JP2013536845A5 - - Google Patents
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- JP2013536845A5 JP2013536845A5 JP2013527146A JP2013527146A JP2013536845A5 JP 2013536845 A5 JP2013536845 A5 JP 2013536845A5 JP 2013527146 A JP2013527146 A JP 2013527146A JP 2013527146 A JP2013527146 A JP 2013527146A JP 2013536845 A5 JP2013536845 A5 JP 2013536845A5
- Authority
- JP
- Japan
- Prior art keywords
- dry powder
- inhalation
- magnesium
- inhalation according
- dry
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000000843 powder Substances 0.000 claims 22
- 239000003814 drug Substances 0.000 claims 13
- 159000000003 magnesium salts Chemical class 0.000 claims 11
- 229940124597 therapeutic agent Drugs 0.000 claims 10
- 239000002245 particle Substances 0.000 claims 9
- 239000000546 pharmaceutical excipient Substances 0.000 claims 7
- TWRXJAOTZQYOKJ-UHFFFAOYSA-L Magnesium chloride Chemical compound [Mg+2].[Cl-].[Cl-] TWRXJAOTZQYOKJ-UHFFFAOYSA-L 0.000 claims 4
- CSNNHWWHGAXBCP-UHFFFAOYSA-L Magnesium sulfate Chemical compound [Mg+2].[O-][S+2]([O-])([O-])[O-] CSNNHWWHGAXBCP-UHFFFAOYSA-L 0.000 claims 4
- 108010067396 dornase alfa Proteins 0.000 claims 3
- OVGXLJDWSLQDRT-UHFFFAOYSA-L magnesium lactate Chemical compound [Mg+2].CC(O)C([O-])=O.CC(O)C([O-])=O OVGXLJDWSLQDRT-UHFFFAOYSA-L 0.000 claims 3
- 239000000626 magnesium lactate Substances 0.000 claims 3
- 229960004658 magnesium lactate Drugs 0.000 claims 3
- 235000015229 magnesium lactate Nutrition 0.000 claims 3
- 238000004519 manufacturing process Methods 0.000 claims 3
- PZSMUPGANZGPBF-UHFFFAOYSA-N 4-[5-(dithiolan-3-yl)pentanoylamino]butanoic acid Chemical compound OC(=O)CCCNC(=O)CCCCC1CCSS1 PZSMUPGANZGPBF-UHFFFAOYSA-N 0.000 claims 2
- 235000017274 Diospyros sandwicensis Nutrition 0.000 claims 2
- 241000282838 Lama Species 0.000 claims 2
- 229940110339 Long-acting muscarinic antagonist Drugs 0.000 claims 2
- JLVVSXFLKOJNIY-UHFFFAOYSA-N Magnesium ion Chemical compound [Mg+2] JLVVSXFLKOJNIY-UHFFFAOYSA-N 0.000 claims 2
- 239000003242 anti bacterial agent Substances 0.000 claims 2
- 229940088710 antibiotic agent Drugs 0.000 claims 2
- 239000003246 corticosteroid Substances 0.000 claims 2
- 229960001334 corticosteroids Drugs 0.000 claims 2
- 229940125389 long-acting beta agonist Drugs 0.000 claims 2
- 229910001629 magnesium chloride Inorganic materials 0.000 claims 2
- 229960002337 magnesium chloride Drugs 0.000 claims 2
- 229910001425 magnesium ion Inorganic materials 0.000 claims 2
- 229910052943 magnesium sulfate Inorganic materials 0.000 claims 2
- 229960003390 magnesium sulfate Drugs 0.000 claims 2
- 235000019341 magnesium sulphate Nutrition 0.000 claims 2
- 239000003195 sodium channel blocking agent Substances 0.000 claims 2
- 239000000021 stimulant Substances 0.000 claims 2
- FBPFZTCFMRRESA-KVTDHHQDSA-N D-Mannitol Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-KVTDHHQDSA-N 0.000 claims 1
- 206010061218 Inflammation Diseases 0.000 claims 1
- ROHFNLRQFUQHCH-UHFFFAOYSA-N Leucine Natural products CC(C)CC(N)C(O)=O ROHFNLRQFUQHCH-UHFFFAOYSA-N 0.000 claims 1
- GSDSWSVVBLHKDQ-JTQLQIEISA-N Levofloxacin Chemical compound C([C@@H](N1C2=C(C(C(C(O)=O)=C1)=O)C=C1F)C)OC2=C1N1CCN(C)CC1 GSDSWSVVBLHKDQ-JTQLQIEISA-N 0.000 claims 1
- -1 Magnesium cations Chemical class 0.000 claims 1
- 229920002774 Maltodextrin Polymers 0.000 claims 1
- 239000005913 Maltodextrin Substances 0.000 claims 1
- 229930195725 Mannitol Natural products 0.000 claims 1
- 206010057190 Respiratory tract infections Diseases 0.000 claims 1
- GIIZNNXWQWCKIB-UHFFFAOYSA-N Serevent Chemical compound C1=C(O)C(CO)=CC(C(O)CNCCCCCCOCCCCC=2C=CC=CC=2)=C1 GIIZNNXWQWCKIB-UHFFFAOYSA-N 0.000 claims 1
- NDAUXUAQIAJITI-UHFFFAOYSA-N albuterol Chemical compound CC(C)(C)NCC(O)C1=CC=C(O)C(CO)=C1 NDAUXUAQIAJITI-UHFFFAOYSA-N 0.000 claims 1
- XSDQTOBWRPYKKA-UHFFFAOYSA-N amiloride Chemical compound NC(=N)NC(=O)C1=NC(Cl)=C(N)N=C1N XSDQTOBWRPYKKA-UHFFFAOYSA-N 0.000 claims 1
- 229960002576 amiloride Drugs 0.000 claims 1
- 150000001413 amino acids Chemical class 0.000 claims 1
- 230000000844 anti-bacterial effect Effects 0.000 claims 1
- 230000003110 anti-inflammatory effect Effects 0.000 claims 1
- 230000000840 anti-viral effect Effects 0.000 claims 1
- 230000004071 biological effect Effects 0.000 claims 1
- 239000010419 fine particle Substances 0.000 claims 1
- 229960002714 fluticasone Drugs 0.000 claims 1
