JP2011520911A5 - - Google Patents

Download PDF

Info

Publication number
JP2011520911A5
JP2011520911A5 JP2011509733A JP2011509733A JP2011520911A5 JP 2011520911 A5 JP2011520911 A5 JP 2011520911A5 JP 2011509733 A JP2011509733 A JP 2011509733A JP 2011509733 A JP2011509733 A JP 2011509733A JP 2011520911 A5 JP2011520911 A5 JP 2011520911A5
Authority
JP
Japan
Prior art keywords
composition
betaine
administered
fluoroquinolone
tobramycin
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP2011509733A
Other languages
English (en)
Japanese (ja)
Other versions
JP2011520911A (ja
JP5727927B2 (ja
Filing date
Publication date
Application filed filed Critical
Priority claimed from PCT/US2009/044116 external-priority patent/WO2009140587A1/en
Publication of JP2011520911A publication Critical patent/JP2011520911A/ja
Publication of JP2011520911A5 publication Critical patent/JP2011520911A5/ja
Application granted granted Critical
Publication of JP5727927B2 publication Critical patent/JP5727927B2/ja
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

JP2011509733A 2008-05-15 2009-05-15 フルオロキノロンの肺送達 Active JP5727927B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US12778008P 2008-05-15 2008-05-15
US61/127,780 2008-05-15
PCT/US2009/044116 WO2009140587A1 (en) 2008-05-15 2009-05-15 Pulmonary delivery of a fluoroquinolone

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2014251869A Division JP5989750B2 (ja) 2008-05-15 2014-12-12 フルオロキノロンの肺送達

Publications (3)

Publication Number Publication Date
JP2011520911A JP2011520911A (ja) 2011-07-21
JP2011520911A5 true JP2011520911A5 (enExample) 2012-07-05
JP5727927B2 JP5727927B2 (ja) 2015-06-03

Family

ID=41099304

Family Applications (2)

Application Number Title Priority Date Filing Date
JP2011509733A Active JP5727927B2 (ja) 2008-05-15 2009-05-15 フルオロキノロンの肺送達
JP2014251869A Expired - Fee Related JP5989750B2 (ja) 2008-05-15 2014-12-12 フルオロキノロンの肺送達

Family Applications After (1)

Application Number Title Priority Date Filing Date
JP2014251869A Expired - Fee Related JP5989750B2 (ja) 2008-05-15 2014-12-12 フルオロキノロンの肺送達

Country Status (11)

Country Link
US (3) US8834930B2 (enExample)
EP (1) EP2285345A1 (enExample)
JP (2) JP5727927B2 (enExample)
KR (1) KR101621986B1 (enExample)
CN (1) CN102099009B (enExample)
AU (1) AU2009246217B2 (enExample)
BR (1) BRPI0913021A2 (enExample)
CA (1) CA2724009C (enExample)
MX (1) MX2010012452A (enExample)
RU (1) RU2497524C2 (enExample)
WO (1) WO2009140587A1 (enExample)

