JP2019504684A - 乾燥粉末吸入器 - Google Patents
乾燥粉末吸入器 Download PDFInfo
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- JP2019504684A JP2019504684A JP2018539341A JP2018539341A JP2019504684A JP 2019504684 A JP2019504684 A JP 2019504684A JP 2018539341 A JP2018539341 A JP 2018539341A JP 2018539341 A JP2018539341 A JP 2018539341A JP 2019504684 A JP2019504684 A JP 2019504684A
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- inhaler
- dry powder
- cartridge
- housing
- mouthpiece
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Abstract
Description
本願は、2016年1月29日に出願した米国仮特許出願第62/289095号についての米国特許法第119条(e)による利益を主張する。この仮特許出願の内容の全体を、参照により、本願明細書に組み込む。
本開示は、肺への及び/又は肺を通る活性成分を、局所的に又は全身に送達するための、乾燥粉末を含む交換可能なカートリッジを備える乾燥粉末吸入器に関する。吸入器は、肺高血圧症、循環器疾患、糖尿病、肥満及び癌のような病気、又は例えば吐き気、嘔吐、痛み及び炎症のような、これらの病気及び他の病気に関連する症状を治療する為の活性剤又は有効成分を含む医薬製剤を主に含む吸入可能な乾燥粉末と共に使用される。
吸入器とともに使用するためのFDKP微粒子粉末を含む、界面活性剤を含まない乾燥粉末の調製
例示的な実施の形態では、FDKP微晶質粒子を含む、界面活性剤を含まない乾燥粉末を調製した。二重供給高剪断ミキサーを使用し、約25℃±5℃に保持された酢酸溶液(表1)及びFDKP溶液(表2)の概ね等しい質量を、2000psiで、0.001−in2のオリフィスを通して入れ、均質化させて沈殿物を生成した。その沈殿物を、ほぼ同等の温度である脱イオン(DI)水に集めた。その懸濁液中のFDKP微結晶の質量%で示す含有量は、約2−3.5%である。懸濁液のFDKPの濃度は、オーブン乾燥法による固体内容物により分析されることができる。FDKP微結晶の懸濁液は、必要に応じて、脱イオン水を使用したタンジェンシャルフローフィルトレーションにより洗浄されることができる。FDKP微結晶は、必要に応じて、ろ過、遠心分離、噴霧乾燥または凍結乾燥により分離することができる。
エピネフリンを含有する微結晶FDKP粒子を含有する乾燥粉末の調製
約5%の酢酸水溶液中の約5重量%のエピネフリンの溶液を、実施例1に記載したようにして得られたFDKP微結晶の懸濁液に添加した。また、必要に応じて、ロイシンを、FDKP微結晶の懸濁液に添加した。その混合物を、高効率サイクロンを備えたBuchi B290噴霧乾燥機を用いて、噴霧乾燥した。プロセスガス(60mm)として窒素が使用された。その混合物を、10−20%のポンプ容量、90−100%の吸引速度、および170−190℃の入り口温度で乾燥した。得られた粉末中のエピネフリン及びロイシンの重量%濃度は、それぞれ2−30%及び0−20%であった。噴霧乾燥器からの放出後のこれらの粉末の送達効率は、約50%〜80%の範囲であった。
パロノセトロンを含有する微結晶FDKP粒子を含有する乾燥粉末の調製
DI水中の約5重量%の塩酸パロノセトロンの溶液を、実施例1に記載したようにして得られたFDKP微結晶の懸濁液に添加した。また、必要に応じて、脱イオン(DI)水中のロイシン及びメチオニンを添加した。その混合物を、水酸化アンモニウムでpH6.5±0.5に滴定した。その混合物を、高効率サイクロンを備えたBuchi B290噴霧乾燥機を用いて、噴霧乾燥した。プロセスガス(60mm)として窒素が使用された。その混合物を、10−12%のポンプ容量、90−100%の吸引速度、および170−190℃の入り口温度で乾燥した。得られた粉末中のパロノセトロン、ロイシン及びメチオニンの重量%濃度は、それぞれ5%、0−20%及び0−10%であった。噴霧乾燥器からの放出後のこれらの粉末の送達効率は、約50%〜70%の範囲であった。
トレプロスチニルを含有する微結晶FDKP粒子を含有する乾燥粉末の調製
エチルアルコール中の0.2−1.0wt%のトレプロスチニルを、実施例1に記載したようにして得られたFDKP微結晶の懸濁液に添加した。その混合物を、高効率サイクロンを備えたBuchi B290噴霧乾燥機を用いて、噴霧乾燥した。プロセスガス(60mm)として窒素が使用された。その混合物を、10−12%のポンプ容量、90−100%の吸引速度、および170−190℃の入り口温度で乾燥した。得られた粉末中のトレプロスチニルの重量%濃度は、0.5−10%であった。噴霧乾燥器からの放出後のこれらの粉末の送達効率は、約50%〜70%の範囲であった。
