JP2015512621A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2015512621A5 JP2015512621A5 JP2014558137A JP2014558137A JP2015512621A5 JP 2015512621 A5 JP2015512621 A5 JP 2015512621A5 JP 2014558137 A JP2014558137 A JP 2014558137A JP 2014558137 A JP2014558137 A JP 2014558137A JP 2015512621 A5 JP2015512621 A5 JP 2015512621A5
- Authority
- JP
- Japan
- Prior art keywords
- binding
- reagent
- receptor
- stationary phase
- affinity
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000003153 chemical reaction reagent Substances 0.000 claims description 223
- 108020003175 receptors Proteins 0.000 claims description 187
- 102000005962 receptors Human genes 0.000 claims description 187
- 210000004027 cell Anatomy 0.000 claims description 135
- 230000005526 G1 to G0 transition Effects 0.000 claims description 120
- 238000000034 method Methods 0.000 claims description 100
- 238000004587 chromatography analysis Methods 0.000 claims description 39
- 239000012504 chromatography matrix Substances 0.000 claims description 36
- 238000001042 affinity chromatography Methods 0.000 claims description 35
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 claims description 30
- 239000011159 matrix material Substances 0.000 claims description 26
- 230000002860 competitive effect Effects 0.000 claims description 18
- 238000002523 gelfiltration Methods 0.000 claims description 16
- 239000000377 silicon dioxide Substances 0.000 claims description 15
- 108090001008 Avidin Proteins 0.000 claims description 13
- 239000000499 gel Substances 0.000 claims description 13
- 238000010494 dissociation reaction Methods 0.000 claims description 12
- 230000005593 dissociations Effects 0.000 claims description 12
- 230000002441 reversible effect Effects 0.000 claims description 12
- 150000004676 glycans Chemical class 0.000 claims description 11
- 229920001282 polysaccharide Polymers 0.000 claims description 11
- 239000005017 polysaccharide Substances 0.000 claims description 11
- 108010090804 Streptavidin Proteins 0.000 claims description 10
- 238000001641 gel filtration chromatography Methods 0.000 claims description 10
- 238000000926 separation method Methods 0.000 claims description 10
- 108091023037 Aptamer Proteins 0.000 claims description 8
- 229920001577 copolymer Polymers 0.000 claims description 8
- 108010021625 Immunoglobulin Fragments Proteins 0.000 claims description 7
- 102000008394 Immunoglobulin Fragments Human genes 0.000 claims description 7
- 239000012530 fluid Substances 0.000 claims description 7
- 230000003100 immobilizing effect Effects 0.000 claims description 7
- YBJHBAHKTGYVGT-ZKWXMUAHSA-N (+)-Biotin Chemical compound N1C(=O)N[C@@H]2[C@H](CCCCC(=O)O)SC[C@@H]21 YBJHBAHKTGYVGT-ZKWXMUAHSA-N 0.000 claims description 6
- 108060003951 Immunoglobulin Proteins 0.000 claims description 6
- 210000003855 cell nucleus Anatomy 0.000 claims description 6
- 102000018358 immunoglobulin Human genes 0.000 claims description 6
- 239000012528 membrane Substances 0.000 claims description 6
- 239000000203 mixture Substances 0.000 claims description 6
- 238000010828 elution Methods 0.000 claims description 5
- 239000000696 magnetic material Substances 0.000 claims description 5
- 239000000463 material Substances 0.000 claims description 5
- NIXOWILDQLNWCW-UHFFFAOYSA-M Acrylate Chemical compound [O-]C(=O)C=C NIXOWILDQLNWCW-UHFFFAOYSA-M 0.000 claims description 4
- 102000017727 Immunoglobulin Variable Region Human genes 0.000 claims description 4
- 108010067060 Immunoglobulin Variable Region Proteins 0.000 claims description 4
- 239000011543 agarose gel Substances 0.000 claims description 4
- 210000001124 body fluid Anatomy 0.000 claims description 4
- 239000010839 body fluid Substances 0.000 claims description 4
- 150000002009 diols Chemical class 0.000 claims description 4
- 229940072221 immunoglobulins Drugs 0.000 claims description 4
- 210000000265 leukocyte Anatomy 0.000 claims description 4
- 210000004698 lymphocyte Anatomy 0.000 claims description 4
- ZIUHHBKFKCYYJD-UHFFFAOYSA-N n,n'-methylenebisacrylamide Chemical compound C=CC(=O)NCNC(=O)C=C ZIUHHBKFKCYYJD-UHFFFAOYSA-N 0.000 claims description 4
- 229920002401 polyacrylamide Polymers 0.000 claims description 4
- 108090000765 processed proteins & peptides Proteins 0.000 claims description 4
- LFJAQMVCRLUOTJ-BYPYZUCNSA-N (2s)-2-amino-n-(2-hydroxyethyl)butanediamide Chemical compound NC(=O)C[C@H](N)C(=O)NCCO LFJAQMVCRLUOTJ-BYPYZUCNSA-N 0.000 claims description 3
- CHRJZRDFSQHIFI-UHFFFAOYSA-N 1,2-bis(ethenyl)benzene;styrene Chemical compound C=CC1=CC=CC=C1.C=CC1=CC=CC=C1C=C CHRJZRDFSQHIFI-UHFFFAOYSA-N 0.000 claims description 3
- HRPVXLWXLXDGHG-UHFFFAOYSA-N Acrylamide Chemical compound NC(=O)C=C HRPVXLWXLXDGHG-UHFFFAOYSA-N 0.000 claims description 3
- 229920003171 Poly (ethylene oxide) Polymers 0.000 claims description 3
- 229960002685 biotin Drugs 0.000 claims description 3
- 235000020958 biotin Nutrition 0.000 claims description 3
- 239000011616 biotin Substances 0.000 claims description 3
- 150000001615 biotins Chemical class 0.000 claims description 3
- 229920002678 cellulose Polymers 0.000 claims description 3
- 239000001913 cellulose Substances 0.000 claims description 3
- 238000004440 column chromatography Methods 0.000 claims description 3
- 239000012634 fragment Substances 0.000 claims description 3
- 238000001292 planar chromatography Methods 0.000 claims description 3
- 229920003023 plastic Polymers 0.000 claims description 3
- 239000004033 plastic Substances 0.000 claims description 3
