JP2013542940A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2013542940A5 JP2013542940A5 JP2013533267A JP2013533267A JP2013542940A5 JP 2013542940 A5 JP2013542940 A5 JP 2013542940A5 JP 2013533267 A JP2013533267 A JP 2013533267A JP 2013533267 A JP2013533267 A JP 2013533267A JP 2013542940 A5 JP2013542940 A5 JP 2013542940A5
- Authority
- JP
- Japan
- Prior art keywords
- fluticasone
- optionally
- pharmaceutical composition
- indacaterol
- ciclesonide
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000008194 pharmaceutical composition Substances 0.000 claims 19
- 229960002714 fluticasone Drugs 0.000 claims 15
- MGNNYOODZCAHBA-GQKYHHCASA-N fluticasone Chemical compound C1([C@@H](F)C2)=CC(=O)C=C[C@]1(C)[C@]1(F)[C@@H]2[C@@H]2C[C@@H](C)[C@@](C(=O)SCF)(O)[C@@]2(C)C[C@@H]1O MGNNYOODZCAHBA-GQKYHHCASA-N 0.000 claims 15
- 229960004078 indacaterol Drugs 0.000 claims 14
- QZZUEBNBZAPZLX-QFIPXVFZSA-N indacaterol Chemical compound N1C(=O)C=CC2=C1C(O)=CC=C2[C@@H](O)CNC1CC(C=C(C(=C2)CC)CC)=C2C1 QZZUEBNBZAPZLX-QFIPXVFZSA-N 0.000 claims 14
- LUKZNWIVRBCLON-GXOBDPJESA-N Ciclesonide Chemical compound C1([C@H]2O[C@@]3([C@H](O2)C[C@@H]2[C@@]3(C[C@H](O)[C@@H]3[C@@]4(C)C=CC(=O)C=C4CC[C@H]32)C)C(=O)COC(=O)C(C)C)CCCCC1 LUKZNWIVRBCLON-GXOBDPJESA-N 0.000 claims 10
- 229960003728 ciclesonide Drugs 0.000 claims 10
- 229960002848 formoterol Drugs 0.000 claims 8
- BPZSYCZIITTYBL-UHFFFAOYSA-N formoterol Chemical compound C1=CC(OC)=CC=C1CC(C)NCC(O)C1=CC=C(O)C(NC=O)=C1 BPZSYCZIITTYBL-UHFFFAOYSA-N 0.000 claims 8
- 239000000203 mixture Substances 0.000 claims 8
- 239000000546 pharmaceutical excipient Substances 0.000 claims 8
- 239000003246 corticosteroid Substances 0.000 claims 7
- 239000003814 drug Substances 0.000 claims 7
- 238000004519 manufacturing process Methods 0.000 claims 7
- 229940110309 tiotropium Drugs 0.000 claims 6
- LERNTVKEWCAPOY-DZZGSBJMSA-N tiotropium Chemical group O([C@H]1C[C@@H]2[N+]([C@H](C1)[C@@H]1[C@H]2O1)(C)C)C(=O)C(O)(C=1SC=CC=1)C1=CC=CS1 LERNTVKEWCAPOY-DZZGSBJMSA-N 0.000 claims 6
- 230000002757 inflammatory effect Effects 0.000 claims 5
- 230000000414 obstructive effect Effects 0.000 claims 5
- 230000002265 prevention Effects 0.000 claims 5
- 230000000241 respiratory effect Effects 0.000 claims 5
- 208000023504 respiratory system disease Diseases 0.000 claims 5
- 239000000556 agonist Substances 0.000 claims 4
- 229940079593 drug Drugs 0.000 claims 4
- XTULMSXFIHGYFS-VLSRWLAYSA-N fluticasone furoate Chemical compound O([C@]1([C@@]2(C)C[C@H](O)[C@]3(F)[C@@]4(C)C=CC(=O)C=C4[C@@H](F)C[C@H]3[C@@H]2C[C@H]1C)C(=O)SCF)C(=O)C1=CC=CO1 XTULMSXFIHGYFS-VLSRWLAYSA-N 0.000 claims 4
- 239000000812 cholinergic antagonist Substances 0.000 claims 3
- 229940071648 metered dose inhaler Drugs 0.000 claims 3
- 229940121948 Muscarinic receptor antagonist Drugs 0.000 claims 2
- 230000001078 anti-cholinergic effect Effects 0.000 claims 2
- 229940021593 formoterol and fluticasone Drugs 0.000 claims 2
- 238000009472 formulation Methods 0.000 claims 2
- 239000000843 powder Substances 0.000 claims 2
- LERNTVKEWCAPOY-VOGVJGKGSA-N C[N+]1(C)[C@H]2C[C@H](C[C@@H]1[C@H]1O[C@@H]21)OC(=O)C(O)(c1cccs1)c1cccs1 Chemical compound C[N+]1(C)[C@H]2C[C@H](C[C@@H]1[C@H]1O[C@@H]21)OC(=O)C(O)(c1cccs1)c1cccs1 LERNTVKEWCAPOY-VOGVJGKGSA-N 0.000 claims 1
- 239000003963 antioxidant agent Substances 0.000 claims 1