Δ9−THC又はCBDを含有する微結晶FDKP粒子を含有する乾燥粉末の調製
実施例1と同様にして調製された分離したFDKP微結晶粒子を、エチルアルコール中に懸濁させた。主に、Δ9−THC又はCBDのいずれかを含むカンナビス抽出物の約1−4重量%の溶液を、FDKP微結晶のエタノール及びエタノール懸濁液に添加した。必要に応じて、エタノールに溶解した添加剤の溶液も添加した。その混合物を、高効率サイクロンを備えたBuchi B290噴霧乾燥機を用いて、噴霧乾燥した。プロセスガス(60mm)として窒素が使用された。その混合物を、12−15%のポンプ容量、70−100%の吸引速度、および110−140℃の入り口温度で乾燥した。Δ9−THC及び添加剤の重量%濃度を、表3に示す。噴霧乾燥器からの放出後のこれらの粉末の送達効率は、約50%〜70%の範囲であった。
(付記1)
ハウジングと、
本体であって、当該本体と一体的に形成されたマウスピースを備える、本体と、
を備え、
前記本体は、カートリッジのための装着領域を有し、前記本体及び前記ハウジングは、互いに対して直線的に移動可能であり、差し込みにより互いに係合して、吸入の際に粉末用量を放出するための空気流路を得るように、前記カートリッジを再構成させるように操作可能に構成されている、
乾燥粉末吸入器。
前記マウスピースは、前記吸入器本体の内部区画と連絡する空気入口を有する、
付記1に記載の乾燥粉末吸入器。
前記吸入器本体上での前記ハウジングの開放配置から閉鎖配置への移行により、前記ハウジングは、前記吸入器に装着された前記カートリッジを再構成する、
付記1に記載の乾燥粉末吸入器。
前記本体に対する前記ハウジングの移動は、長手方向軸に沿って構成され、前記吸入器本体の右側及び/又は左側から延びるガイドレールにより、容易になる、
付記1に記載の乾燥粉末吸入器。
開放又は装着位置、及び閉鎖又は投薬位置を得られるように構成されている、
付記1に記載の乾燥粉末吸入器。
前記ハウジングは、さらに、格納配置から投薬位置にカートリッジを押しこむ突出剛性要素を含む、
付記1に記載の乾燥粉末吸入器。
さらに、剛性の流導管を有するように構成されている、
付記1に記載の乾燥粉末吸入器。
前記ハウジングは、前記吸入器本体の一部を覆うカバーを含む、
付記1に記載の乾燥粉末吸入器。
さらに、前記マウスピースは、第1の入口ポートから出口ポートに延びる内部容積を有し、
前記内部容積は、0.2立方センチメートルより大きい、
付記1に記載の乾燥粉末吸入器。
前記吸入器本体は、組み立てられた吸入器において、前記ハウジングから、前記本体が分離するのを防ぐ戻り止めを備える、
付記1に記載の乾燥粉末吸入器。
前記吸入器本体上での前記ハウジングの開放配置から閉鎖配置への移行により、前記ハウジングが、前記マウスピースと整列するように、前記カートリッジを位置決めする、
付記1に記載の乾燥粉末吸入器。
さらに、乾燥粉末を含む、
付記1に記載の乾燥粉末吸入器。
前記乾燥粉末が、吸入用の医薬組成物である、
付記12に記載の乾燥粉末吸入器。
前記乾燥粉末は、3,6−ビス(N−フマリル−4−アミノブチル)−2,5−ジケトピペラジンを含む、
付記12に記載の乾燥粉末吸入器。
前記乾燥粉末は、1%〜40%(w/w)の量のカンナビノイドを含む、
付記14に記載の乾燥粉末吸入器。
前記カンナビノイドが、テトラヒドロカンナビノール又はカンナビジオールである、
付記15に記載の乾燥粉末吸入器。
さらに、前記乾燥粉末は、1,2−ジパルミトイル−sn−グリセロ−3−ホスホコリン及び1,2−ジステアロイル−sn−グリセロ−3−ホスホコリンから選択される、リン脂質を含む、
付記14に記載の乾燥粉末吸入器。
本体と、ハウジングと、カートリッジと、マウスピースと、
を含む、乾燥粉末吸入器であって、
前記本体は、前記カートリッジのための装着領域を有し、
前記カートリッジは、フマリルジケトピペラジン及び薬物の微結晶粒子を含む、乾燥粉末組成物を含み、
前記ハウジングは、前記吸入器を開放するために、前記本体上を近位方向から遠位方向に並進的に滑り、又は、前記吸入器を閉鎖するために、前記本体上を遠位方向から近位方向に並進的に滑り、
前記吸入器が閉鎖された時に、前記吸入器が前記乾燥粉末を分配するための1以上の剛性空気導管を備える、
乾燥粉末吸入器。
前記薬物は、
テトラヒドロカンナビノール又はカンナビジオールである、
付記18に記載の乾燥粉末吸入器。
さらに、前記乾燥粉末は、1,2−ジパルミトイル−sn−グリセロ−3−ホスホコリン及び1,2−ジステアロイル−sn−グリセロ−3−ホスホコリンから選択される、リン脂質を含む、
付記18に記載の乾燥粉末吸入器。
Claims (20)
- ハウジングと、
本体であって、当該本体と一体的に形成されたマウスピースを備える、本体と、
を備え、
前記本体は、カートリッジのための装着領域を有し、前記本体及び前記ハウジングは、互いに対して直線的に移動可能であり、差し込みにより互いに係合して、吸入の際に粉末用量を放出するための空気流路を得るように、前記カートリッジを再構成させるように操作可能に構成されている、
乾燥粉末吸入器。 - 前記マウスピースは、前記吸入器本体の内部区画と連絡する空気入口を有する、
請求項1に記載の乾燥粉末吸入器。 - 前記吸入器本体上での前記ハウジングの開放配置から閉鎖配置への移行により、前記ハウジングは、前記吸入器に装着された前記カートリッジを再構成する、