- 229920003213 poly(N-isopropyl acrylamide) Polymers 0.000 claims description 3
- 229920000058 polyacrylate Polymers 0.000 claims description 3
- 229920000036 polyvinylpyrrolidone Polymers 0.000 claims description 3
- 239000001267 polyvinylpyrrolidone Substances 0.000 claims description 3
- 235000013855 polyvinylpyrrolidone Nutrition 0.000 claims description 3
- 108010018381 streptavidin-binding peptide Proteins 0.000 claims description 3
- 102000001706 Immunoglobulin Fab Fragments Human genes 0.000 claims description 2
- 108010054477 Immunoglobulin Fab Fragments Proteins 0.000 claims description 2
- 239000011230 binding agent Substances 0.000 claims description 2
- 210000004369 blood Anatomy 0.000 claims description 2
- 239000008280 blood Substances 0.000 claims description 2
- 239000012503 blood component Substances 0.000 claims description 2
- 239000003795 chemical substances by application Substances 0.000 claims description 2
- 239000000306 component Substances 0.000 claims description 2
- 230000003993 interaction Effects 0.000 claims description 2
- 210000004962 mammalian cell Anatomy 0.000 claims description 2
- 239000002245 particle Substances 0.000 claims description 2
- 239000011148 porous material Substances 0.000 claims description 2
- 210000000130 stem cell Anatomy 0.000 claims description 2
- 238000005406 washing Methods 0.000 claims description 2
- 102000004169 proteins and genes Human genes 0.000 claims 2
- 108090000623 proteins and genes Proteins 0.000 claims 2
- 102000008102 Ankyrins Human genes 0.000 claims 1
- 108010049777 Ankyrins Proteins 0.000 claims 1
- 108050006654 Lipocalin Proteins 0.000 claims 1
- 102000019298 Lipocalin Human genes 0.000 claims 1
- 239000013078 crystal Substances 0.000 claims 1
- 229920001184 polypeptide Polymers 0.000 claims 1
- 102000004196 processed proteins & peptides Human genes 0.000 claims 1
- 238000003259 recombinant expression Methods 0.000 description 4
- 238000012216 screening Methods 0.000 description 4
- 229920005654 Sephadex Polymers 0.000 description 2
- 239000012541 Fractogel® Substances 0.000 description 1
- 239000012506 Sephacryl® Substances 0.000 description 1
- 239000012507 Sephadex™ Substances 0.000 description 1
- 229920002684 Sepharose Polymers 0.000 description 1
- 108020004707 nucleic acids Proteins 0.000 description 1
- 150000007523 nucleic acids Chemical class 0.000 description 1
- 102000039446 nucleic acids Human genes 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261602150P | 2012-02-23 | 2012-02-23 | |
| US61/602,150 | 2012-02-23 | ||
| PCT/EP2013/053650 WO2013124474A2 (en) | 2012-02-23 | 2013-02-25 | Chromatographic isolation of cells and other complex biological materials |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018034273A Division JP6857626B2 (ja) | 2012-02-23 | 2018-02-28 | 細胞および他の複雑な生物学的材料のクロマトグラフィーによる単離 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2015512621A JP2015512621A (ja) | 2015-04-30 |
| JP2015512621A5 true JP2015512621A5 (enExample) | 2016-04-14 |
| JP6362543B2 JP6362543B2 (ja) | 2018-07-25 |
Family
ID=47891608
Family Applications (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014558137A Active JP6362543B2 (ja) | 2012-02-23 | 2013-02-25 | 細胞および他の複雑な生物学的材料のクロマトグラフィーによる単離 |
| JP2018034273A Active JP6857626B2 (ja) | 2012-02-23 | 2018-02-28 | 細胞および他の複雑な生物学的材料のクロマトグラフィーによる単離 |
| JP2021046729A Active JP7192014B2 (ja) | 2012-02-23 | 2021-03-22 | 細胞および他の複雑な生物学的材料のクロマトグラフィーによる単離 |
| JP2022195658A Active JP7710427B2 (ja) | 2012-02-23 | 2022-12-07 | 細胞および他の複雑な生物学的材料のクロマトグラフィーによる単離 |
Family Applications After (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018034273A Active JP6857626B2 (ja) | 2012-02-23 | 2018-02-28 | 細胞および他の複雑な生物学的材料のクロマトグラフィーによる単離 |
| JP2021046729A Active JP7192014B2 (ja) | 2012-02-23 | 2021-03-22 | 細胞および他の複雑な生物学的材料のクロマトグラフィーによる単離 |
| JP2022195658A Active JP7710427B2 (ja) | 2012-02-23 | 2022-12-07 | 細胞および他の複雑な生物学的材料のクロマトグラフィーによる単離 |
Country Status (11)
| Country | Link |
|---|---|
| US (4) | US10228312B2 (enExample) |
| EP (2) | EP4545964A3 (enExample) |
| JP (4) | JP6362543B2 (enExample) |
| CN (2) | CN106940268B (enExample) |
| AU (4) | AU2013224027B2 (enExample) |
| CA (1) | CA2865033C (enExample) |
| ES (1) | ES3011307T3 (enExample) |
| IN (1) | IN2014DN06475A (enExample) |
| RU (1) | RU2746407C1 (enExample) |
| SG (2) | SG10201606970UA (enExample) |
| WO (1) | WO2013124474A2 (enExample) |
Families Citing this family (66)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2015154048A1 (en) * | 2014-04-03 | 2015-10-08 | Gjerde Douglas T | Devices and methods for purification, detection and use of biological cells |
| US9637719B2 (en) | 2013-12-06 | 2017-05-02 | Douglas T. Gjerde | Devices and methods for purification of biological cells |
| RU2746407C1 (ru) | 2012-02-23 | 2021-04-13 | Стейдж Селл Терапеутикс Гмбх | Хроматографическое выделение клеток и других сложных биологических материалов |
| MX386422B (es) | 2013-12-20 | 2025-03-18 | Fred Hutchinson Cancer Center | Moléculas efectoras químericas etiquetadas y receptores de las mismas. |
| MY184699A (en) | 2014-04-16 | 2021-04-18 | Juno Therapeutics Gmbh | Methods, kits and apparatus for expanding a population of cells |
| AU2015249554B2 (en) | 2014-04-23 | 2021-08-19 | Juno Therapeutics, Inc. | Methods for isolating, culturing, and genetically engineering immune cell populations for adoptive therapy |
| AU2015254588B2 (en) * | 2014-04-30 | 2020-05-21 | Iba Gmbh | Method of isolating a target cell |
| EP2955521A1 (en) * | 2014-06-11 | 2015-12-16 | Centre Hospitalier Universitaire Vaudois (CHUV) | Methods for separating cells |
