61
• MYPYJXKWCTUITO-LYRMYLQWSA-N vancomycin Chemical compound O([C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@H]1OC1=C2C=C3C=C1OC1=CC=C(C=C1Cl)[C@@H](O)[C@H](C(N[C@@H](CC(N)=O)C(=O)N[C@H]3C(=O)N[C@H]1C(=O)N[C@H](C(N[C@@H](C3=CC(O)=CC(O)=C3C=3C(O)=CC=C1C=3)C(O)=O)=O)[C@H](O)C1=CC=C(C(=C1)Cl)O2)=O)NC(=O)[C@@H](CC(C)C)NC)[C@H]1C[C@](C)(N)[C@H](O)[C@H](C)O1 MYPYJXKWCTUITO-LYRMYLQWSA-N 0.000 claims 52
• 102000004506 Blood Proteins Human genes 0.000 claims 25
• 108010017384 Blood Proteins Proteins 0.000 claims 25
• 208000035143 Bacterial infection Diseases 0.000 claims 19
• 208000022362 bacterial infectious disease Diseases 0.000 claims 19
• 239000003814 drug Substances 0.000 claims 12
• 238000005259 measurement Methods 0.000 claims 11
• 238000004519 manufacturing process Methods 0.000 claims 6
• 239000000203 mixture Substances 0.000 claims 6
• 108010006945 oritavancin Proteins 0.000 claims 6
• VHFGEBVPHAGQPI-MYYQHNLBSA-N oritavancin Chemical compound O([C@@H]1C2=CC=C(C(=C2)Cl)OC=2C=C3C=C(C=2O[C@H]2[C@@H]([C@@H](O)[C@H](O)[C@@H](CO)O2)O[C@@H]2O[C@@H](C)[C@H](O)[C@@](C)(NCC=4C=CC(=CC=4)C=4C=CC(Cl)=CC=4)C2)OC2=CC=C(C=C2Cl)[C@@H](O)[C@H](C(N[C@@H](CC(N)=O)C(=O)N[C@H]3C(=O)N[C@H]2C(=O)N[C@@H]1C(N[C@H](C1=CC(O)=CC(O)=C1C=1C(O)=CC=C2C=1)C(O)=O)=O)=O)NC(=O)[C@@H](CC(C)C)NC)[C@H]1C[C@](C)(N)[C@@H](O)[C@H](C)O1 VHFGEBVPHAGQPI-MYYQHNLBSA-N 0.000 claims 6
• 229960001607 oritavancin Drugs 0.000 claims 6
• 230000002265 prevention Effects 0.000 claims 6
• 150000003839 salts Chemical class 0.000 claims 6
• 239000012453 solvate Substances 0.000 claims 6
• 229940079593 drug Drugs 0.000 claims 4
• 230000008506 pathogenesis Effects 0.000 claims 2
• AEMRFAOFKBGASW-UHFFFAOYSA-M Glycolate Chemical compound OCC([O-])=O AEMRFAOFKBGASW-UHFFFAOYSA-M 0.000 claims 1
• 238000000502 dialysis Methods 0.000 claims 1
• 239000003085 diluting agent Substances 0.000 claims 1
• 239000003937 drug carrier Substances 0.000 claims 1
• 208000015181 infectious disease Diseases 0.000 claims 1
• 238000001990 intravenous administration Methods 0.000 claims 1
• 239000008194 pharmaceutical composition Substances 0.000 claims 1
• 238000000108 ultra-filtration Methods 0.000 claims 1
• 238000005199 ultracentrifugation Methods 0.000 claims 1