請求項1に記載の乾燥粉末吸入器。 - 前記本体に対する前記ハウジングの移動は、長手方向軸に沿って構成され、前記吸入器本体の右側及び/又は左側から延びるガイドレールにより、容易になる、
請求項1に記載の乾燥粉末吸入器。 - 開放又は装着位置、及び閉鎖又は投薬位置を得られるように構成されている、
請求項1に記載の乾燥粉末吸入器。 - 前記ハウジングは、さらに、格納配置から投薬位置にカートリッジを押しこむ突出剛性要素を含む、
請求項1に記載の乾燥粉末吸入器。 - さらに、剛性の流導管を有するように構成されている、
請求項1に記載の乾燥粉末吸入器。 - 前記ハウジングは、前記吸入器本体の一部を覆うカバーを含む、
請求項1に記載の乾燥粉末吸入器。 - さらに、前記マウスピースは、第1の入口ポートから出口ポートに延びる内部容積を有し、
前記内部容積は、0.2立方センチメートルより大きい、
請求項1に記載の乾燥粉末吸入器。 - 前記吸入器本体は、組み立てられた吸入器において、前記ハウジングから、前記本体が分離するのを防ぐ戻り止めを備える、
請求項1に記載の乾燥粉末吸入器。 - 前記吸入器本体上での前記ハウジングの開放配置から閉鎖配置への移行により、前記ハウジングが、前記マウスピースと整列するように、前記カートリッジを位置決めする、
請求項1に記載の乾燥粉末吸入器。 - さらに、乾燥粉末を含む、
請求項1に記載の乾燥粉末吸入器。 - 前記乾燥粉末が、吸入用の医薬組成物である、
請求項12に記載の乾燥粉末吸入器。 - 前記乾燥粉末は、3,6−ビス(N−フマリル−4−アミノブチル)−2,5−ジケトピペラジンを含む、
請求項12に記載の乾燥粉末吸入器。 - 前記乾燥粉末は、1%〜40%(w/w)の量のカンナビノイドを含む、
請求項14に記載の乾燥粉末吸入器。 - 前記カンナビノイドが、テトラヒドロカンナビノール又はカンナビジオールである、
請求項15に記載の乾燥粉末吸入器。 - さらに、前記乾燥粉末は、1,2−ジパルミトイル−sn−グリセロ−3−ホスホコリン及び1,2−ジステアロイル−sn−グリセロ−3−ホスホコリンから選択される、リン脂質を含む、
請求項14に記載の乾燥粉末吸入器。 - 本体と、ハウジングと、カートリッジと、マウスピースと、
を含む、乾燥粉末吸入器であって、
前記本体は、前記カートリッジのための装着領域を有し、
前記カートリッジは、フマリルジケトピペラジン及び薬物の微結晶粒子を含む、乾燥粉末組成物を含み、
前記ハウジングは、前記吸入器を開放するために、前記本体上を近位方向から遠位方向に並進的に滑り、又は、前記吸入器を閉鎖するために、前記本体上を遠位方向から近位方向に並進的に滑り、
前記吸入器が閉鎖された時に、前記吸入器が前記乾燥粉末を分配するための1以上の剛性空気導管を備える、
乾燥粉末吸入器。 - 前記薬物は、
テトラヒドロカンナビノール又はカンナビジオールである、
請求項18に記載の乾燥粉末吸入器。 - さらに、前記乾燥粉末は、1,2−ジパルミトイル−sn−グリセロ−3−ホスホコリン及び1,2−ジステアロイル−sn−グリセロ−3−ホスホコリンから選択される、リン脂質を含む、
請求項18に記載の乾燥粉末吸入器。
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Families Citing this family (30)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
KR101644250B1 (ko) | 2004-08-23 | 2016-07-29 | 맨카인드 코포레이션 | 약물 전달용 디케토피페라진염, 디케토모르포린염 또는 디케토디옥산염 |
AU2006290227B2 (en) | 2005-09-14 | 2012-08-02 | Mannkind Corporation | Method of drug formulation based on increasing the affinity of crystalline microparticle surfaces for active agents |
US8485180B2 (en) | 2008-06-13 | 2013-07-16 | Mannkind Corporation | Dry powder drug delivery system |
CA2728230C (en) | 2008-06-13 | 2017-10-17 | Mannkind Corporation | A dry powder inhaler and system for drug delivery |
AU2009259883B2 (en) | 2008-06-20 | 2015-02-05 | Mannkind Corporation | An interactive apparatus and method for real-time profiling of inhalation efforts |
TWI494123B (zh) | 2008-08-11 | 2015-08-01 | Mannkind Corp | 超快起作用胰島素之用途 |