- 230000003078 antioxidant effect Effects 0.000 claims 1
- 208000006673 asthma Diseases 0.000 claims 1
- 239000006172 buffering agent Substances 0.000 claims 1
- 150000001720 carbohydrates Chemical class 0.000 claims 1
- 239000008139 complexing agent Substances 0.000 claims 1
- ALEXXDVDDISNDU-JZYPGELDSA-N cortisol 21-acetate Chemical compound C1CC2=CC(=O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@@](C(=O)COC(=O)C)(O)[C@@]1(C)C[C@@H]2O ALEXXDVDDISNDU-JZYPGELDSA-N 0.000 claims 1
- 239000006184 cosolvent Substances 0.000 claims 1
- 201000010099 disease Diseases 0.000 claims 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 150000002148 esters Chemical class 0.000 claims 1
- 239000000945 filler Substances 0.000 claims 1
- 229960001469 fluticasone furoate Drugs 0.000 claims 1
- 229960004735 indacaterol maleate Drugs 0.000 claims 1
- IREJFXIHXRZFER-PCBAQXHCSA-N indacaterol maleate Chemical compound OC(=O)\C=C/C(O)=O.N1C(=O)C=CC2=C1C(O)=CC=C2[C@@H](O)CNC1CC(C=C(C(=C2)CC)CC)=C2C1 IREJFXIHXRZFER-PCBAQXHCSA-N 0.000 claims 1
- 239000000314 lubricant Substances 0.000 claims 1
- 238000000034 method Methods 0.000 claims 1
- 239000002357 osmotic agent Substances 0.000 claims 1
- 239000003002 pH adjusting agent Substances 0.000 claims 1
- 239000003380 propellant Substances 0.000 claims 1
- 150000005846 sugar alcohols Chemical class 0.000 claims 1
- 239000004094 surface-active agent Substances 0.000 claims 1
- 239000000725 suspension Substances 0.000 claims 1
- 229960000257 tiotropium bromide Drugs 0.000 claims 1
- 239000003981 vehicle Substances 0.000 claims 1
- 239000000080 wetting agent Substances 0.000 claims 1
Applications Claiming Priority (11)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IN2847/MUM/2010 | 2010-10-12 | ||
| IN2847MU2010 | 2010-10-12 | ||
| IN69MU2011 | 2011-01-10 | ||
| IN69/MUM/2011 | 2011-01-10 | ||
| IN106/MUM/2011 | 2011-01-12 | ||
| IN106MU2011 | 2011-01-12 | ||
| IN135/MUM/2011 | 2011-01-14 | ||
| IN135MU2011 | 2011-01-14 | ||
| IN143MU2011 | 2011-01-17 | ||
| IN143/MUM/2011 | 2011-01-17 | ||
| PCT/GB2011/001115 WO2012049444A1 (en) | 2010-10-12 | 2011-07-25 | Pharmaceutical composition |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016197697A Division JP2017039746A (ja) | 2010-10-12 | 2016-10-06 | 医薬組成物 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2013542940A JP2013542940A (ja) | 2013-11-28 |
| JP2013542940A5 true JP2013542940A5 (enExample) | 2014-09-11 |
Family
ID=44651863
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013533267A Pending JP2013542940A (ja) | 2010-10-12 | 2011-07-25 | 医薬組成物 |
| JP2016197697A Pending JP2017039746A (ja) | 2010-10-12 | 2016-10-06 | 医薬組成物 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016197697A Pending JP2017039746A (ja) | 2010-10-12 | 2016-10-06 | 医薬組成物 |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US10179139B2 (enExample) |
| EP (1) | EP2627325A1 (enExample) |
| JP (2) | JP2013542940A (enExample) |
| KR (2) | KR20180028563A (enExample) |
| CN (2) | CN107998109A (enExample) |
| AU (1) | AU2011315315B2 (enExample) |
| BR (1) | BR112013008974A2 (enExample) |
| CA (1) | CA2814445A1 (enExample) |
| MX (1) | MX2013004137A (enExample) |
| NZ (1) | NZ609358A (enExample) |
| RU (1) | RU2642624C2 (enExample) |
| WO (1) | WO2012049444A1 (enExample) |
