JP2015512621A5 - - Google Patents
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- JP2015512621A5 JP2015512621A5 JP2014558137A JP2014558137A JP2015512621A5 JP 2015512621 A5 JP2015512621 A5 JP 2015512621A5 JP 2014558137 A JP2014558137 A JP 2014558137A JP 2014558137 A JP2014558137 A JP 2014558137A JP 2015512621 A5 JP2015512621 A5 JP 2015512621A5
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- 239000003153 chemical reaction reagent Substances 0.000 claims description 223
- 108020003175 receptors Proteins 0.000 claims description 187
- 102000005962 receptors Human genes 0.000 claims description 187
- 210000004027 cell Anatomy 0.000 claims description 135
- 230000005526 G1 to G0 transition Effects 0.000 claims description 120
- 238000000034 method Methods 0.000 claims description 100
- 238000004587 chromatography analysis Methods 0.000 claims description 39
- 239000012504 chromatography matrix Substances 0.000 claims description 36
- 238000001042 affinity chromatography Methods 0.000 claims description 35
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 claims description 30
- 239000011159 matrix material Substances 0.000 claims description 26
- 230000002860 competitive effect Effects 0.000 claims description 18
- 238000002523 gelfiltration Methods 0.000 claims description 16
- 239000000377 silicon dioxide Substances 0.000 claims description 15
- 108090001008 Avidin Proteins 0.000 claims description 13
- 239000000499 gel Substances 0.000 claims description 13
- 238000010494 dissociation reaction Methods 0.000 claims description 12
- 230000005593 dissociations Effects 0.000 claims description 12
- 230000002441 reversible effect Effects 0.000 claims description 12
- 150000004676 glycans Chemical class 0.000 claims description 11
- 229920001282 polysaccharide Polymers 0.000 claims description 11
- 239000005017 polysaccharide Substances 0.000 claims description 11
- 108010090804 Streptavidin Proteins 0.000 claims description 10
- 238000001641 gel filtration chromatography Methods 0.000 claims description 10
- 238000000926 separation method Methods 0.000 claims description 10
- 108091023037 Aptamer Proteins 0.000 claims description 8
- 229920001577 copolymer Polymers 0.000 claims description 8
- 108010021625 Immunoglobulin Fragments Proteins 0.000 claims description 7
- 102000008394 Immunoglobulin Fragments Human genes 0.000 claims description 7
- 239000012530 fluid Substances 0.000 claims description 7
- 230000003100 immobilizing effect Effects 0.000 claims description 7
- YBJHBAHKTGYVGT-ZKWXMUAHSA-N (+)-Biotin Chemical compound N1C(=O)N[C@@H]2[C@H](CCCCC(=O)O)SC[C@@H]21 YBJHBAHKTGYVGT-ZKWXMUAHSA-N 0.000 claims description 6
- 108060003951 Immunoglobulin Proteins 0.000 claims description 6
- 210000003855 cell nucleus Anatomy 0.000 claims description 6
- 102000018358 immunoglobulin Human genes 0.000 claims description 6
- 239000012528 membrane Substances 0.000 claims description 6
- 239000000203 mixture Substances 0.000 claims description 6
- 238000010828 elution Methods 0.000 claims description 5
- 239000000696 magnetic material Substances 0.000 claims description 5
- 239000000463 material Substances 0.000 claims description 5
- NIXOWILDQLNWCW-UHFFFAOYSA-M Acrylate Chemical compound [O-]C(=O)C=C NIXOWILDQLNWCW-UHFFFAOYSA-M 0.000 claims description 4
- 102000017727 Immunoglobulin Variable Region Human genes 0.000 claims description 4
- 108010067060 Immunoglobulin Variable Region Proteins 0.000 claims description 4
- 239000011543 agarose gel Substances 0.000 claims description 4
- 210000001124 body fluid Anatomy 0.000 claims description 4
- 239000010839 body fluid Substances 0.000 claims description 4
- 150000002009 diols Chemical class 0.000 claims description 4
- 229940072221 immunoglobulins Drugs 0.000 claims description 4
- 210000000265 leukocyte Anatomy 0.000 claims description 4