US8314106B2 (en) | 2008-12-29 | 2012-11-20 | Mannkind Corporation | Substituted diketopiperazine analogs for use as drug delivery agents |
WO2012174472A1 (en) | 2011-06-17 | 2012-12-20 | Mannkind Corporation | High capacity diketopiperazine microparticles |
CA2852536A1 (en) | 2011-10-24 | 2013-05-02 | Mannkind Corporation | Methods and compositions for treating pain |
BR112016000937A8 (pt) | 2013-07-18 | 2021-06-22 | Mannkind Corp | formulações farmacêuticas de pó seco, método para a fabricação de uma formulação de pó seco e uso de uma formulação farmacêutica de pó seco |
US10307464B2 (en) | 2014-03-28 | 2019-06-04 | Mannkind Corporation | Use of ultrarapid acting insulin |
CA3111682A1 (en) | 2014-06-26 | 2015-12-30 | Island Breeze Systems Ca, Llc | Mdi related products and methods of use |
USD824510S1 (en) * | 2016-01-29 | 2018-07-31 | Mannkind Corporation | Inhaler |
USD824015S1 (en) * | 2016-01-29 | 2018-07-24 | Mannkind Corporation | Inhaler |
USD841798S1 (en) * | 2016-01-29 | 2019-02-26 | Mannkind Corporation | Inhaler |
USD824016S1 (en) * | 2016-01-29 | 2018-07-24 | Mannkind Corporation | Inhaler |
IL262720B1 (en) | 2016-05-05 | 2024-02-01 | Liquidia Tech Inc | Terfostinil in dry powder form for the treatment of pulmonary hypertension |
US20180271826A1 (en) * | 2017-03-22 | 2018-09-27 | Colorado Can Llc | Dry powders of cannabinoids and methods for preparing dry powders |
USD834178S1 (en) * | 2017-05-19 | 2018-11-20 | Mannkind Corporation | Inhaler |
US11666714B2 (en) * | 2017-06-23 | 2023-06-06 | Københavns Universitet | Inhaler with acoustic flow monitoring |
USD851748S1 (en) * | 2017-11-08 | 2019-06-18 | Mannkind Corporation | Inhaler |
CN111526870A (zh) * | 2018-01-26 | 2020-08-11 | 诺华股份有限公司 | 吸入治疗药物的高剂量递送 |
WO2019237028A1 (en) * | 2018-06-07 | 2019-12-12 | Mannkind Corporation | Composition and method for inhalation |
MX2021011491A (es) * | 2019-03-22 | 2022-01-18 | Mannkind Corp | Polvos secos inhalables. |
USD898187S1 (en) * | 2019-05-21 | 2020-10-06 | Receptor Holdings, Inc. | Inhaler device |
CN115151248A (zh) * | 2019-09-18 | 2022-10-04 | 得克萨斯州大学系统董事会 | 用于通过吸入递送的大麻素组合物 |
WO2021188748A1 (en) * | 2020-03-19 | 2021-09-23 | Tff Pharmaceuticals, Inc. | Dried particle inhalation for delivery of cannabis |
AU2021291438A1 (en) * | 2020-06-19 | 2023-02-16 | Cannovex Bv | Pulmonary formulation comprising cannabinoids |