- MGNNYOODZCAHBA-GQKYHHCASA-N fluticasone Chemical compound C1([C@@H](F)C2)=CC(=O)C=C[C@]1(C)[C@]1(F)[C@@H]2[C@@H]2C[C@@H](C)[C@@](C(=O)SCF)(O)[C@@]2(C)C[C@@H]1O MGNNYOODZCAHBA-GQKYHHCASA-N 0.000 claims 1
- 229960002848 formoterol Drugs 0.000 claims 1
- BPZSYCZIITTYBL-UHFFFAOYSA-N formoterol Chemical compound C1=CC(OC)=CC=C1CC(C)NCC(O)C1=CC=C(O)C(NC=O)=C1 BPZSYCZIITTYBL-UHFFFAOYSA-N 0.000 claims 1
- 150000004676 glycans Chemical class 0.000 claims 1
- 230000004054 inflammatory process Effects 0.000 claims 1
- 125000001909 leucine group Chemical group [H]N(*)C(C(*)=O)C([H])([H])C(C([H])([H])[H])C([H])([H])[H] 0.000 claims 1
- 229960003376 levofloxacin Drugs 0.000 claims 1
- 239000011777 magnesium Substances 0.000 claims 1
- 229910052749 magnesium Inorganic materials 0.000 claims 1
- ZLNQQNXFFQJAID-UHFFFAOYSA-L magnesium carbonate Chemical compound [Mg+2].[O-]C([O-])=O ZLNQQNXFFQJAID-UHFFFAOYSA-L 0.000 claims 1
- 239000001095 magnesium carbonate Substances 0.000 claims 1
- 229910000021 magnesium carbonate Inorganic materials 0.000 claims 1
- 229960001708 magnesium carbonate Drugs 0.000 claims 1
- 235000014380 magnesium carbonate Nutrition 0.000 claims 1
- 235000011147 magnesium chloride Nutrition 0.000 claims 1
- 229960005336 magnesium citrate Drugs 0.000 claims 1
- 235000002538 magnesium citrate Nutrition 0.000 claims 1
- 239000004337 magnesium citrate Substances 0.000 claims 1
- GVALZJMUIHGIMD-UHFFFAOYSA-H magnesium phosphate Chemical compound [Mg+2].[Mg+2].[Mg+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O GVALZJMUIHGIMD-UHFFFAOYSA-H 0.000 claims 1
- 239000004137 magnesium phosphate Substances 0.000 claims 1
- 229960002261 magnesium phosphate Drugs 0.000 claims 1
- 229910000157 magnesium phosphate Inorganic materials 0.000 claims 1
- 235000010994 magnesium phosphates Nutrition 0.000 claims 1
- 229940091250 magnesium supplement Drugs 0.000 claims 1
- 229940035034 maltodextrin Drugs 0.000 claims 1
- 235000010355 mannitol Nutrition 0.000 claims 1
- 239000000594 mannitol Substances 0.000 claims 1
- 229920001282 polysaccharide Polymers 0.000 claims 1
- 239000005017 polysaccharide Substances 0.000 claims 1
- 230000002265 prevention Effects 0.000 claims 1
- 208000023504 respiratory system disease Diseases 0.000 claims 1
- 229960002052 salbutamol Drugs 0.000 claims 1
- 229960004017 salmeterol Drugs 0.000 claims 1
- 235000000346 sugar Nutrition 0.000 claims 1
- 150000005846 sugar alcohols Chemical class 0.000 claims 1
- 150000008163 sugars Chemical class 0.000 claims 1
- 229940110309 tiotropium Drugs 0.000 claims 1
- LERNTVKEWCAPOY-DZZGSBJMSA-N tiotropium Chemical compound O([C@H]1C[C@@H]2[N+]([C@H](C1)[C@@H]1[C@H]2O1)(C)C)C(=O)C(O)(C=1SC=CC=1)C1=CC=CS1 LERNTVKEWCAPOY-DZZGSBJMSA-N 0.000 claims 1
- PLSARIKBYIPYPF-UHFFFAOYSA-H trimagnesium dicitrate Chemical compound [Mg+2].[Mg+2].[Mg+2].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O.[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O PLSARIKBYIPYPF-UHFFFAOYSA-H 0.000 claims 1
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US37814610P | 2010-08-30 | 2010-08-30 | |
| US61/378,146 | 2010-08-30 | ||
| US38792510P | 2010-09-29 | 2010-09-29 | |
| US61/387,925 | 2010-09-29 | ||
| US201161431242P | 2011-01-10 | 2011-01-10 | |
| US61/431,242 | 2011-01-10 | ||
| PCT/US2011/049435 WO2012030664A1 (en) | 2010-08-30 | 2011-08-26 | Dry powder formulations and methods for treating pulmonary diseases |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2013536845A JP2013536845A (ja) | 2013-09-26 |
| JP2013536845A5 true JP2013536845A5 (enExample) | 2014-10-09 |
| JP5877201B2 JP5877201B2 (ja) | 2016-03-02 |
Family
ID=45773220
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013527146A Active JP5877201B2 (ja) | 2010-08-30 | 2011-08-26 | 肺疾患を治療するための乾燥粉末製剤および方法 |
Country Status (7)
| Country | Link |
|---|---|
| US (3) | US9061352B2 (enExample) |
| EP (1) | EP2611438B1 (enExample) |
| JP (1) | JP5877201B2 (enExample) |
| CN (2) | CN105640925B (enExample) |
| AU (1) | AU2011296343B2 (enExample) |
| CA (1) | CA2809666C (enExample) |
| WO (1) | WO2012030664A1 (enExample) |
Families Citing this family (56)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PT1993360T (pt) | 2005-12-28 | 2017-05-25 | Vertex Pharma | Formas sólidas de n-[2,4-bis(1,1-dimetiletil)-5-hidroxifenil]-1,4-di-hidro-4-oxoquinolina-3-carboxamida |