- 210000004698 lymphocyte Anatomy 0.000 claims description 4
- ZIUHHBKFKCYYJD-UHFFFAOYSA-N n,n'-methylenebisacrylamide Chemical compound C=CC(=O)NCNC(=O)C=C ZIUHHBKFKCYYJD-UHFFFAOYSA-N 0.000 claims description 4
- 229920002401 polyacrylamide Polymers 0.000 claims description 4
- 108090000765 processed proteins & peptides Proteins 0.000 claims description 4
- LFJAQMVCRLUOTJ-BYPYZUCNSA-N (2s)-2-amino-n-(2-hydroxyethyl)butanediamide Chemical compound NC(=O)C[C@H](N)C(=O)NCCO LFJAQMVCRLUOTJ-BYPYZUCNSA-N 0.000 claims description 3
- CHRJZRDFSQHIFI-UHFFFAOYSA-N 1,2-bis(ethenyl)benzene;styrene Chemical compound C=CC1=CC=CC=C1.C=CC1=CC=CC=C1C=C CHRJZRDFSQHIFI-UHFFFAOYSA-N 0.000 claims description 3
- HRPVXLWXLXDGHG-UHFFFAOYSA-N Acrylamide Chemical compound NC(=O)C=C HRPVXLWXLXDGHG-UHFFFAOYSA-N 0.000 claims description 3
- 229920003171 Poly (ethylene oxide) Polymers 0.000 claims description 3
- 229960002685 biotin Drugs 0.000 claims description 3
- 235000020958 biotin Nutrition 0.000 claims description 3
- 239000011616 biotin Substances 0.000 claims description 3
- 150000001615 biotins Chemical class 0.000 claims description 3
- 229920002678 cellulose Polymers 0.000 claims description 3
- 239000001913 cellulose Substances 0.000 claims description 3
- 238000004440 column chromatography Methods 0.000 claims description 3
- 239000012634 fragment Substances 0.000 claims description 3
- 238000001292 planar chromatography Methods 0.000 claims description 3
- 229920003023 plastic Polymers 0.000 claims description 3
- 239000004033 plastic Substances 0.000 claims description 3
- 229920003213 poly(N-isopropyl acrylamide) Polymers 0.000 claims description 3
- 229920000058 polyacrylate Polymers 0.000 claims description 3
- 229920000036 polyvinylpyrrolidone Polymers 0.000 claims description 3
- 239000001267 polyvinylpyrrolidone Substances 0.000 claims description 3
- 235000013855 polyvinylpyrrolidone Nutrition 0.000 claims description 3
- 108010018381 streptavidin-binding peptide Proteins 0.000 claims description 3
- 102000001706 Immunoglobulin Fab Fragments Human genes 0.000 claims description 2
- 108010054477 Immunoglobulin Fab Fragments Proteins 0.000 claims description 2
- 239000011230 binding agent Substances 0.000 claims description 2
- 210000004369 blood Anatomy 0.000 claims description 2
- 239000008280 blood Substances 0.000 claims description 2
- 239000012503 blood component Substances 0.000 claims description 2
- 239000003795 chemical substances by application Substances 0.000 claims description 2
- 239000000306 component Substances 0.000 claims description 2
- 230000003993 interaction Effects 0.000 claims description 2
- 210000004962 mammalian cell Anatomy 0.000 claims description 2
- 239000002245 particle Substances 0.000 claims description 2
- 239000011148 porous material Substances 0.000 claims description 2
- 210000000130 stem cell Anatomy 0.000 claims description 2
- 238000005406 washing Methods 0.000 claims description 2
- 102000004169 proteins and genes Human genes 0.000 claims 2
- 108090000623 proteins and genes Proteins 0.000 claims 2
- 102000008102 Ankyrins Human genes 0.000 claims 1
- 108010049777 Ankyrins Proteins 0.000 claims 1
- 108050006654 Lipocalin Proteins 0.000 claims 1
- 102000019298 Lipocalin Human genes 0.000 claims 1
- 239000013078 crystal Substances 0.000 claims 1
- 229920001184 polypeptide Polymers 0.000 claims 1
- 102000004196 processed proteins & peptides Human genes 0.000 claims 1
- 238000003259 recombinant expression Methods 0.000 description 4
- 238000012216 screening Methods 0.000 description 4
- 229920005654 Sephadex Polymers 0.000 description 2
- 239000012541 Fractogel® Substances 0.000 description 1
- 239000012506 Sephacryl® Substances 0.000 description 1
- 239000012507 Sephadex™ Substances 0.000 description 1