Families Citing this family (49)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9006175B2 (en) 1999-06-29 2015-04-14 Mannkind Corporation Potentiation of glucose elimination
WO2003080149A2 (en) 2002-03-20 2003-10-02 Mannkind Corporation Inhalation apparatus
ATE486064T1 (de) 2004-08-20 2010-11-15 Mannkind Corp Katalyse der diketopiperazinsynthese
HUE025151T2 (en) 2004-08-23 2016-01-28 Mannkind Corp Diceto-piperazine salts for drug delivery
US8524735B2 (en) 2005-05-18 2013-09-03 Mpex Pharmaceuticals, Inc. Aerosolized fluoroquinolones and uses thereof
KR101486397B1 (ko) 2005-09-14 2015-01-28 맨카인드 코포레이션 활성제에 대한 결정질 미립자 표면의 친화력의 증가를 기반으로 하는 약물 제제화의 방법
KR20080096809A (ko) 2006-02-22 2008-11-03 맨카인드 코포레이션 디케토피페라진 및 활성제를 포함하는 마이크로입자의 약학특성의 개선 방법
DK2230934T3 (da) 2007-12-14 2012-11-26 Aerodesigns Inc Afgivelse af aerosoliserbare næringsmiddelprodukter
US8485180B2 (en) 2008-06-13 2013-07-16 Mannkind Corporation Dry powder drug delivery system
ES2929343T3 (es) 2008-06-13 2022-11-28 Mannkind Corp Inhalador de polvo seco accionado por aspiración para la administración de fármacos
MX2010014240A (es) 2008-06-20 2011-03-25 Mankind Corp Un metodo y aparato interactivo para perfilar en tiempo real esfuerzos de inhalacion.
TWI494123B (zh) 2008-08-11 2015-08-01 Mannkind Corp 超快起作用胰島素之用途
CA2739893C (en) 2008-10-07 2016-10-04 Mpex Pharmaceuticals, Inc. Inhalation of levofloxacin for reducing lung inflammation
CA2739897C (en) 2008-10-07 2017-10-03 Mpex Pharmaceuticals, Inc. Aerosol fluoroquinolone formulations for improved pharmacokinetics
US8314106B2 (en) 2008-12-29 2012-11-20 Mannkind Corporation Substituted diketopiperazine analogs for use as drug delivery agents
WO2010105094A1 (en) 2009-03-11 2010-09-16 Mannkind Corporation Apparatus, system and method for measuring resistance of an inhaler
ES2625260T5 (es) 2009-03-26 2020-07-29 Pulmatrix Operating Co Inc Formulaciones de polvo seco y métodos para el tratamiento de enfermedades pulmonares
MX339077B (es) 2009-04-24 2016-05-10 Mpex Pharmaceuticals Inc Metodos para tratar una infeccion bacteriana pulmonar utilizando fluoro-quinolonas.
MY157166A (en) 2009-06-12 2016-05-13 Mankind Corp Diketopiperazine microparticles with defined specific surface areas
SI2473170T1 (sl) 2009-09-04 2019-10-30 Horizon Orphan Llc Uporaba aerosoliziranega levofloksacina za zdravljenje cistične fibroze
WO2011056889A1 (en) 2009-11-03 2011-05-12 Mannkind Corporation An apparatus and method for simulating inhalation efforts
BR112012033060A2 (pt) 2010-06-21 2018-02-27 Mannkind Corp métodos de sistema de liberação de fármaco em pó seco
EP2611438B1 (en) 2010-08-30 2020-04-01 Pulmatrix Operating Company, Inc. Dry powder formulations and methods for treating pulmonary diseases
JP5877204B2 (ja) 2010-09-29 2016-03-02 パルマトリックス，インコーポレイテッド 吸入用の一価金属カチオン乾燥粉末
DK2621488T3 (en) * 2010-09-29 2019-03-04 Pulmatrix Operating Co Inc CATIONIC DRY POWDER
AU2012236150B2 (en) 2011-04-01 2016-03-31 Mannkind Corporation Blister package for pharmaceutical cartridges
WO2012174472A1 (en) 2011-06-17 2012-12-20 Mannkind Corporation High capacity diketopiperazine microparticles
BR112014009686A2 (pt) 2011-10-24 2018-08-07 Mannkind Corp composição analgésica inalável, pó seco e método para tratar dor
EP2790761B1 (en) * 2011-12-16 2022-05-11 Novartis AG Passive powder aerosolization apparatus
CN107596518B (zh) 2012-02-29 2021-04-23 普马特里克斯营业公司 可吸入干粉剂
AU2013289957B2 (en) 2012-07-12 2017-02-23 Mannkind Corporation Dry powder drug delivery systems and methods
WO2014066856A1 (en) 2012-10-26 2014-05-01 Mannkind Corporation Inhalable influenza vaccine compositions and methods
US9757529B2 (en) * 2012-12-20 2017-09-12 Otitopic Inc. Dry powder inhaler and methods of use
US9452139B2 (en) 2013-03-14 2016-09-27 Novartis Ag Respirable agglomerates of porous carrier particles and micronized drug
KR102246914B1 (ko) 2013-03-15 2021-04-30 맨카인드 코포레이션 미세결정성 디케토피페라진 조성물 및 방법
WO2014165303A1 (en) 2013-04-01 2014-10-09 Pulmatrix, Inc. Tiotropium dry powders
CN114848614A (zh) 2013-07-18 2022-08-05 曼金德公司 热稳定性干粉药物组合物和方法
EP3030294B1 (en) 2013-08-05 2020-10-07 MannKind Corporation Insufflation apparatus
US10194693B2 (en) * 2013-09-20 2019-02-05 Fontem Holdings 1 B.V. Aerosol generating device
US9427376B2 (en) * 2013-10-10 2016-08-30 Chiesi Farmaceutici S.P.A. Process for preparing pharmaceutical formulations for inhalation comprising a high-dosage strength active ingredient
CA2940560A1 (en) * 2014-02-28 2015-09-03 Algipharma As Use of alginate oligomers in the treatment of cystic fibrosis and other conditions associated with defective cftr ion channel function
US10307464B2 (en) 2014-03-28 2019-06-04 Mannkind Corporation Use of ultrarapid acting insulin
CN107072944B (zh) * 2014-04-08 2021-11-02 阿拉迪姆公司 具有抗非结核分枝杆菌活性的脂质体环丙沙星制剂
EP3191162B1 (en) * 2014-09-10 2022-02-23 Fontem Holdings 1 B.V. Methods and devices for modulating air flow in delivery devices
US10561806B2 (en) 2014-10-02 2020-02-18 Mannkind Corporation Mouthpiece cover for an inhaler
EP3247235B1 (en) 2015-01-22 2020-09-02 Fontem Holdings 1 B.V. Electronic vaporization devices
RU2731212C2 (ru) * 2015-09-09 2020-08-31 Новартис Аг Направленная доставка высушенных распылением композиций в легкие
WO2020163416A1 (en) * 2019-02-05 2020-08-13 Mylan Inc Devices and methods for tobramycin inhalation treatment
WO2024233921A1 (en) * 2023-05-10 2024-11-14 Cornell University Compositions for the transtympanic delivery of antibiotics and methods for using the same