| WO2016073602A2 (en) * | 2014-11-05 | 2016-05-12 | Juno Therapeutics, Inc. | Methods for transduction and cell processing |
| DE202014105965U1 (de) | 2014-12-10 | 2015-01-26 | Cell.Copedia GmbH | Spritzengehäuse zum Pipettieren eines biologischen Materials mit integrierten Membranen |
| WO2016166568A1 (en) | 2015-04-16 | 2016-10-20 | Juno Therapeutics Gmbh | Methods, kits and apparatus for expanding a population of cells |
| US11827904B2 (en) | 2015-04-29 | 2023-11-28 | Fred Hutchinson Cancer Center | Modified stem cells and uses thereof |
| CN105606815A (zh) * | 2015-05-18 | 2016-05-25 | 烟台载通生物技术有限公司 | 一种用于免疫检测的多单元装置 |
| MA45488A (fr) | 2015-10-22 | 2018-08-29 | Juno Therapeutics Gmbh | Procédés, kits et appareil de culture de cellules |
| MA45489A (fr) * | 2015-10-22 | 2018-08-29 | Juno Therapeutics Gmbh | Procédés de culture de cellules, kits et appareil associés |
| CN108474002B (zh) | 2015-10-22 | 2023-05-23 | 朱诺治疗学有限公司 | 用于转导的方法、反应剂盒、反应剂和设备 |
| GB201521784D0 (en) | 2015-12-10 | 2016-01-27 | Univ Birmingham | Cell purification |
| US20240018268A1 (en) | 2016-07-29 | 2024-01-18 | Juno Therapeutics, Inc. | Anti-idiotypic antibodies against anti-cd19 antibodies |
| US10294454B2 (en) | 2016-08-24 | 2019-05-21 | General Electric Company | Methods and kits for cell activation |
| WO2018112557A1 (en) * | 2016-12-23 | 2018-06-28 | Altnia Operations Pty Ltd | Methods and compositions for purification or isolation of microvesicles and exosomes |
| MX2019008538A (es) | 2017-01-20 | 2019-11-05 | Juno Therapeutics Gmbh | Conjugados de superficie celular y composiciones y métodos celulares relacionados. |
| SG11201909931PA (en) * | 2017-04-27 | 2019-11-28 | Juno Therapeutics Gmbh | Oligomeric particle reagents and methods of use thereof |
| BR112020001719A2 (pt) | 2017-07-29 | 2020-07-21 | Juno Therapeutics Inc | reagentes para expansão de células que expressam receptores recombinantes |
| MX2020001490A (es) | 2017-08-09 | 2020-08-06 | Juno Therapeutics Inc | Metodos para producir composiciones de celulas geneticamente modificadas y composiciones relacionadas. |
| PL3704230T3 (pl) | 2017-11-01 | 2025-02-24 | Juno Therapeutics, Inc. | Proces wytwarzania kompozycji terapeutycznych z komórek zmodyfikowanych genetycznie |
| WO2019113557A1 (en) | 2017-12-08 | 2019-06-13 | Juno Therapeutics, Inc. | Process for producing a composition of engineered t cells |
| EP3731947B1 (en) | 2017-12-29 | 2023-03-01 | The United States of America, as represented by the Secretary, Department of Health and Human Services | Purification and labeling of extracellular vesicles using a mixed mode resin composition |
| WO2019183334A1 (en) * | 2018-03-21 | 2019-09-26 | Waters Technologies Corporation | Non-antibody high-affinity-based sample preparation, sorbents, devices and methods |
| EA202190022A1 (ru) | 2018-06-18 | 2021-03-18 | Эксофарм Лимитид | Способы и композиции для очистки или выделения микровезикул и экзосом |
| KR20210031927A (ko) * | 2018-07-17 | 2021-03-23 | 유니버시티 오브 워싱톤 | 압타머 기반 가역적 세포 선택과 관련된 조성물 및 방법 |
| CN113474450A (zh) | 2018-08-09 | 2021-10-01 | 朱诺治疗学股份有限公司 | 产生工程化细胞的方法以及所述工程化细胞的组合物 |
| US12366580B2 (en) | 2018-09-11 | 2025-07-22 | Juno Therapeutics, Inc. | Methods for mass spectrometry analysis of engineered cell compositions |
| JP7582940B2 (ja) | 2018-10-31 | 2024-11-13 | ジュノ セラピューティクス ゲーエムベーハー | 細胞の選択および刺激のための方法ならびにそのための装置 |
| EP3877054B1 (en) | 2018-11-06 | 2023-11-01 | Juno Therapeutics, Inc. | Process for producing genetically engineered t cells |
| AU2020287882A1 (en) | 2019-06-07 | 2022-01-20 | Juno Therapeutics, Inc. | Automated T cell culture |
| JP2022538125A (ja) * | 2019-06-27 | 2022-08-31 | バイオイミュネイト テクノロジーズ リミテッド | 多発性硬化症関連ｔ細胞の除去のためのフィルター |
| US12444491B2 (en) | 2019-08-30 | 2025-10-14 | Juno Therapeutics, Inc. | Machine learning methods for classifying cells |
| CN114502717A (zh) * | 2019-08-30 | 2022-05-13 | 弗洛设计声能学公司 | 多靶受体的声学亲和细胞选择 |
| CN114555204A (zh) * | 2019-09-10 | 2022-05-27 | 皮尔斯生物科技有限公司 | 样品制备组合物、装置、系统和方法 |
| CN114929360A (zh) | 2019-10-30 | 2022-08-19 | 朱诺治疗学有限公司 | 细胞选择和/或刺激装置及使用方法 |
| US20230019849A1 (en) * | 2019-12-09 | 2023-01-19 | St. Jude Children's Research Hospital, Inc. | Method for Preparing CD7-Negative, CD3-Positive T Cells |
| KR20220146480A (ko) | 2020-01-28 | 2022-11-01 | 주노 쎄러퓨티크스 인코퍼레이티드 | Ｔ 세포 형질도입 방법 |
| US11965882B2 (en) | 2020-01-31 | 2024-04-23 | Cell.Copedia GmbH | Methods of isolating a biological entity |
| BR112022015968A2 (pt) | 2020-02-12 | 2022-10-11 | Juno Therapeutics Inc | Composições de células t do receptor de antígeno quimérico direcionado a bcma e métodos e usos das mesmas |
| CN115768443A (zh) | 2020-02-12 | 2023-03-07 | 朱诺治疗学股份有限公司 | Cd19定向嵌合抗原受体t细胞组合物和方法及其用途 |
| JP2023526278A (ja) | 2020-05-13 | 2023-06-21 | ジュノー セラピューティクス インコーポレイテッド | 組み換え受容体を発現しているドナーバッチ細胞を産生するための方法 |
| KR20240018454A (ko) | 2021-05-06 | 2024-02-13 | 주노 테라퓨틱스 게엠베하 | T 세포의 자극 및 형질도입 방법 |
| WO2023017115A1 (en) * | 2021-08-11 | 2023-02-16 | Iba Lifesciences Gmbh | Fractionation of cells based on a marker protein |
| CN113908589B (zh) * | 2021-10-08 | 2022-09-27 | 天津工业大学 | 一种表面印迹抗体的疏水电荷诱导模式膜层析介质及其制备方法 |
| WO2023147510A1 (en) | 2022-01-28 | 2023-08-03 | Juno Therapeutics, Inc. | Chromatography arrays and related methods and kits |
| EP4223381B1 (en) * | 2022-02-02 | 2025-04-02 | Sartorius BIA Separations d.o.o. | Method of purifying or removing a target component from full plasma |
| WO2023213969A1 (en) | 2022-05-05 | 2023-11-09 | Juno Therapeutics Gmbh | Viral-binding protein and related reagents, articles, and methods of use |