CN115089825A (zh) * | 2022-07-06 | 2022-09-23 | 苏州易合医药有限公司 | 肺部给药装置 |
WO2024059819A2 (en) | 2022-09-15 | 2024-03-21 | Tff Pharmaceuticals, Inc. | Compositions of cannabinoids for delivery by inhalation |
Citations (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2005530765A (ja) * | 2002-05-07 | 2005-10-13 | ネクター セラピューティクス | 乾燥粉末吸入器のためのカプセル及びそれを製造及び使用する方法 |
JP2008510824A (ja) * | 2004-08-23 | 2008-04-10 | マンカインド コーポレイション | 薬物送達のためのジケトピペラジン塩、ジケトモルホリン塩、又はジケトジオキサン塩 |
JP2009519972A (ja) * | 2005-12-15 | 2009-05-21 | アキュスフィア, インコーポレイテッド | 粒子ベースの経肺投与または経鼻投与用製薬の製造方法 |
JP2011524210A (ja) * | 2008-06-13 | 2011-09-01 | マンカインド コーポレイション | 薬物送達用の乾燥粉末吸入器およびシステム |
JP2013540123A (ja) * | 2010-09-29 | 2013-10-31 | パルマトリックス,インコーポレイテッド | 吸入用の一価金属カチオン乾燥粉末 |
JP2015509788A (ja) * | 2012-02-29 | 2015-04-02 | パルマトリックス,インコーポレイテッド | 吸入に適した乾燥粉末 |
Family Cites Families (41)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5352461A (en) * | 1992-03-11 | 1994-10-04 | Pharmaceutical Discovery Corporation | Self assembling diketopiperazine drug delivery system |
US20060165606A1 (en) * | 1997-09-29 | 2006-07-27 | Nektar Therapeutics | Pulmonary delivery particles comprising water insoluble or crystalline active agents |
AU1251999A (en) * | 1997-12-03 | 1999-06-16 | Britannia Pharmaceuticals Limited | Improvements in medicaments for asthma treatment |
US7305986B1 (en) | 1999-07-23 | 2007-12-11 | Mannkind Corporation | Unit dose capsules for use in a dry powder inhaler |
US7464706B2 (en) | 1999-07-23 | 2008-12-16 | Mannkind Corporation | Unit dose cartridge and dry powder inhaler |
US20010036481A1 (en) * | 1999-08-25 | 2001-11-01 | Advanced Inhalation Research, Inc. | Modulation of release from dry powder formulations |
MXPA05006321A (es) * | 2002-12-13 | 2005-08-26 | Otsuka Pharma Co Ltd | Dispositivo de inhalacion para administracion transpulmonar. |
US20040265238A1 (en) * | 2003-06-27 | 2004-12-30 | Imtiaz Chaudry | Inhalable formulations for treating pulmonary hypertension and methods of using same |
US20050126562A1 (en) * | 2003-12-15 | 2005-06-16 | Alexza Molecular Delivery Corporation | Treatment of breakthrough pain by drug aerosol inhalation |
US7452524B2 (en) * | 2004-01-27 | 2008-11-18 | Gilead Sciences, Inc. | Method for improvement of tolerance for therapeutically effective agents delivered by inhalation |
