JP2013509389A5 - - Google Patents
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- Publication number
- JP2013509389A5 JP2013509389A5 JP2012535924A JP2012535924A JP2013509389A5 JP 2013509389 A5 JP2013509389 A5 JP 2013509389A5 JP 2012535924 A JP2012535924 A JP 2012535924A JP 2012535924 A JP2012535924 A JP 2012535924A JP 2013509389 A5 JP2013509389 A5 JP 2013509389A5
- Authority
- JP
- Japan
- Prior art keywords
- amino acid
- therapeutic agent
- peptidomimetic
- peptide
- cytolytic
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000000816 peptidomimetic Substances 0.000 claims description 18
- 108090000765 processed proteins & peptides Proteins 0.000 claims description 18
- 150000001413 amino acids Chemical class 0.000 claims description 6
- 238000009472 formulation Methods 0.000 claims description 6
- 239000000203 mixture Substances 0.000 claims description 6
- 239000002246 antineoplastic agent Substances 0.000 claims description 4
- 210000004881 tumor cell Anatomy 0.000 claims description 4
- 230000000844 anti-bacterial effect Effects 0.000 claims description 3
- 208000015181 infectious disease Diseases 0.000 claims description 3
- 239000003242 anti bacterial agent Substances 0.000 claims description 2
- 229940088710 antibiotic agent Drugs 0.000 claims description 2
- 230000003115 biocidal effect Effects 0.000 claims description 2
- 150000003862 amino acid derivatives Chemical class 0.000 claims 13
- 239000003814 drug Substances 0.000 claims 13
- 229940124597 therapeutic agent Drugs 0.000 claims 11
- 230000001461 cytolytic effect Effects 0.000 claims 10
- 125000001424 substituent group Chemical group 0.000 claims 9
- 125000004122 cyclic group Chemical group 0.000 claims 6
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims 6
- 102000004196 processed proteins & peptides Human genes 0.000 claims 5
- 150000001576 beta-amino acids Chemical class 0.000 claims 4
- 229910052799 carbon Inorganic materials 0.000 claims 3
- 125000004432 carbon atom Chemical group C* 0.000 claims 2
- 125000000113 cyclohexyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C([H])([H])C1([H])[H] 0.000 claims 2
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 2
- HOKSRCHGQCOMHM-CYBMUJFWSA-N (2R)-2-[3-(benzylamino)propanoylamino]-5-(diaminomethylideneamino)pentanoic acid Chemical compound C1(=CC=CC=C1)CNCCC(=O)N[C@H](CCCNC(N)=N)C(=O)O HOKSRCHGQCOMHM-CYBMUJFWSA-N 0.000 claims 1
- 239000004475 Arginine Substances 0.000 claims 1
- 208000035143 Bacterial infection Diseases 0.000 claims 1
- 239000004472 Lysine Substances 0.000 claims 1
- KDXKERNSBIXSRK-UHFFFAOYSA-N Lysine Natural products NCCCCC(N)C(O)=O KDXKERNSBIXSRK-UHFFFAOYSA-N 0.000 claims 1
- 206010027476 Metastases Diseases 0.000 claims 1
- ODKSFYDXXFIFQN-UHFFFAOYSA-N arginine Natural products OC(=O)C(N)CCCNC(N)=N ODKSFYDXXFIFQN-UHFFFAOYSA-N 0.000 claims 1
- 125000004429 atom Chemical group 0.000 claims 1
- 208000022362 bacterial infectious disease Diseases 0.000 claims 1
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 claims 1
- -1 cationic amino acid Chemical class 0.000 claims 1
- 230000006037 cell lysis Effects 0.000 claims 1
- 239000003795 chemical substances by application Substances 0.000 claims 1
- 150000001875 compounds Chemical class 0.000 claims 1
- 239000003085 diluting agent Substances 0.000 claims 1