Families Citing this family (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MX2013000642A (es) | 2010-07-16 | 2013-04-03 | Cipla Ltd | Composiciones farmaceuticas. |
| KR20180028563A (ko) | 2010-10-12 | 2018-03-16 | 시플라 리미티드 | 약학 조성물 |
| CN103784420A (zh) * | 2014-02-18 | 2014-05-14 | 青岛市城阳区人民医院 | 马来酸茚达特罗液体制剂及其制备方法 |
| US20170189329A1 (en) | 2014-07-29 | 2017-07-06 | 3M Innovative Properties Company | Method of preparing a pharmaceutical composition |
| BR112017023351B1 (pt) * | 2015-05-01 | 2023-11-28 | Board Of Regents, The University Of Texas System | Composição farmacêutica e uso da composição farmacêutica |
| EP3297607B1 (en) * | 2015-05-18 | 2020-07-22 | Glenmark Specialty S.A. | Tiotropium inhalation solution for nebulization |
| CN109789131B (zh) * | 2016-09-19 | 2022-08-26 | 墨西哥氟石股份公司 | 药物组合物 |
| MY210122A (en) * | 2016-09-19 | 2025-08-28 | Mexichem Fluor Sa De Cv | Pharmaceutical composition |
| GB2554090A (en) * | 2016-09-19 | 2018-03-28 | Mexichem Fluor Sa De Cv | Pharmaceutical compound |
| TR201712424A2 (tr) * | 2017-08-21 | 2019-03-21 | Arven Ilac Sanayi Ve Ticaret Anonim Sirketi | Kuru toz i̇nhalasyon bi̇leşi̇mleri̇ |
| WO2019142214A1 (en) * | 2018-01-19 | 2019-07-25 | Cipla Limited | Pharmaceutical composition comprising tiotropium for inhalation |
| US20210385101A1 (en) | 2018-01-24 | 2021-12-09 | Sony Corporation | Information processing apparatus and information processing method |
| WO2019236559A1 (en) * | 2018-06-04 | 2019-12-12 | Lupin Inc. | Stable pharmaceutical compositions for pressurized metered dose inhalers |
| WO2020105012A1 (en) * | 2018-11-22 | 2020-05-28 | Glenmark Specialty S.A. | Sterile compositions of indacaterol suitable for nebulization |
| WO2020141472A1 (en) * | 2019-01-03 | 2020-07-09 | Glenmark Specialty S.A. | Nebulization composition comprising tiotropium and indacaterol |
| CN115337292A (zh) * | 2019-10-11 | 2022-11-15 | 四川海思科制药有限公司 | 一种吸入溶液药物组合物及其制备方法 |
| CN110840864B (zh) * | 2019-12-20 | 2022-02-22 | 广州健康元呼吸药物工程技术有限公司 | 一种β2受体激动剂吸入气雾剂及包含该吸入气雾剂的产品 |
| CN111467498A (zh) * | 2020-05-14 | 2020-07-31 | 王兆霖 | 药物组合物制剂 |
| EP4221707A4 (en) * | 2020-09-29 | 2024-08-28 | Aerorx Therapeutics LLC | Liquid formulations of indacaterol |
| IL320125A (en) | 2022-11-03 | 2025-06-01 | Dana Farber Cancer Inst Inc | Methods for treating anemia using formoterol or its pharmaceutical salt |
Family Cites Families (40)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SE9700135D0 (sv) | 1997-01-20 | 1997-01-20 | Astra Ab | New formulation |
| US6120752A (en) * | 1997-05-21 | 2000-09-19 | 3M Innovative Properties Company | Medicinal aerosol products containing formulations of ciclesonide and related steroids |
| US5879715A (en) | 1997-09-02 | 1999-03-09 | Ceramem Corporation | Process and system for production of inorganic nanoparticles |
| GB9903759D0 (en) * | 1999-02-18 | 1999-04-14 | Novartis Ag | Organic compounds |
| GB9913083D0 (en) | 1999-06-04 | 1999-08-04 | Novartis Ag | Organic compounds |
| GB0009591D0 (en) | 2000-04-18 | 2000-06-07 | Glaxo Group Ltd | Medical combinations |
| US7011776B2 (en) | 2000-04-28 | 2006-03-14 | Tanabe Seiman Co., Ltd. | Method and apparatus for preparing microspheres |
| FI20002216A0 (fi) | 2000-10-06 | 2000-10-06 | Orion Yhtymae Oyj | Yhdistelmäpartikkelit astman hoitoon |