| GB2463181B (en) | 2007-05-14 | 2013-03-27 | Univ New York State Res Found | Induction of a physiological dispersion response in bacterial cells in a biofilm |
| AU2011296343B2 (en) | 2010-08-30 | 2015-12-10 | Pulmatrix Operating Company, Inc. | Dry powder formulations and methods for treating pulmonary diseases |
| US20130164338A1 (en) | 2010-08-30 | 2013-06-27 | Pulmatrix, Inc. | Treatment of cystic fibrosis using calcium lactate, leucine and sodium chloride in a respiraple dry powder |
| CA3086367A1 (en) | 2010-09-29 | 2012-04-05 | Pulmatrix Operating Company, Inc. | Monovalent metal cation dry powders for inhalation |
| PT2621488T (pt) | 2010-09-29 | 2019-02-12 | Pulmatrix Operating Co Inc | Pós secos catiónicos |
| WO2013052844A1 (en) | 2011-10-07 | 2013-04-11 | Pulmatrix, Inc. | Methods for treating and diagnosing respiratory tract infections |
| CN104487075A (zh) | 2012-02-29 | 2015-04-01 | 普马特里克斯公司 | 可吸入干粉剂 |
| WO2013169633A1 (en) * | 2012-05-07 | 2013-11-14 | Jiin-Huey Chern Lin | Antibacterial calcium-based materials |
| WO2014007767A1 (en) * | 2012-07-05 | 2014-01-09 | Sanovel Ilac Sanayi Ve Ticaret Anonim Sirketi | Dry powder inhalers comprising a carrier other than lactose and a ternary component |
| US10105316B2 (en) | 2012-07-05 | 2018-10-23 | Arven llac Sanayi Ve Ticaret A.S. | Inhalation compositions comprising muscarinic receptor antagonist |
| WO2014007772A2 (en) | 2012-07-05 | 2014-01-09 | Sanovel Ilac Sanayi Ve Ticaret Anonim Sirketi | Inhalation compositions comprising glucose anhydrous |
| ES2604855T3 (es) | 2012-08-01 | 2017-03-09 | Purac Biochem Bv | Polvo de lactato y procedimiento de preparación del mismo |
| WO2014074797A1 (en) * | 2012-11-09 | 2014-05-15 | Civitas Therapeutics, Inc. | Ultra low density pulmonary powders |
| US9757529B2 (en) | 2012-12-20 | 2017-09-12 | Otitopic Inc. | Dry powder inhaler and methods of use |
| US9757395B2 (en) | 2012-12-20 | 2017-09-12 | Otitopic Inc. | Dry powder inhaler and methods of use |
| EP2769630B1 (en) | 2013-02-26 | 2016-04-27 | Purac Biochem N.V. | Improved nisin production process |
| EP2754356A1 (en) | 2013-01-15 | 2014-07-16 | Purac Biochem N.V. | Improved nisin production process |
| AU2014248455B2 (en) | 2013-04-01 | 2018-12-06 | Pulmatrix Operating Company, Inc. | Tiotropium dry powders |
| US10149823B2 (en) | 2013-04-30 | 2018-12-11 | Otitopic Inc. | Dry powder formulations and methods of use |
| CN105451716A (zh) * | 2013-07-18 | 2016-03-30 | 曼金德公司 | 热稳定性干粉药物组合物和方法 |
| HUE045868T2 (hu) * | 2013-11-22 | 2020-01-28 | Teva Branded Pharmaceutical Products R&D Inc | Inhalálható gyógykészítmény |
| CN107250113B (zh) | 2014-10-07 | 2019-03-29 | 弗特克斯药品有限公司 | 囊性纤维化跨膜传导调节蛋白的调节剂的共晶 |
| AU2015328153A1 (en) * | 2014-10-08 | 2017-04-27 | Pulmatrix Operating Company, Inc. | Formulations containing tiotropium, amino acid and acid and methods thereof |
| WO2016057644A1 (en) * | 2014-10-08 | 2016-04-14 | Pulmatrix Operating Company, Inc. | Improved stability of dry powders containing tiotropium and amino acid |
| CA2965759C (en) | 2014-10-31 | 2023-12-12 | Glaxosmithkline Intellectual Property Development Limited | Powdered polypeptides with decreased disulfide impurities comprising divalent cationic materials |
| US12121538B2 (en) | 2015-06-04 | 2024-10-22 | Amorphical Ltd. | Compositions of amorphous calcium carbonate for inhalation, sublingual or buccal administration |
| IL256065B2 (en) | 2015-06-04 | 2024-04-01 | Amorphical Ltd | Amorphous calcium carbonate stabilized with polyphosphates or bisphosphonates |
| US10046007B2 (en) | 2015-06-24 | 2018-08-14 | Prescient Pharma, Llc | Compositions and methods for treatment of short telomere disorders |
| DE102016122768A1 (de) * | 2015-12-02 | 2017-06-14 | Miz Company Limited | Vorrichtung und Verfahren zum Erzeugen einer wasserstoffhaltigen Flüssigkeit |
| AU2017341815B2 (en) | 2016-10-14 | 2023-06-15 | Pulmatrix Operating Company, Inc. | Antifungal dry powders |
| CN114948992A (zh) | 2016-10-25 | 2022-08-30 | 艾玛菲克有限公司 | 用于治疗白血病的无定形碳酸钙 |
| EP3618824A4 (en) * | 2017-05-02 | 2021-06-23 | Neuronasal, LLC | Use of n-acetylcysteine to treat central nervous system disorders |
| CN115919780A (zh) | 2017-09-22 | 2023-04-07 | 维克图拉公司 | 含有硬脂酸镁的干粉组合物 |
| US10786456B2 (en) | 2017-09-22 | 2020-09-29 | Otitopic Inc. | Inhaled aspirin and magnesium to treat inflammation |