- 230000002401 inhibitory effect Effects 0.000 claims 1
- 230000009401 metastasis Effects 0.000 claims 1
- 229910052757 nitrogen Inorganic materials 0.000 claims 1
- 229910052760 oxygen Inorganic materials 0.000 claims 1
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
- 229910052717 sulfur Inorganic materials 0.000 claims 1
- 238000002560 therapeutic procedure Methods 0.000 claims 1
- 230000004614 tumor growth Effects 0.000 claims 1
- 230000002265 prevention Effects 0.000 description 2
- 0 **(*)(*(*)(*)N)C(*)=O Chemical compound **(*)(*(*)(*)N)C(*)=O 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB0919194.1A GB0919194D0 (en) | 2009-11-02 | 2009-11-02 | Compounds |
| GB0919194.1 | 2009-11-02 | ||
| PCT/GB2010/002024 WO2011051692A1 (en) | 2009-11-02 | 2010-11-02 | Therapeutic peptides |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2013509389A JP2013509389A (ja) | 2013-03-14 |
| JP2013509389A5 true JP2013509389A5 (enExample) | 2013-12-19 |
| JP5810090B2 JP5810090B2 (ja) | 2015-11-11 |
Family
ID=41435032
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012535924A Active JP5810090B2 (ja) | 2009-11-02 | 2010-11-02 | 治療用ペプチド |
Country Status (14)
| Country | Link |
|---|---|
| US (1) | US8809280B2 (enExample) |
| EP (1) | EP2496596B1 (enExample) |
| JP (1) | JP5810090B2 (enExample) |
| KR (1) | KR101730680B1 (enExample) |
| CN (1) | CN102762586B (enExample) |
| AU (1) | AU2010311186B2 (enExample) |
| CA (1) | CA2777749C (enExample) |
| DK (1) | DK2496596T3 (enExample) |
| ES (1) | ES2621188T3 (enExample) |
| GB (1) | GB0919194D0 (enExample) |
| NZ (1) | NZ599791A (enExample) |
| PL (1) | PL2496596T3 (enExample) |
| RU (2) | RU2548905C2 (enExample) |
| WO (1) | WO2011051692A1 (enExample) |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| HUE054006T2 (hu) | 2011-12-28 | 2021-08-30 | Chugai Pharmaceutical Co Ltd | Eljárás peptid vegyület ciklizálására |
| US10815489B2 (en) | 2015-03-13 | 2020-10-27 | Chugai Seiyaku Kabushiki Kaisha | Modified aminoacyl-tRNA synthetase and use thereof |
| GB201601868D0 (en) | 2016-02-02 | 2016-03-16 | Lytix Biopharma As | Methods |
| KR20180133463A (ko) * | 2016-04-14 | 2018-12-14 | 타오 헬스 라이프 파마 가부시키가이샤 | 아밀로스페로이드(aspd) 결합 저해 펩타이드, 및 평가 및 스크리닝 방법 |
| US12391971B2 (en) | 2017-01-31 | 2025-08-19 | Chugai Seiyaku Kabushiki Kaisha | Method for synthesizing peptides in cell-free translation system |
| GB201705255D0 (en) * | 2017-03-31 | 2017-05-17 | Univ I Tromsø - Norges Arktiske Univ | Bioactive cyclic compounds |
| WO2018188761A1 (en) | 2017-04-13 | 2018-10-18 | Lytix Biopharma As | Method of reducing population size of tregs and/or mdscs |
| KR102744693B1 (ko) | 2017-06-09 | 2024-12-18 | 추가이 세이야쿠 가부시키가이샤 | N-치환 아미노산을 포함하는 펩타이드의 합성 방법 |
| CN111479819B (zh) | 2017-12-15 | 2024-06-14 | 中外制药株式会社 | 制备肽的方法和处理碱的方法 |
| KR102841441B1 (ko) | 2018-11-07 | 2025-07-31 | 추가이 세이야쿠 가부시키가이샤 | O-치환 세린 유도체의 제조 방법 |
| CN113056475B (zh) | 2018-11-30 | 2024-09-24 | 中外制药株式会社 | 用于肽化合物或酰胺化合物的脱保护方法和在固相反应中的树脂脱除方法以及用于生产肽化合物的方法 |
| JP7472101B2 (ja) | 2019-03-15 | 2024-04-22 | 中外製薬株式会社 | 芳香族アミノ酸誘導体の製造方法 |
| CN110294793B (zh) * | 2019-06-24 | 2023-10-27 | 合肥科生景肽生物科技有限公司 | Sumo荧光探针及其制备方法 |
| BR112022007535A2 (pt) | 2019-11-07 | 2022-07-12 | Chugai Pharmaceutical Co Ltd | Composto peptídico cíclico tendo ação inibitória de kras |