| GB0029562D0 (en) | 2000-12-04 | 2001-01-17 | Novartis Ag | Organic compounds |
| US20030055026A1 (en) | 2001-04-17 | 2003-03-20 | Dey L.P. | Formoterol/steroid bronchodilating compositions and methods of use thereof |
| DE10130371A1 (de) | 2001-06-23 | 2003-01-02 | Boehringer Ingelheim Pharma | Neue Arzneimittelkompositionen auf der Basis von Anticholinergika, Corticosteroiden und Betamimetika |
| ES2305438T5 (es) | 2002-02-04 | 2012-06-05 | Glaxo Group Limited | Formulación para inhalación que comprende un glucocorticoide y un agonista del ?2-adreno-receptor. |
| EP1531866A1 (en) * | 2002-08-29 | 2005-05-25 | Cipla Ltd. | Pharmaceutical products and compositions comprising specific anticholinergic agents, beta-2 agonists and corticosteroids |
| AU2003263717A1 (en) | 2002-09-25 | 2004-04-19 | Astrazeneca Ab | A COMBINATION OF A LONG-ACTING Beta2-AGONIST AND A GLUCOCORTICOSTEROID IN THE TREATMENT OF FIBROTIC DISEASES |
| ES2312844T3 (es) | 2002-12-12 | 2009-03-01 | Nycomed Gmbh | Medicamento de combinacion de r, r-formoterol y ciclesonida. |
| US6962006B2 (en) | 2002-12-19 | 2005-11-08 | Acusphere, Inc. | Methods and apparatus for making particles using spray dryer and in-line jet mill |
| AU2004246819A1 (en) | 2003-06-13 | 2004-12-23 | Nycomed Gmbh | Formoterol and ciclesonide combination |
| SE527190C2 (sv) | 2003-06-19 | 2006-01-17 | Microdrug Ag | Inhalatoranordning samt kombinerade doser av en beta2-agonist, ett antikolinergiskt medel och ett antiinflammatorisk steroid |
| SE527200C2 (sv) | 2003-06-19 | 2006-01-17 | Microdrug Ag | Inhalatoranordning samt kombinerade doser av formaterol och fluticason |
| WO2005053851A1 (en) | 2003-11-26 | 2005-06-16 | E.I. Dupont De Nemours And Company | High pressure media milling system and process of milling particles |
| US20060008498A1 (en) | 2004-07-12 | 2006-01-12 | Chen Tzer-Fen D | Nano-particle production |
| DE102004056578A1 (de) | 2004-11-23 | 2006-05-24 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Inhalative Arzneimittel enthaltend ein neues Anticholinergikum, Formoterol und ein Steroid |
| CN101102740A (zh) | 2005-01-07 | 2008-01-09 | 卫材R&D管理有限公司 | 药用组合物以及其制备方法 |
| EP2484382A1 (en) * | 2005-03-30 | 2012-08-08 | Schering Corporation | Medicament comprising a phosphodiesterase IV inhibitor in an inhalable form |
| GB0511066D0 (en) * | 2005-05-31 | 2005-07-06 | Novartis Ag | Organic compounds |
| PL1971369T3 (pl) | 2005-12-21 | 2010-01-29 | Meda Pharma Gmbh & Co Kg | Połączenie R,R-glikopirolanu, rolipramu i budesonidu dla potrzeb leczenia chorób zapalnych |
| WO2008064357A2 (en) | 2006-11-22 | 2008-05-29 | University Of Florida Research Foundation, Inc. | Nanoparticles for protection of cells from oxidative stress |
| EP2124915A2 (en) | 2007-02-19 | 2009-12-02 | Cipla Limited | Pharmaceutical combinations of at least two bronchodilators or of a bronchodilator with a corticosteroid |
| TWI405590B (zh) | 2007-04-06 | 2013-08-21 | 活效製藥股份有限公司 | 微粉碎化有機化合物粒子之製法 |
| JP5109515B2 (ja) | 2007-07-17 | 2012-12-26 | 株式会社ジェイテクト | 摺動式トリポード形等速ジョイント |
| US20100329996A1 (en) * | 2007-09-12 | 2010-12-30 | Glaxo Group Limited | Novel Combination of Therapeutic Agents |
| DE102007054885A1 (de) | 2007-11-15 | 2009-05-20 | Evonik Degussa Gmbh | Verfahren zur Fraktionierung oxidischer Nanopartikel durch Querstrom-Membranfiltration |