| KR102745548B1 (ko) * | 2017-10-05 | 2024-12-23 | 푸락 바이오켐 비.브이. | 락테이트 분말 및 이의 제조방법 |
| AU2018392458B2 (en) * | 2017-12-21 | 2025-06-26 | Merz Pharmaceuticals, Llc | Surfactant formulations for inhalation |
| KR102868782B1 (ko) * | 2018-01-12 | 2025-10-13 | (주)메티메디제약 | 만성 염증성 질환의 치료 방법 |
| WO2019163520A1 (ja) | 2018-02-26 | 2019-08-29 | 株式会社新日本科学 | 粉末製剤、カートリッジ、及びデバイス |
| CN112423755A (zh) * | 2018-04-18 | 2021-02-26 | 希普拉技术有限责任公司 | 治疗真菌感染的方法 |
| EP3787801B1 (en) * | 2018-05-04 | 2023-07-12 | Microbase Technology Corp. | Microstructured nozzle |
| US11541105B2 (en) | 2018-06-01 | 2023-01-03 | The Research Foundation For The State University Of New York | Compositions and methods for disrupting biofilm formation and maintenance |
| EP3910324A1 (en) * | 2018-08-07 | 2021-11-17 | Norton (Waterford) Limited | Application of raman spectroscopy for the manufacture of inhalation powders |
| US12337064B2 (en) | 2018-09-05 | 2025-06-24 | Sensory Cloud, Inc. | Formulations and compositions for ortho- and/or retro-nasal delivery and associated systems, methods and articles |
| WO2020083412A1 (de) * | 2018-10-22 | 2020-04-30 | Ioi Oleo Gmbh | Additiv für ein zur verpressung zu formkörpern vorgesehenes pulver |
| US20220025019A1 (en) | 2018-11-30 | 2022-01-27 | Csl Behring Ag | Methods and compositions for preventing or treating acute exacerbations with polyclonal immunoglobulin |
| RU2714679C1 (ru) * | 2019-03-21 | 2020-02-19 | Федеральное государственное бюджетное научное учреждение "Томский национальный исследовательский медицинский центр Российской академии наук" (Томский НИМЦ) | Способ моделирования сочетанной патологии метаболического синдрома и хронической обструктивной болезни легких |
| CN109827875A (zh) * | 2019-04-10 | 2019-05-31 | 上海市食品药品检验所 | 一种用于测定吸入制剂溶出度的装置和方法 |
| CA3144221A1 (en) | 2019-07-23 | 2021-01-28 | Amorphical Ltd | Amorphous calcium carbonate for improving athletic performance |
| WO2021203001A1 (en) * | 2020-04-03 | 2021-10-07 | Millennium Pharmaceuticals, Inc. | Method of treating patients infected with a viral infection with an inhibitor of small ubiquitin like modifier activating enzyme |
| AU2021276611A1 (en) * | 2020-05-18 | 2022-12-15 | Orexo Ab | New pharmaceutical composition for drug delivery |
| CN112163350B (zh) * | 2020-11-02 | 2023-05-23 | 国能黄金埠发电有限公司 | 一种制粉系统双模型的煤粉细度实时在线软测量系统及方法 |
| EP4429643A4 (en) * | 2021-11-09 | 2025-11-12 | Agency Science Tech & Res | Salt-based platform antifungal powder formulation for aerosolization |
| GB202117016D0 (en) | 2021-11-25 | 2022-01-12 | Orexo Ab | New pharmaceutical device |
| JP2024541470A (ja) | 2021-11-25 | 2024-11-08 | オレクソ・アクチエボラゲット | アドレナリンを含む医薬組成物 |
| EP4447951A2 (en) * | 2021-12-16 | 2024-10-23 | Alveolus Bio, Inc. | Inhalable or ingestible lactic acid compositions for the treatment of chronic lung disease |
Family Cites Families (141)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4069819A (en) | 1973-04-13 | 1978-01-24 | Societa Farmaceutici S.P.A. | Inhalation device |
| US4233405A (en) | 1979-10-10 | 1980-11-11 | Rohm And Haas Company | Process for spray drying enzymes |
| DE3229179C2 (de) | 1982-08-05 | 1986-04-17 | A. Nattermann & Cie GmbH, 5000 Köln | Lungensurfactant |
| US4637815A (en) | 1985-08-06 | 1987-01-20 | Lemole Gerald M | Irrigational hemostatic solution |
| US5511726A (en) | 1988-09-23 | 1996-04-30 | Battelle Memorial Institute | Nebulizer device |
| US4899914A (en) | 1988-11-04 | 1990-02-13 | Ciba-Geigy Corporation | Method for producing a sterile preservative-free aerosol saline solution |
| IT1228459B (it) | 1989-02-23 | 1991-06-19 | Phidea S R L | Inalatore con svuotamento regolare e completo della capsula. |
| US5230884A (en) | 1990-09-11 | 1993-07-27 | University Of Wales College Of Cardiff | Aerosol formulations including proteins and peptides solubilized in reverse micelles and process for making the aerosol formulations |
| US5175152A (en) | 1990-09-28 | 1992-12-29 | Singh Nikhilesh N | Composition containing ephedrine base and alkyl salicylate for the delivery of ephedrine base in vapor form |
| US5211944A (en) | 1990-10-12 | 1993-05-18 | Shaman Pharmaceuticals, Inc. | Proanthocyanidin polymers having antiviral activity and methods of obtaining same |
| US5571535A (en) | 1990-11-30 | 1996-11-05 | Flowers; Marianne | Treatment of topical infections |
| JPH0512398A (ja) | 1990-12-28 | 1993-01-22 | Mutoh Ind Ltd | 画像編集方法および装置 |