- 229920002684 Sepharose Polymers 0.000 description 1
- 108020004707 nucleic acids Proteins 0.000 description 1
- 150000007523 nucleic acids Chemical class 0.000 description 1
- 102000039446 nucleic acids Human genes 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261602150P | 2012-02-23 | 2012-02-23 | |
| US61/602,150 | 2012-02-23 | ||
| PCT/EP2013/053650 WO2013124474A2 (en) | 2012-02-23 | 2013-02-25 | Chromatographic isolation of cells and other complex biological materials |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018034273A Division JP6857626B2 (ja) | 2012-02-23 | 2018-02-28 | 細胞および他の複雑な生物学的材料のクロマトグラフィーによる単離 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2015512621A JP2015512621A (ja) | 2015-04-30 |
| JP2015512621A5 true JP2015512621A5 (enExample) | 2016-04-14 |
| JP6362543B2 JP6362543B2 (ja) | 2018-07-25 |
Family
ID=47891608
Family Applications (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014558137A Active JP6362543B2 (ja) | 2012-02-23 | 2013-02-25 | 細胞および他の複雑な生物学的材料のクロマトグラフィーによる単離 |
| JP2018034273A Active JP6857626B2 (ja) | 2012-02-23 | 2018-02-28 | 細胞および他の複雑な生物学的材料のクロマトグラフィーによる単離 |
| JP2021046729A Active JP7192014B2 (ja) | 2012-02-23 | 2021-03-22 | 細胞および他の複雑な生物学的材料のクロマトグラフィーによる単離 |
| JP2022195658A Active JP7710427B2 (ja) | 2012-02-23 | 2022-12-07 | 細胞および他の複雑な生物学的材料のクロマトグラフィーによる単離 |
Family Applications After (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018034273A Active JP6857626B2 (ja) | 2012-02-23 | 2018-02-28 | 細胞および他の複雑な生物学的材料のクロマトグラフィーによる単離 |
| JP2021046729A Active JP7192014B2 (ja) | 2012-02-23 | 2021-03-22 | 細胞および他の複雑な生物学的材料のクロマトグラフィーによる単離 |
| JP2022195658A Active JP7710427B2 (ja) | 2012-02-23 | 2022-12-07 | 細胞および他の複雑な生物学的材料のクロマトグラフィーによる単離 |
Country Status (11)
| Country | Link |
|---|---|
| US (4) | US10228312B2 (enExample) |
| EP (2) | EP2817625B1 (enExample) |
| JP (4) | JP6362543B2 (enExample) |
| CN (2) | CN106940268B (enExample) |
| AU (4) | AU2013224027B2 (enExample) |
| CA (1) | CA2865033C (enExample) |
| ES (1) | ES3011307T3 (enExample) |
| IN (1) | IN2014DN06475A (enExample) |
| RU (1) | RU2746407C1 (enExample) |
| SG (2) | SG10201606970UA (enExample) |
| WO (1) | WO2013124474A2 (enExample) |
Families Citing this family (68)
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| US9637719B2 (en) | 2013-12-06 | 2017-05-02 | Douglas T. Gjerde | Devices and methods for purification of biological cells |
| WO2013124474A2 (en) | 2012-02-23 | 2013-08-29 | Stage Cell Therapeutics Gmbh | Chromatographic isolation of cells and other complex biological materials |
| SG11201605046YA (en) | 2013-12-20 | 2016-07-28 | Hutchinson Fred Cancer Res | Tagged chimeric effector molecules and receptors thereof |
| GB2587768B (en) * | 2014-04-03 | 2021-08-18 | T Gjerde Douglas | Devices and methods for purification, detection and use of biological cells |
| EP3132247B1 (en) | 2014-04-16 | 2021-08-18 | Juno Therapeutics GmbH | Methods, kits and apparatus for expanding a population of cells |
| ES2995052T3 (en) | 2014-04-23 | 2025-02-05 | Juno Therapeutics Inc | Methods for isolating, culturing, and genetically engineering immune cell populations for adoptive therapy |
| CA2945414C (en) | 2014-04-30 | 2023-05-09 | Iba Gmbh | Method of isolating a target cell |
| EP2955521A1 (en) * | 2014-06-11 | 2015-12-16 | Centre Hospitalier Universitaire Vaudois (CHUV) | Methods for separating cells |
| WO2016073602A2 (en) * | 2014-11-05 | 2016-05-12 | Juno Therapeutics, Inc. | Methods for transduction and cell processing |
| DE202014105965U1 (de) | 2014-12-10 | 2015-01-26 | Cell.Copedia GmbH | Spritzengehäuse zum Pipettieren eines biologischen Materials mit integrierten Membranen |
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| CN105606815A (zh) * | 2015-05-18 | 2016-05-25 | 烟台载通生物技术有限公司 | 一种用于免疫检测的多单元装置 |
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