| FR2929136B1 (fr) | 2008-03-25 | 2011-11-11 | Sprainnov | Procede et tete de pulverisation, procede et tour associes pour fabriquer un produit pulverulent |
| WO2010007447A1 (en) * | 2008-07-18 | 2010-01-21 | Prosonix Limited | Process for improving crystallinity |
| CN101474191B (zh) * | 2009-01-21 | 2011-03-23 | 李虎山 | 一种治疗哮喘和慢性阻塞性肺病的药物组合物 |
| US8668901B2 (en) * | 2009-02-04 | 2014-03-11 | Activaero Gmbh Research & Development | Use of a glucocorticoid composition for the treatment of severe and uncontrolled asthma |
| EP2221048A1 (en) | 2009-02-18 | 2010-08-25 | Siegfried Generics International AG | Pharmaceutical composition for inhalation |
| CA2759109A1 (en) | 2009-04-24 | 2010-10-28 | Iceutica Pty Ltd | A solid dosage form of ciprofloxacin having small particle size and improved powder handling characteristics |
| GB0918431D0 (en) | 2009-10-21 | 2009-12-09 | Prosonix Ltd | Process for improving crystallinity |
| KR20180028563A (ko) | 2010-10-12 | 2018-03-16 | 시플라 리미티드 | 약학 조성물 |
-
2011
- 2011-07-25 KR KR1020187006863A patent/KR20180028563A/ko not_active Ceased
- 2011-07-25 US US13/879,145 patent/US10179139B2/en active Active
- 2011-07-25 CN CN201711377918.8A patent/CN107998109A/zh active Pending
- 2011-07-25 NZ NZ60935811A patent/NZ609358A/en not_active IP Right Cessation
- 2011-07-25 JP JP2013533267A patent/JP2013542940A/ja active Pending
- 2011-07-25 KR KR1020137012107A patent/KR20140025308A/ko not_active Ceased
- 2011-07-25 WO PCT/GB2011/001115 patent/WO2012049444A1/en not_active Ceased
- 2011-07-25 AU AU2011315315A patent/AU2011315315B2/en not_active Ceased
- 2011-07-25 RU RU2013119938A patent/RU2642624C2/ru not_active IP Right Cessation
- 2011-07-25 EP EP11752315.9A patent/EP2627325A1/en not_active Ceased
- 2011-07-25 BR BR112013008974A patent/BR112013008974A2/pt not_active IP Right Cessation
- 2011-07-25 CN CN2011800597356A patent/CN103269694A/zh active Pending
- 2011-07-25 CA CA2814445A patent/CA2814445A1/en not_active Abandoned
- 2011-07-25 MX MX2013004137A patent/MX2013004137A/es unknown
-
2016
- 2016-10-06 JP JP2016197697A patent/JP2017039746A/ja active Pending
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| RU2013119938A (ru) | Фармацевтическая композиция | |
| RU2013142268A (ru) | Фармацевтическая композиция | |
| JP2018199684A5 (enExample) | ||
| JP2013531056A5 (enExample) | ||
| RU2013106866A (ru) | Фармацевтические композиции | |
| RU2019100425A (ru) | Новая доза и препаративная форма | |
| JP2006188534A (ja) | 抗コリン作用化合物及びβ−擬似剤に基づく新規医薬組成物 | |
| JP2011520911A5 (enExample) | ||
| HRP20191686T4 (hr) | Mikronizirane čestice aktivnih tvari za praškaste formulacije za inhalaciju u niskim dozama | |
| JP2015519356A5 (enExample) | ||
| JP2012517987A5 (ja) | 吸入用の医薬組成物のｆｐｄ特性を設定する方法 | |
| WO2014016548A2 (en) | Pharmaceutical composition | |
| JP2014514271A5 (enExample) | ||
| JP2019528316A5 (enExample) | ||
| JP2020023536A (ja) | Ｃｏｐｄの治療のためのフォルモテロール及びブデソニドの組み合わせ | |
| CN103476412B (zh) | 用于改善呼吸系统疾病患者睡眠质量的阿地铵 | |
| RU2014144145A (ru) | Фармацевтическая композиция, содержащая арформотерол и флутиказона фуроат | |
| NZ707754B2 (en) | Combination of glycopyrrolate and a beta2 -agonist | |
| TW201605440A (zh) | 阿地銨之新用途 | |
| JP2013001677A (ja) | 抗コリン作動薬を含む再発性多発軟骨炎を含む気管気管支軟化症の治療剤 |