| US5993805A (en) | 1991-04-10 | 1999-11-30 | Quadrant Healthcare (Uk) Limited | Spray-dried microparticles and their use as therapeutic vehicles |
| JPH05123398A (ja) | 1991-11-06 | 1993-05-21 | Tsunemasa Kamiyama | 咽喉保護吸入剤並びに吸入器具 |
| GB2265845B (en) | 1991-11-12 | 1996-05-01 | Medix Ltd | A nebuliser and nebuliser control system |
| US5466680A (en) | 1992-03-26 | 1995-11-14 | Cytologics, Inc. | Method and compositions for enhancing white blood cell functioning on a mucosal or cutaneous surface |
| JP3961029B2 (ja) | 1992-06-24 | 2007-08-15 | 博 木戸 | インフルエンザウィルス感染防止剤 |
| US6582728B1 (en) | 1992-07-08 | 2003-06-24 | Inhale Therapeutic Systems, Inc. | Spray drying of macromolecules to produce inhaleable dry powders |
| US5785049A (en) | 1994-09-21 | 1998-07-28 | Inhale Therapeutic Systems | Method and apparatus for dispersion of dry powder medicaments |
| US5898037A (en) | 1992-11-13 | 1999-04-27 | Marx; Alvin J. | Formulations of magnesium compounds for local application and methods of treatment using the same |
| US6098620A (en) | 1993-01-29 | 2000-08-08 | Aradigm Corporation | Device for aerosolizing narcotics |
| US5724957A (en) | 1993-01-29 | 1998-03-10 | Aradigm Corporation | Intrapulmonary delivery of narcotics |
| US5709202A (en) | 1993-05-21 | 1998-01-20 | Aradigm Corporation | Intrapulmonary delivery of aerosolized formulations |
| NZ328476A (en) | 1993-06-24 | 1999-05-28 | Astra Ab | Use of a two component insulin preparation in an inhalation device |
| AUPM411494A0 (en) | 1994-02-25 | 1994-03-24 | Central Sydney Area Health Service | Method and device for the provocation of upper or lower airway narrowing and/or the induction of sputum |
| US5633003A (en) | 1994-03-31 | 1997-05-27 | Cantor; Jerome O. | Use of intratracheally administered hyaluronic acid to ameliorate emphysema |
| JP3414539B2 (ja) | 1994-05-11 | 2003-06-09 | 有限会社ドット | 経鼻吸収用組成物 |
| US6290991B1 (en) | 1994-12-02 | 2001-09-18 | Quandrant Holdings Cambridge Limited | Solid dose delivery vehicle and methods of making same |
| US6586006B2 (en) | 1994-08-04 | 2003-07-01 | Elan Drug Delivery Limited | Solid delivery systems for controlled release of molecules incorporated therein and methods of making same |
| TW381088B (en) | 1994-10-14 | 2000-02-01 | Yamanouchi Pharma Co Ltd | Azole derivative |
| US5863563A (en) | 1994-10-20 | 1999-01-26 | Alphagene Inc. | Treatment of pulmonary conditions associated with insufficient secretion of surfactant |
| US5747002A (en) | 1995-04-05 | 1998-05-05 | Genentech, Inc. | Preparation of sodium chloride aerosol formulations |
| US5612053A (en) | 1995-04-07 | 1997-03-18 | Edward Mendell Co., Inc. | Controlled release insufflation carrier for medicaments |
| US6165463A (en) | 1997-10-16 | 2000-12-26 | Inhale Therapeutic Systems, Inc. | Dispersible antibody compositions and methods for their preparation and use |
| WO1996032151A1 (en) | 1995-04-14 | 1996-10-17 | Glaxo Wellcome Inc. | Metered dose inhaler for fluticasone propionate |
| ES2237767T3 (es) | 1995-04-14 | 2005-08-01 | Nektar Therapeutics | Composiciones farmaceuticas en polvo que tienen una dispersabilidad mejorada. |
| US6258341B1 (en) * | 1995-04-14 | 2001-07-10 | Inhale Therapeutic Systems, Inc. | Stable glassy state powder formulations |
| US5654007A (en) | 1995-06-07 | 1997-08-05 | Inhale Therapeutic Systems | Methods and system for processing dispersible fine powders |
| GB9515182D0 (en) | 1995-07-24 | 1995-09-20 | Co Ordinated Drug Dev | Improvements in and relating to powders for use in dry powder inhalers |
| US5628984A (en) | 1995-07-31 | 1997-05-13 | University Of North Carolina At Chapel Hill | Method of detecting lung disease |
| US20050054682A1 (en) | 1996-01-04 | 2005-03-10 | Phillips Jeffrey O. | Pharmaceutical compositions comprising substituted benzimidazoles and methods of using same |
| GB9606677D0 (en) | 1996-03-29 | 1996-06-05 | Glaxo Wellcome Inc | Process and device |
| US6083922A (en) | 1996-04-02 | 2000-07-04 | Pathogenesis, Corp. | Method and a tobramycin aerosol formulation for treatment prevention and containment of tuberculosis |
| US5855913A (en) | 1997-01-16 | 1999-01-05 | Massachusetts Instite Of Technology | Particles incorporating surfactants for pulmonary drug delivery |
| US5985309A (en) | 1996-05-24 | 1999-11-16 | Massachusetts Institute Of Technology | Preparation of particles for inhalation |