| WO2023230581A1 (en) | 2022-05-25 | 2023-11-30 | Celgene Corporation | Methods of manufacturing t cell therapies |
| EP4615960A1 (en) | 2022-11-09 | 2025-09-17 | C3S2 GmbH | Methods for manufacturing engineered immune cells |
| KR20250121074A (ko) | 2022-12-09 | 2025-08-11 | 주노 쎄러퓨티크스 인코퍼레이티드 | 홀로그래픽 이미징을 사용하여 세포 표현형을 예측하기 위한 기계 학습 방법 |
| CN121002052A (zh) | 2023-02-03 | 2025-11-21 | C3S2 有限公司 | 用于非病毒生产工程化免疫细胞的方法 |
| AU2024230609A1 (en) | 2023-02-28 | 2025-09-04 | Juno Therapeutics, Inc. | Cell therapy for treating systemic autoimmune diseases |
| WO2025049247A1 (en) | 2023-08-25 | 2025-03-06 | Juno Therapeutics, Inc. | 5,6-core silacycle based inhibitors of dna-dependent protein kinase and compositions and application in gene editing |
| WO2025049254A1 (en) | 2023-08-25 | 2025-03-06 | Juno Therapeutics, Inc. | Pyrazolopyridine based inhibitors of dna-dependent protein kinase and compositions and application in gene editing |
| WO2025049250A1 (en) | 2023-08-25 | 2025-03-06 | Juno Therapeutics, Inc. | 6,6-core silacycle based inhibitors of dna-dependent protein kinase and compositions and application in gene editing |
| WO2025049253A1 (en) | 2023-08-25 | 2025-03-06 | Juno Therapeutics, Inc. | Bridged cycle‑based inhibitors of dna‑dependent protein kinase and compositions and application in gene editing |
| WO2025083196A1 (en) | 2023-10-18 | 2025-04-24 | Tq Therapeutics Gmbh | A method of manufacturing a cellular therapy product and respective kits and devices |
| US12434218B2 (en) | 2023-11-28 | 2025-10-07 | Phenomenex, Inc. | Pore structure for separation of adeno-associated viruses (AAVS) from their aggregates |
| US20250241912A1 (en) | 2024-01-25 | 2025-07-31 | Juno Therapeutics, Inc. | Use of bridged cycle-based inhibitors of dna-dependent protein kinase in combination of dna polymerase theta inhibitor and compositions and application in gene editing |
| WO2025179188A1 (en) | 2024-02-22 | 2025-08-28 | Juno Therapeutics, Inc. | Pyrazole-based inhibitors of dna-dependent protein kinase and compositions and applications in gene editing |
| WO2025235851A1 (en) | 2024-05-10 | 2025-11-13 | Juno Therapeutics, Inc. | Genetically engineered t cells expressing a cd19 chimeric antigen receptor (car) and uses thereof for allogeneic cell therapy |
Family Cites Families (168)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2467434A (en) | 1947-05-10 | 1949-04-19 | Air Associates Inc | Servomotor and pressure responsive valve therefor |
| US4235871A (en) | 1978-02-24 | 1980-11-25 | Papahadjopoulos Demetrios P | Method of encapsulating biologically active materials in lipid vesicles |
| US4361549A (en) | 1979-04-26 | 1982-11-30 | Ortho Pharmaceutical Corporation | Complement-fixing monoclonal antibody to human T cells, and methods of preparing same |
| US4816567A (en) | 1983-04-08 | 1989-03-28 | Genentech, Inc. | Recombinant immunoglobin preparations |
| DE3583940D1 (de) | 1984-10-02 | 1991-10-02 | Harry M Meade | Herstellung von streptavidinaehnlichen polypeptiden. |
| US4851341A (en) | 1986-12-19 | 1989-07-25 | Immunex Corporation | Immunoaffinity purification system |
| US6352694B1 (en) | 1994-06-03 | 2002-03-05 | Genetics Institute, Inc. | Methods for inducing a population of T cells to proliferate using agents which recognize TCR/CD3 and ligands which stimulate an accessory molecule on the surface of the T cells |
| US6534055B1 (en) | 1988-11-23 | 2003-03-18 | Genetics Institute, Inc. | Methods for selectively stimulating proliferation of T cells |
| GB9215540D0 (en) | 1992-07-22 | 1992-09-02 | Celltech Ltd | Protein expression system |
| DE4237113B4 (de) | 1992-11-03 | 2006-10-12 | "Iba Gmbh" | Peptide und deren Fusionsproteine, Expressionsvektor und Verfahren zur Herstellung eines Fusionsproteins |
| DE4417598A1 (de) | 1994-05-19 | 1995-12-14 | Max Planck Gesellschaft | Verwendung des Tetracyclinpromotors zur stringent regulierten Produktion von rekombinanten Proteinen in prokaryontischen Zellen |
| US7074904B2 (en) | 1994-07-29 | 2006-07-11 | Altor Bioscience Corporation | MHC complexes and uses thereof |
| DE69534880T2 (de) | 1994-07-29 | 2007-02-22 | Sunol Molecular Corp., Miramar | Mhc-komplexe und verwendungen davon |
| WO1996023879A1 (en) | 1995-01-30 | 1996-08-08 | Terrapin Technologies, Inc. | Glubodies - multiplicities of proteins capable of binding a variety of small molecules |
| JPH11501008A (ja) | 1995-02-09 | 1999-01-26 | ユニバーシティ オブ ワシントン | 改変−アフィニティーストレプトアビジン |
| CA2222035A1 (en) | 1995-04-11 | 1997-03-27 | Trustees Of Boston University | Streptavidin mutants |
| US5629205A (en) | 1995-05-19 | 1997-05-13 | Allelix Biopharmaceuticals Inc. | Promoters for gene expression |
| WO1997005266A1 (en) | 1995-07-25 | 1997-02-13 | Introgene B.V. | Methods and means for targeted gene delivery |
| AR005035A1 (es) | 1995-12-11 | 1999-04-07 | Merck Patent Ges Mit Beschränkter Haftung | Procedimiento para preparar proteinas recombinantes en e. coli, mediante fermentacion con gran concentracion de celulas. |
| US5869270A (en) | 1996-01-31 | 1999-02-09 | Sunol Molecular Corporation | Single chain MHC complexes and uses thereof |
| US5773224A (en) | 1996-02-12 | 1998-06-30 | Grandics; Peter | Immunoselection system for cell elution |
| DE19637718A1 (de) | 1996-04-01 | 1997-10-02 | Boehringer Mannheim Gmbh | Rekombinante inaktive Core-Streptavidin Mutanten |
| US6022688A (en) | 1996-05-13 | 2000-02-08 | Sequenom, Inc. | Method for dissociating biotin complexes |
| NZ333915A (en) | 1996-08-16 | 2000-11-24 | Harvard College | Soluble monovalent and multivalent MHC class II fusion proteins |