Family Cites Families (64)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4069819A (en) 1973-04-13 1978-01-24 Societa Farmaceutici S.P.A. Inhalation device
IT1016489B (it) 1974-03-18 1977-05-30 Isf Spa Inalatore
SE408265B (sv) 1975-12-12 1979-06-05 Draco Ab Anordning for koldioxiddriven endosaerosol, avsedd for inhalering
US4247066A (en) 1978-02-21 1981-01-27 General Dynamics Corporation Airfoil variable cambering device and method
IT1116047B (it) 1979-04-27 1986-02-10 Sigma Tau Ind Farmaceuti Dispositivo per la rapida inalazione di farmaci in polvere da parte di persone sofferenti di asma
DE3634952A1 (de) 1986-10-14 1988-04-21 Bayer Ag Imidazo-pyrrolo-pyridin-derivate
IT1228459B (it) 1989-02-23 1991-06-19 Phidea S R L Inalatore con svuotamento regolare e completo della capsula.
DE69230613T2 (de) 1991-07-02 2000-12-28 Inhale Inc Verfahren und vorrichtung zum abgeben von medikamenten in aerosolform
US6582728B1 (en) 1992-07-08 2003-06-24 Inhale Therapeutic Systems, Inc. Spray drying of macromolecules to produce inhaleable dry powders
US5785049A (en) 1994-09-21 1998-07-28 Inhale Therapeutic Systems Method and apparatus for dispersion of dry powder medicaments
GB9313642D0 (en) 1993-07-01 1993-08-18 Glaxo Group Ltd Method and apparatus for the formation of particles
US6051256A (en) * 1994-03-07 2000-04-18 Inhale Therapeutic Systems Dispersible macromolecule compositions and methods for their preparation and use
GB9413202D0 (en) 1994-06-30 1994-08-24 Univ Bradford Method and apparatus for the formation of particles
JP3388896B2 (ja) 1994-08-08 2003-03-24 株式会社日立ユニシアオートモティブ 吸入式投薬器
US5508269A (en) 1994-10-19 1996-04-16 Pathogenesis Corporation Aminoglycoside formulation for aerosolization
DE4440337A1 (de) 1994-11-11 1996-05-15 Dds Drug Delivery Services Ges Pharmazeutische Nanosuspensionen zur Arzneistoffapplikation als Systeme mit erhöhter Sättigungslöslichkeit und Lösungsgeschwindigkeit
KR19980703876A (ko) 1995-04-14 1998-12-05 스티븐 엘. 허스트 분산성이 개선된 분말화된 약학적 조성물
US5985309A (en) 1996-05-24 1999-11-16 Massachusetts Institute Of Technology Preparation of particles for inhalation
US6503480B1 (en) 1997-05-23 2003-01-07 Massachusetts Institute Of Technology Aerodynamically light particles for pulmonary drug delivery
US5874064A (en) 1996-05-24 1999-02-23 Massachusetts Institute Of Technology Aerodynamically light particles for pulmonary drug delivery
US5855913A (en) 1997-01-16 1999-01-05 Massachusetts Instite Of Technology Particles incorporating surfactants for pulmonary drug delivery
JP2001507701A (ja) 1996-12-31 2001-06-12 インヘイル・セラピューティック・システムズ・インコーポレーテッド 親水性賦形剤を有する疎水性薬剤の溶液を噴霧乾燥するための方法及びその方法によって作製された組成物
GB9703673D0 (en) 1997-02-21 1997-04-09 Bradford Particle Design Ltd Method and apparatus for the formation of particles
US5940778A (en) 1997-07-31 1999-08-17 Bp Amoco Corporation Method of seismic attribute generation and seismic exploration
ATE239447T1 (de) 1997-09-29 2003-05-15 Inhale Therapeutic Syst In verneblern verwendbare, stabilisierte zubereitungen
US20020017295A1 (en) 2000-07-07 2002-02-14 Weers Jeffry G. Phospholipid-based powders for inhalation
US6565885B1 (en) * 1997-09-29 2003-05-20 Inhale Therapeutic Systems, Inc. Methods of spray drying pharmaceutical compositions
US20060165606A1 (en) 1997-09-29 2006-07-27 Nektar Therapeutics Pulmonary delivery particles comprising water insoluble or crystalline active agents
WO1999016420A1 (en) 1997-09-29 1999-04-08 Inhale Therapeutic Systems, Inc. Stabilized preparations for use in nebulizers
US6257233B1 (en) 1998-06-04 2001-07-10 Inhale Therapeutic Systems Dry powder dispersing apparatus and methods for their use
DE19835346A1 (de) 1998-08-05 2000-02-10 Boehringer Ingelheim Pharma Zweiteilige Kapsel zur Aufnahme von pharmazeutischen Zubereitungen für Pulverinhalatoren