| US6254854B1 (en) | 1996-05-24 | 2001-07-03 | The Penn Research Foundation | Porous particles for deep lung delivery |
| USRE37053E1 (en) | 1996-05-24 | 2001-02-13 | Massachusetts Institute Of Technology | Particles incorporating surfactants for pulmonary drug delivery |
| US5874064A (en) | 1996-05-24 | 1999-02-23 | Massachusetts Institute Of Technology | Aerodynamically light particles for pulmonary drug delivery |
| US6131570A (en) | 1998-06-30 | 2000-10-17 | Aradigm Corporation | Temperature controlling device for aerosol drug delivery |
| DE19653969A1 (de) | 1996-12-20 | 1998-06-25 | Boehringer Ingelheim Kg | Neue wässrige Arzneimittelzubereitung zur Erzeugung treibgasfreier Aerosole |
| GB9707934D0 (en) | 1997-04-18 | 1997-06-04 | Danbiosyst Uk | Improved delivery of drugs to mucosal surfaces |
| US20010031244A1 (en) | 1997-06-13 | 2001-10-18 | Chiesi Farmaceutici S.P.A. | Pharmaceutical aerosol composition |
| DE69814428T2 (de) | 1997-09-29 | 2004-05-13 | Nektar Therapeutics, San Carlos | In verneblern verwendbare, stabilisierte zubereitungen |
| US6565885B1 (en) | 1997-09-29 | 2003-05-20 | Inhale Therapeutic Systems, Inc. | Methods of spray drying pharmaceutical compositions |
| GB9807232D0 (en) | 1998-04-03 | 1998-06-03 | Univ Cardiff | Aerosol composition |
| BR9909492A (pt) | 1998-04-08 | 2000-12-12 | Lilly Co Eli | Liberação pulmonar e nasal de raloxifeno |
| US5883084A (en) | 1998-06-08 | 1999-03-16 | Clarion Pharmaceuticals Inc. | Treatment of respiratory diseases utilizing α-tocopheryl-phosphocholine |
| SE9802073D0 (sv) | 1998-06-11 | 1998-06-11 | Astra Ab | New use |
| WO2000000215A1 (en) | 1998-06-29 | 2000-01-06 | Inhale Therapeutic Systems, Inc. | Particulate delivery systems and methods of use |
| FR2780285B1 (fr) | 1998-06-29 | 2001-10-05 | Goemar Lab Sa | Utilisation de solutions salines isoosmotiques, leur procede de preparation et medicaments anti-inflammatoires a base de ces solutions |
| GB9814172D0 (en) | 1998-06-30 | 1998-08-26 | Andaris Ltd | Formulation for inhalation |
| US6333051B1 (en) | 1998-09-03 | 2001-12-25 | Supratek Pharma, Inc. | Nanogel networks and biological agent compositions thereof |
| US6926911B1 (en) | 1998-12-22 | 2005-08-09 | The University Of North Carolina At Chapel Hill | Compounds and methods for the treatment of airway diseases and for the delivery of airway drugs |
| MXPA01007895A (es) | 1999-02-03 | 2003-07-21 | Biosante Pharmaceuticals Inc | Particulas terapeuticas de fosfato de calcio, metodos de manufactura y usos. |
| MXPA01011283A (es) | 1999-05-03 | 2002-11-04 | Battelle Memorial Institute | Composiciones par aerosolizacion e inhalacion. |
| US6858199B1 (en) | 2000-06-09 | 2005-02-22 | Advanced Inhalation Research, Inc. | High efficient delivery of a large therapeutic mass aerosol |
| US6749835B1 (en) | 1999-08-25 | 2004-06-15 | Advanced Inhalation Research, Inc. | Formulation for spray-drying large porous particles |
| US7678364B2 (en) | 1999-08-25 | 2010-03-16 | Alkermes, Inc. | Particles for inhalation having sustained release properties |
| ATE285755T1 (de) * | 1999-08-25 | 2005-01-15 | Advanced Inhalation Res Inc | Grosse poröse partikel erhältlich durch sprühtrocknung und geeignet zur pulmonalen anwendung |
| CN1188111C (zh) | 1999-10-29 | 2005-02-09 | 耐科塔医药公司 | 分散性得到改进的干粉组合物 |
| AU772096B2 (en) | 2000-03-14 | 2004-04-08 | Sumika Enviro-Science Co., Ltd. | Method for denaturing allergens |
| US7871598B1 (en) | 2000-05-10 | 2011-01-18 | Novartis Ag | Stable metal ion-lipid powdered pharmaceutical compositions for drug delivery and methods of use |
| CA2382133C (en) | 2000-05-10 | 2010-11-23 | Alliance Pharmaceutical Corporation | Phospholipid-based powders for drug delivery |
| EP1296651B2 (en) | 2000-06-27 | 2019-07-17 | Vectura Limited | Method of making particles for use in a pharmaceutical composition |
| US7575761B2 (en) | 2000-06-30 | 2009-08-18 | Novartis Pharma Ag | Spray drying process control of drying kinetics |
| WO2002009574A2 (en) | 2000-08-01 | 2002-02-07 | Shofner Engineering Associates, Inc. | Generation, delivery, measurement and control of aerosol boli for diagnostics and treatment of the respiratory tract |
| AU2001291159A1 (en) | 2000-09-20 | 2002-04-02 | Shahinian Jr., Lee | Self-preserved nasal, inhalable, and topical ophthalmic preparations and medications |