| US20050003431A1 (en) | 1996-08-16 | 2005-01-06 | Wucherpfennig Kai W. | Monovalent, multivalent, and multimeric MHC binding domain fusion proteins and conjugates, and uses therefor |
| DE19641876B4 (de) | 1996-10-10 | 2011-09-29 | Iba Gmbh | Streptavidinmuteine |
| JP2001514524A (ja) | 1997-03-14 | 2001-09-11 | トラスティーズ オブ ボストン ユニバーシティー | マルチフレイバーストレプトアビジン |
| US6391571B1 (en) | 1997-04-01 | 2002-05-21 | Roche Diagnostics Gmbh | Recombinant inactive avidin mutants |
| ES2323098T3 (es) | 1997-09-16 | 2009-07-06 | Oregon Health And Science University | Moleculas de mhc recombinantes utiles para la manipulacion de celulas t especificas de antigeno. |
| US6232445B1 (en) | 1997-10-29 | 2001-05-15 | Sunol Molecular Corporation | Soluble MHC complexes and methods of use thereof |
| US5985658A (en) * | 1997-11-14 | 1999-11-16 | Health Research Incorporated | Calmodulin-based cell separation technique |
| IL137706A0 (en) | 1998-02-19 | 2001-10-31 | Harvard College | Mhc fusion proteins and conjugates |
| US6664042B1 (en) | 1999-01-26 | 2003-12-16 | Cornell Research Foundation, Inc. | Determining viral load in double negative T cells |
| WO2000046349A1 (en) | 1999-02-04 | 2000-08-10 | Technion Research & Development Foundation Ltd. | Method and apparatus for maintenance and expansion of hemopoietic stem cells and/or progenitor cells |
| EP1048732A1 (de) | 1999-04-26 | 2000-11-02 | F. Hoffmann-La Roche Ag | Verfahren zur Herstellung von natürlich gefalteten und sekretierten Proteinen |
| US6849185B1 (en) | 1999-05-14 | 2005-02-01 | Pall Corp | Charged membrane |
| WO2000069549A1 (en) | 1999-05-14 | 2000-11-23 | Pall Corporation | Charged membrane |
| EP1669129A1 (en) | 1999-05-14 | 2006-06-14 | Pall Corporation | Charged membrane |
| AU783233B2 (en) | 1999-06-07 | 2005-10-06 | Tet Systems Holding Gmbh & Co. Kg | Novel TET repressor-based transcriptional regulatory proteins |
| DE19932688B4 (de) | 1999-07-13 | 2009-10-08 | Scil Proteins Gmbh | Design von Beta-Faltblatt-Proteinen des gamma-II-kristallins antikörperähnlichen |
| US20030235908A1 (en) | 2000-02-24 | 2003-12-25 | Xcyte Therapies, Inc. | Activation and expansion of cells |
| ES2283399T3 (es) | 2000-04-25 | 2007-11-01 | Otsuka Pharmaceutical Co., Ltd. | Peptidomimetico de gd3. |
| US6638728B1 (en) | 2000-06-16 | 2003-10-28 | Pierce Biotechnology, Inc. | Coated surfaces with high capacity for capturing target molecules |
| ES2324645T3 (es) | 2000-11-03 | 2009-08-12 | Genentech, Inc. | Cambios de tasa metabolica en fermentaciones que expresen proteinas recombinantes. |
| US6979556B2 (en) | 2000-12-14 | 2005-12-27 | Genentech, Inc. | Separate-cistron contructs for secretion of aglycosylated antibodies from prokaryotes |
| EP1227321A1 (en) | 2000-12-28 | 2002-07-31 | Institut für Bioanalytik GmbH | Reversible MHC multimer staining for functional purification of antigen-specific T cells |
| EP1349569B1 (en) | 2001-01-12 | 2007-04-18 | Becton Dickinson and Company | Intrinsically fluorescent, self-multimerizing mhc fusion proteins and complexes thereof |
| GB0102568D0 (en) | 2001-02-01 | 2001-03-21 | Magnetic Biosolutions Sweden A | Method |
| DE10113776B4 (de) | 2001-03-21 | 2012-08-09 | "Iba Gmbh" | Isoliertes streptavidinbindendes, kompetitiv eluierbares Peptid, dieses umfassendes Fusionspeptid, dafür codierende Nukleinsäure, Expressionsvektor, Verfahren zur Herstellung eines rekombinanten Fusionsproteins und Verfahren zum Nachweis und/oder zur Gewinnung des Fusionsproteins |
| ATE382053T1 (de) | 2001-08-27 | 2008-01-15 | Genentech Inc | System zur antikörperexpression und- synthese |
| EP1908769A1 (en) | 2001-08-27 | 2008-04-09 | Genentech, Inc. | A system for antibody expression and assembly |
| WO2003029462A1 (en) | 2001-09-27 | 2003-04-10 | Pieris Proteolab Ag | Muteins of human neutrophil gelatinase-associated lipocalin and related proteins |
| US7094579B2 (en) | 2002-02-13 | 2006-08-22 | Xoma Technology Ltd. | Eukaryotic signal sequences for prokaryotic expression |
| EP1481004B1 (de) * | 2002-03-01 | 2009-12-02 | Volker A. Erdmann | Streptavidin-bindungspeptid |
| US7754155B2 (en) * | 2002-03-15 | 2010-07-13 | Ross Amelia A | Devices and methods for isolating target cells |
| WO2003090781A1 (en) | 2002-04-23 | 2003-11-06 | Meir Strahilevitz | Methods and devices for targeting a site in a mammal and for removing species from a mammal |
| RU2344425C2 (ru) | 2002-06-24 | 2009-01-20 | Профос АГ | Способ идентификации и экстракции эндотоксина |
| FR2841905B1 (fr) | 2002-07-05 | 2004-09-03 | Centre Nat Rech Scient | Fragments fab mutants de l'anticorps anti-cd4 chimere 13b8.2 et leurs applications |
| EP1532167B1 (en) | 2002-07-17 | 2012-01-25 | Cytos Biotechnology AG | Molecular antigen arrays using a virus like particle derived from the ap205 coat protein |
| GB2392158B (en) | 2002-08-21 | 2005-02-16 | Proimmune Ltd | Chimeric MHC protein and oligomer thereof |
| JP2006501449A (ja) | 2002-09-27 | 2006-01-12 | ザ ジェネラル ホスピタル コーポレーション | 細胞分離のためのマイクロ流体デバイスおよびその使用 |
| US7112439B2 (en) | 2003-01-09 | 2006-09-26 | Macrogenics, Inc. | Dual expression vector system for antibody expression in bacterial and mammalian cells |
| JP2006525013A (ja) | 2003-05-02 | 2006-11-09 | インセプション バイオサイエンス インコーポレイティッド | 血液幹細胞の数の増幅のための装置および方法 |
| DK1623017T3 (da) | 2003-05-08 | 2011-01-10 | Life Technologies Corp | Frembringelse og isolering af antigenspecifikke T-celler |
| US7943393B2 (en) | 2003-07-14 | 2011-05-17 | Phynexus, Inc. | Method and device for extracting an analyte |