US6630169B1 (en) 1999-03-31 2003-10-07 Nektar Therapeutics Particulate delivery systems and methods of use
MXPA01012246A (es) 1999-05-28 2002-08-12 Inhale Therapeutic Syst Aparato y metodo para distribuir una cantidad medida de medicamento en aerosol.
US20020103165A1 (en) 2000-02-29 2002-08-01 Alliance Pharmaceutical Corp., Engineered spray-dried lipid-based microparticles for cellular targeting
US7871598B1 (en) 2000-05-10 2011-01-18 Novartis Ag Stable metal ion-lipid powdered pharmaceutical compositions for drug delivery and methods of use
WO2001085136A2 (en) 2000-05-10 2001-11-15 Alliance Pharmaceutical Corporation Phospholipid-based powders for drug delivery
WO2002009674A2 (en) 2000-07-28 2002-02-07 Inhale Therapeutic Systems, Inc. Methods and compositions to upregulate, redirect or limit immune responses to bioactive compounds
US6357490B1 (en) 2000-08-22 2002-03-19 Advanced Inhalation Research, Inc. System, method and apparatus for filling containers
CA2432319A1 (en) 2000-12-21 2002-07-18 Nektar Therapeutics Pulmonary delivery of polyene antifungal agents
US6766799B2 (en) 2001-04-16 2004-07-27 Advanced Inhalation Research, Inc. Inhalation device
JP2004528339A (ja) 2001-04-26 2004-09-16 ネクター セラピューティクス 気道に対して又は気道を介して高分子を送達するための新規方法及び組成物
JP4437040B2 (ja) 2001-11-14 2010-03-24 ネクター セラピューティクス 接続可能な本体およびエンドピースを備えるエーロゾル化装置
WO2003041777A1 (en) 2001-11-14 2003-05-22 Nektar Therapeutics Aerosolization device with improved endpiece connection
JP4739672B2 (ja) 2001-12-21 2011-08-03 ネクター セラピューティクス 湿気のバリアを有するカプセルパッケージ
US7754242B2 (en) * 2002-03-20 2010-07-13 Alkermes, Inc. Inhalable sustained therapeutic formulations
JP2005530765A (ja) * 2002-05-07 2005-10-13 ネクター セラピューティクス 乾燥粉末吸入器のためのカプセル及びそれを製造及び使用する方法
US7516741B2 (en) 2002-12-06 2009-04-14 Novartis Ag Aerosolization apparatus with feedback mechanism
US20040206350A1 (en) 2002-12-19 2004-10-21 Nektar Therapeutics Aerosolization apparatus with non-circular aerosolization chamber
EP1589947B2 (en) 2002-12-31 2019-01-30 Novartis AG Pharmaceutical formulation with an insoluble active agent for pulmonary administration
DE10305318A1 (de) * 2003-02-10 2004-08-19 Bayer Healthcare Ag Behandlung bakteriell verursachter Lungenkrankheiten
DE10305319A1 (de) * 2003-02-10 2004-08-26 Bayer Healthcare Ag Behandlung bakteriell verursachter Lungenkrankheiten
JP4828405B2 (ja) * 2003-02-10 2011-11-30 バイエル・シェーリング・ファルマ・アクチェンゲゼルシャフト 呼吸器官の細菌性疾患の処置
EP1615689B1 (en) 2003-04-09 2016-02-03 Novartis AG Aerosolization apparatus with capsule puncture alignment guide
DK1610850T3 (da) 2003-04-09 2012-06-25 Novartis Ag Aerosolapparat med luftindløbsskærm
US20050214224A1 (en) 2003-11-04 2005-09-29 Nektar Therapeutics Lipid formulations for spontaneous drug encapsulation
WO2006002178A1 (en) 2004-06-18 2006-01-05 Novartis Vaccines And Diagnostics Inc. Methods of treatment of endobronchial infections
EP1773301A2 (en) 2004-06-21 2007-04-18 Nektar Therapeutics Compositions comprising amphotericinb methods and systems
WO2006033713A2 (en) 2004-08-09 2006-03-30 Chiron Corporation Methods for ciprofloxacin inhalation
TWI254288B (en) * 2004-09-30 2006-05-01 Benq Corp Optical disk drive with mechanism of protecting pick-up head
MX359219B (es) 2005-05-18 2018-09-19 Raptor Pharmaceuticals Inc Fluoroquinolonas aerosolizadas y sus usos.
US20060280691A1 (en) * 2005-06-13 2006-12-14 University Of Alberta Spray freeze dried liposomal ciprofloxacin powder aerosol drug delivery
US7947308B2 (en) 2005-07-20 2011-05-24 Raimar Loebenberg Effervescent powders for inhalation
US7256576B2 (en) 2005-07-29 2007-08-14 General Electric Company ID-OD discrimination sensor
DE102005036921A1 (de) 2005-08-05 2007-02-08 Bayerische Motoren Werke Ag Pulsationsminderer für hydraulische Systeme