| DK1337240T4 (en) * | 2000-11-30 | 2015-01-05 | Vectura Ltd | A process for the preparation of particles for use in a pharmaceutical composition |
| WO2002054868A2 (en) | 2000-12-21 | 2002-07-18 | Inhale Therapeutic Syst | Pulmonary delivery of polyene antifungal agents |
| DE60144291D1 (de) | 2000-12-27 | 2011-05-05 | Gilead Sciences Inc | Inhalierbares aztreonam zur behandlung und vorbeugung von bakteriellen lungeninfektionen |
| US20020141946A1 (en) | 2000-12-29 | 2002-10-03 | Advanced Inhalation Research, Inc. | Particles for inhalation having rapid release properties |
| US6766799B2 (en) | 2001-04-16 | 2004-07-27 | Advanced Inhalation Research, Inc. | Inhalation device |
| US6667344B2 (en) | 2001-04-17 | 2003-12-23 | Dey, L.P. | Bronchodilating compositions and methods |
| US20030138403A1 (en) | 2001-06-29 | 2003-07-24 | Maxygen Aps | Interferon formulations |
| US20050123509A1 (en) | 2001-10-19 | 2005-06-09 | Lehrman S. R. | Modulating charge density to produce improvements in the characteristics of spray-dried proteins |
| CA2465675C (en) | 2001-11-20 | 2008-06-10 | Advanced Inhalation Research, Inc. | Improved particulate compositions for pulmonary delivery |
| AU2002349513B2 (en) | 2001-11-26 | 2007-10-18 | Asubio Pharma Co., Ltd. | Medicinal compositions for nasal absorption |
| AU2003215334A1 (en) | 2002-02-22 | 2003-09-09 | Advanced Inhalation Research, Inc. | Inhalable formulations for sustained release |
| US7008644B2 (en) | 2002-03-20 | 2006-03-07 | Advanced Inhalation Research, Inc. | Method and apparatus for producing dry particles |
| SI2630954T1 (sl) | 2002-03-20 | 2017-02-28 | Civitas Therapeutics, Inc. | Pulmonalno dovajanje za levodopo |
| GB0207906D0 (en) | 2002-04-05 | 2002-05-15 | 3M Innovative Properties Co | Formoterol and mometasone aerosol formulations |
| US20050220720A1 (en) | 2002-05-02 | 2005-10-06 | David Edwards | Formulations limiting spread of pulmonary infections |
| US8003080B2 (en) | 2002-05-13 | 2011-08-23 | Alexza Pharmaceuticals, Inc. | Delivery of drug amines through an inhalation route |
| EP1511467A1 (en) | 2002-06-10 | 2005-03-09 | Elan Pharma International Limited | Nanoparticulate polycosanol formulations and novel polycosanol combinations |
| US7947742B2 (en) | 2002-06-28 | 2011-05-24 | Civitas Therapeutics, Inc. | Inhalable epinephrine |
| US7371729B2 (en) | 2002-09-09 | 2008-05-13 | Trigen Limited | Boronic acid salts useful in parenteral formulations |
| CN1694689A (zh) | 2002-09-30 | 2005-11-09 | 阿库斯菲尔公司 | 供吸入的缓释多孔微粒 |
| US8084036B2 (en) | 2002-11-22 | 2011-12-27 | Nexbio, Inc. | Broad spectrum anti-viral therapeutics and prophylaxis |
| US7534781B2 (en) | 2003-03-21 | 2009-05-19 | Dsm Ip Assets B.V. | Crystalline amoxicillin trihydrate powder |
| CN1194062C (zh) | 2003-04-04 | 2005-03-23 | 王泽斌 | 一种融雪融冰组合物及其制备方法和应用 |
| CA2523740C (en) | 2003-05-01 | 2012-05-15 | Innogene Kalbiotech Pte Ltd | Lactate containing pharmaceutical composition and uses thereof |
| EP1646370A1 (en) | 2003-07-11 | 2006-04-19 | Glaxo Group Limited | Pharmaceutical formulations |
| GB0324897D0 (en) | 2003-10-24 | 2003-11-26 | Glaxo Group Ltd | Composition |
| GB0324918D0 (en) | 2003-10-24 | 2003-11-26 | Glaxo Group Ltd | Composition |
| KR20050056622A (ko) | 2003-12-10 | 2005-06-16 | 주식회사 대우일렉트로닉스 | 플레쉬롬 다운로드 장치 |
| WO2005067898A2 (en) | 2004-01-07 | 2005-07-28 | Nektar Therapeutics | Improved sustained release compositions for pulmonary administration of insulin |
| US20050207983A1 (en) | 2004-03-05 | 2005-09-22 | Pulmatrix, Inc. | Formulations decreasing particle exhalation |
| SE528121C2 (sv) | 2004-03-29 | 2006-09-05 | Mederio Ag | Preparering av torrpulver för på förhand uppmätt DPI |
| WO2005094869A1 (en) | 2004-03-30 | 2005-10-13 | Malcolm King | Compositions and methods for improved mucus function |
| US20050281740A1 (en) | 2004-06-16 | 2005-12-22 | Glen Gong | Imaging damaged lung tissue |
| CN101090714A (zh) | 2004-07-26 | 2007-12-19 | 康泽里克斯公司 | 通过吸入伊洛前列素和微粒制剂治疗肺动脉高血压症 |
| US20060073173A1 (en) | 2004-10-04 | 2006-04-06 | Maria Banach | Large-scale manufacturing process for the production of pharmaceutical compositions |
| GB0425758D0 (en) * | 2004-11-23 | 2004-12-22 | Vectura Ltd | Preparation of pharmaceutical compositions |
| US8627821B2 (en) | 2005-01-10 | 2014-01-14 | Pulmatrix, Inc. | Method and device for decreasing contamination |