| EP1656455B1 (en) | 2003-08-13 | 2012-09-19 | Sandoz Ag | Process for the purification of recombinant polypeptides |
| GB0319601D0 (en) | 2003-08-20 | 2003-09-24 | Sandoz Ag | Production process |
| GB0321100D0 (en) | 2003-09-09 | 2003-10-08 | Celltech R&D Ltd | Biological products |
| GB2408507B (en) | 2003-10-06 | 2005-12-14 | Proimmune Ltd | Chimeric MHC protein and oligomer thereof for specific targeting |
| KR100570422B1 (ko) | 2003-10-16 | 2006-04-11 | 한미약품 주식회사 | 대장균 분비서열을 이용하여 항체 단편을 분비·생산하는 발현벡터 및 이를 이용하여 항체 단편을 대량 생산하는 방법 |
| JP2007512528A (ja) * | 2003-11-20 | 2007-05-17 | バイオセンサー、アプリケーションズ、スエーデン、アクチボラグ | 所定の抗原混合物に特異的な少なくとも２種類の異なる抗体の混合物およびその混合物の使用 |
| EP2336153B1 (en) | 2003-11-21 | 2016-03-30 | Pfenex Inc. | Improved expression systems with SEC-system secretion |
| SE0400181D0 (sv) * | 2004-01-29 | 2004-01-29 | Gyros Ab | Segmented porous and preloaded microscale devices |
| US7592431B2 (en) | 2004-02-26 | 2009-09-22 | Immunovative Therapies, Ltd. | Biodegradable T-cell Activation device |
| SI1733037T1 (sl) | 2004-03-11 | 2015-02-27 | Genentech, Inc. | Postopek za izdelavo polipeptidov |
| EP1766400B1 (en) * | 2004-06-03 | 2009-04-15 | Meso Scale Technologies, LLC | Methods for conducting whole blood assays |
| GB0422431D0 (en) * | 2004-10-08 | 2004-11-10 | Affitech As | Method |
| CN101044405B (zh) * | 2004-10-15 | 2015-06-10 | 金克克国际有限公司 | 竞争性示差筛选 |
| WO2006058226A2 (en) | 2004-11-24 | 2006-06-01 | The Trustees Of Boston University | Modified dimeric streptavidins and uses thereof |
| US20060252087A1 (en) * | 2005-01-18 | 2006-11-09 | Biocept, Inc. | Recovery of rare cells using a microchannel apparatus with patterned posts |
| EP1931383A1 (en) | 2005-09-28 | 2008-06-18 | Cytos Biotechnology AG | Interleukin-1 conjugates and uses thereof |
| US7704708B2 (en) | 2006-02-13 | 2010-04-27 | Uti Limited Partnership | Monomeric streptavidin muteins |
| US7855057B2 (en) | 2006-03-23 | 2010-12-21 | Millipore Corporation | Protein splice variant/isoform discrimination and quantitative measurements thereof |
| US20090208471A1 (en) | 2006-04-07 | 2009-08-20 | Yun Theodore J | Isolation and Use of Human Regulatory T Cells |
| US20070238169A1 (en) | 2006-04-11 | 2007-10-11 | The Board Of Trustees Of The Leland Stanford Junior University | Cell sorter and culture system |
| GB2442048B (en) | 2006-07-25 | 2009-09-30 | Proimmune Ltd | Biotinylated MHC complexes and their uses |
| US20080085532A1 (en) | 2006-09-18 | 2008-04-10 | Jorn Gorlach | Method for determining the immune status of a subject |
| DK1905839T4 (da) | 2006-09-22 | 2019-10-07 | Wacker Chemie Ag | Fremgangsmåde til fermentativ fremstilling af proteiner |
| DE102006044841A1 (de) | 2006-09-22 | 2008-04-03 | Wacker Chemie Ag | Signalpeptid zur Produktion von rekombinanten Proteinen |
| DE502006006800D1 (de) | 2006-09-22 | 2010-06-02 | Wacker Chemie Ag | Verfahren zur fermentativen Herstellung von Proteinen |
| EP1903115B1 (de) | 2006-09-22 | 2011-03-09 | Wacker Chemie AG | Verfahren zur fermentativen Herstellung von Antikörpern |
| BRPI0717651A2 (pt) | 2006-10-17 | 2013-12-24 | Oncotherapy Science Inc | Vacinas de peptídeo para cânceres que expressam polipeptídeos mphosph1 ou depdc1 |
| CA2668001C (en) * | 2006-11-02 | 2016-05-03 | Kyowa Medex Co., Ltd. | A method of immunoassaying a component to be measured in a sample containing hemoglobin |
| AU2007353319A1 (en) | 2006-11-15 | 2008-11-20 | Invitrogen Dynal As | Methods for reversibly binding a biotin compound to a support |
| US20080131415A1 (en) | 2006-11-30 | 2008-06-05 | Riddell Stanley R | Adoptive transfer of cd8 + t cell clones derived from central memory cells |
| CN101226118B (zh) * | 2007-01-19 | 2010-06-16 | 中国医学科学院肿瘤研究所 | 一种兼容免疫荧光分析的细胞化学染色方法及其用途 |
| CN102517280A (zh) | 2007-01-31 | 2012-06-27 | 菲尼克斯股份有限公司 | 用于提高表达的细菌前导序列 |
| KR20080076622A (ko) | 2007-02-16 | 2008-08-20 | 포항공과대학교 산학협력단 | 올리고머화된 단백질 전달체와 이를 이용한 세포내바이러스 벡터 전달 방법 |
| WO2008116468A2 (en) | 2007-03-26 | 2008-10-02 | Dako Denmark A/S | Mhc peptide complexes and uses thereof in infectious diseases |
| EP2617827A1 (en) | 2007-03-26 | 2013-07-24 | Celexion, LLC | Method for displaying engineered proteins on a cell surface |
| WO2009003493A2 (en) | 2007-07-03 | 2009-01-08 | Dako Denmark A/S | Mhc multimers, methods for their generation, labeling and use |
| WO2009024591A1 (en) | 2007-08-20 | 2009-02-26 | Bio-Medisinsk Innovasjon As | Pvii phage display |
| JP4962215B2 (ja) | 2007-08-28 | 2012-06-27 | パナソニック株式会社 | 墨出し器の精度確認装置及び墨出し器の精度確認方法 |
| ES2319061B1 (es) | 2007-09-11 | 2010-02-10 | Biomedal, S.L. | Metodo de conservacion de peptidos o proteinas. |
| US10611818B2 (en) | 2007-09-27 | 2020-04-07 | Agilent Technologies, Inc. | MHC multimers in tuberculosis diagnostics, vaccine and therapeutics |
| DK2520643T3 (da) | 2007-12-07 | 2020-01-20 | Miltenyi Biotec Bv & Co Kg | Prøvebehandlingssystemer og -fremgangsmåder |
| CN101978269A (zh) | 2008-01-18 | 2011-02-16 | 哈佛大学校长及研究员协会 | 在体液中检测疾病或病症标志的方法 |
| ES2890729T3 (es) | 2008-01-29 | 2022-01-21 | Hutchinson Fred Cancer Res | Identificación de células T CD8+ que son CD161hi y/o IL-18Rahi y que tienen una capacidad de evacuación rápida de fármacos |
| CN101932598B (zh) | 2008-01-30 | 2016-12-21 | 皮里斯股份公司 | 具有对人c-met受体酪氨酸激酶的亲和性的泪脂质运载蛋白的突变蛋白及其获得方法 |
| EP2254592B1 (en) | 2008-02-28 | 2019-06-05 | Dako Denmark A/S | Mhc multimers in borrelia diagnostics and disease |
| US20110318380A1 (en) | 2008-10-01 | 2011-12-29 | Dako Denmark A/S | MHC Multimers in Cancer Vaccines and Immune Monitoring |
| CN101446576B (zh) | 2008-12-29 | 2011-06-22 | 江苏省苏微微生物研究有限公司 | 一种微囊藻毒素-lr单抗免疫亲和柱的制备和使用方法 |