Similar Documents

Publication Publication Date Title
JP2011520911A5 (enExample)
AU2025204271A1 (en) Microcrystalline diketopiperazine compositions and methods
NZ585856A (en) Inhalation composition containing aclidinium for treatment of asthma and chronic obstructive pulmonary disease
RU2010150839A (ru) Внутрилегочное введения флуорохинолона
JP2009269923A5 (enExample)
NZ585857A (en) Inhalation composition containing aclidinium for treatment of asthma and chronic obstructive pulmonary disease
JP6099609B2 (ja) 肺炎症を低減するためのレボフロキサシンの吸入
JP2013224331A5 (enExample)
JP2016040316A5 (enExample)
JP2013542940A5 (enExample)
JP2019517597A5 (enExample)
JP2012522009A (ja) 肺炎および人工呼吸器関連気管気管支炎を治療および予防するための方法
JP2013536845A5 (enExample)
JP2007520506A5 (enExample)
RU2010121827A (ru) Композиции для лечения болезни паркинсона
NZ606548A (en) Dry powder formulation comprising a phosphodiesterase inhibitor
JP2015519356A5 (enExample)
UA107499C2 (uk) Склад сухого порошку, який містить антимускариновий засіб
RU2013119938A (ru) Фармацевтическая композиция
HK1203149A1 (en) Novel dosage form and formulation of abediterol
JP2014514271A5 (enExample)
WO2006008517A3 (en) Use of dry powder compositions for pulmonary delivery
RU2008124825A (ru) Органические соединения, включающие соль гликопиррония
JP5501451B2 (ja) 咳の治療のためのテオブロミン
JP2011500731A5 (enExample)