| WO2006102438A2 (en) | 2005-03-23 | 2006-09-28 | Ihc Intellectual Asset Management, Llc | Methods and compositions for irrigation of mucosal tissues |
| JP2008539890A (ja) | 2005-05-05 | 2008-11-20 | プルマトリックス インコーポレイテッド | 超音波式エアロゾルゼネレーター |
| AU2006247077A1 (en) | 2005-05-18 | 2006-11-23 | Pulmatrix Inc. | Formulations for alteration of biophysical properties of mucosal lining |
| US7838532B2 (en) | 2005-05-18 | 2010-11-23 | Mpex Pharmaceuticals, Inc. | Aerosolized fluoroquinolones and uses thereof |
| GB0520794D0 (en) | 2005-10-12 | 2005-11-23 | Innovata Biomed Ltd | Inhaler |
| GB0523576D0 (en) | 2005-11-18 | 2005-12-28 | Theradeas Ltd | Drug composition and its use in therapy |
| US20070202051A1 (en) | 2006-02-10 | 2007-08-30 | Pari Gmbh | Aerosols for sinunasal drug delivery |
| WO2008025560A1 (en) | 2006-09-01 | 2008-03-06 | Pari Pharma Gmbh | Methods for taste masking of nebulised compositions for nasal and pulmonary inhalation therapy |
| US20080063722A1 (en) | 2006-09-08 | 2008-03-13 | Advanced Inhalation Research, Inc. | Composition of a Spray-Dried Powder for Pulmonary Delivery of a Long Acting Neuraminidase Inhibitor (LANI) |
| US8501255B2 (en) | 2006-12-14 | 2013-08-06 | Purac Biochem B.V. | Particulate composition comprising calcium lactate and calcium citrate microparticles |
| GB0625322D0 (en) | 2006-12-19 | 2007-01-24 | Pharmakodex Ltd | Pharmaceutical compositions |
| WO2009037503A2 (en) | 2007-09-18 | 2009-03-26 | Astrazeneca Ab | New combination - 012 for the treatment of respiratory diseases |
| PL2303267T3 (pl) | 2008-02-04 | 2013-11-29 | Pfizer Ltd | Polimorficzna postać pochodnej [1,2,4]triazolo[4,3-a]pirydyny do leczenia chorób zapalnych |
| DK2252275T3 (en) | 2008-02-13 | 2018-03-05 | Univ Texas | CREATED NON-OPEN FLOCKS OF ANISOTROPIC PARTICLES FOR IMPROVED TRANSPORT INTO THE Lungs |
| EP2098219A1 (en) * | 2008-03-05 | 2009-09-09 | PARI Pharma GmbH | Macrolide compositions having improved taste and stability |
| KR101621986B1 (ko) | 2008-05-15 | 2016-05-17 | 노파르티스 아게 | 플루오로퀴놀론의 폐 전달 |
| EP2379070A4 (en) | 2008-07-21 | 2013-11-13 | Imi Internat Medical Innovations D B A Procris Pharmaceuticals | WATER BASED TOPICAL STABLE PHARMACEUTICAL CREAMES AND METHODS FOR PREPARING AND USING SAME |
| GB0818476D0 (en) | 2008-10-09 | 2008-11-12 | Vectura Delivery Device Ltd | Inhaler |
| CN102448438A (zh) | 2009-03-26 | 2012-05-09 | 普马特里克斯公司 | 抗流行性感冒调配物及方法 |
| US20120058198A1 (en) | 2009-03-26 | 2012-03-08 | Pulmatrix, Inc. | Methods for treating and preventing pneumonia and ventilator-associated tracheobronchitis |
| US20120083531A1 (en) * | 2009-03-26 | 2012-04-05 | Clarke Robert W | Calcium citrate and calcium lactate formulations for alteration of biophysical properties of mucosal lining |
| DK2315580T3 (da) | 2009-03-26 | 2012-04-10 | Pulmatrix Inc | Farmaceutiske formuleringer og fremgangsmåder til behandling af luftvejsinfektioner |
| PT2410981T (pt) | 2009-03-26 | 2017-05-25 | Pulmatrix Inc | Formulações em pó seco e métodos para tratar doenças pulmonares |
| GB0918450D0 (en) | 2009-10-21 | 2009-12-09 | Innovata Ltd | Composition |
| AU2011296343B2 (en) | 2010-08-30 | 2015-12-10 | Pulmatrix Operating Company, Inc. | Dry powder formulations and methods for treating pulmonary diseases |
| US20130164338A1 (en) | 2010-08-30 | 2013-06-27 | Pulmatrix, Inc. | Treatment of cystic fibrosis using calcium lactate, leucine and sodium chloride in a respiraple dry powder |
| PT106094A (pt) | 2012-01-13 | 2013-07-15 | Hovione Farmaciencia S A | Administração por inalação de formulações com dose elevada |
-
2011
- 2011-08-26 AU AU2011296343A patent/AU2011296343B2/en active Active
- 2011-08-26 CA CA2809666A patent/CA2809666C/en active Active
- 2011-08-26 US US13/817,963 patent/US9061352B2/en active Active
- 2011-08-26 EP EP11751775.5A patent/EP2611438B1/en active Active
- 2011-08-26 WO PCT/US2011/049435 patent/WO2012030664A1/en not_active Ceased
- 2011-08-26 CN CN201610054941.2A patent/CN105640925B/zh active Active
- 2011-08-26 JP JP2013527146A patent/JP5877201B2/ja active Active
- 2011-08-26 CN CN201180052479.8A patent/CN103200938B/zh not_active Expired - Fee Related
-
2015
- 2015-05-20 US US14/717,243 patent/US9233158B2/en active Active
-
2017
- 2017-09-29 US US15/720,445 patent/US20180153996A1/en not_active Abandoned
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