DE102004006450B4 (de) * | 2004-02-05 | 2012-09-27 | Ing. Erich Pfeiffer Gmbh | Dosiervorrichtung |
AU2005269465A1 (en) * | 2004-07-26 | 2006-02-09 | Cotherix, Inc. | Treatment of pulmonary hypertension by inhaled iloprost with a microparticle formulation |
CN101010305B (zh) | 2004-08-20 | 2010-08-11 | 曼金德公司 | 二酮哌嗪合成的催化反应 |
US20090170775A1 (en) * | 2004-10-08 | 2009-07-02 | Transition Therapeutics, Inc. | Vasoactive intestinal polypeptide compositions |
EP1874339A1 (en) * | 2005-04-21 | 2008-01-09 | Gastrotech Pharma A/S | Pharmaceutical preparations of a glp-1 molecule and an anti-emetic drug |
AU2006290227B2 (en) * | 2005-09-14 | 2012-08-02 | Mannkind Corporation | Method of drug formulation based on increasing the affinity of crystalline microparticle surfaces for active agents |
WO2007134292A2 (en) * | 2006-05-15 | 2007-11-22 | United Therapeutics Corporation | Treprostinil administration using a metered dose inhaler |
US20080078382A1 (en) * | 2006-09-20 | 2008-04-03 | Lemahieu Edward | Methods and Systems of Delivering Medication Via Inhalation |
US20090036465A1 (en) * | 2006-10-18 | 2009-02-05 | United Therapeutics Corporation | Combination therapy for pulmonary arterial hypertension |
US8614255B2 (en) * | 2007-08-21 | 2013-12-24 | Civitas Therapeutics, Inc. | Pulmonary pharmaceutical formulations |
EP2214647A2 (en) * | 2007-10-24 | 2010-08-11 | MannKind Corporation | Delivery of active agents |
WO2009152160A1 (en) * | 2008-06-10 | 2009-12-17 | Gilead Sciences, Inc. | Inhaled carbaprostacyclin and prostacyclin prodrugs for the treatment of pulmonary arterial hypertension |
EP2330893A4 (en) * | 2008-09-25 | 2013-01-09 | Aradigm Corp | DEEP PULMONARY ADMINISTRATION OF TREPROSTINIL |
DK2408499T3 (da) | 2009-03-18 | 2014-05-12 | Mannkind Corp | Inhalatoradaptor til et laserdiffraktionsapparat og fremgangsmåde til at måle partikelstørrelsesfordeling |
SG10201403147SA (en) * | 2009-06-12 | 2014-10-30 | Mannkind Corp | Diketopiperazine microparticles with defined isomer contents |
SG176738A1 (en) | 2009-06-12 | 2012-01-30 | Mannkind Corp | Diketopiperazine microparticles with defined specific surface areas |
CN102596379B (zh) * | 2009-11-02 | 2015-04-01 | 曼康公司 | 以沉淀过程产生药物颗粒的反应器 |
EP2496295A1 (en) | 2009-11-03 | 2012-09-12 | MannKind Corporation | An apparatus and method for simulating inhalation efforts |
