JP2015509788A5 - - Google Patents

Info

Publication number

JP2015509788A5

JP2015509788A5 JP2014560032A JP2014560032A JP2015509788A5 JP 2015509788 A5 JP2015509788 A5 JP 2015509788A5 JP 2014560032 A JP2014560032 A JP 2014560032A JP 2014560032 A JP2014560032 A JP 2014560032A JP 2015509788 A5 JP2015509788 A5 JP 2015509788A5

Authority

JP

Japan

Prior art keywords

dry powder

processable

respirable

sodium

dry

Prior art date

2013-02-28

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Pending

Links

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• 239000000843 powder Substances 0.000 claims 14
• 239000003814 drug Substances 0.000 claims 12
• 239000002245 particle Substances 0.000 claims 10
• 229940124597 therapeutic agent Drugs 0.000 claims 10
• 239000000546 pharmaceutical excipient Substances 0.000 claims 7
• 159000000000 sodium salts Chemical class 0.000 claims 7
• FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 claims 6
• VHVPQPYKVGDNFY-DFMJLFEVSA-N 2-[(2r)-butan-2-yl]-4-[4-[4-[4-[[(2r,4s)-2-(2,4-dichlorophenyl)-2-(1,2,4-triazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy]phenyl]piperazin-1-yl]phenyl]-1,2,4-triazol-3-one Chemical compound O=C1N([C@H](C)CC)N=CN1C1=CC=C(N2CCN(CC2)C=2C=CC(OC[C@@H]3O[C@](CN4N=CN=C4)(OC3)C=3C(=CC(Cl)=CC=3)Cl)=CC=2)C=C1 VHVPQPYKVGDNFY-DFMJLFEVSA-N 0.000 claims 5
• 229960004130 itraconazole Drugs 0.000 claims 5
• ROHFNLRQFUQHCH-UHFFFAOYSA-N Leucine Natural products CC(C)CC(N)C(O)=O ROHFNLRQFUQHCH-UHFFFAOYSA-N 0.000 claims 4
• 230000002209 hydrophobic effect Effects 0.000 claims 4
• PMZURENOXWZQFD-UHFFFAOYSA-L Sodium Sulfate Chemical compound [Na+].[Na+].[O-]S([O-])(=O)=O PMZURENOXWZQFD-UHFFFAOYSA-L 0.000 claims 3
• 239000011780 sodium chloride Substances 0.000 claims 3
• 235000002639 sodium chloride Nutrition 0.000 claims 3
• 229910052938 sodium sulfate Inorganic materials 0.000 claims 3
• 235000011152 sodium sulphate Nutrition 0.000 claims 3
• 206010017533 Fungal infection Diseases 0.000 claims 2
• ROHFNLRQFUQHCH-YFKPBYRVSA-N L-leucine Chemical compound CC(C)C[C@H](N)C(O)=O ROHFNLRQFUQHCH-YFKPBYRVSA-N 0.000 claims 2
• 208000031888 Mycoses Diseases 0.000 claims 2
• 125000001909 leucine group Chemical group [H]N(*)C(C(*)=O)C([H])([H])C(C([H])([H])[H])C([H])([H])[H] 0.000 claims 2
• 238000004519 manufacturing process Methods 0.000 claims 2
• 208000023504 respiratory system disease Diseases 0.000 claims 2
• CYDQOEWLBCCFJZ-UHFFFAOYSA-N 4-(4-fluorophenyl)oxane-4-carboxylic acid Chemical compound C=1C=C(F)C=CC=1C1(C(=O)O)CCOCC1 CYDQOEWLBCCFJZ-UHFFFAOYSA-N 0.000 claims 1
• 208000035473 Communicable disease Diseases 0.000 claims 1
• 206010057190 Respiratory tract infections Diseases 0.000 claims 1
• 150000001413 amino acids Chemical class 0.000 claims 1
• 235000014633 carbohydrates Nutrition 0.000 claims 1
• 150000001720 carbohydrates Chemical class 0.000 claims 1
• 208000015181 infectious disease Diseases 0.000 claims 1
• 230000029058 respiratory gaseous exchange Effects 0.000 claims 1
• 208000020029 respiratory tract infectious disease Diseases 0.000 claims 1
• 239000001509 sodium citrate Substances 0.000 claims 1
• NLJMYIDDQXHKNR-UHFFFAOYSA-K sodium citrate Chemical compound O.O.[Na+].[Na+].[Na+].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O NLJMYIDDQXHKNR-UHFFFAOYSA-K 0.000 claims 1
• 235000011083 sodium citrates Nutrition 0.000 claims 1
• 239000001540 sodium lactate Substances 0.000 claims 1
• 229940005581 sodium lactate Drugs 0.000 claims 1
• 235000011088 sodium lactate Nutrition 0.000 claims 1
• 239000007921 spray Substances 0.000 claims 1
• 150000005846 sugar alcohols Chemical class 0.000 claims 1