| WO2010080032A2 (en) | 2009-01-09 | 2010-07-15 | Stichting Het Nederlands Kanker Instituut | Bead-assisted viral transduction |
| DE102009018647A1 (de) | 2009-04-23 | 2010-10-28 | Osram Opto Semiconductors Gmbh | Strahlungsemittierende Vorrichtung |
| US20110070581A1 (en) | 2009-04-27 | 2011-03-24 | Amit Gupta | Separation of Leukocytes |
| WO2011053971A2 (en) | 2009-11-02 | 2011-05-05 | Fina Biosolutions, Llc | Method for enhancing the sensitivity of antibody based assays |
| MX2012005168A (es) | 2009-11-05 | 2012-06-08 | Genentech Inc | Metodos y composicion para secrecion de polipeptidos heterologos. |
| WO2011062862A1 (en) | 2009-11-17 | 2011-05-26 | Centocor Ortho Biotech Inc. | Improved bacterial membrane protein secrection |
| US20120321665A1 (en) | 2009-12-14 | 2012-12-20 | Benaroya Research Institute At Virginia Mason | Compositions and methods for treating airway inflammatory diseases |
| US9891148B2 (en) | 2010-02-09 | 2018-02-13 | Douglas T. Gjerde | Method and apparatus for pipette tip columns |
| US9637719B2 (en) | 2013-12-06 | 2017-05-02 | Douglas T. Gjerde | Devices and methods for purification of biological cells |
| US9242244B2 (en) | 2010-02-09 | 2016-01-26 | Douglas T. Gjerde | Method and apparatus for pipette tip columns |
| US9370732B2 (en) | 2013-02-15 | 2016-06-21 | Douglas T. Gjerde | Methods for purifying biological cells |
| GB201002730D0 (en) | 2010-02-18 | 2010-04-07 | Uni I Oslo | Product |
| EP2363501A1 (en) | 2010-03-02 | 2011-09-07 | Universitätsklinikum Hamburg-Eppendorf | Method for isolating target cells |
| JP5665021B2 (ja) | 2010-03-08 | 2015-02-04 | 国立大学法人東京農工大学 | 融合ｍｈｃ分子連結磁気微粒子、抗原ペプチドのスクリーニング方法、組換えベクター、及び磁性細菌の形質転換体 |
| EP2585579A2 (en) | 2010-06-23 | 2013-05-01 | Stobbe Tech A/s | Device and method for industrial cultivation of cells |
| GB201012603D0 (en) | 2010-07-27 | 2010-09-08 | Ucb Pharma Sa | Protein purification |
| US9410157B2 (en) | 2010-07-30 | 2016-08-09 | Wisconsin Alumni Research Foundation | Systems and methods for the secretion of recombinant proteins in gram negative bacteria |
| EP3376225A1 (en) * | 2010-08-06 | 2018-09-19 | Ludwig-Maximilians-Universität München | Identification of t cell target antigens |
| WO2012044999A2 (en) | 2010-10-01 | 2012-04-05 | Ludwig Institute For Cancer Research Ltd. | Reversible protein multimers, methods for their production and use |
| WO2012058627A2 (en) | 2010-10-29 | 2012-05-03 | Miqin Zhang | Pre-targeted nanoparticle system and method for labeling biological particles |
| CN110200997A (zh) | 2011-03-23 | 2019-09-06 | 弗雷德哈钦森癌症研究中心 | 用于细胞免疫治疗的方法和组合物 |
| JP5840857B2 (ja) | 2011-04-08 | 2016-01-06 | 国立大学法人 東京大学 | 細胞傷害性ｔ細胞誘導用組成物 |
| ES2682750T5 (en) | 2011-07-18 | 2025-02-04 | Iba Lifesciences Gmbh | Method of reversibly staining a target cell |
| WO2013038272A2 (en) | 2011-09-13 | 2013-03-21 | Uti Limited Partnership | Streptavidin mutein exhibiting reversible binding for biotin and streptavidin binding peptide tagged proteins |
| WO2013062365A2 (ko) | 2011-10-26 | 2013-05-02 | 국립암센터 | 변이 ｃｔｌａ4 유전자 이입 ｔ 세포 및 이를 포함하는 항암 면역치료용 조성물 |
| RU2746407C1 (ru) | 2012-02-23 | 2021-04-13 | Стейдж Селл Терапеутикс Гмбх | Хроматографическое выделение клеток и других сложных биологических материалов |
| UA114108C2 (uk) | 2012-07-10 | 2017-04-25 | Борд Оф Ріджентс, Дзе Юніверсіті Оф Техас Сістем | Моноклональне антитіло для застосування в діагностиці і терапії злоякісних пухлин і аутоімунного захворювання |
| WO2014011996A1 (en) | 2012-07-13 | 2014-01-16 | The Trustees Of The University Of Pennsylvania | Methods of assessing the suitability of transduced t cells for administration |
| IL293944A (en) | 2012-08-20 | 2022-08-01 | Hutchinson Fred Cancer Res | Method and preparations for cellular immunotherapy |
| EP2711418B1 (en) | 2012-09-25 | 2017-08-23 | Miltenyi Biotec GmbH | Method for polyclonal stimulation of T cells by flexible nanomatrices |
| CA2891820A1 (en) | 2012-11-16 | 2014-05-22 | Iba Gmbh | Streptavidin muteins and methods of using them |
| BR112015017994A2 (pt) | 2013-01-31 | 2017-07-11 | Glaxo Group Ltd | método para produzir uma proteína recombinante, método para clarificar uma coleta microbiana, e, coleta modificada de célula de escherichia coli |
| US10220332B2 (en) | 2013-02-15 | 2019-03-05 | Douglas T. Gjerde | Columns for isolation, detection and use of biological cells |
| US10107729B2 (en) | 2013-02-15 | 2018-10-23 | Douglas T. Gjerde | Isolation, detection and use of biological cells |
| US9920294B2 (en) | 2013-02-15 | 2018-03-20 | Douglas T. Gjerde | Devices and methods for purification, detection and use of biological cells |
| CN103305464B (zh) | 2013-06-05 | 2015-04-15 | 南昌大学 | 直接分离cd4+和cd8+淋巴细胞的方法 |
| MX386422B (es) | 2013-12-20 | 2025-03-18 | Fred Hutchinson Cancer Center | Moléculas efectoras químericas etiquetadas y receptores de las mismas. |
| MY184699A (en) | 2014-04-16 | 2021-04-18 | Juno Therapeutics Gmbh | Methods, kits and apparatus for expanding a population of cells |
| AU2015249554B2 (en) | 2014-04-23 | 2021-08-19 | Juno Therapeutics, Inc. | Methods for isolating, culturing, and genetically engineering immune cell populations for adoptive therapy |
| CA2946222C (en) | 2014-04-24 | 2020-12-22 | Miltenyi Biotec Gmbh | Method for automated generation of genetically modified t cells |
| SG11201608744VA (en) | 2014-04-25 | 2016-11-29 | Bluebird Bio Inc | Improved methods for manufacturing adoptive cell therapies |
| AU2015254588B2 (en) | 2014-04-30 | 2020-05-21 | Iba Gmbh | Method of isolating a target cell |