EP2582421A1 (en) * | 2010-06-21 | 2013-04-24 | MannKind Corporation | Dry powder drug delivery system and methods |
EP2621488B1 (en) * | 2010-09-29 | 2018-11-07 | Pulmatrix Operating Company, Inc. | Cationic dry powders |
EP2526926A1 (de) * | 2011-05-25 | 2012-11-28 | Justus-Liebig-Universität Gießen | Biokompatible Nanopolymerpartikel mit Wirkstoffen für die pulmonale Applikation |
EP2890391A4 (en) * | 2012-08-29 | 2016-03-09 | Mannkind Corp | METHOD AND COMPOSITION FOR TREATING HYPERGLYCEMIA |
CA2895805A1 (en) * | 2012-12-18 | 2014-06-26 | Kotzker Consulting Llc | Use of cannabinoids and terpenes for treatment of organophosphate and carbamate toxicity |
EP3587404B1 (en) * | 2013-03-15 | 2022-07-13 | MannKind Corporation | Microcrystalline diketopiperazine compositions, methods for preparation and use thereof |
ITMI20130572A1 (it) * | 2013-04-10 | 2014-10-11 | Eratech Srl | Composizione comprendente almeno due polveri secche ottenute per spray dry per aumentare la stabilita' della formulazione |
BR112016000937A8 (pt) * | 2013-07-18 | 2021-06-22 | Mannkind Corp | formulações farmacêuticas de pó seco, método para a fabricação de uma formulação de pó seco e uso de uma formulação farmacêutica de pó seco |
KR20160117596A (ko) * | 2014-02-07 | 2016-10-10 | 오스펙스 파마슈티칼스, 인코포레이티드 | 신규 제약 제제 |
WO2015138423A1 (en) * | 2014-03-11 | 2015-09-17 | Insmed Incorporated | Prostacylin compositions and methods for using the same |
TWI685348B (zh) * | 2014-05-08 | 2020-02-21 | 美國禮來大藥廠 | 速效胰島素組合物 |
EP3405175A4 (en) * | 2016-01-20 | 2019-09-25 | Flurry Powders, LLC | Encapsulation of Lipophilic Ingredients in Dispersible Aerosol Powder Incorporated Powder |
US20210085897A1 (en) * | 2018-04-06 | 2021-03-25 | Lupin Inc. | Medicament dispenser |
-
2017
- 2017-01-27 SG SG11201806304PA patent/SG11201806304PA/en unknown
- 2017-01-27 EP EP17745037.6A patent/EP3407870B1/en active Active
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- 2017-01-27 CA CA3012679A patent/CA3012679C/en active Active
- 2017-01-27 US US15/418,388 patent/US20170216538A1/en not_active Abandoned
- 2017-01-27 CN CN202210468404.8A patent/CN114904100A/zh active Pending
- 2017-01-27 WO PCT/US2017/015486 patent/WO2017132601A1/en active Application Filing
-
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- 2018-07-26 MX MX2023001592A patent/MX2023001592A/es unknown