| CN114790151B (zh) * | 2022-02-14 | 2023-03-31 | 湖南省湘中制药有限公司 | 一种2-氰基-2-丙戊酸甲酯的复合催化制备方法 |
| KR20250122523A (ko) | 2022-12-20 | 2025-08-13 | 리틱스 바이오파마 에이에스 | 종양 용해성 펩티드 및 키토산을 포함하는 조성물 |
Family Cites Families (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4342705A (en) | 1979-11-23 | 1982-08-03 | Monsanto Company | Methylene thioethers |
| AU565221B2 (en) | 1982-06-03 | 1987-09-10 | Montedison S.P.A. | 2-(1,2,4-triazol-1-yl) propanone derivatives |
| IT1161927B (it) | 1983-03-31 | 1987-03-18 | Montedison Spa | Furano-derivati ad attivita' fungicida |
| DK523288A (da) | 1987-10-06 | 1989-04-07 | Hoffmann La Roche | Aminosyrederivater |
| CA1328333C (en) | 1988-03-04 | 1994-04-05 | Quirico Branca | Amino acid derivatives |
| US5593967A (en) | 1990-08-31 | 1997-01-14 | Warner-Lambert Company | Cholecystokinin antagonists, their preparation and therapeutic use |
| NZ239595A (en) | 1990-08-31 | 1994-06-27 | Warner Lambert Co | Cholecystokinin antagonistic compounds ; pharmaceutical compositions and use thereof |
| US5387671A (en) * | 1990-12-27 | 1995-02-07 | Abbott Laboratories | Hexa- and heptapeptide anaphylatoxin-receptor ligands |
| US5885782A (en) | 1994-09-13 | 1999-03-23 | Nce Pharmaceuticals, Inc. | Synthetic antibiotics |
| DE69628856T2 (de) | 1996-01-02 | 2004-05-06 | Aventis Pharmaceuticals Inc. | Substituierte n-[(aminoiminomethyl oder aminomethyl)phenyl]propylamide |
| US6080767A (en) | 1996-01-02 | 2000-06-27 | Aventis Pharmaceuticals Products Inc. | Substituted n-[(aminoiminomethyl or aminomethyl)phenyl]propyl amides |
| US6323227B1 (en) | 1996-01-02 | 2001-11-27 | Aventis Pharmaceuticals Products Inc. | Substituted N-[(aminoiminomethyl or aminomethyl)phenyl]propyl amides |
| JP3734907B2 (ja) | 1996-12-19 | 2006-01-11 | 富士写真フイルム株式会社 | 現像処理方法 |
| DE102006018080A1 (de) * | 2006-04-13 | 2007-10-18 | Aicuris Gmbh & Co. Kg | Lysobactinamide |
| EP2046363A1 (en) * | 2006-07-10 | 2009-04-15 | Österreichische Akademie der Wissenschaften | Antimicrobial peptides |
| GB0724951D0 (en) * | 2007-12-20 | 2008-01-30 | Lytix Biopharma As | Compounds |
| ATE482186T1 (de) | 2008-03-18 | 2010-10-15 | Univ Dresden Tech | Modulares gerüst zur gestaltung von spezifischen molekülen zur verwendung als pepitmimetika und hemmer für die proteininteraktion |
-
2009
- 2009-11-02 GB GBGB0919194.1A patent/GB0919194D0/en not_active Ceased
-
2010
- 2010-11-02 CN CN201080049560.6A patent/CN102762586B/zh active Active
- 2010-11-02 EP EP10784830.1A patent/EP2496596B1/en active Active
- 2010-11-02 RU RU2012121264/04A patent/RU2548905C2/ru active
- 2010-11-02 NZ NZ599791A patent/NZ599791A/en unknown
- 2010-11-02 PL PL10784830T patent/PL2496596T3/pl unknown
- 2010-11-02 RU RU2015111706A patent/RU2676713C2/ru active
- 2010-11-02 KR KR1020127014266A patent/KR101730680B1/ko active Active
- 2010-11-02 US US13/505,625 patent/US8809280B2/en active Active
- 2010-11-02 CA CA2777749A patent/CA2777749C/en active Active
- 2010-11-02 ES ES10784830.1T patent/ES2621188T3/es active Active
- 2010-11-02 DK DK10784830.1T patent/DK2496596T3/en active
- 2010-11-02 WO PCT/GB2010/002024 patent/WO2011051692A1/en not_active Ceased
- 2010-11-02 AU AU2010311186A patent/AU2010311186B2/en active Active
- 2010-11-02 JP JP2012535924A patent/JP5810090B2/ja active Active
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