| EP2955196A1 (en) | 2014-06-10 | 2015-12-16 | Effimune | Antibodies directed against CD127 |
| WO2016012623A1 (en) | 2014-07-25 | 2016-01-28 | Theravectys | Lentiviral vectors for regulated expression of a chimeric antigen receptor molecule |
| GB201415344D0 (en) | 2014-08-29 | 2014-10-15 | Ucl Business Plc | Protein |
| WO2016166568A1 (en) | 2015-04-16 | 2016-10-20 | Juno Therapeutics Gmbh | Methods, kits and apparatus for expanding a population of cells |
| MA45488A (fr) | 2015-10-22 | 2018-08-29 | Juno Therapeutics Gmbh | Procédés, kits et appareil de culture de cellules |
| CN108474002B (zh) | 2015-10-22 | 2023-05-23 | 朱诺治疗学有限公司 | 用于转导的方法、反应剂盒、反应剂和设备 |
| MA45489A (fr) | 2015-10-22 | 2018-08-29 | Juno Therapeutics Gmbh | Procédés de culture de cellules, kits et appareil associés |
| MX2018006789A (es) | 2015-12-03 | 2019-02-13 | Juno Therapeutics Inc | Receptores quimericos modificados y composiciones y metodos relacionados. |
| EP3440191A4 (en) | 2016-04-07 | 2019-12-11 | Bluebird Bio, Inc. | CHIMERIC ANTIGEN RECEPTOR T-CELL COMPOSITIONS |
| MX2019008538A (es) | 2017-01-20 | 2019-11-05 | Juno Therapeutics Gmbh | Conjugados de superficie celular y composiciones y métodos celulares relacionados. |
| SG11201909931PA (en) | 2017-04-27 | 2019-11-28 | Juno Therapeutics Gmbh | Oligomeric particle reagents and methods of use thereof |
| US20190247846A1 (en) | 2018-02-09 | 2019-08-15 | Chris Suh | Method and Apparatus for Pipette Tip Columns |
| CN113474450A (zh) | 2018-08-09 | 2021-10-01 | 朱诺治疗学股份有限公司 | 产生工程化细胞的方法以及所述工程化细胞的组合物 |
| JP7582940B2 (ja) | 2018-10-31 | 2024-11-13 | ジュノ セラピューティクス ゲーエムベーハー | 細胞の選択および刺激のための方法ならびにそのための装置 |
-
2013
- 2013-02-25 RU RU2014138172A patent/RU2746407C1/ru active
- 2013-02-25 CN CN201710137379.4A patent/CN106940268B/zh active Active
- 2013-02-25 CA CA2865033A patent/CA2865033C/en active Active
- 2013-02-25 SG SG10201606970UA patent/SG10201606970UA/en unknown
- 2013-02-25 EP EP24222803.9A patent/EP4545964A3/en active Pending
- 2013-02-25 EP EP13709791.1A patent/EP2817625B1/en active Active
- 2013-02-25 CN CN201380010911.6A patent/CN104254780B/zh active Active
- 2013-02-25 JP JP2014558137A patent/JP6362543B2/ja active Active
- 2013-02-25 AU AU2013224027A patent/AU2013224027B2/en active Active
- 2013-02-25 ES ES13709791T patent/ES3011307T3/es active Active
- 2013-02-25 WO PCT/EP2013/053650 patent/WO2013124474A2/en not_active Ceased
- 2013-02-25 SG SG11201404991YA patent/SG11201404991YA/en unknown
- 2013-02-25 US US14/380,699 patent/US10228312B2/en active Active
-
2014
- 2014-08-01 IN IN6475DEN2014 patent/IN2014DN06475A/en unknown
-
2018
- 2018-02-28 JP JP2018034273A patent/JP6857626B2/ja active Active
- 2018-12-21 US US16/231,193 patent/US12135265B2/en active Active
- 2018-12-21 US US16/231,188 patent/US12066365B2/en active Active
-
2019
- 2019-01-11 AU AU2019200178A patent/AU2019200178B2/en active Active
-
2021
- 2021-03-22 JP JP2021046729A patent/JP7192014B2/ja active Active
- 2021-12-08 AU AU2021282451A patent/AU2021282451B2/en active Active
-
2022
- 2022-12-07 JP JP2022195658A patent/JP7710427B2/ja active Active
-
2024
- 2024-10-01 US US18/904,030 patent/US20250020556A1/en active Pending
-
2025
- 2025-01-22 AU AU2025200426A patent/AU2025200426A1/en active Pending
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2015512621A5 (enExample) | ||
| JP7710427B2 (ja) | 細胞および他の複雑な生物学的材料のクロマトグラフィーによる単離 | |
| Chase | Prediction of the performance of preparative affinity chromatography | |
| Pfaunmiller et al. | Affinity monolith chromatography: a review of principles and recent analytical applications | |
| JP2004523747A5 (enExample) | ||
| Fitzgerald et al. | Immunoaffinity chromatography: concepts and applications | |
| JP4831697B2 (ja) | 精製方法 | |
| Hage et al. | Affinity chromatography: a historical perspective | |
| Noppe et al. | Macroporous monolithic gels, cryogels, with immobilized phages from phage-display library as a new platform for fast development of affinity adsorbent capable of target capture from crude feeds | |
| US20110166332A1 (en) | Enhanced antibody aggregate removal with capto adhere in the presence of protein-excluded zwitterions | |
| Gajdosik et al. | Sample displacement chromatography as a method for purification of proteins and peptides from complex mixtures | |
| WO2010005364A1 (en) | Separation medium for chromatography of various biomolecules | |
| JPH06510600A (ja) | 痕跡量混入物の検出方法及び装置 | |
| JP2020509928A (ja) | 分離マトリックス及び抗体を分離する方法 | |
| CN104624167B (zh) | 固载核酸适体的整体材料的制备和在蛋白在线检测的应用 | |
| Subramanian et al. | Use of a modified zirconia support in the separation of immunoproteins | |
| Fitzgerald et al. | Immunoaffinity chromatography | |
| González-González et al. | Recent advances in antibody-based monolith chromatography for therapeutic applications | |
| Hearn | General strategies in the separation of proteins by high-performance liquid chromatographic methods | |
| Jmeian et al. | Multicolumn separation platform for simultaneous depletion and prefractionation prior to 2-DE for facilitating in-depth serum proteomics profiling | |
| JP7228236B2 (ja) | 遠心分離カラム及び分析対象物質の分析方法 | |
| Jenkins et al. | Albumin and immunoglobulin depletion of human plasma | |
| Bresolin et al. | Purification of anti-interleukin-6 monoclonal antibody using precipitation and immobilized metal-ion affinity chromatography | |
| US8653239B2 (en) | Method for isolating polypeptides | |
| Pfaunmiller | Development of novel monoliths and affinity microcolumns for use in high performance affinity chromatography and pharmaceutical applications |