-
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- 2019-01-28 HK HK19101435.0A patent/HK1258955A1/zh unknown
- 2019-10-14 US US16/601,440 patent/US20200046917A1/en active Pending
-
2021
- 2021-01-26 US US17/158,997 patent/US20210146071A1/en active Pending
-
2022
- 2022-08-12 JP JP2022128971A patent/JP2022160697A/ja active Pending
- 2022-09-01 AU AU2022224822A patent/AU2022224822A1/en active Pending
- 2022-11-09 US US17/983,915 patent/US20230098083A1/en active Pending
-
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- 2023-08-18 JP JP2023133295A patent/JP2023154079A/ja active Pending
Patent Citations (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2005530765A (ja) * | 2002-05-07 | 2005-10-13 | ネクター セラピューティクス | 乾燥粉末吸入器のためのカプセル及びそれを製造及び使用する方法 |
JP2008510824A (ja) * | 2004-08-23 | 2008-04-10 | マンカインド コーポレイション | 薬物送達のためのジケトピペラジン塩、ジケトモルホリン塩、又はジケトジオキサン塩 |
JP2009519972A (ja) * | 2005-12-15 | 2009-05-21 | アキュスフィア, インコーポレイテッド | 粒子ベースの経肺投与または経鼻投与用製薬の製造方法 |
JP2011524210A (ja) * | 2008-06-13 | 2011-09-01 | マンカインド コーポレイション | 薬物送達用の乾燥粉末吸入器およびシステム |
JP2013540123A (ja) * | 2010-09-29 | 2013-10-31 | パルマトリックス,インコーポレイテッド | 吸入用の一価金属カチオン乾燥粉末 |
JP2015509788A (ja) * | 2012-02-29 | 2015-04-02 | パルマトリックス,インコーポレイテッド | 吸入に適した乾燥粉末 |
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CN114904100A (zh) | 2022-08-16 |
EP4079291A1 (en) | 2022-10-26 |
AU2022224822A1 (en) | 2022-09-29 |
IL260823B1 (en) | 2024-04-01 |
EP3407870A1 (en) | 2018-12-05 |
JP2023154079A (ja) | 2023-10-18 |
MX2018009159A (es) | 2019-06-13 |
AU2017211410B2 (en) | 2022-10-13 |
IL260823A (ja) | 2024-04-01 |
CA3012679C (en) | 2023-12-12 |
MX2023001592A (es) | 2023-03-15 |
WO2017132601A1 (en) | 2017-08-03 |
EP3407870A4 (en) | 2019-07-31 |
JP2022160697A (ja) | 2022-10-19 |
US20200046917A1 (en) | 2020-02-13 |
BR112018015444B1 (pt) | 2023-12-19 |
AU2017211410A1 (en) | 2018-08-09 |
US20210146071A1 (en) | 2021-05-20 |
HK1258955A1 (zh) | 2019-11-22 |
CN108778249A (zh) | 2018-11-09 |
EP3407870B1 (en) | 2022-06-29 |
US20170216538A1 (en) | 2017-08-03 |
US20230098083A1 (en) | 2023-03-30 |
CA3199504A1 (en) | 2017-08-03 |
BR112018015444A2 (pt) | 2018-12-18 |
SG11201806304PA (en) | 2018-08-30 |
CN108778249B (zh) | 2022-05-27 |
CA3012679A1 (en) | 2017-08-03 |
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